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P14574 (COX3_LOCMI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COIII
Encoded onMitochondrion
OrganismLocusta migratoria (Migratory locust)
Taxonomic identifier7004 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Orthoptera › Caelifera › Acridomorpha › Acridoidea › Acrididae › Oedipodinae › Locusta

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Cytochrome c oxidase subunit 3
PRO_0000183800

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane198 – 21821Helical; Potential
Transmembrane241 – 26121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P14574 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: C5ED6EDB148B37BD

FASTA26330,353
        10         20         30         40         50         60 
MLTNNNNHPF HMVDYSPWPL TGAIGAMILT SGMTKWFHTF NMNLLMIGMT VIVLTMIQWW 

        70         80         90        100        110        120 
RDVVREGTFQ GLHTKLVSKG LRWGMILFIA SEVLFFASFF WAFFNSSLAP TIELGMKWPP 

       130        140        150        160        170        180 
MGIQPFNPIQ IPLLNTAILL ASGVTITWAH HSIMECNHSQ ALQGLFFTVM LGFYFTLLQM 

       190        200        210        220        230        240 
YEYWEAPFTI ADAVYGSTFF VATGFHGLHV IIGTTFLLTC LIRHMMNQFS SNHHFGFEAA 

       250        260 
AWYWHFVDVV WLFLYLSIYW WGS

« Hide

References

[1]"Different mitochondrial gene orders among insects: exchanged tRNA gene positions in the COII/COIII region between an orthopteran and a dipteran species."
Haucke H.R., Gellissen G.
Curr. Genet. 14:471-476(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence, organization, and evolution of the Locusta migratoria mitochondrial genome."
Flook P.K., Rowell C.H.F., Gellissen G.
J. Mol. Evol. 41:928-941(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X13975 Genomic DNA. Translation: CAA32156.1.
X80245 Genomic DNA. Translation: CAA56529.1.
PIRT11469.
RefSeqNP_007295.1. NC_001712.1.

3D structure databases

ProteinModelPortalP14574.
SMRP14574. Positions 5-263.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807961.

Organism-specific databases

CTD4514.

Phylogenomic databases

ProtClustDBMTH00155.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. CytC_oxdse_III. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_LOCMI
AccessionPrimary (citable) accession number: P14574
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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