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P14574

- COX3_LOCMI

UniProt

P14574 - COX3_LOCMI

Protein

Cytochrome c oxidase subunit 3

Gene

COIII

Organism
Locusta migratoria (Migratory locust)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:COIII
    Encoded oniMitochondrion
    OrganismiLocusta migratoria (Migratory locust)
    Taxonomic identifieri7004 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeOedipodinaeLocusta

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Cytochrome c oxidase subunit 3PRO_0000183800Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP14574.
    SMRiP14574. Positions 5-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14574-1 [UniParc]FASTAAdd to Basket

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    MLTNNNNHPF HMVDYSPWPL TGAIGAMILT SGMTKWFHTF NMNLLMIGMT    50
    VIVLTMIQWW RDVVREGTFQ GLHTKLVSKG LRWGMILFIA SEVLFFASFF 100
    WAFFNSSLAP TIELGMKWPP MGIQPFNPIQ IPLLNTAILL ASGVTITWAH 150
    HSIMECNHSQ ALQGLFFTVM LGFYFTLLQM YEYWEAPFTI ADAVYGSTFF 200
    VATGFHGLHV IIGTTFLLTC LIRHMMNQFS SNHHFGFEAA AWYWHFVDVV 250
    WLFLYLSIYW WGS 263
    Length:263
    Mass (Da):30,353
    Last modified:January 1, 1990 - v1
    Checksum:iC5ED6EDB148B37BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13975 Genomic DNA. Translation: CAA32156.1.
    X80245 Genomic DNA. Translation: CAA56529.1.
    PIRiT11469.
    RefSeqiNP_007295.1. NC_001712.1.

    Genome annotation databases

    GeneIDi807961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13975 Genomic DNA. Translation: CAA32156.1 .
    X80245 Genomic DNA. Translation: CAA56529.1 .
    PIRi T11469.
    RefSeqi NP_007295.1. NC_001712.1.

    3D structure databases

    ProteinModelPortali P14574.
    SMRi P14574. Positions 5-263.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807961.

    Organism-specific databases

    CTDi 4514.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Different mitochondrial gene orders among insects: exchanged tRNA gene positions in the COII/COIII region between an orthopteran and a dipteran species."
      Haucke H.R., Gellissen G.
      Curr. Genet. 14:471-476(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The sequence, organization, and evolution of the Locusta migratoria mitochondrial genome."
      Flook P.K., Rowell C.H.F., Gellissen G.
      J. Mol. Evol. 41:928-941(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_LOCMI
    AccessioniPrimary (citable) accession number: P14574
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3