P14575 (COX3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	cox3
ORF Names:	SPMIT.04

Encoded on

Mitochondrion

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro cellular response to stress Inferred from expression pattern PubMed 12529438. Source: PomBase
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Cytochrome c oxidase subunit 3		PRO_0000183851
Regions
	Transmembrane	19 – 39	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Transmembrane	170 – 190	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P14575 [UniParc]. Last modified December 15, 1998. Version 4. Checksum: DD1788A4AEDE1775	FASTA	269	30,408
	10 20 30 40 50 60 MNLSTKFQGH PYHIVSASPW PFFLSVVLFF NCLAATLYLH GYKHSSVFFG ISFLGLLATM 70 80 90 100 110 120 YLWFRDMSTE ANIHGAHTKA VTKGLKIGFM LFLISETFLF ASIFWAFFHS SLSPTFELGA 130 140 150 160 170 180 VWPPVGIADK TIDPLEVPLL NTVILLTSGA SLTYAHYSLI ARNRENALKG LYMTIALSFL 190 200 210 220 230 240 FLGGQAYEYW NAPFTISDSV YGASFYFATG LHGIHIIVGT ILLLAATYNI YTYHLTNTHH 250 260 NGFECGIYYW HFCDVVWLFL YLTIYIWGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the gene encoding subunit 3 of cytochrome c oxidase (cox3) in the mitochondrial genome of Schizosaccharomyces pombe strain EF1." Trinkl H., Wolf K. Nucleic Acids Res. 17:10104-10104(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: EF1.
[2]	"The mitochondrial genome of Schizosaccharomyces pombe." Lang B.F. (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AD7-50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16868 Genomic DNA. Translation: CAA34755.1. X54421 Genomic DNA. No translation available.
PIR	S10080.
3D structure databases
ProteinModelPortal	P14575.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
PomBase	SPMIT.04.
Phylogenomic databases
OrthoDB	EOG4578GM.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_SCHPO

Accession

Primary (citable) accession number: P14575

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	December 15, 1998
Last modified:	April 3, 2013
This is version 81 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program