P14546 (COX3_LEITA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cytochrome c oxidase subunit 3 EC=1.9.3.1 Alternative name(s): Cytochrome c oxidase polypeptide III
Encoded on	Mitochondrion
Organism	Leishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifier	5689 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmaniinae › Leishmania › lizard Leishmania

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Cytochrome c oxidase subunit 3		PRO_0000183797
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	46 – 66	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	124 – 144	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Transmembrane	198 – 220	23	Helical; Potential
	Transmembrane	224 – 241	18	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P14546 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: EA52C947C71CF6CB	FASTA	284	34,152
	10 20 30 40 50 60 KRRRGFDFCL FCWFVLPAIC IVYLTFCLCG LFCIMFGSFI FIDYCFICFF ACLLFCLVCL 70 80 90 100 110 120 LCDLFVDSLR GLFDVCCFIR CIQYCFVWFI ISELLLFLSL FYVVFSLVLF VSVEFAFVFV 130 140 150 160 170 180 IPVMFSCLIC DFGFVFYWYF IDIFNLLINT FLLFVSGLFV NFVLFLFWFR FFLCVLFMLW 190 200 210 220 230 240 VGILFGFLFL WNQVWEFALL FVTCSCGVFG SILFLIDLLH FSHVFLGIFL LFLCFSRCFN 250 260 270 280 FLCMDTRFVF LYVVCLYWHF VDCVWFFLLR FVYFDVLSVV YLYA

References

[1]	"Sequences of six genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae." de la Cruz V.F., Neckelmann N., Simpson L. J. Biol. Chem. 259:15136-15147(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
PIR	G22848.
3D structure databases
ProteinModelPortal	P14546.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_LEITA

Accession

Primary (citable) accession number: P14546

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)