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P14562 (LAMP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 1

Short name=LAMP-1
Short name=Lysosome-associated membrane protein 1
Alternative name(s):
120 kDa lysosomal membrane glycoprotein
Short name=LGP-120
CD107 antigen-like family member A
CD_antigen=CD107a
Gene names
Name:Lamp1
Synonyms:Lamp-1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome By similarity. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.

Post-translational modification

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans By similarity.

Sequence similarities

Belongs to the LAMP family.

Ontologies

Keywords
   Cellular componentCell membrane
Endosome
Lysosome
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processautophagic cell death

Inferred from direct assay PubMed 18690537. Source: RGD

autophagy

Inferred from expression pattern PubMed 17665967. Source: RGD

protein stabilization

Inferred from sequence or structural similarity. Source: UniProt

   Cellular_componentalveolar lamellar body

Inferred from direct assay PubMed 7868367. Source: RGD

cytolytic granule

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from direct assay PubMed 18690537. Source: RGD

dendrite

Inferred from direct assay PubMed 20410104. Source: BHF-UCL

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

melanosome

Inferred from electronic annotation. Source: Ensembl

multivesicular body

Inferred from direct assay PubMed 7868367. Source: RGD

neuronal cell body

Inferred from direct assay PubMed 20410104. Source: BHF-UCL

sarcolemma

Inferred from electronic annotation. Source: Ensembl

vacuole

Inferred from direct assay PubMed 22147702. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 407386Lysosome-associated membrane glycoprotein 1
PRO_0000017106

Regions

Topological domain22 – 371350Lumenal Potential
Transmembrane372 – 39524Helical; Potential
Topological domain396 – 40712Cytoplasmic Potential
Region22 – 189168First lumenal domain
Region190 – 21930Hinge
Region220 – 371152Second lumenal domain

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 75 By similarity
Disulfide bond150 ↔ 186 By similarity
Disulfide bond223 ↔ 260 By similarity
Disulfide bond328 ↔ 365 By similarity

Experimental info

Sequence conflict293 – 2942GV → EF in AAB19108. Ref.4
Sequence conflict3291N → T in AAB19108. Ref.4
Sequence conflict356 – 3572SD → VT Ref.4

Sequences

Sequence LengthMass (Da)Tools
P14562 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 25947490749A7C88

FASTA40743,969
        10         20         30         40         50         60 
MAAPGARRPL LLLLLAGLAH SAPALFEVKD NNGTACIMAS FSASFLTTYD AGHVSKVSNM 

        70         80         90        100        110        120 
TLPASAEVLK NSSSCGEKNA SEPTLAITFG EGYLLKLTFT KNTTRYSVQH MYFTYNLSDT 

       130        140        150        160        170        180 
QFFPNASSKG PDTVDSTTDI KADINKTYRC VSDIRVYMKN VTIVLWDATI QAYLPSSNFS 

       190        200        210        220        230        240 
KEETRCPQDQ PSPTTGPPSP SPPLVPTNPS VSKYNVTGDN GTCLLASMAL QLNITYMKKD 

       250        260        270        280        290        300 
NTTVTRAFNI NPSDKYSGTC GAQLVTLKVG NKSRVLELQF GMNATSSLFF LQGVQLNMTL 

       310        320        330        340        350        360 
PDAIEPTFST SNYSLKALQA SVGNSYKCNS EEHIFVSKAL ALNVFSVQVQ AFRVESDRFG 

       370        380        390        400 
SVEECVQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS HAGYQTI 

« Hide

References

[1]"Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins."
Howe C.L., Granger B.L., Hull M., Green S.A., Gabel C.A., Helenius A., Mellman I.
Proc. Natl. Acad. Sci. U.S.A. 85:7577-7581(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes."
Himeno M., Noguchi Y., Sasaki H., Tanaka Y., Furuno K., Kono A., Sakaki Y., Kato K.
FEBS Lett. 244:351-356(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-407.
[3]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 130-141; 147-155; 247-268 AND 317-353, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
[4]Adams L.A., Werny I., Schwartz S.M.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 283-357.
Strain: Wistar Kyoto.
Tissue: Aortic smooth muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34959 mRNA. Translation: AAA41525.1.
X14765 mRNA. Translation: CAA32873.1.
U75406 mRNA. Translation: AAB19108.1.
PIRA30200.
RefSeqNP_036989.1. NM_012857.2.
XP_006253490.1. XM_006253428.1.
UniGeneRn.40177.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP14562. 1 interaction.
STRING10116.ENSRNOP00000026580.

PTM databases

PhosphoSiteP14562.

Proteomic databases

PaxDbP14562.
PRIDEP14562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026580; ENSRNOP00000026580; ENSRNOG00000019629.
GeneID25328.
KEGGrno:25328.
UCSCRGD:2989. rat.

Organism-specific databases

CTD3916.
RGD2989. Lamp1.

Phylogenomic databases

eggNOGNOG301998.
GeneTreeENSGT00530000063068.
HOGENOMHOG000230942.
HOVERGENHBG052303.
KOK06528.
OMAGTACIMA.
OrthoDBEOG7ZD1VH.
PhylomeDBP14562.

Gene expression databases

GenevestigatorP14562.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio606197.
PROP14562.

Entry information

Entry nameLAMP1_RAT
AccessionPrimary (citable) accession number: P14562
Secondary accession number(s): P97620
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families