Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P14544

- COX1_LEITA

UniProt

P14544 - COX1_LEITA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand)Curated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi292 – 2921Copper BCurated
Metal bindingi293 – 2931Copper BCurated
Metal bindingi378 – 3781Iron (heme A3 axial ligand)Curated
Metal bindingi380 – 3801Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei402 – 42221HelicalSequence AnalysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Transmembranei520 – 54021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Cytochrome c oxidase subunit 1PRO_0000183350Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP14544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14544-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFWLCLVCLS VSHKMIGLCY LLVAILSGFV GYVYSLFIRL ELSLIGCGIL
60 70 80 90 100
FGDYQFYNVL ITSHGLIMVF AFIMPVMMGG LVNYFIPVMA GFPDMVFPRL
110 120 130 140 150
NNMSFWMYLA GFGCVVNGFL TEEGMGVGWT LYPTLICIDF HSSLACDFVM
160 170 180 190 200
FAVHLLGISS ILNSINLLGT LFCCRRKFFS FLSWSLFIWA ALITAILLII
210 220 230 240 250
TLPVLAGGVT LILCDRNFNT SFYDVVGGGD LILFQHIFWF FGHPEVYIIL
260 270 280 290 300
LPVFGLISTI VEVIGFRCVF STVAMIYSMI LIAILGMFVW AHHMFVVGMD
310 320 330 340 350
VDSRAYFGGV SILIGLPTCV KLFNWIYSFL YTDMIITFEV YFVIMFIFMF
360 370 380 390 400
LIGAVTGLFL SNVGIDIMLH DTYFVVGHFH YVLSLGAVVG FFTGFIHFLA
410 420 430 440 450
KWLPIELYLF WMFYFISTLF IGSNMLFFPM HSLGMYAFPR RISDYPVSFL
460 470 480 490 500
FWSSFMLYGM LLLASLILFL CALFCVFLFW DYCLFFVSLF VFSLYCFFYF
510 520 530 540
STWLPCVMVL YLLLVDFAHI VLDYLFLILC FCFVFFIFFW QSLFLFFYI
Length:549
Mass (Da):63,272
Last modified:January 1, 1990 - v1
Checksum:iF6DD04815A4917C2
GO

Sequence databases

PIRiD30010.

Cross-referencesi

Sequence databases

PIRi D30010.

3D structure databases

ProteinModelPortali P14544.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences of six genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae."
    de la Cruz V.F., Neckelmann N., Simpson L.
    J. Biol. Chem. 259:15136-15147(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiCOX1_LEITA
AccessioniPrimary (citable) accession number: P14544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3