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P14560

- BLA2_STRCI

UniProt

P14560 - BLA2_STRCI

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Protein

Beta-lactamase 2

Gene
blaU
Organism
Streptomyces cacaoi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Acyl-ester intermediate

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 2 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:blaU
OrganismiStreptomyces cacaoi
Taxonomic identifieri1898 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 314288Beta-lactamase 2PRO_0000017017Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14560.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni258 – 2603Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14560-1 [UniParc]FASTAAdd to Basket

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MLHTRIRRAT LGAVAALSLV PVMACGQESS ADAAEPAGSA PSSSAAAHKP    50
GEVEPYAAEL KALEDEFDVR LGVYAVDTGS GREVAYRDGE RFPYNSTFKA 100
LECGAVLDKH TDREMDRVVK YSEDDLVDNS PVTEKHVEDG MTLTALCDAA 150
VRYSDNTAAN LLFETVGGPK GLDKTLEGLG DHVTRMERVE PFLSRWEPGS 200
KRDTSTPRAF AKDLRAYVLG DVLAEGDRKQ LTTWLRNNTT GDGLIRAGVR 250
QGWVVGDKTG TGSYYGARND MAVVWRPDGR PLVLNVMVHG HTKDAELDSE 300
LIARATEVVA DRLG 314
Length:314
Mass (Da):34,023
Last modified:April 1, 1990 - v2
Checksum:iF895674E3B22ACD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15708 Genomic DNA. Translation: CAA33739.1.
PIRiS06967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15708 Genomic DNA. Translation: CAA33739.1 .
PIRi S06967.

3D structure databases

ProteinModelPortali P14560.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcriptional induction of Streptomyces cacaoi beta-lactamase by a beta-lactam compound."
    Forsman M., Lindgren L., Haeggstroem B., Jaurin B.
    Mol. Microbiol. 3:1425-1432(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 40057.
  2. "Two different beta-lactamase genes are present in Streptomyces cacaoi."
    Magdalena J., Forsman M., Lenzini M.V., Brans A., Dusart J.
    FEMS Microbiol. Lett. 78:101-105(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPARISON OF BLAU AND BLAL.

Entry informationi

Entry nameiBLA2_STRCI
AccessioniPrimary (citable) accession number: P14560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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