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P14546

- COX3_LEITA

UniProt

P14546 - COX3_LEITA

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Protein

Cytochrome c oxidase subunit 3

Gene
N/A
Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Encoded oniMitochondrion
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Transmembranei46 – 6621Helical; Reviewed predictionAdd
BLAST
Transmembranei78 – 9821Helical; Reviewed predictionAdd
BLAST
Transmembranei124 – 14421Helical; Reviewed predictionAdd
BLAST
Transmembranei147 – 16721Helical; Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST
Transmembranei198 – 22023Helical; Reviewed predictionAdd
BLAST
Transmembranei224 – 24118Helical; Reviewed predictionAdd
BLAST
Transmembranei248 – 26821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Cytochrome c oxidase subunit 3PRO_0000183797Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14546.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14546-1 [UniParc]FASTAAdd to Basket

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KRRRGFDFCL FCWFVLPAIC IVYLTFCLCG LFCIMFGSFI FIDYCFICFF    50
ACLLFCLVCL LCDLFVDSLR GLFDVCCFIR CIQYCFVWFI ISELLLFLSL 100
FYVVFSLVLF VSVEFAFVFV IPVMFSCLIC DFGFVFYWYF IDIFNLLINT 150
FLLFVSGLFV NFVLFLFWFR FFLCVLFMLW VGILFGFLFL WNQVWEFALL 200
FVTCSCGVFG SILFLIDLLH FSHVFLGIFL LFLCFSRCFN FLCMDTRFVF 250
LYVVCLYWHF VDCVWFFLLR FVYFDVLSVV YLYA 284
Length:284
Mass (Da):34,152
Last modified:January 1, 1990 - v1
Checksum:iEA52C947C71CF6CB
GO

Sequence databases

PIRiG22848.

Cross-referencesi

Sequence databases

PIRi G22848.

3D structure databases

ProteinModelPortali P14546.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of six genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae."
    de la Cruz V.F., Neckelmann N., Simpson L.
    J. Biol. Chem. 259:15136-15147(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiCOX3_LEITA
AccessioniPrimary (citable) accession number: P14546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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