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Protein

Cytochrome c oxidase subunit 3

Gene

cox3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:cox3
ORF Names:SPMIT.04
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Mitochondrion

Organism-specific databases

PomBaseiSPMIT.04.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183851Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP14575.
OrthoDBiEOG7V76HP.
PhylomeDBiP14575.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSTKFQGH PYHIVSASPW PFFLSVVLFF NCLAATLYLH GYKHSSVFFG
60 70 80 90 100
ISFLGLLATM YLWFRDMSTE ANIHGAHTKA VTKGLKIGFM LFLISETFLF
110 120 130 140 150
ASIFWAFFHS SLSPTFELGA VWPPVGIADK TIDPLEVPLL NTVILLTSGA
160 170 180 190 200
SLTYAHYSLI ARNRENALKG LYMTIALSFL FLGGQAYEYW NAPFTISDSV
210 220 230 240 250
YGASFYFATG LHGIHIIVGT ILLLAATYNI YTYHLTNTHH NGFECGIYYW
260
HFCDVVWLFL YLTIYIWGS
Length:269
Mass (Da):30,408
Last modified:December 14, 1998 - v4
Checksum:iDD1788A4AEDE1775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16868 Genomic DNA. Translation: CAA34755.1.
X54421 Genomic DNA. No translation available.
PIRiS10080.

Genome annotation databases

EnsemblFungiiSPMIT.04.1; SPMIT.04.1:pep; SPMIT.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16868 Genomic DNA. Translation: CAA34755.1.
X54421 Genomic DNA. No translation available.
PIRiS10080.

3D structure databases

ProteinModelPortaliP14575.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPMIT.04.1; SPMIT.04.1:pep; SPMIT.04.

Organism-specific databases

PomBaseiSPMIT.04.

Phylogenomic databases

InParanoidiP14575.
OrthoDBiEOG7V76HP.
PhylomeDBiP14575.

Miscellaneous databases

PROiP14575.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the gene encoding subunit 3 of cytochrome c oxidase (cox3) in the mitochondrial genome of Schizosaccharomyces pombe strain EF1."
    Trinkl H., Wolf K.
    Nucleic Acids Res. 17:10104-10104(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EF1.
  2. "The mitochondrial genome of Schizosaccharomyces pombe."
    Lang B.F.
    (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1992)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD7-50.

Entry informationi

Entry nameiCOX3_SCHPO
AccessioniPrimary (citable) accession number: P14575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 31, 1989
Last sequence update: December 14, 1998
Last modified: March 31, 2015
This is version 94 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.