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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme A axial ligand)Curated1
Metal bindingi243Copper BCurated1
Metal bindingi247Copper BCurated1
Metal bindingi292Copper BCurated1
Metal bindingi293Copper BCurated1
Metal bindingi378Iron (heme A3 axial ligand)Curated1
Metal bindingi380Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Transmembranei520 – 540HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833501 – 549Cytochrome c oxidase subunit 1Add BLAST549

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiP14544.

Structurei

3D structure databases

ProteinModelPortaliP14544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWLCLVCLS VSHKMIGLCY LLVAILSGFV GYVYSLFIRL ELSLIGCGIL
60 70 80 90 100
FGDYQFYNVL ITSHGLIMVF AFIMPVMMGG LVNYFIPVMA GFPDMVFPRL
110 120 130 140 150
NNMSFWMYLA GFGCVVNGFL TEEGMGVGWT LYPTLICIDF HSSLACDFVM
160 170 180 190 200
FAVHLLGISS ILNSINLLGT LFCCRRKFFS FLSWSLFIWA ALITAILLII
210 220 230 240 250
TLPVLAGGVT LILCDRNFNT SFYDVVGGGD LILFQHIFWF FGHPEVYIIL
260 270 280 290 300
LPVFGLISTI VEVIGFRCVF STVAMIYSMI LIAILGMFVW AHHMFVVGMD
310 320 330 340 350
VDSRAYFGGV SILIGLPTCV KLFNWIYSFL YTDMIITFEV YFVIMFIFMF
360 370 380 390 400
LIGAVTGLFL SNVGIDIMLH DTYFVVGHFH YVLSLGAVVG FFTGFIHFLA
410 420 430 440 450
KWLPIELYLF WMFYFISTLF IGSNMLFFPM HSLGMYAFPR RISDYPVSFL
460 470 480 490 500
FWSSFMLYGM LLLASLILFL CALFCVFLFW DYCLFFVSLF VFSLYCFFYF
510 520 530 540
STWLPCVMVL YLLLVDFAHI VLDYLFLILC FCFVFFIFFW QSLFLFFYI
Length:549
Mass (Da):63,272
Last modified:January 1, 1990 - v1
Checksum:iF6DD04815A4917C2
GO

Sequence databases

PIRiD30010.

Cross-referencesi

Sequence databases

PIRiD30010.

3D structure databases

ProteinModelPortaliP14544.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP14544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_LEITA
AccessioniPrimary (citable) accession number: P14544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.