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P14616

- INSRR_HUMAN

UniProt

P14616 - INSRR_HUMAN

Protein

Insulin receptor-related protein

Gene

INSRR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1013 – 10131ATPPROSITE-ProRule annotation
    Active sitei1115 – 11151Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi985 – 9939ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. cellular response to alkaline pH Source: UniProtKB
    3. male sex determination Source: Ensembl
    4. peptidyl-tyrosine phosphorylation Source: GOC
    5. protein autophosphorylation Source: UniProtKB
    6. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin receptor-related protein (EC:2.7.10.1)
    Short name:
    IRR
    Alternative name(s):
    IR-related receptor
    Cleaved into the following 2 chains:
    Gene namesi
    Name:INSRR
    Synonyms:IRR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6093. INSRR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. receptor complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1145 – 11462YY → FF: Abolishes autophosphorylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA29899.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 12971271Insulin receptor-related proteinPRO_0000016701Add
    BLAST
    Chaini27 – 742716Insulin receptor-related protein alpha chainCuratedPRO_0000016702Add
    BLAST
    Chaini747 – 1297551Insulin receptor-related protein beta chainCuratedPRO_0000016703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi214 ↔ 222By similarity
    Disulfide bondi216 ↔ 228By similarity
    Disulfide bondi229 ↔ 237By similarity
    Disulfide bondi233 ↔ 246By similarity
    Disulfide bondi249 ↔ 258By similarity
    Disulfide bondi262 ↔ 274By similarity
    Disulfide bondi280 ↔ 300By similarity
    Disulfide bondi304 ↔ 317By similarity
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 324By similarity
    Glycosylationi411 – 4111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi616 – 6161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi634 – 6341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi657 ↔ 864Interchain (between alpha and beta chains)Sequence Analysis
    Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi885 – 8851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi898 – 8981N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1145 – 11451Phosphotyrosine; by autocatalysisCurated
    Modified residuei1146 – 11461Phosphotyrosine; by autocatalysisCurated

    Post-translational modificationi

    Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP14616.
    PaxDbiP14616.
    PRIDEiP14616.

    PTM databases

    PhosphoSiteiP14616.

    Expressioni

    Gene expression databases

    ArrayExpressiP14616.
    BgeeiP14616.
    CleanExiHS_INSRR.
    GenevestigatoriP14616.

    Organism-specific databases

    HPAiHPA025285.

    Interactioni

    Subunit structurei

    Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.

    Protein-protein interaction databases

    BioGridi109856. 3 interactions.
    IntActiP14616. 1 interaction.
    STRINGi9606.ENSP00000357178.

    Structurei

    3D structure databases

    ProteinModelPortaliP14616.
    SMRiP14616. Positions 971-1262.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini747 – 921175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini944 – 1297354CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei922 – 94322HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini483 – 603121Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini607 – 707101Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini818 – 91396Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini979 – 1254276Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The extracellular domain is required for sensing alterations in external pH.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000038045.
    HOVERGENiHBG006134.
    InParanoidiP14616.
    KOiK05086.
    OMAiFARTMPH.
    OrthoDBiEOG73RB9N.
    PhylomeDBiP14616.
    TreeFamiTF351636.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR003961. Fibronectin_type3.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR028792. INSRR.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016246. Tyr_kinase_insulin-like_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PANTHERiPTHR24416:SF107. PTHR24416:SF107. 1 hit.
    PfamiPF00041. fn3. 1 hit.
    PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00261. FU. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 4 hits.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS50853. FN3. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14616-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPSLWPWG ACLPVIFLSL GFGLDTVEVC PSLDIRSEVA ELRQLENCSV     50
    VEGHLQILLM FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN 100
    LAVIRGTRLF LGYALVIFEM PHLRDVALPA LGAVLRGAVR VEKNQELCHL 150
    STIDWGLLQP APGANHIVGN KLGEECADVC PGVLGAAGEP CAKTTFSGHT 200
    DYRCWTSSHC QRVCPCPHGM ACTARGECCH TECLGGCSQP EDPRACVACR 250
    HLYFQGACLW ACPPGTYQYE SWRCVTAERC ASLHSVPGRA STFGIHQGSC 300
    LAQCPSGFTR NSSSIFCHKC EGLCPKECKV GTKTIDSIQA AQDLVGCTHV 350
    EGSLILNLRQ GYNLEPQLQH SLGLVETITG FLKIKHSFAL VSLGFFKNLK 400
    LIRGDAMVDG NYTLYVLDNQ NLQQLGSWVA AGLTIPVGKI YFAFNPRLCL 450
    EHIYRLEEVT GTRGRQNKAE INPRTNGDRA ACQTRTLRFV SNVTEADRIL 500
    LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT QSWNLLDVEL 550
    PLSRTQEPGV TLASLKPWTQ YAVFVRAITL TTEEDSPHQG AQSPIVYLRT 600
    LPAAPTVPQD VISTSNSSSH LLVRWKPPTQ RNGNLTYYLV LWQRLAEDGD 650
    LYLNDYCHRG LRLPTSNNDP RFDGEDGDPE AEMESDCCPC QHPPPGQVLP 700
    PLEAQEASFQ KKFENFLHNA ITIPISPWKV TSINKSPQRD SGRHRRAAGP 750
    LRLGGNSSDF EIQEDKVPRE RAVLSGLRHF TEYRIDIHAC NHAAHTVGCS 800
    AATFVFARTM PHREADGIPG KVAWEASSKN SVLLRWLEPP DPNGLILKYE 850
    IKYRRLGEEA TVLCVSRLRY AKFGGVHLAL LPPGNYSARV RATSLAGNGS 900
    WTDSVAFYIL GPEEEDAGGL HVLLTATPVG LTLLIVLAAL GFFYGKKRNR 950
    TLYASVNPEY FSASDMYVPD EWEVPREQIS IIRELGQGSF GMVYEGLARG 1000
    LEAGEESTPV ALKTVNELAS PRECIEFLKE ASVMKAFKCH HVVRLLGVVS 1050
    QGQPTLVIME LMTRGDLKSH LRSLRPEAEN NPGLPQPALG EMIQMAGEIA 1100
    DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV YETDYYRKGG 1150
    KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 1200
    VLKFVMDGGV LEELEGCPLQ LQELMSRCWQ PNPRLRPSFT HILDSIQEEL 1250
    RPSFRLLSFY YSPECRGARG SLPTTDAEPD SSPTPRDCSP QNGGPGH 1297
    Length:1,297
    Mass (Da):143,720
    Last modified:January 11, 2001 - v2
    Checksum:iBB22C7FF61E3065D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti127 – 1271A → E.1 Publication
    Corresponds to variant rs55757706 [ dbSNP | Ensembl ].
    VAR_041434
    Natural varianti161 – 1611A → V.1 Publication
    Corresponds to variant rs55971900 [ dbSNP | Ensembl ].
    VAR_041435
    Natural varianti244 – 2441R → H.1 Publication
    Corresponds to variant rs55951840 [ dbSNP | Ensembl ].
    VAR_041436
    Natural varianti246 – 2461C → R.1 Publication
    Corresponds to variant rs56377825 [ dbSNP | Ensembl ].
    VAR_041437
    Natural varianti278 – 2781E → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041438
    Natural varianti554 – 5541R → C.1 Publication
    Corresponds to variant rs56068937 [ dbSNP | Ensembl ].
    VAR_041439
    Natural varianti928 – 9281P → L.1 Publication
    Corresponds to variant rs56252149 [ dbSNP | Ensembl ].
    VAR_041440
    Natural varianti1065 – 10651G → E in a glioblastoma multiforme sample; somatic mutation. 1 Publication
    VAR_041441

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064078 mRNA. Translation: AAC17167.1.
    AL158169 Genomic DNA. Translation: CAH70009.1.
    CH471121 Genomic DNA. Translation: EAW52903.1.
    J05046 mRNA. Translation: AAC31759.1.
    CCDSiCCDS1160.1.
    PIRiB36502.
    RefSeqiNP_055030.1. NM_014215.2.
    UniGeneiHs.248138.

    Genome annotation databases

    EnsembliENST00000368195; ENSP00000357178; ENSG00000027644.
    GeneIDi3645.
    KEGGihsa:3645.
    UCSCiuc010pht.2. human.

    Polymorphism databases

    DMDMi12644000.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064078 mRNA. Translation: AAC17167.1 .
    AL158169 Genomic DNA. Translation: CAH70009.1 .
    CH471121 Genomic DNA. Translation: EAW52903.1 .
    J05046 mRNA. Translation: AAC31759.1 .
    CCDSi CCDS1160.1.
    PIRi B36502.
    RefSeqi NP_055030.1. NM_014215.2.
    UniGenei Hs.248138.

    3D structure databases

    ProteinModelPortali P14616.
    SMRi P14616. Positions 971-1262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109856. 3 interactions.
    IntActi P14616. 1 interaction.
    STRINGi 9606.ENSP00000357178.

    Chemistry

    BindingDBi P14616.
    ChEMBLi CHEMBL5483.
    GuidetoPHARMACOLOGYi 1802.

    PTM databases

    PhosphoSitei P14616.

    Polymorphism databases

    DMDMi 12644000.

    Proteomic databases

    MaxQBi P14616.
    PaxDbi P14616.
    PRIDEi P14616.

    Protocols and materials databases

    DNASUi 3645.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368195 ; ENSP00000357178 ; ENSG00000027644 .
    GeneIDi 3645.
    KEGGi hsa:3645.
    UCSCi uc010pht.2. human.

    Organism-specific databases

    CTDi 3645.
    GeneCardsi GC01M156809.
    H-InvDB HIX0028530.
    HGNCi HGNC:6093. INSRR.
    HPAi HPA025285.
    MIMi 147671. gene.
    neXtProti NX_P14616.
    PharmGKBi PA29899.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000038045.
    HOVERGENi HBG006134.
    InParanoidi P14616.
    KOi K05086.
    OMAi FARTMPH.
    OrthoDBi EOG73RB9N.
    PhylomeDBi P14616.
    TreeFami TF351636.

    Miscellaneous databases

    GeneWikii INSRR.
    GenomeRNAii 3645.
    NextBioi 14267.
    PROi P14616.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14616.
    Bgeei P14616.
    CleanExi HS_INSRR.
    Genevestigatori P14616.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR003961. Fibronectin_type3.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR028792. INSRR.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016246. Tyr_kinase_insulin-like_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    PANTHERi PTHR24416:SF107. PTHR24416:SF107. 1 hit.
    Pfami PF00041. fn3. 1 hit.
    PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000620. Insulin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00261. FU. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 4 hits.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS50853. FN3. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor."
      Haenze J., Berthold A., Klammt J., Gallaher B., Siebler T., Kratzsch J., Elmlinger M., Kiess W.
      Horm. Metab. Res. 31:77-79(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Primary structure of a putative receptor for a ligand of the insulin family."
      Shier P., Watt V.M.
      J. Biol. Chem. 264:14605-14608(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-1297.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-127; VAL-161; HIS-244; ARG-246; GLN-278; CYS-554; LEU-928 AND GLU-1065.
    6. Cited for: FUNCTION, MUTAGENESIS OF 1145-TYR-TYR-1146, AUTOPHOSPHORYLATION.

    Entry informationi

    Entry nameiINSRR_HUMAN
    AccessioniPrimary (citable) accession number: P14616
    Secondary accession number(s): O60724, Q5VZS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 151 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3