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P14546 (COX3_LEITA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Encoded onMitochondrion
OrganismLeishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifier5689 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Cytochrome c oxidase subunit 3
PRO_0000183797

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane198 – 22023Helical; Potential
Transmembrane224 – 24118Helical; Potential
Transmembrane248 – 26821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P14546 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: EA52C947C71CF6CB

FASTA28434,152
        10         20         30         40         50         60 
KRRRGFDFCL FCWFVLPAIC IVYLTFCLCG LFCIMFGSFI FIDYCFICFF ACLLFCLVCL 

        70         80         90        100        110        120 
LCDLFVDSLR GLFDVCCFIR CIQYCFVWFI ISELLLFLSL FYVVFSLVLF VSVEFAFVFV 

       130        140        150        160        170        180 
IPVMFSCLIC DFGFVFYWYF IDIFNLLINT FLLFVSGLFV NFVLFLFWFR FFLCVLFMLW 

       190        200        210        220        230        240 
VGILFGFLFL WNQVWEFALL FVTCSCGVFG SILFLIDLLH FSHVFLGIFL LFLCFSRCFN 

       250        260        270        280 
FLCMDTRFVF LYVVCLYWHF VDCVWFFLLR FVYFDVLSVV YLYA 

« Hide

References

[1]"Sequences of six genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae."
de la Cruz V.F., Neckelmann N., Simpson L.
J. Biol. Chem. 259:15136-15147(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

PIRG22848.

3D structure databases

ProteinModelPortalP14546.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_LEITA
AccessionPrimary (citable) accession number: P14546
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families