Substance-P receptor - Rattus norvegicus (Rat)

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P14600 (NK1R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Substance-P receptor
Short name=SPR

Alternative name(s):
NK-1 receptor
Short name=NK-1R
Tachykinin receptor 1

Gene names

Name:	Tacr1
Synonyms:	Tac1r

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Subunit structure	Interacts with ARRB1.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute inflammatory response Inferred from expression pattern PubMed 10430499. Source: RGD aggressive behavior Inferred from mutant phenotype PubMed 17678879. Source: RGD angiotensin-mediated drinking behavior Inferred from mutant phenotype PubMed 9437747. Source: RGD associative learning Inferred from mutant phenotype PubMed 19071162. Source: RGD behavioral response to pain Inferred from mutant phenotype PubMed 18407414. Source: RGD eating behavior Inferred from mutant phenotype PubMed 17141213. Source: RGD elevation of cytosolic calcium ion concentration Inferred from mutant phenotype PubMed 17435548 PubMed 21777465. Source: RGD long-term memory Inferred from mutant phenotype PubMed 19071162. Source: RGD operant conditioning Inferred from mutant phenotype PubMed 17324063. Source: RGD positive regulation of action potential Inferred from mutant phenotype PubMed 18440151. Source: RGD positive regulation of blood pressure Inferred from mutant phenotype PubMed 18337316. Source: RGD positive regulation of epithelial cell migration Inferred from mutant phenotype PubMed 17435548. Source: RGD positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 18390473. Source: RGD positive regulation of hormone secretion Inferred from mutant phenotype PubMed 15613740. Source: RGD positive regulation of leukocyte migration Inferred from mutant phenotype PubMed 11803123. Source: RGD positive regulation of lymphocyte proliferation Inferred from mutant phenotype PubMed 18621988. Source: RGD positive regulation of ossification Inferred from mutant phenotype PubMed 17204323. Source: RGD positive regulation of renal sodium excretion Inferred from mutant phenotype PubMed 18364471. Source: RGD positive regulation of saliva secretion Inferred from mutant phenotype PubMed 11448478. Source: RGD positive regulation of stress fiber assembly Inferred from mutant phenotype PubMed 17435548. Source: RGD positive regulation of synaptic transmission, GABAergic Inferred from mutant phenotype PubMed 19261870. Source: RGD positive regulation of synaptic transmission, cholinergic Inferred from mutant phenotype PubMed 17949415. Source: RGD positive regulation of uterine smooth muscle contraction Inferred from direct assay PubMed 12390879. Source: RGD positive regulation of vascular permeability Inferred from mutant phenotype PubMed 18326823. Source: RGD positive regulation of vasoconstriction Inferred from mutant phenotype PubMed 18602450. Source: RGD regulation of smooth muscle cell migration Inferred from mutant phenotype PubMed 21777465. Source: RGD regulation of smooth muscle cell proliferation Inferred from mutant phenotype PubMed 21777465. Source: RGD response to auditory stimulus Inferred from direct assay PubMed 18178320. Source: RGD response to estradiol stimulus Inferred from expression pattern PubMed 10342838. Source: RGD response to ethanol Inferred from mutant phenotype PubMed 18555214. Source: RGD response to heat Inferred from mutant phenotype PubMed 17978048. Source: RGD response to morphine Inferred from expression pattern PubMed 17950674. Source: RGD response to nicotine Inferred from mutant phenotype PubMed 18037142. Source: RGD response to ozone Inferred from mutant phenotype PubMed 18390473. Source: RGD response to progesterone stimulus Inferred from expression pattern PubMed 10342838. Source: RGD sensory perception of pain Inferred from mutant phenotype PubMed 18407414. Source: RGD smooth muscle contraction involved in micturition Inferred from mutant phenotype PubMed 18945947. Source: RGD sperm ejaculation Inferred from mutant phenotype PubMed 19170843. Source: RGD
Cellular_component	cell body Inferred from direct assay PubMed 21611833. Source: RGD cell surface Inferred from direct assay PubMed 19261870. Source: RGD cytoplasm Inferred from direct assay PubMed 19261870. Source: RGD dendrite Inferred from direct assay PubMed 18178320. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 20967467. Source: RGD
Molecular_function	substance P receptor activity Inferred from direct assay PubMed 7683643. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 407

407

Substance-P receptor

PRO_0000069888

Regions

Topological domain

1 – 31

Extracellular Potential

Transmembrane

32 – 54

Helical; Name=1; Potential

Topological domain

55 – 64

Cytoplasmic Potential

Transmembrane

65 – 86

Helical; Name=2; Potential

Topological domain

87 – 106

Extracellular Potential

Transmembrane

107 – 128

Helical; Name=3; Potential

Topological domain

129 – 148

Cytoplasmic Potential

Transmembrane

149 – 169

Helical; Name=4; Potential

Topological domain

170 – 194

Extracellular Potential

Transmembrane

195 – 219

Helical; Name=5; Potential

Topological domain

220 – 248

Cytoplasmic Potential

Transmembrane

249 – 270

Helical; Name=6; Potential

Topological domain

271 – 283

Extracellular Potential

Transmembrane

284 – 308

Helical; Name=7; Potential

Topological domain

309 – 407

Cytoplasmic Potential

Amino acid modifications

Lipidation

322

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

105 ↔ 180

By similarity

Experimental info

Sequence conflict

N → D in AAB59726. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P14600 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: ADF885A0BF551C96
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FASTA

407

46,366

        10         20         30         40         50         60 
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN VVVIWIILAH 

        70         80         90        100        110        120 
KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY GLFYCKFHNF FPIAALFASI 

       130        140        150        160        170        180 
YSMTAVAFDR YMAIIHPLQP RLSATATKVV IFVIWVLALL LAFPQGYYST TETMPSRVVC 

       190        200        210        220        230        240 
MIEWPEHPNR TYEKAYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV 

       250        260        270        280        290        300 
SAKRKVVKMM IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY 

       310        320        330        340        350        360 
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK VSRLETTIST 

       370        380        390        400 
VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS FYSNMLA

« Hide

References

[1]	"Organization, structure, and expression of the gene encoding the rat substance P receptor." Hershey A.D., Dykema P.E., Krause J.E. J. Biol. Chem. 266:4366-4374(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular characterization of a functional cDNA for rat substance P receptor." Yokota Y., Sasai Y., Tanaka K., Fujiwara T., Tsuchida K., Shigemoto R., Kakizuka A., Ohkubo H., Nakanishi S. J. Biol. Chem. 264:17649-17652(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular characterization of a functional cDNA encoding the rat substance P receptor." Hershey A.D., Krause J.E. Science 247:958-962(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
[4]	Hershey A.D. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 213.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64236 , M64232, M64233, M64234, M64235 Genomic DNA. Translation: AAA42176.1. J05097 mRNA. Translation: AAA42175.1. M31477 mRNA. Translation: AAB59726.1.
IPI	IPI00207210.
PIR	A34357. A38692.
RefSeq	NP_036799.1. NM_012667.2. XP_003753959.1. XM_003753911.1.
UniGene	Rn.89609.
3D structure databases
ProteinModelPortal	P14600.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1510212.
STRING	10116.ENSRNOP00000007984.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P14600.
Proteomic databases
PRIDE	P14600.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853.
GeneID	24807.
KEGG	rno:24807.
UCSC	RGD:3811. rat.
Organism-specific databases
CTD	6869.
RGD	3811. Tacr1.
Phylogenomic databases
eggNOG	NOG331485.
GeneTree	ENSGT00610000085813.
HOGENOM	HOG000013018.
HOVERGEN	HBG103412.
InParanoid	P14600.
KO	K04222.
OMA	LPFHVFF.
OrthoDB	EOG4WQ12N.
Gene expression databases
Genevestigator	P14600.
GermOnline	ENSRNOG00000005853. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001681. Neurokn_rcpt. IPR000046. NK1_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01024. NEUROKININ1R. PR00244. NEUROKININR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P14600.
ChEMBL	CHEMBL4027.
NextBio	604484.

Entry information

Entry name

NK1R_RAT

Accession

Primary (citable) accession number: P14600

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents