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Protein

Beta-lactamase 2

Gene

blaU

Organism
Streptomyces cacaoi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Acyl-ester intermediate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 2 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:blaU
OrganismiStreptomyces cacaoi
Taxonomic identifieri1898 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001701727 – 314Beta-lactamase 2Add BLAST288

Structurei

3D structure databases

ProteinModelPortaliP14560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 260Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHTRIRRAT LGAVAALSLV PVMACGQESS ADAAEPAGSA PSSSAAAHKP
60 70 80 90 100
GEVEPYAAEL KALEDEFDVR LGVYAVDTGS GREVAYRDGE RFPYNSTFKA
110 120 130 140 150
LECGAVLDKH TDREMDRVVK YSEDDLVDNS PVTEKHVEDG MTLTALCDAA
160 170 180 190 200
VRYSDNTAAN LLFETVGGPK GLDKTLEGLG DHVTRMERVE PFLSRWEPGS
210 220 230 240 250
KRDTSTPRAF AKDLRAYVLG DVLAEGDRKQ LTTWLRNNTT GDGLIRAGVR
260 270 280 290 300
QGWVVGDKTG TGSYYGARND MAVVWRPDGR PLVLNVMVHG HTKDAELDSE
310
LIARATEVVA DRLG
Length:314
Mass (Da):34,023
Last modified:April 1, 1990 - v2
Checksum:iF895674E3B22ACD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15708 Genomic DNA. Translation: CAA33739.1.
PIRiS06967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15708 Genomic DNA. Translation: CAA33739.1.
PIRiS06967.

3D structure databases

ProteinModelPortaliP14560.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLA2_STRCI
AccessioniPrimary (citable) accession number: P14560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: September 16, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.