Reviewed, UniProtKB/Swiss-Prot P14610 (THIL_PIG)

Names and origin

Protein names	Recommended name:     Acetyl-CoA acetyltransferase     EC=2.3.1.9 Alternative name(s):     Acetoacetyl-CoA thiolase
Organism	Sus scrofa (Pig)
Taxonomic identifier	9823 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	26 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2 acetyl-CoA = CoA + acetoacetyl-CoA.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the thiolase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Molecular function	Acyltransferase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA C-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›26	›26	Acetyl-CoA acetyltransferase		PRO_0000206408
Sites
	Active site	21	1	Acyl-thioester intermediate By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	26	1

Sequences

	Sequence		Length	Mass (Da)
	P14610-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 7A4D306BC9BE35CE	FASTA	26	2,561
	10 20 QAVLGAGLPC NTTTSPIIKV CASGMK

References

[1]	"The active site cysteines of thiolase." Gehring U., Harris J.I. Eur. J. Biochem. 16:492-498(1970) [PubMed: 5477295] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Heart.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P14610.
Enzyme and pathway databases
BRENDA	2.3.1.9. 249.
Family and domain databases
InterPro	IPR002155. Thiolase. [Graphical view]
PANTHER	PTHR18919. Thiolase. 1 hit.
PROSITE	PS00098. THIOLASE_1. Partial match. PS00737. THIOLASE_2. Partial match. PS00099. THIOLASE_3. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIL_PIG

Accession

Primary (citable) accession number: P14610

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)