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P14568

- ASSY_BOVIN

UniProt

P14568 - ASSY_BOVIN

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Protein

Argininosuccinate synthase

Gene

ASS1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Is indirectly involved in the control of blood pressure.By similarity

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361ATP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei87 – 871CitrullineBy similarity
Binding sitei92 – 921CitrullineBy similarity
Binding sitei119 – 1191AspartateBy similarity
Binding sitei123 – 1231AspartateBy similarity
Binding sitei123 – 1231CitrullineBy similarity
Binding sitei124 – 1241AspartateBy similarity
Binding sitei127 – 1271CitrullineBy similarity
Binding sitei180 – 1801CitrullineBy similarity
Binding sitei189 – 1891CitrullineBy similarity
Binding sitei270 – 2701CitrullineBy similarity
Binding sitei282 – 2821CitrullineBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPBy similarity
Nucleotide bindingi115 – 1239ATPBy similarity

GO - Molecular functioni

  1. amino acid binding Source: Ensembl
  2. argininosuccinate synthase activity Source: UniProtKB-EC
  3. ATP binding Source: UniProtKB-KW
  4. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
  2. argininosuccinate metabolic process Source: Ensembl
  3. aspartate metabolic process Source: Ensembl
  4. cellular response to laminar fluid shear stress Source: Ensembl
  5. citrulline metabolic process Source: Ensembl
  6. negative regulation of leukocyte cell-cell adhesion Source: Ensembl
  7. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  8. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_208559. Urea cycle.
SABIO-RKP14568.
UniPathwayiUPA00068; UER00113.
UPA00158; UER00272.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:ASS1
Synonyms:ASS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Defects in ASS1 are the cause of a bovine form of citrullinemia.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Argininosuccinate synthasePRO_0000148553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP14568.

Expressioni

Gene expression databases

ExpressionAtlasiP14568. baseline.

Interactioni

Subunit structurei

Homotetramer. Interacts with NMRAL1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP14568.
SMRiP14568. Positions 4-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
GeneTreeiENSGT00390000004524.
HOGENOMiHOG000230093.
HOVERGENiHBG001717.
InParanoidiP14568.
KOiK01940.
OMAiQGDYEPA.
OrthoDBiEOG7PVWPB.
TreeFamiTF300736.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14568-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK
60 70 80 90 100
ALKLGAKKVF IEDISKEFVE EFIWPAIQSS ALYEDRYLLG TSLARPCIAR
110 120 130 140 150
KQVEIAQREG AKYVSHGATG KGNDQIRFEL TCYSLAPQIK VIAPWRMPEF
160 170 180 190 200
YNRFQGRNDL MEYAKQHGIP VPVTPKNPWS MDENLMHISY EAGILENPKN
210 220 230 240 250
QAPPGLYTKT QDPAKAPNSP DMLEIEFKKG VPVKVTNVGD GTTHSTALEL
260 270 280 290 300
FLYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF
310 320 330 340 350
TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIAK SQERVEGKVQ
360 370 380 390 400
VSVFKGQVYI LGRESPLSLY NEELVSMNVQ GDYEPVDATG FININSLRLK
410
EYHRLQNKVT AK
Length:412
Mass (Da):46,417
Last modified:January 1, 1990 - v1
Checksum:i6F74C7F445EE0D86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26198 mRNA. Translation: AAA30388.1.
BC102474 mRNA. Translation: AAI02475.1.
PIRiA33986. AJBORS.
RefSeqiNP_776317.1. NM_173892.4.
UniGeneiBt.1370.

Genome annotation databases

EnsembliENSBTAT00000027649; ENSBTAP00000027649; ENSBTAG00000020747.
GeneIDi280726.
KEGGibta:280726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26198 mRNA. Translation: AAA30388.1 .
BC102474 mRNA. Translation: AAI02475.1 .
PIRi A33986. AJBORS.
RefSeqi NP_776317.1. NM_173892.4.
UniGenei Bt.1370.

3D structure databases

ProteinModelPortali P14568.
SMRi P14568. Positions 4-407.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P14568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000027649 ; ENSBTAP00000027649 ; ENSBTAG00000020747 .
GeneIDi 280726.
KEGGi bta:280726.

Organism-specific databases

CTDi 445.

Phylogenomic databases

eggNOGi COG0137.
GeneTreei ENSGT00390000004524.
HOGENOMi HOG000230093.
HOVERGENi HBG001717.
InParanoidi P14568.
KOi K01940.
OMAi QGDYEPA.
OrthoDBi EOG7PVWPB.
TreeFami TF300736.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
UPA00158 ; UER00272 .
Reactomei REACT_208559. Urea cycle.
SABIO-RK P14568.

Miscellaneous databases

NextBioi 20804902.

Gene expression databases

ExpressionAtlasi P14568. baseline.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular definition of bovine argininosuccinate synthetase deficiency."
    Dennis J.A., Healy P.J., Beaudet A.L., O'Brien W.E.
    Proc. Natl. Acad. Sci. U.S.A. 86:7947-7951(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiASSY_BOVIN
AccessioniPrimary (citable) accession number: P14568
Secondary accession number(s): Q3T0A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3