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P14562

- LAMP1_RAT

UniProt

P14562 - LAMP1_RAT

Protein

Lysosome-associated membrane glycoprotein 1

Gene

Lamp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

    GO - Biological processi

    1. autophagic cell death Source: RGD
    2. autophagy Source: RGD
    3. protein stabilization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 1
    Short name:
    LAMP-1
    Short name:
    Lysosome-associated membrane protein 1
    Alternative name(s):
    120 kDa lysosomal membrane glycoprotein
    Short name:
    LGP-120
    CD107 antigen-like family member A
    CD_antigen: CD107a
    Gene namesi
    Name:Lamp1
    Synonyms:Lamp-1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi2989. Lamp1.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome By similarity
    Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.By similarity

    GO - Cellular componenti

    1. alveolar lamellar body Source: RGD
    2. cytolytic granule Source: Ensembl
    3. cytoplasmic vesicle Source: RGD
    4. dendrite Source: BHF-UCL
    5. endosome membrane Source: UniProtKB-SubCell
    6. external side of plasma membrane Source: Ensembl
    7. integral component of membrane Source: UniProtKB-KW
    8. lysosomal membrane Source: UniProtKB-SubCell
    9. melanosome Source: Ensembl
    10. multivesicular body Source: RGD
    11. neuronal cell body Source: BHF-UCL
    12. sarcolemma Source: Ensembl
    13. vacuole Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 407386Lysosome-associated membrane glycoprotein 1PRO_0000017106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi36 ↔ 75PROSITE-ProRule annotation
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 186PROSITE-ProRule annotation
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 260PROSITE-ProRule annotation
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi328 ↔ 365PROSITE-ProRule annotation

    Post-translational modificationi

    O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP14562.
    PRIDEiP14562.

    PTM databases

    PhosphoSiteiP14562.

    Expressioni

    Gene expression databases

    GenevestigatoriP14562.

    Interactioni

    Protein-protein interaction databases

    IntActiP14562. 3 interactions.
    STRINGi10116.ENSRNOP00000026580.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 371350LumenalSequence AnalysisAdd
    BLAST
    Topological domaini396 – 40712CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei372 – 39524HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 189168First lumenal domainAdd
    BLAST
    Regioni190 – 21930HingeAdd
    BLAST
    Regioni220 – 371152Second lumenal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301998.
    GeneTreeiENSGT00530000063068.
    HOGENOMiHOG000230942.
    HOVERGENiHBG052303.
    KOiK06528.
    OMAiENNMLIP.
    OrthoDBiEOG7ZD1VH.
    PhylomeDBiP14562.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00310. LAMP_1. 2 hits.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14562-1 [UniParc]FASTAAdd to Basket

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    MAAPGARRPL LLLLLAGLAH SAPALFEVKD NNGTACIMAS FSASFLTTYD    50
    AGHVSKVSNM TLPASAEVLK NSSSCGEKNA SEPTLAITFG EGYLLKLTFT 100
    KNTTRYSVQH MYFTYNLSDT QFFPNASSKG PDTVDSTTDI KADINKTYRC 150
    VSDIRVYMKN VTIVLWDATI QAYLPSSNFS KEETRCPQDQ PSPTTGPPSP 200
    SPPLVPTNPS VSKYNVTGDN GTCLLASMAL QLNITYMKKD NTTVTRAFNI 250
    NPSDKYSGTC GAQLVTLKVG NKSRVLELQF GMNATSSLFF LQGVQLNMTL 300
    PDAIEPTFST SNYSLKALQA SVGNSYKCNS EEHIFVSKAL ALNVFSVQVQ 350
    AFRVESDRFG SVEECVQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS 400
    HAGYQTI 407
    Length:407
    Mass (Da):43,969
    Last modified:January 1, 1990 - v1
    Checksum:i25947490749A7C88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2942GV → EF in AAB19108. 1 PublicationCurated
    Sequence conflicti329 – 3291N → T in AAB19108. 1 PublicationCurated
    Sequence conflicti356 – 3572SD → VT1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34959 mRNA. Translation: AAA41525.1.
    X14765 mRNA. Translation: CAA32873.1.
    U75406 mRNA. Translation: AAB19108.1.
    PIRiA30200.
    RefSeqiNP_036989.1. NM_012857.2.
    XP_006253490.1. XM_006253428.1.
    UniGeneiRn.40177.

    Genome annotation databases

    EnsembliENSRNOT00000026580; ENSRNOP00000026580; ENSRNOG00000019629.
    GeneIDi25328.
    KEGGirno:25328.
    UCSCiRGD:2989. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34959 mRNA. Translation: AAA41525.1 .
    X14765 mRNA. Translation: CAA32873.1 .
    U75406 mRNA. Translation: AAB19108.1 .
    PIRi A30200.
    RefSeqi NP_036989.1. NM_012857.2.
    XP_006253490.1. XM_006253428.1.
    UniGenei Rn.40177.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P14562. 3 interactions.
    STRINGi 10116.ENSRNOP00000026580.

    PTM databases

    PhosphoSitei P14562.

    Proteomic databases

    PaxDbi P14562.
    PRIDEi P14562.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026580 ; ENSRNOP00000026580 ; ENSRNOG00000019629 .
    GeneIDi 25328.
    KEGGi rno:25328.
    UCSCi RGD:2989. rat.

    Organism-specific databases

    CTDi 3916.
    RGDi 2989. Lamp1.

    Phylogenomic databases

    eggNOGi NOG301998.
    GeneTreei ENSGT00530000063068.
    HOGENOMi HOG000230942.
    HOVERGENi HBG052303.
    KOi K06528.
    OMAi ENNMLIP.
    OrthoDBi EOG7ZD1VH.
    PhylomeDBi P14562.

    Miscellaneous databases

    NextBioi 606197.
    PROi P14562.

    Gene expression databases

    Genevestigatori P14562.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00310. LAMP_1. 2 hits.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins."
      Howe C.L., Granger B.L., Hull M., Green S.A., Gabel C.A., Helenius A., Mellman I.
      Proc. Natl. Acad. Sci. U.S.A. 85:7577-7581(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes."
      Himeno M., Noguchi Y., Sasaki H., Tanaka Y., Furuno K., Kono A., Sakaki Y., Kato K.
      FEBS Lett. 244:351-356(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-407.
    3. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 130-141; 147-155; 247-268 AND 317-353, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    4. Adams L.A., Werny I., Schwartz S.M.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 283-357.
      Strain: Wistar Kyoto.
      Tissue: Aortic smooth muscle.

    Entry informationi

    Entry nameiLAMP1_RAT
    AccessioniPrimary (citable) accession number: P14562
    Secondary accession number(s): P97620
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3