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P14562

- LAMP1_RAT

UniProt

P14562 - LAMP1_RAT

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Protein

Lysosome-associated membrane glycoprotein 1

Gene

Lamp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

GO - Biological processi

  1. autophagic cell death Source: RGD
  2. autophagy Source: RGD
  3. establishment of protein localization to organelle Source: Ensembl
  4. Golgi to lysosome transport Source: Ensembl
  5. granzyme-mediated apoptotic signaling pathway Source: Ensembl
  6. positive regulation of natural killer cell degranulation Source: Ensembl
  7. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  8. protein stabilization Source: UniProt
  9. regulation of organelle transport along microtubule Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
120 kDa lysosomal membrane glycoprotein
Short name:
LGP-120
CD107 antigen-like family member A
CD_antigen: CD107a
Gene namesi
Name:Lamp1
Synonyms:Lamp-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi2989. Lamp1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome (By similarity).By similarity

GO - Cellular componenti

  1. alveolar lamellar body Source: RGD
  2. cytolytic granule Source: Ensembl
  3. cytoplasmic vesicle Source: RGD
  4. dendrite Source: BHF-UCL
  5. external side of plasma membrane Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. melanosome Source: Ensembl
  9. multivesicular body Source: RGD
  10. neuronal cell body Source: BHF-UCL
  11. phagolysosome membrane Source: Ensembl
  12. sarcolemma Source: Ensembl
  13. vacuole Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 407386Lysosome-associated membrane glycoprotein 1PRO_0000017106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi36 ↔ 75PROSITE-ProRule annotation
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi150 ↔ 186PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 260PROSITE-ProRule annotation
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi328 ↔ 365PROSITE-ProRule annotation

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14562.
PRIDEiP14562.

PTM databases

PhosphoSiteiP14562.

Expressioni

Gene expression databases

GenevestigatoriP14562.

Interactioni

Protein-protein interaction databases

IntActiP14562. 3 interactions.
STRINGi10116.ENSRNOP00000026580.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 371350LumenalSequence AnalysisAdd
BLAST
Topological domaini396 – 40712CytoplasmicPROSITE-ProRule annotationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei372 – 39524HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 189168First lumenal domainAdd
BLAST
Regioni190 – 21930HingeAdd
BLAST
Regioni220 – 371152Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiP14562.
KOiK06528.
OMAiENNMLIP.
OrthoDBiEOG7ZD1VH.
PhylomeDBiP14562.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14562-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPGARRPL LLLLLAGLAH SAPALFEVKD NNGTACIMAS FSASFLTTYD
60 70 80 90 100
AGHVSKVSNM TLPASAEVLK NSSSCGEKNA SEPTLAITFG EGYLLKLTFT
110 120 130 140 150
KNTTRYSVQH MYFTYNLSDT QFFPNASSKG PDTVDSTTDI KADINKTYRC
160 170 180 190 200
VSDIRVYMKN VTIVLWDATI QAYLPSSNFS KEETRCPQDQ PSPTTGPPSP
210 220 230 240 250
SPPLVPTNPS VSKYNVTGDN GTCLLASMAL QLNITYMKKD NTTVTRAFNI
260 270 280 290 300
NPSDKYSGTC GAQLVTLKVG NKSRVLELQF GMNATSSLFF LQGVQLNMTL
310 320 330 340 350
PDAIEPTFST SNYSLKALQA SVGNSYKCNS EEHIFVSKAL ALNVFSVQVQ
360 370 380 390 400
AFRVESDRFG SVEECVQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS

HAGYQTI
Length:407
Mass (Da):43,969
Last modified:January 1, 1990 - v1
Checksum:i25947490749A7C88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2942GV → EF in AAB19108. 1 PublicationCurated
Sequence conflicti329 – 3291N → T in AAB19108. 1 PublicationCurated
Sequence conflicti356 – 3572SD → VT1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34959 mRNA. Translation: AAA41525.1.
X14765 mRNA. Translation: CAA32873.1.
U75406 mRNA. Translation: AAB19108.1.
PIRiA30200.
RefSeqiNP_036989.1. NM_012857.2.
UniGeneiRn.40177.

Genome annotation databases

EnsembliENSRNOT00000026580; ENSRNOP00000026580; ENSRNOG00000019629.
GeneIDi25328.
KEGGirno:25328.
UCSCiRGD:2989. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34959 mRNA. Translation: AAA41525.1 .
X14765 mRNA. Translation: CAA32873.1 .
U75406 mRNA. Translation: AAB19108.1 .
PIRi A30200.
RefSeqi NP_036989.1. NM_012857.2.
UniGenei Rn.40177.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P14562. 3 interactions.
STRINGi 10116.ENSRNOP00000026580.

PTM databases

PhosphoSitei P14562.

Proteomic databases

PaxDbi P14562.
PRIDEi P14562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026580 ; ENSRNOP00000026580 ; ENSRNOG00000019629 .
GeneIDi 25328.
KEGGi rno:25328.
UCSCi RGD:2989. rat.

Organism-specific databases

CTDi 3916.
RGDi 2989. Lamp1.

Phylogenomic databases

eggNOGi NOG301998.
GeneTreei ENSGT00530000063068.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
InParanoidi P14562.
KOi K06528.
OMAi ENNMLIP.
OrthoDBi EOG7ZD1VH.
PhylomeDBi P14562.

Miscellaneous databases

NextBioi 606197.
PROi P14562.

Gene expression databases

Genevestigatori P14562.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins."
    Howe C.L., Granger B.L., Hull M., Green S.A., Gabel C.A., Helenius A., Mellman I.
    Proc. Natl. Acad. Sci. U.S.A. 85:7577-7581(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes."
    Himeno M., Noguchi Y., Sasaki H., Tanaka Y., Furuno K., Kono A., Sakaki Y., Kato K.
    FEBS Lett. 244:351-356(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-407.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 130-141; 147-155; 247-268 AND 317-353, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. Adams L.A., Werny I., Schwartz S.M.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 283-357.
    Strain: Wistar Kyoto.
    Tissue: Aortic smooth muscle.

Entry informationi

Entry nameiLAMP1_RAT
AccessioniPrimary (citable) accession number: P14562
Secondary accession number(s): P97620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3