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Protein

Beta-lactamase

Gene
N/A
Organism
Streptomyces albus G
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Acyl-ester intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
OrganismiStreptomyces albus G
Taxonomic identifieri1962 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Tat-type signalAdd BLAST39
ChainiPRO_000001701240 – 314Beta-lactamaseAdd BLAST275

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven.

Structurei

Secondary structure

1314
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi48 – 60Combined sources13
Beta strandi62 – 70Combined sources9
Turni71 – 73Combined sources3
Beta strandi76 – 80Combined sources5
Helixi88 – 91Combined sources4
Helixi92 – 102Combined sources11
Beta strandi105 – 107Combined sources3
Turni108 – 111Combined sources4
Helixi118 – 124Combined sources7
Turni129 – 132Combined sources4
Helixi134 – 139Combined sources6
Helixi144 – 153Combined sources10
Helixi157 – 167Combined sources11
Helixi171 – 179Combined sources9
Helixi193 – 195Combined sources3
Helixi208 – 219Combined sources12
Beta strandi221 – 224Combined sources4
Helixi226 – 237Combined sources12
Turni243 – 245Combined sources3
Helixi246 – 249Combined sources4
Beta strandi254 – 262Combined sources9
Beta strandi268 – 275Combined sources8
Beta strandi282 – 289Combined sources8
Helixi299 – 312Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSGX-ray1.85A47-314[»]
ProteinModelPortaliP14559.
SMRiP14559.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14559.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 261Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPSTSRPSR RTLLTATAGA ALAAATLVPG TAHASSGGRG HGSGSVSDAE
60 70 80 90 100
RRLAGLERAS GARLGVYAYD TGSGRTVAYR ADELFPMCSV FKTLSSAAVL
110 120 130 140 150
RDLDRNGEFL SRRILYTQDD VEQADGAGPE TGKPQNLANA QLTVEELCEV
160 170 180 190 200
SITASDNCAA NLMLRELGGP AAVTRFVRSL GDRVTRLDRW EPELNSAEPG
210 220 230 240 250
RVTDTTSPRA ITRTYGRLVL GDALNPRDRR LLTSWLLANT TSGDRFRAGL
260 270 280 290 300
PDDWTLGDKT GAGRYGTNND AGVTWPPGRA PIVLTVLTAK TEQDAARDDG
310
LVADAARVLA ETLG
Length:314
Mass (Da):33,265
Last modified:January 1, 1990 - v1
Checksum:i5A17D7D19C84E511
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28303 Genomic DNA. Translation: AAA26775.1.
PIRiS00057. PNSM1U.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28303 Genomic DNA. Translation: AAA26775.1.
PIRiS00057. PNSM1U.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSGX-ray1.85A47-314[»]
ProteinModelPortaliP14559.
SMRiP14559.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP14559.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLAC_STRAL
AccessioniPrimary (citable) accession number: P14559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.