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Reviewed, UniProtKB/Swiss-Prot P14605 (CYAA_SCHPO)

Last modified November 3, 2009. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Adenylate cyclase
    EC=4.6.1.1
Alternative name(s):
    ATP pyrophosphate-lyase
    Adenylyl cyclase
Gene names
Name: cyr1
ORF Names: SPBC19C7.03
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1692 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Enzyme regulation

In contrast to yeast cyclase, S.pombe cyclase is not likely to be regulated by RAS proteins. Activated by git1.

Subunit structure

Interacts with git1. Ref.4

Subcellular location

Cytoplasm. Ref.4

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Contains 1 guanylate cyclase domain.

Contains 21 LRR (leucine-rich) repeats.

Contains 1 PP2C-like domain.

Contains 1 Ras-associating domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

git1Q9P7K51EBI-1542835,EBI-1542810

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16921692Adenylate cyclase
PRO_0000195733

Regions

Domain292 – 38089Ras-associating
Repeat385 – 40319LRR 1
Repeat404 – 42724LRR 2
Repeat429 – 45123LRR 3
Repeat452 – 47524LRR 4
Repeat476 – 49823LRR 5
Repeat501 – 52424LRR 6
Repeat525 – 54723LRR 7
Repeat548 – 57023LRR 8
Repeat572 – 59423LRR 9
Repeat595 – 61824LRR 10
Repeat658 – 68124LRR 11
Repeat682 – 70524LRR 12
Repeat728 – 75124LRR 13
Repeat753 – 77624LRR 14
Repeat781 – 80525LRR 15
Repeat807 – 82822LRR 16
Repeat829 – 85224LRR 17
Repeat854 – 87623LRR 18
Repeat877 – 89923LRR 19
Repeat900 – 92223LRR 20
Repeat928 – 95427LRR 21
Domain1008 – 1276269PP2C-like
Domain1332 – 1469138Guanylate cyclase

Sites

Metal binding13371Magnesium By similarity
Metal binding13801Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P14605-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: D137CBE8770A8655

FASTA1,692190,334
        10         20         30         40         50         60 
MDQSKRLLKS AVPNPPEHFK TGISWLDDLD EKDDDSATSV NYDIPEITEA NLCNDSHEAL 

        70         80         90        100        110        120 
SPCTQPVGNS GRPVEAFKTY PSTPAVPSKS VLFHFYEPDE NFSLSDTGRT KSDTALAARE 

       130        140        150        160        170        180 
SSEKSEVPRD TRSAGIKPYK ENNSSNCAIS KEAGLRRLID KDRESFDKNL NQSFTNLTFP 

       190        200        210        220        230        240 
EPISDDSDSV EFQRDSLNNN WPASLEGSIH ELPRNSDDDG IPASAAHILD LDYHRDSYDS 

       250        260        270        280        290        300 
PWKKFLPYPS ILSDDSWKAP ESWGTSLPTE AIPKQVFTTR FFARPSLGNR KKEFFLRVYR 

       310        320        330        340        350        360 
DDRTSVSFIC PIGIQTHEVI KLLARLFFLP SSANFYLLLI QFNTERILLP HEQPCIIFER 

       370        380        390        400        410        420 
LLSLFGCKVT SDEEINEEDN YSVARLVFTT MDIGADVLRK FSEKKITANL DISRSNLEVI 

       430        440        450        460        470        480 
PVKIYPYAHE LISLNVSHNL SLDLPLDFME RCVKLKRLDI SNNLRSPRGK PITALRQLEV 

       490        500        510        520        530        540 
LNMSRNDIYE LDPLIFSGLS RNSLKELNIA NNKLFFLPHS TRYLVNLTYL DLSYNNFVTF 

       550        560        570        580        590        600 
PLIITELSQL ETLNFSHNLL SQISSKIGSL VKLKHLYLQF NDLSNRLPQE IGLLKNLETI 

       610        620        630        640        650        660 
DLSYNAITNI ASLSECPKLN SINVACNLLS FYEYSNPSAT FIDFSFCPLT TIDPAFSYSN 

       670        680        690        700        710        720 
LVYFDISHAK LIGLKDSVIE TLVNVETVKV NYNHFTSISD AISAMQNLKY LSCTNCEMSY 

       730        740        750        760        770        780 
VSPNLGKLKH LVHLDLHANN IKIFPEEVWQ VSSLKVVNLS SNILEKIKLP VATSKKLTRT 

       790        800        810        820        830        840 
ISQLKIMRTL SGNPVSSLSS QEFVMPTVEE LYLVDNRLGN DCFTALEYFK CLKVLNLSYN 

       850        860        870        880        890        900 
YLTEIPSKFF QNFSDLKHLF VSGNELANLS ISSTAQVLLE TLYANGNRLS SFPKNEALSK 

       910        920        930        940        950        960 
SLRFLDISTN NLQNLAVEKA EKKSLTKLPQ LEYLNLSGNT WFRFSEHEDT NFTKSYLKNL 

       970        980        990       1000       1010       1020 
KFLSIMDLNT KFSNAPSDVL NHFIQRNSPQ PNILRYGVCG YLSRSIPVIS ACELVVNNFL 

      1030       1040       1050       1060       1070       1080 
HPQSSLYCVL DSDISAGKNN RVLKFVYDNL ASCLAHEINA ADSSSEQICN ALRRGFLRLN 

      1090       1100       1110       1120       1130       1140 
KKLGNVIHYD LRKSSEGDVD SNYVTTMNIS EKGYSMDSSC LDIGVSIILV YVRDTRAFVA 

      1150       1160       1170       1180       1190       1200 
NVGTSMAIMS TRNDSEPTTL SVMHDVYNRD EIRRIVDSCG FISGEIKSTT TRAIGRLSQF 

      1210       1220       1230       1240       1250       1260 
PGVQAVPYVN VQYLSELNEF IILANQEFWS VLSKRTVIDV VRANRHSPLL ASTKLRDYAI 

      1270       1280       1290       1300       1310       1320 
AYGAEKNVLV VIVELNGLFE ENSLNFNQLR GDEKTLAISE KNDNMSFVQD LPDDSSLARM 

      1330       1340       1350       1360       1370       1380 
NREVSPPKGC IAMVFTDIKN STLLWERHPI AMRSAIKTHN TIMRRQLRAT GGYEVKTEGD 

      1390       1400       1410       1420       1430       1440 
AFMVCFQTVP AALLWCFSVQ LQLLSADWPN EIVESVQGRL VLGSKNEVLY RGLSVRIGVN 

      1450       1460       1470       1480       1490       1500 
YGVTVSELDP ITRRMDYYGP VVNRTSRVVS VADGGQIAVS AEVVSVLNQL DSETMSSEKT 

      1510       1520       1530       1540       1550       1560 
NVNEMEVRAL KQIGYIIHNL GEFKLKGLDT TEMISLVYPV QLQGRLERLI KSRSLGTPTA 

      1570       1580       1590       1600       1610       1620 
LPETQTYTPV RSRSNSLRPM LARLSDSKSV HGEEGGSGKR SVSSLRNVSP SESTGGYEGC 

      1630       1640       1650       1660       1670       1680 
IFDDQQYQLL YELCERLEDH AAILHGFPEP PPCDTGLAAP VNQAEEYSLF YRLTLRIENT 

      1690 
IYCVSQMLGH TG 

« Hide

References

« Hide 'large scale' references
[1]"The adenylyl cyclase gene from Schizosaccharomyces pombe."
Young D., Riggs M., Field J., Vojtek A., Broek D., Wigler M.
Proc. Natl. Acad. Sci. U.S.A. 86:7989-7993(1989) [PubMed: 2682634] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae."
Yamawaki-Kataoka Y., Tamaoki T., Choe H.-R., Tanaka H., Kataoka T.
Proc. Natl. Acad. Sci. U.S.A. 86:5693-5697(1989) [PubMed: 2668944] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[4]"Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase."
Kao R.S., Morreale E., Wang L., Ivey F.D., Hoffman C.S.
Genetics 173:49-61(2006) [PubMed: 16489217] [Abstract]
Cited for: ACTIVATION BY GIT1, INTERACTION WITH GIT1, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

M26699 Genomic DNA. Translation: AAA35284.1.
M24942 Genomic DNA. Translation: AAA35301.1.
CU329671 Genomic DNA. Translation: CAA19571.1.
PIRA33988.
RefSeqNP_596159.1.

3D structure databases

HSSPHSSP built from PDB template 1FX4 based on UniProtKB Q99280.
ModBaseSearch...

Protein-protein interaction databases

IntActP14605. 1 interaction.
STRINGP14605.

Genome annotation databases

GeneID2540810.
GenomeReviewsGene locus cyr1 in contig CU329671_GR.
KEGGspo:SPBC19C7.03.
NMPDRfig|4896.1.peg.2025.

Organism-specific databases

GeneDB_SpombeSPBC19C7.03.

Phylogenomic databases

OMANSTHLWE.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004193-MON.
BRENDA4.6.1.1. 653.

Gene expression databases

ArrayExpressP14605.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR013716. Adenylate_cyclase_G-a-bd.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001932. PP2C-related.
IPR014045. PP2C_N.
IPR000159. Ras-assoc.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 1 hit.
G3DSA:3.60.40.10. PP2C-related. 1 hit.
PfamPF08509. Ad_cyc_g-alpha. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF00560. LRR_1. 5 hits.
PF00481. PP2C. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00332. PP2Cc. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
PROSITEPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_SCHPO
AccessionPrimary (citable) accession number: P14605
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 3, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents