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P14543

- NID1_HUMAN

UniProt

P14543 - NID1_HUMAN

Protein

Nidogen-1

Gene

NID1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 168 (01 Oct 2014)
      Sequence version 3 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. collagen binding Source: BHF-UCL
    3. laminin binding Source: BHF-UCL
    4. proteoglycan binding Source: BHF-UCL

    GO - Biological processi

    1. basement membrane organization Source: BHF-UCL
    2. cell-matrix adhesion Source: Ensembl
    3. extracellular matrix disassembly Source: Reactome
    4. extracellular matrix organization Source: Reactome
    5. glomerular basement membrane development Source: Ensembl
    6. positive regulation of cell-substrate adhesion Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_118572. Degradation of the extracellular matrix.
    REACT_169262. Laminin interactions.

    Protein family/group databases

    MEROPSiI63.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nidogen-1
    Short name:
    NID-1
    Alternative name(s):
    Entactin
    Gene namesi
    Name:NID1
    Synonyms:NID
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7821. NID1.

    Subcellular locationi

    GO - Cellular componenti

    1. basal lamina Source: Ensembl
    2. basement membrane Source: BHF-UCL
    3. cell periphery Source: Ensembl
    4. extracellular region Source: Reactome
    5. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31625.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Add
    BLAST
    Chaini29 – 12471219Nidogen-1PRO_0000007669Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei289 – 2891SulfotyrosineSequence Analysis
    Modified residuei296 – 2961SulfotyrosineSequence Analysis
    Disulfide bondi390 ↔ 403By similarity
    Disulfide bondi397 ↔ 412By similarity
    Disulfide bondi411 ↔ 618By similarity
    Disulfide bondi414 ↔ 425By similarity
    Disulfide bondi672 ↔ 685By similarity
    Disulfide bondi679 ↔ 695By similarity
    Disulfide bondi697 ↔ 708By similarity
    Disulfide bondi714 ↔ 727By similarity
    Disulfide bondi721 ↔ 736By similarity
    Disulfide bondi738 ↔ 750By similarity
    Disulfide bondi762 ↔ 777By similarity
    Disulfide bondi769 ↔ 787By similarity
    Disulfide bondi789 ↔ 800By similarity
    Disulfide bondi806 ↔ 817By similarity
    Disulfide bondi811 ↔ 826By similarity
    Disulfide bondi828 ↔ 839By similarity
    Disulfide bondi849 ↔ 878By similarity
    Disulfide bondi889 ↔ 896By similarity
    Disulfide bondi898 ↔ 919By similarity
    Glycosylationi1137 – 11371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1212 ↔ 1223By similarity
    Disulfide bondi1219 ↔ 1232By similarity
    Disulfide bondi1234 ↔ 1243By similarity

    Post-translational modificationi

    N- and O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Proteomic databases

    MaxQBiP14543.
    PaxDbiP14543.
    PRIDEiP14543.

    PTM databases

    PhosphoSiteiP14543.

    Expressioni

    Gene expression databases

    BgeeiP14543.
    CleanExiHS_NID1.
    GenevestigatoriP14543.

    Organism-specific databases

    HPAiCAB010044.

    Interactioni

    Subunit structurei

    Interacts with FBLN1 and LGALS3BP By similarity. Interacts with PLXDC1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi110876. 12 interactions.
    IntActiP14543. 9 interactions.
    MINTiMINT-1193369.
    STRINGi9606.ENSP00000264187.

    Structurei

    Secondary structure

    1
    1247
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi945 – 9506
    Beta strandi953 – 9586
    Beta strandi971 – 9744
    Beta strandi978 – 9858
    Beta strandi989 – 9968
    Beta strandi1001 – 10099
    Beta strandi1012 – 10176
    Beta strandi1023 – 10308
    Turni1031 – 10333
    Beta strandi1034 – 10396
    Turni1040 – 10423
    Beta strandi1045 – 10495
    Turni1050 – 10534
    Beta strandi1054 – 10585
    Beta strandi1066 – 10716
    Beta strandi1075 – 10828
    Beta strandi1089 – 10946
    Turni1095 – 10973
    Beta strandi1100 – 11045
    Beta strandi1111 – 11166
    Beta strandi1123 – 11275
    Helixi1128 – 11303
    Beta strandi1132 – 11376
    Turni1138 – 11414
    Beta strandi1142 – 11476
    Beta strandi1153 – 11575
    Beta strandi1162 – 11676
    Turni1168 – 11714
    Beta strandi1172 – 11776
    Turni1178 – 11814
    Beta strandi1182 – 11876
    Beta strandi1191 – 11933
    Beta strandi1195 – 120410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NDXmodel-A941-1206[»]
    ProteinModelPortaliP14543.
    SMRiP14543. Positions 389-661, 671-912, 914-1235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini106 – 268163NIDOPROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 42641EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 667238Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd
    BLAST
    Domaini668 – 70942EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini710 – 75142EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini758 – 80144EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini802 – 84039EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini846 – 91974Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST
    Repeati990 – 103243LDL-receptor class B 1Add
    BLAST
    Repeati1033 – 107543LDL-receptor class B 2Add
    BLAST
    Repeati1076 – 112045LDL-receptor class B 3Add
    BLAST
    Repeati1121 – 116242LDL-receptor class B 4Add
    BLAST
    Domaini1208 – 124437EGF-like 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi702 – 7043Cell attachment site

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 4 LDL-receptor class B repeats.PROSITE-ProRule annotation
    Contains 1 NIDO domain.PROSITE-ProRule annotation
    Contains 1 nidogen G2 beta-barrel domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG282695.
    HOGENOMiHOG000072712.
    HOVERGENiHBG006498.
    InParanoidiP14543.
    KOiK06826.
    OMAiDYRPDYR.
    OrthoDBiEOG7M0NQN.
    PhylomeDBiP14543.
    TreeFamiTF320666.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    2.40.155.10. 2 hits.
    4.10.800.10. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR006605. G2_nidogen/fibulin_G2F.
    IPR009017. GFP.
    IPR023413. GFP_like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000033. LDLR_classB_rpt.
    IPR003886. Nidogen_extracell_dom.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF12947. EGF_3. 2 hits.
    PF07645. EGF_CA. 1 hit.
    PF07474. G2F. 1 hit.
    PF00058. Ldl_recept_b. 3 hits.
    PF06119. NIDO. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00682. G2F. 1 hit.
    SM00135. LY. 5 hits.
    SM00539. NIDO. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54511. SSF54511. 1 hit.
    SSF57184. SSF57184. 5 hits.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 5 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 2 hits.
    PS51120. LDLRB. 4 hits.
    PS51220. NIDO. 1 hit.
    PS50993. NIDOGEN_G2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P14543-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD     50
    DFVSPALELS GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT 100
    FGAVAPFLAD LDTTDGLGKV YYREDLSPSI TQRAAECVHR GFPEISFQPS 150
    SAVVVTWESV APYQGPSRDP DQKGKRNTFQ AVLASSDSSS YAIFLYPEDG 200
    LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA NDRESVENLA 250
    KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 300
    TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT 350
    RSFQLAVETF HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH 400
    AECRDYATGF CCSCVAGYTG NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP 450
    IVFENTDLHS YVVMNHGRSY TAISTIPETV GYSLLPLAPV GGIIGWMFAV 500
    EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI DEHGHLTIDT 550
    ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 600
    PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR 650
    YALSNSIGPV REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG 700
    FRGDGRTCYD IDECSEQPSV CGSHTICNNH PGTFRCECVE GYQFSDEGTC 750
    VAVVDQRPIN YCETGLHNCD IPQRAQCIYT GGSSYTCSCL PGFSGDGQAC 800
    QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV PGEVEKTRCQ 850
    HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD 900
    RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ 950
    TGKIERLPLE GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP 1000
    SIGRASLHGG EPTTIIRQDL GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL 1050
    DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW TDWNRDNPKI ETSYMDGTNR 1100
    RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ PSRRKALEGL 1150
    QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT 1200
    ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK 1247
    Length:1,247
    Mass (Da):136,377
    Last modified:July 7, 2009 - v3
    Checksum:iFCC839416525CD48
    GO
    Isoform 2 (identifier: P14543-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         710-842: Missing.

    Show »
    Length:1,114
    Mass (Da):122,017
    Checksum:i177A25689611C3BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 342EL → SS in CAA57709. (PubMed:7557988)Curated
    Sequence conflicti37 – 426FGPGQG → SAPDR in CAA57709. (PubMed:7557988)Curated
    Sequence conflicti653 – 6531L → F in AAA59932. (PubMed:2574658)Curated
    Sequence conflicti653 – 6531L → F in CAA57709. (PubMed:7557988)Curated
    Sequence conflicti1115 – 11151T → H in AAA59932. (PubMed:2574658)Curated
    Sequence conflicti1115 – 11151T → H in CAA57709. (PubMed:7557988)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311R → L.
    Corresponds to variant rs2071529 [ dbSNP | Ensembl ].
    VAR_055760
    Natural varianti60 – 601S → R.1 Publication
    Corresponds to variant rs17857302 [ dbSNP | Ensembl ].
    VAR_058123
    Natural varianti246 – 2461V → I.4 Publications
    Corresponds to variant rs10733133 [ dbSNP | Ensembl ].
    VAR_024264
    Natural varianti302 – 3021R → H.
    Corresponds to variant rs16833183 [ dbSNP | Ensembl ].
    VAR_055761
    Natural varianti335 – 3351R → H.
    Corresponds to variant rs34406281 [ dbSNP | Ensembl ].
    VAR_055762
    Natural varianti387 – 3871R → H.
    Corresponds to variant rs16833154 [ dbSNP | Ensembl ].
    VAR_055763
    Natural varianti669 – 6691Q → R.
    Corresponds to variant rs3738534 [ dbSNP | Ensembl ].
    VAR_021904
    Natural varianti807 – 8071Q → H.1 Publication
    Corresponds to variant rs3738531 [ dbSNP | Ensembl ].
    VAR_058124
    Natural varianti970 – 9701K → E.
    Corresponds to variant rs16833060 [ dbSNP | Ensembl ].
    VAR_055764
    Natural varianti1036 – 10361F → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035835
    Natural varianti1163 – 11631L → V.
    Corresponds to variant rs16833032 [ dbSNP | Ensembl ].
    VAR_055765
    Natural varianti1226 – 12261T → I.
    Corresponds to variant rs6662744 [ dbSNP | Ensembl ].
    VAR_055766
    Natural varianti1246 – 12461Q → R.3 Publications
    Corresponds to variant rs3213190 [ dbSNP | Ensembl ].
    VAR_058125

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei710 – 842133Missing in isoform 2. 2 PublicationsVSP_017254Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30269 mRNA. Translation: AAA59932.1.
    X82245
    , X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
    AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
    AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
    AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
    AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
    BC045606 mRNA. Translation: AAH45606.1.
    AB209448 mRNA. Translation: BAD92685.1.
    M27445 mRNA. Translation: AAA57261.1.
    CCDSiCCDS1608.1. [P14543-1]
    PIRiA33322. MMHUND.
    RefSeqiNP_002499.2. NM_002508.2. [P14543-1]
    UniGeneiHs.356624.

    Genome annotation databases

    EnsembliENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
    ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
    GeneIDi4811.
    KEGGihsa:4811.
    UCSCiuc001hxo.3. human. [P14543-1]
    uc009xgd.3. human. [P14543-2]

    Polymorphism databases

    DMDMi251757450.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30269 mRNA. Translation: AAA59932.1 .
    X82245
    , X84819 , X84820 , X84821 , X84822 , X84823 , X84824 , X84825 , X84826 , X84827 , X84828 , X84829 , X84830 , X84831 , X84832 , X84833 , X84834 , X84835 , X84836 , X84837 Genomic DNA. Translation: CAA57709.1 .
    AL122018 , AL139161 Genomic DNA. Translation: CAI22680.1 .
    AL122018 , AL139161 Genomic DNA. Translation: CAI22681.1 .
    AL139161 , AL122018 Genomic DNA. Translation: CAI23421.1 .
    AL139161 , AL122018 Genomic DNA. Translation: CAI23422.1 .
    BC045606 mRNA. Translation: AAH45606.1 .
    AB209448 mRNA. Translation: BAD92685.1 .
    M27445 mRNA. Translation: AAA57261.1 .
    CCDSi CCDS1608.1. [P14543-1 ]
    PIRi A33322. MMHUND.
    RefSeqi NP_002499.2. NM_002508.2. [P14543-1 ]
    UniGenei Hs.356624.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NDX model - A 941-1206 [» ]
    ProteinModelPortali P14543.
    SMRi P14543. Positions 389-661, 671-912, 914-1235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110876. 12 interactions.
    IntActi P14543. 9 interactions.
    MINTi MINT-1193369.
    STRINGi 9606.ENSP00000264187.

    Chemistry

    DrugBanki DB00102. Becaplermin.
    DB00013. Urokinase.

    Protein family/group databases

    MEROPSi I63.001.

    PTM databases

    PhosphoSitei P14543.

    Polymorphism databases

    DMDMi 251757450.

    Proteomic databases

    MaxQBi P14543.
    PaxDbi P14543.
    PRIDEi P14543.

    Protocols and materials databases

    DNASUi 4811.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264187 ; ENSP00000264187 ; ENSG00000116962 . [P14543-1 ]
    ENST00000366595 ; ENSP00000355554 ; ENSG00000116962 . [P14543-2 ]
    GeneIDi 4811.
    KEGGi hsa:4811.
    UCSCi uc001hxo.3. human. [P14543-1 ]
    uc009xgd.3. human. [P14543-2 ]

    Organism-specific databases

    CTDi 4811.
    GeneCardsi GC01M236139.
    H-InvDB HIX0023622.
    HGNCi HGNC:7821. NID1.
    HPAi CAB010044.
    MIMi 131390. gene.
    neXtProti NX_P14543.
    PharmGKBi PA31625.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282695.
    HOGENOMi HOG000072712.
    HOVERGENi HBG006498.
    InParanoidi P14543.
    KOi K06826.
    OMAi DYRPDYR.
    OrthoDBi EOG7M0NQN.
    PhylomeDBi P14543.
    TreeFami TF320666.

    Enzyme and pathway databases

    Reactomei REACT_118572. Degradation of the extracellular matrix.
    REACT_169262. Laminin interactions.

    Miscellaneous databases

    ChiTaRSi NID1. human.
    GeneWikii Entactin.
    GenomeRNAii 4811.
    NextBioi 18544.
    PROi P14543.
    SOURCEi Search...

    Gene expression databases

    Bgeei P14543.
    CleanExi HS_NID1.
    Genevestigatori P14543.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    2.40.155.10. 2 hits.
    4.10.800.10. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR006605. G2_nidogen/fibulin_G2F.
    IPR009017. GFP.
    IPR023413. GFP_like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000033. LDLR_classB_rpt.
    IPR003886. Nidogen_extracell_dom.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF12947. EGF_3. 2 hits.
    PF07645. EGF_CA. 1 hit.
    PF07474. G2F. 1 hit.
    PF00058. Ldl_recept_b. 3 hits.
    PF06119. NIDO. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00682. G2F. 1 hit.
    SM00135. LY. 5 hits.
    SM00539. NIDO. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54511. SSF54511. 1 hit.
    SSF57184. SSF57184. 5 hits.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 5 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 2 hits.
    PS51120. LDLRB. 4 hits.
    PS51220. NIDO. 1 hit.
    PS50993. NIDOGEN_G2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
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    Publicationsi

    1. "Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene."
      Nagayoshi T., Sanborn D., Hickok N.J., Olsen D.R., Fazio M.J., Chu M.-L., Knowlton R., Mann K., Deutzmann R., Timpl R., Uitto J.
      DNA 8:581-594(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-246 AND ARG-1246.
    2. "Genomic sequences and structural organization of the human nidogen gene (NID)."
      Zimmermann K., Hoischen S., Hafner M., Nischt R.
      Genomics 27:245-250(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-246 AND ARG-1246.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-60 AND ILE-246.
      Tissue: Testis.
    5. "Human nidogen gene: structural and functional characterization of the 5'-flanking region."
      Fazio M.J., O'Leary J., Kahari V.M., Chen Y.Q., Saitta B., Uitto J.
      J. Invest. Dermatol. 97:281-285(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1247 (ISOFORM 2), VARIANTS ILE-246 AND HIS-807.
      Tissue: Brain.
    7. "Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43."
      Olsen D.R., Nagayoshi T., Fazio M., Mattei M.-G., Passage E., Weil D., Timpl R., Chu M.-L., Uitto J.
      Am. J. Hum. Genet. 44:876-885(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-1247 (ISOFORM 1), VARIANT ARG-1246.
      Tissue: Placenta.
    8. "Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
      Lee H.K., Seo I.A., Park H.K., Park H.T.
      FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLXDC1.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1036.

    Entry informationi

    Entry nameiNID1_HUMAN
    AccessioniPrimary (citable) accession number: P14543
    Secondary accession number(s): Q14942
    , Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 168 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3