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P14546

- COX3_LEITA

UniProt

P14546 - COX3_LEITA

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Protein

Cytochrome c oxidase subunit 3

Gene
N/A
Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Encoded oniMitochondrion
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Cytochrome c oxidase subunit 3PRO_0000183797Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14546.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei198 – 22023HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24118HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14546 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KRRRGFDFCL FCWFVLPAIC IVYLTFCLCG LFCIMFGSFI FIDYCFICFF
60 70 80 90 100
ACLLFCLVCL LCDLFVDSLR GLFDVCCFIR CIQYCFVWFI ISELLLFLSL
110 120 130 140 150
FYVVFSLVLF VSVEFAFVFV IPVMFSCLIC DFGFVFYWYF IDIFNLLINT
160 170 180 190 200
FLLFVSGLFV NFVLFLFWFR FFLCVLFMLW VGILFGFLFL WNQVWEFALL
210 220 230 240 250
FVTCSCGVFG SILFLIDLLH FSHVFLGIFL LFLCFSRCFN FLCMDTRFVF
260 270 280
LYVVCLYWHF VDCVWFFLLR FVYFDVLSVV YLYA
Length:284
Mass (Da):34,152
Last modified:January 1, 1990 - v1
Checksum:iEA52C947C71CF6CB
GO

Sequence databases

PIRiG22848.

Cross-referencesi

Sequence databases

PIRi G22848.

3D structure databases

ProteinModelPortali P14546.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of six genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae."
    de la Cruz V.F., Neckelmann N., Simpson L.
    J. Biol. Chem. 259:15136-15147(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiCOX3_LEITA
AccessioniPrimary (citable) accession number: P14546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3