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Protein

Lysosome-associated membrane glycoprotein 1

Gene

Lamp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
120 kDa lysosomal membrane glycoprotein
Short name:
LGP-120
CD107 antigen-like family member A
CD_antigen: CD107a
Gene namesi
Name:Lamp1
Synonyms:Lamp-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2989. Lamp1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Endosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Lysosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Late endosome By similarity

  • Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 371LumenalSequence analysisAdd BLAST350
Transmembranei372 – 395HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini396 – 407CytoplasmicPROSITE-ProRule annotationAdd BLAST12

GO - Cellular componenti

  • alveolar lamellar body Source: RGD
  • cytolytic granule Source: Ensembl
  • cytoplasmic vesicle Source: RGD
  • cytosol Source: GOC
  • dendrite Source: BHF-UCL
  • endosome membrane Source: UniProtKB
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
  • melanosome Source: Ensembl
  • multivesicular body Source: RGD
  • neuronal cell body Source: BHF-UCL
  • perinuclear region of cytoplasm Source: Ensembl
  • phagolysosome membrane Source: Ensembl
  • plasma membrane Source: UniProtKB
  • sarcolemma Source: Ensembl
  • synaptic vesicle Source: Ensembl
  • vacuole Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001710622 – 407Lysosome-associated membrane glycoprotein 1Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi36 ↔ 75PROSITE-ProRule annotation
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi150 ↔ 186PROSITE-ProRule annotation
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi223 ↔ 260PROSITE-ProRule annotation
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi328 ↔ 365PROSITE-ProRule annotation

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14562.
PRIDEiP14562.

PTM databases

PhosphoSitePlusiP14562.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019629.
ExpressionAtlasiP14562. baseline and differential.
GenevisibleiP14562. RN.

Interactioni

Protein-protein interaction databases

IntActiP14562. 3 interactors.
STRINGi10116.ENSRNOP00000026580.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 189First lumenal domainAdd BLAST168
Regioni190 – 219HingeAdd BLAST30
Regioni220 – 371Second lumenal domainAdd BLAST152

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP14562.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
PhylomeDBiP14562.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGARRPL LLLLLAGLAH SAPALFEVKD NNGTACIMAS FSASFLTTYD
60 70 80 90 100
AGHVSKVSNM TLPASAEVLK NSSSCGEKNA SEPTLAITFG EGYLLKLTFT
110 120 130 140 150
KNTTRYSVQH MYFTYNLSDT QFFPNASSKG PDTVDSTTDI KADINKTYRC
160 170 180 190 200
VSDIRVYMKN VTIVLWDATI QAYLPSSNFS KEETRCPQDQ PSPTTGPPSP
210 220 230 240 250
SPPLVPTNPS VSKYNVTGDN GTCLLASMAL QLNITYMKKD NTTVTRAFNI
260 270 280 290 300
NPSDKYSGTC GAQLVTLKVG NKSRVLELQF GMNATSSLFF LQGVQLNMTL
310 320 330 340 350
PDAIEPTFST SNYSLKALQA SVGNSYKCNS EEHIFVSKAL ALNVFSVQVQ
360 370 380 390 400
AFRVESDRFG SVEECVQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS

HAGYQTI
Length:407
Mass (Da):43,969
Last modified:January 1, 1990 - v1
Checksum:i25947490749A7C88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293 – 294GV → EF in AAB19108 (Ref. 4) Curated2
Sequence conflicti329N → T in AAB19108 (Ref. 4) Curated1
Sequence conflicti356 – 357SD → VT (Ref. 4) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34959 mRNA. Translation: AAA41525.1.
X14765 mRNA. Translation: CAA32873.1.
U75406 mRNA. Translation: AAB19108.1.
PIRiA30200.
RefSeqiNP_036989.1. NM_012857.2.
XP_017455483.1. XM_017599994.1.
UniGeneiRn.40177.

Genome annotation databases

EnsembliENSRNOT00000026580; ENSRNOP00000026580; ENSRNOG00000019629.
GeneIDi25328.
KEGGirno:25328.
UCSCiRGD:2989. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34959 mRNA. Translation: AAA41525.1.
X14765 mRNA. Translation: CAA32873.1.
U75406 mRNA. Translation: AAB19108.1.
PIRiA30200.
RefSeqiNP_036989.1. NM_012857.2.
XP_017455483.1. XM_017599994.1.
UniGeneiRn.40177.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14562. 3 interactors.
STRINGi10116.ENSRNOP00000026580.

PTM databases

PhosphoSitePlusiP14562.

Proteomic databases

PaxDbiP14562.
PRIDEiP14562.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026580; ENSRNOP00000026580; ENSRNOG00000019629.
GeneIDi25328.
KEGGirno:25328.
UCSCiRGD:2989. rat.

Organism-specific databases

CTDi3916.
RGDi2989. Lamp1.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP14562.
KOiK06528.
OMAiETRCEQD.
OrthoDBiEOG091G09EV.
PhylomeDBiP14562.

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP14562.

Gene expression databases

BgeeiENSRNOG00000019629.
ExpressionAtlasiP14562. baseline and differential.
GenevisibleiP14562. RN.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP1_RAT
AccessioniPrimary (citable) accession number: P14562
Secondary accession number(s): P97620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.