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P14560 (BLA2_STRCI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase 2

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:blaU
OrganismStreptomyces cacaoi
Taxonomic identifier1898 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 314288Beta-lactamase 2
PRO_0000017017

Regions

Region258 – 2603Substrate binding By similarity

Sites

Active site961Acyl-ester intermediate

Sequences

Sequence LengthMass (Da)Tools
P14560 [UniParc].

Last modified April 1, 1990. Version 2.
Checksum: F895674E3B22ACD3

FASTA31434,023
        10         20         30         40         50         60 
MLHTRIRRAT LGAVAALSLV PVMACGQESS ADAAEPAGSA PSSSAAAHKP GEVEPYAAEL 

        70         80         90        100        110        120 
KALEDEFDVR LGVYAVDTGS GREVAYRDGE RFPYNSTFKA LECGAVLDKH TDREMDRVVK 

       130        140        150        160        170        180 
YSEDDLVDNS PVTEKHVEDG MTLTALCDAA VRYSDNTAAN LLFETVGGPK GLDKTLEGLG 

       190        200        210        220        230        240 
DHVTRMERVE PFLSRWEPGS KRDTSTPRAF AKDLRAYVLG DVLAEGDRKQ LTTWLRNNTT 

       250        260        270        280        290        300 
GDGLIRAGVR QGWVVGDKTG TGSYYGARND MAVVWRPDGR PLVLNVMVHG HTKDAELDSE 

       310 
LIARATEVVA DRLG 

« Hide

References

[1]"Transcriptional induction of Streptomyces cacaoi beta-lactamase by a beta-lactam compound."
Forsman M., Lindgren L., Haeggstroem B., Jaurin B.
Mol. Microbiol. 3:1425-1432(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 40057.
[2]"Two different beta-lactamase genes are present in Streptomyces cacaoi."
Magdalena J., Forsman M., Lenzini M.V., Brans A., Dusart J.
FEMS Microbiol. Lett. 78:101-105(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: COMPARISON OF BLAU AND BLAL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15708 Genomic DNA. Translation: CAA33739.1.
PIRS06967.

3D structure databases

ProteinModelPortalP14560.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA2_STRCI
AccessionPrimary (citable) accession number: P14560
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families