Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nidogen-1

Gene

NID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. collagen binding Source: BHF-UCL
  3. laminin binding Source: BHF-UCL
  4. proteoglycan binding Source: BHF-UCL

GO - Biological processi

  1. basement membrane organization Source: BHF-UCL
  2. cell-matrix adhesion Source: Ensembl
  3. extracellular matrix disassembly Source: Reactome
  4. extracellular matrix organization Source: Reactome
  5. glomerular basement membrane development Source: Ensembl
  6. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_169262. Laminin interactions.

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Nidogen-1
Short name:
NID-1
Alternative name(s):
Entactin
Gene namesi
Name:NID1
Synonyms:NID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7821. NID1.

Subcellular locationi

GO - Cellular componenti

  1. basal lamina Source: Ensembl
  2. basement membrane Source: BHF-UCL
  3. cell periphery Source: Ensembl
  4. extracellular matrix Source: UniProtKB
  5. extracellular region Source: Reactome
  6. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31625.

Chemistry

DrugBankiDB00013. Urokinase.

Polymorphism and mutation databases

BioMutaiNID1.
DMDMi251757450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 12471219Nidogen-1PRO_0000007669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891SulfotyrosineSequence Analysis
Modified residuei296 – 2961SulfotyrosineSequence Analysis
Disulfide bondi390 ↔ 403By similarity
Disulfide bondi397 ↔ 412By similarity
Disulfide bondi411 ↔ 618By similarity
Disulfide bondi414 ↔ 425By similarity
Disulfide bondi672 ↔ 685By similarity
Disulfide bondi679 ↔ 695By similarity
Disulfide bondi697 ↔ 708By similarity
Disulfide bondi714 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 750By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi769 ↔ 787By similarity
Disulfide bondi789 ↔ 800By similarity
Disulfide bondi806 ↔ 817By similarity
Disulfide bondi811 ↔ 826By similarity
Disulfide bondi828 ↔ 839By similarity
Disulfide bondi849 ↔ 878By similarity
Disulfide bondi889 ↔ 896By similarity
Disulfide bondi898 ↔ 919By similarity
Glycosylationi1137 – 11371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1212 ↔ 1223By similarity
Disulfide bondi1219 ↔ 1232By similarity
Disulfide bondi1234 ↔ 1243By similarity

Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

MaxQBiP14543.
PaxDbiP14543.
PRIDEiP14543.

PTM databases

PhosphoSiteiP14543.

Expressioni

Gene expression databases

BgeeiP14543.
CleanExiHS_NID1.
GenevestigatoriP14543.

Organism-specific databases

HPAiCAB010044.

Interactioni

Subunit structurei

Interacts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1.By similarity1 Publication

Protein-protein interaction databases

BioGridi110876. 15 interactions.
IntActiP14543. 9 interactions.
MINTiMINT-1193369.
STRINGi9606.ENSP00000264187.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
ProteinModelPortaliP14543.
SMRiP14543. Positions 389-661, 683-912, 914-1235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 268163NIDOPROSITE-ProRule annotationAdd
BLAST
Domaini386 – 42641EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 667238Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd
BLAST
Domaini668 – 70942EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 75142EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini758 – 80144EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini802 – 84039EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini846 – 91974Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST
Repeati990 – 103243LDL-receptor class B 1Add
BLAST
Repeati1033 – 107543LDL-receptor class B 2Add
BLAST
Repeati1076 – 112045LDL-receptor class B 3Add
BLAST
Repeati1121 – 116242LDL-receptor class B 4Add
BLAST
Domaini1208 – 124437EGF-like 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi702 – 7043Cell attachment site

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 4 LDL-receptor class B repeats.PROSITE-ProRule annotation
Contains 1 NIDO domain.PROSITE-ProRule annotation
Contains 1 nidogen G2 beta-barrel domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG282695.
GeneTreeiENSGT00760000118968.
HOGENOMiHOG000072712.
HOVERGENiHBG006498.
InParanoidiP14543.
KOiK06826.
OMAiDYRPDYR.
OrthoDBiEOG7M0NQN.
PhylomeDBiP14543.
TreeFamiTF320666.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR003886. Nidogen_extracell_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 2 hits.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD
60 70 80 90 100
DFVSPALELS GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT
110 120 130 140 150
FGAVAPFLAD LDTTDGLGKV YYREDLSPSI TQRAAECVHR GFPEISFQPS
160 170 180 190 200
SAVVVTWESV APYQGPSRDP DQKGKRNTFQ AVLASSDSSS YAIFLYPEDG
210 220 230 240 250
LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA NDRESVENLA
260 270 280 290 300
KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT
310 320 330 340 350
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT
360 370 380 390 400
RSFQLAVETF HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH
410 420 430 440 450
AECRDYATGF CCSCVAGYTG NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP
460 470 480 490 500
IVFENTDLHS YVVMNHGRSY TAISTIPETV GYSLLPLAPV GGIIGWMFAV
510 520 530 540 550
EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI DEHGHLTIDT
560 570 580 590 600
ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS
610 620 630 640 650
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR
660 670 680 690 700
YALSNSIGPV REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG
710 720 730 740 750
FRGDGRTCYD IDECSEQPSV CGSHTICNNH PGTFRCECVE GYQFSDEGTC
760 770 780 790 800
VAVVDQRPIN YCETGLHNCD IPQRAQCIYT GGSSYTCSCL PGFSGDGQAC
810 820 830 840 850
QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV PGEVEKTRCQ
860 870 880 890 900
HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD
910 920 930 940 950
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ
960 970 980 990 1000
TGKIERLPLE GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP
1010 1020 1030 1040 1050
SIGRASLHGG EPTTIIRQDL GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL
1060 1070 1080 1090 1100
DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW TDWNRDNPKI ETSYMDGTNR
1110 1120 1130 1140 1150
RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ PSRRKALEGL
1160 1170 1180 1190 1200
QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT
1210 1220 1230 1240
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK
Length:1,247
Mass (Da):136,377
Last modified:July 7, 2009 - v3
Checksum:iFCC839416525CD48
GO
Isoform 2 (identifier: P14543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Show »
Length:1,114
Mass (Da):122,017
Checksum:i177A25689611C3BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 342EL → SS in CAA57709 (PubMed:7557988).Curated
Sequence conflicti37 – 426FGPGQG → SAPDR in CAA57709 (PubMed:7557988).Curated
Sequence conflicti653 – 6531L → F in AAA59932 (PubMed:2574658).Curated
Sequence conflicti653 – 6531L → F in CAA57709 (PubMed:7557988).Curated
Sequence conflicti1115 – 11151T → H in AAA59932 (PubMed:2574658).Curated
Sequence conflicti1115 – 11151T → H in CAA57709 (PubMed:7557988).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311R → L.
Corresponds to variant rs2071529 [ dbSNP | Ensembl ].
VAR_055760
Natural varianti60 – 601S → R.1 Publication
Corresponds to variant rs17857302 [ dbSNP | Ensembl ].
VAR_058123
Natural varianti246 – 2461V → I.4 Publications
Corresponds to variant rs10733133 [ dbSNP | Ensembl ].
VAR_024264
Natural varianti302 – 3021R → H.
Corresponds to variant rs16833183 [ dbSNP | Ensembl ].
VAR_055761
Natural varianti335 – 3351R → H.
Corresponds to variant rs34406281 [ dbSNP | Ensembl ].
VAR_055762
Natural varianti387 – 3871R → H.
Corresponds to variant rs16833154 [ dbSNP | Ensembl ].
VAR_055763
Natural varianti669 – 6691Q → R.
Corresponds to variant rs3738534 [ dbSNP | Ensembl ].
VAR_021904
Natural varianti807 – 8071Q → H.1 Publication
Corresponds to variant rs3738531 [ dbSNP | Ensembl ].
VAR_058124
Natural varianti970 – 9701K → E.
Corresponds to variant rs16833060 [ dbSNP | Ensembl ].
VAR_055764
Natural varianti1036 – 10361F → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035835
Natural varianti1163 – 11631L → V.
Corresponds to variant rs16833032 [ dbSNP | Ensembl ].
VAR_055765
Natural varianti1226 – 12261T → I.
Corresponds to variant rs6662744 [ dbSNP | Ensembl ].
VAR_055766
Natural varianti1246 – 12461Q → R.3 Publications
Corresponds to variant rs3213190 [ dbSNP | Ensembl ].
VAR_058125

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei710 – 842133Missing in isoform 2. 2 PublicationsVSP_017254Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30269 mRNA. Translation: AAA59932.1.
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.
CCDSiCCDS1608.1. [P14543-1]
PIRiA33322. MMHUND.
RefSeqiNP_002499.2. NM_002508.2. [P14543-1]
UniGeneiHs.356624.

Genome annotation databases

EnsembliENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
GeneIDi4811.
KEGGihsa:4811.
UCSCiuc001hxo.3. human. [P14543-1]
uc009xgd.3. human. [P14543-2]

Polymorphism and mutation databases

BioMutaiNID1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30269 mRNA. Translation: AAA59932.1.
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.
CCDSiCCDS1608.1. [P14543-1]
PIRiA33322. MMHUND.
RefSeqiNP_002499.2. NM_002508.2. [P14543-1]
UniGeneiHs.356624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
ProteinModelPortaliP14543.
SMRiP14543. Positions 389-661, 683-912, 914-1235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110876. 15 interactions.
IntActiP14543. 9 interactions.
MINTiMINT-1193369.
STRINGi9606.ENSP00000264187.

Chemistry

DrugBankiDB00013. Urokinase.

Protein family/group databases

MEROPSiI63.001.

PTM databases

PhosphoSiteiP14543.

Polymorphism and mutation databases

BioMutaiNID1.
DMDMi251757450.

Proteomic databases

MaxQBiP14543.
PaxDbiP14543.
PRIDEiP14543.

Protocols and materials databases

DNASUi4811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
GeneIDi4811.
KEGGihsa:4811.
UCSCiuc001hxo.3. human. [P14543-1]
uc009xgd.3. human. [P14543-2]

Organism-specific databases

CTDi4811.
GeneCardsiGC01M236139.
H-InvDBHIX0023622.
HGNCiHGNC:7821. NID1.
HPAiCAB010044.
MIMi131390. gene.
neXtProtiNX_P14543.
PharmGKBiPA31625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG282695.
GeneTreeiENSGT00760000118968.
HOGENOMiHOG000072712.
HOVERGENiHBG006498.
InParanoidiP14543.
KOiK06826.
OMAiDYRPDYR.
OrthoDBiEOG7M0NQN.
PhylomeDBiP14543.
TreeFamiTF320666.

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_169262. Laminin interactions.

Miscellaneous databases

ChiTaRSiNID1. human.
GeneWikiiEntactin.
GenomeRNAii4811.
NextBioi18544.
PROiP14543.
SOURCEiSearch...

Gene expression databases

BgeeiP14543.
CleanExiHS_NID1.
GenevestigatoriP14543.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR003886. Nidogen_extracell_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 2 hits.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene."
    Nagayoshi T., Sanborn D., Hickok N.J., Olsen D.R., Fazio M.J., Chu M.-L., Knowlton R., Mann K., Deutzmann R., Timpl R., Uitto J.
    DNA 8:581-594(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-246 AND ARG-1246.
  2. "Genomic sequences and structural organization of the human nidogen gene (NID)."
    Zimmermann K., Hoischen S., Hafner M., Nischt R.
    Genomics 27:245-250(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-246 AND ARG-1246.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-60 AND ILE-246.
    Tissue: Testis.
  5. "Human nidogen gene: structural and functional characterization of the 5'-flanking region."
    Fazio M.J., O'Leary J., Kahari V.M., Chen Y.Q., Saitta B., Uitto J.
    J. Invest. Dermatol. 97:281-285(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1247 (ISOFORM 2), VARIANTS ILE-246 AND HIS-807.
    Tissue: Brain.
  7. "Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43."
    Olsen D.R., Nagayoshi T., Fazio M., Mattei M.-G., Passage E., Weil D., Timpl R., Chu M.-L., Uitto J.
    Am. J. Hum. Genet. 44:876-885(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-1247 (ISOFORM 1), VARIANT ARG-1246.
    Tissue: Placenta.
  8. "Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
    Lee H.K., Seo I.A., Park H.K., Park H.T.
    FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXDC1.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1036.

Entry informationi

Entry nameiNID1_HUMAN
AccessioniPrimary (citable) accession number: P14543
Secondary accession number(s): Q14942
, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: April 29, 2015
This is version 174 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.