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P14568

- ASSY_BOVIN

UniProt

P14568 - ASSY_BOVIN

Protein

Argininosuccinate synthase

Gene

ASS1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Is indirectly involved in the control of blood pressure.By similarity

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei87 – 871CitrullineBy similarity
    Binding sitei92 – 921CitrullineBy similarity
    Binding sitei119 – 1191AspartateBy similarity
    Binding sitei123 – 1231AspartateBy similarity
    Binding sitei123 – 1231CitrullineBy similarity
    Binding sitei124 – 1241AspartateBy similarity
    Binding sitei127 – 1271CitrullineBy similarity
    Binding sitei180 – 1801CitrullineBy similarity
    Binding sitei189 – 1891CitrullineBy similarity
    Binding sitei270 – 2701CitrullineBy similarity
    Binding sitei282 – 2821CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPBy similarity
    Nucleotide bindingi115 – 1239ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-UniPathway
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_208559. Urea cycle.
    SABIO-RKP14568.
    UniPathwayiUPA00068; UER00113.
    UPA00158; UER00272.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:ASS1
    Synonyms:ASS
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 11

    Pathology & Biotechi

    Involvement in diseasei

    Defects in ASS1 are the cause of a bovine form of citrullinemia.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Argininosuccinate synthasePRO_0000148553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei180 – 1801PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP14568.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with NMRAL1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP14568.
    SMRiP14568. Positions 4-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    GeneTreeiENSGT00390000004524.
    HOGENOMiHOG000230093.
    HOVERGENiHBG001717.
    InParanoidiP14568.
    KOiK01940.
    OMAiQGDYEPA.
    OrthoDBiEOG7PVWPB.
    TreeFamiTF300736.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14568-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKGSVVLA YSGGLDTSCI LVWLKEQGYD VIAYLANIGQ KEDFEEARKK    50
    ALKLGAKKVF IEDISKEFVE EFIWPAIQSS ALYEDRYLLG TSLARPCIAR 100
    KQVEIAQREG AKYVSHGATG KGNDQIRFEL TCYSLAPQIK VIAPWRMPEF 150
    YNRFQGRNDL MEYAKQHGIP VPVTPKNPWS MDENLMHISY EAGILENPKN 200
    QAPPGLYTKT QDPAKAPNSP DMLEIEFKKG VPVKVTNVGD GTTHSTALEL 250
    FLYLNEVAGK HGVGRIDIVE NRFIGMKSRG IYETPAGTIL YHAHLDIEAF 300
    TMDREVRKIK QGLGLKFAEL VYTGFWHSPE CEFVRHCIAK SQERVEGKVQ 350
    VSVFKGQVYI LGRESPLSLY NEELVSMNVQ GDYEPVDATG FININSLRLK 400
    EYHRLQNKVT AK 412
    Length:412
    Mass (Da):46,417
    Last modified:January 1, 1990 - v1
    Checksum:i6F74C7F445EE0D86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26198 mRNA. Translation: AAA30388.1.
    BC102474 mRNA. Translation: AAI02475.1.
    PIRiA33986. AJBORS.
    RefSeqiNP_776317.1. NM_173892.4.
    UniGeneiBt.1370.

    Genome annotation databases

    EnsembliENSBTAT00000027649; ENSBTAP00000027649; ENSBTAG00000020747.
    GeneIDi280726.
    KEGGibta:280726.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26198 mRNA. Translation: AAA30388.1 .
    BC102474 mRNA. Translation: AAI02475.1 .
    PIRi A33986. AJBORS.
    RefSeqi NP_776317.1. NM_173892.4.
    UniGenei Bt.1370.

    3D structure databases

    ProteinModelPortali P14568.
    SMRi P14568. Positions 4-407.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P14568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000027649 ; ENSBTAP00000027649 ; ENSBTAG00000020747 .
    GeneIDi 280726.
    KEGGi bta:280726.

    Organism-specific databases

    CTDi 445.

    Phylogenomic databases

    eggNOGi COG0137.
    GeneTreei ENSGT00390000004524.
    HOGENOMi HOG000230093.
    HOVERGENi HBG001717.
    InParanoidi P14568.
    KOi K01940.
    OMAi QGDYEPA.
    OrthoDBi EOG7PVWPB.
    TreeFami TF300736.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    UPA00158 ; UER00272 .
    Reactomei REACT_208559. Urea cycle.
    SABIO-RK P14568.

    Miscellaneous databases

    NextBioi 20804902.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular definition of bovine argininosuccinate synthetase deficiency."
      Dennis J.A., Healy P.J., Beaudet A.L., O'Brien W.E.
      Proc. Natl. Acad. Sci. U.S.A. 86:7947-7951(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiASSY_BOVIN
    AccessioniPrimary (citable) accession number: P14568
    Secondary accession number(s): Q3T0A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3