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Protein

Substance-P receptor

Gene

Tacr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

GO - Molecular functioni

  • substance P receptor activity Source: RGD

GO - Biological processi

  • acute inflammatory response Source: RGD
  • aggressive behavior Source: RGD
  • angiotensin-mediated drinking behavior Source: RGD
  • associative learning Source: RGD
  • behavioral response to pain Source: RGD
  • eating behavior Source: RGD
  • learning or memory Source: RGD
  • long-term memory Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • operant conditioning Source: RGD
  • positive regulation of action potential Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of epithelial cell migration Source: RGD
  • positive regulation of epithelial cell proliferation Source: RGD
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of leukocyte migration Source: RGD
  • positive regulation of lymphocyte proliferation Source: RGD
  • positive regulation of ossification Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of saliva secretion Source: RGD
  • positive regulation of stress fiber assembly Source: RGD
  • positive regulation of synaptic transmission, cholinergic Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • regulation of blood pressure Source: RGD
  • regulation of smooth muscle cell migration Source: RGD
  • regulation of smooth muscle cell proliferation Source: RGD
  • response to auditory stimulus Source: RGD
  • response to electrical stimulus Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to heat Source: RGD
  • response to hormone Source: RGD
  • response to morphine Source: RGD
  • response to nicotine Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to ozone Source: RGD
  • response to progesterone Source: RGD
  • sensory perception of pain Source: RGD
  • smooth muscle contraction involved in micturition Source: RGD
  • sperm ejaculation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-P receptor
Short name:
SPR
Alternative name(s):
NK-1 receptor
Short name:
NK-1R
Tachykinin receptor 1
Gene namesi
Name:Tacr1
Synonyms:Tac1r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3811. Tacr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6410CytoplasmicSequence analysis
Transmembranei65 – 8622Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini87 – 10620ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 14820CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini170 – 19425ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21925Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 24829CytoplasmicSequence analysisAdd
BLAST
Transmembranei249 – 27022Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini271 – 28313ExtracellularSequence analysisAdd
BLAST
Transmembranei284 – 30825Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 40799CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell body Source: RGD
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4027.
GuidetoPHARMACOLOGYi360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Substance-P receptorPRO_0000069888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 180PROSITE-ProRule annotation
Lipidationi322 – 3221S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP14600.
PRIDEiP14600.

PTM databases

PhosphoSiteiP14600.

Expressioni

Gene expression databases

GenevisibleiP14600. RN.

Interactioni

Subunit structurei

Interacts with ARRB1.

Protein-protein interaction databases

BioGridi246930. 1 interaction.
MINTiMINT-1510212.
STRINGi10116.ENSRNOP00000007984.

Chemistry

BindingDBiP14600.

Structurei

3D structure databases

ProteinModelPortaliP14600.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP14600.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG7N37FW.
PhylomeDBiP14600.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY
110 120 130 140 150
GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK
360 370 380 390 400
VSRLETTIST VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS

FYSNMLA
Length:407
Mass (Da):46,366
Last modified:April 1, 1990 - v1
Checksum:iADF885A0BF551C96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731N → D in AAB59726 (PubMed:2154852).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64236
, M64232, M64233, M64234, M64235 Genomic DNA. Translation: AAA42176.1.
J05097 mRNA. Translation: AAA42175.1.
M31477 mRNA. Translation: AAB59726.1.
PIRiA38692. A34357.
RefSeqiNP_036799.1. NM_012667.2.
UniGeneiRn.89609.

Genome annotation databases

EnsembliENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853.
GeneIDi24807.
KEGGirno:24807.
UCSCiRGD:3811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64236
, M64232, M64233, M64234, M64235 Genomic DNA. Translation: AAA42176.1.
J05097 mRNA. Translation: AAA42175.1.
M31477 mRNA. Translation: AAB59726.1.
PIRiA38692. A34357.
RefSeqiNP_036799.1. NM_012667.2.
UniGeneiRn.89609.

3D structure databases

ProteinModelPortaliP14600.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246930. 1 interaction.
MINTiMINT-1510212.
STRINGi10116.ENSRNOP00000007984.

Chemistry

BindingDBiP14600.
ChEMBLiCHEMBL4027.
GuidetoPHARMACOLOGYi360.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP14600.

Proteomic databases

PaxDbiP14600.
PRIDEiP14600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007984; ENSRNOP00000007984; ENSRNOG00000005853.
GeneIDi24807.
KEGGirno:24807.
UCSCiRGD:3811. rat.

Organism-specific databases

CTDi6869.
RGDi3811. Tacr1.

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP14600.
KOiK04222.
OMAiMIIVVCT.
OrthoDBiEOG7N37FW.
PhylomeDBiP14600.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-RNO-380095. Tachykinin receptors bind tachykinins.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi604484.
PROiP14600.

Gene expression databases

GenevisibleiP14600. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000046. NK1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01024. NEUROKININ1R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Organization, structure, and expression of the gene encoding the rat substance P receptor."
    Hershey A.D., Dykema P.E., Krause J.E.
    J. Biol. Chem. 266:4366-4374(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular characterization of a functional cDNA for rat substance P receptor."
    Yokota Y., Sasai Y., Tanaka K., Fujiwara T., Tsuchida K., Shigemoto R., Kakizuka A., Ohkubo H., Nakanishi S.
    J. Biol. Chem. 264:17649-17652(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular characterization of a functional cDNA encoding the rat substance P receptor."
    Hershey A.D., Krause J.E.
    Science 247:958-962(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  4. Hershey A.D.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 213.

Entry informationi

Entry nameiNK1R_RAT
AccessioniPrimary (citable) accession number: P14600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.