P14543 (NID1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nidogen-1
Short name=NID-1

Alternative name(s):
Entactin

Gene names

Name:	NID1
Synonyms:	NID

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1247 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
Subunit structure	Interacts with FBLN1 and LGALS3BP By similarity. Interacts with PLXDC1. Ref.8
Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane.
Post-translational modification	N- and O-glycosylated.
Sequence similarities	Contains 6 EGF-like domains. Contains 4 LDL-receptor class B repeats. Contains 1 NIDO domain. Contains 1 nidogen G2 beta-barrel domain. Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Basement membrane Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein Sulfation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-matrix adhesion Inferred from electronic annotation. Source: Compara glomerular basement membrane development Inferred from electronic annotation. Source: Compara positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	basal lamina Inferred from electronic annotation. Source: Compara cell periphery Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro extracellular matrix binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P14543-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P14543-2)

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Chain

29 – 1247

1219

Nidogen-1

PRO_0000007669

Regions

Domain

106 – 268

163

NIDO

Domain

386 – 426

41

EGF-like 1

Domain

430 – 667

238

Nidogen G2 beta-barrel

Domain

668 – 709

42

EGF-like 2

Domain

710 – 751

42

EGF-like 3; calcium-binding Potential

Domain

758 – 801

44

EGF-like 4

Domain

802 – 840

39

EGF-like 5; calcium-binding Potential

Domain

846 – 919

74

Thyroglobulin type-1

Repeat

990 – 1032

43

LDL-receptor class B 1

Repeat

1033 – 1075

43

LDL-receptor class B 2

Repeat

1076 – 1120

45

LDL-receptor class B 3

Repeat

1121 – 1162

42

LDL-receptor class B 4

Domain

1208 – 1244

37

EGF-like 6

Motif

702 – 704

3

Cell attachment site

Amino acid modifications

Modified residue

289

1

Sulfotyrosine Potential

Modified residue

296

1

Sulfotyrosine Potential

Glycosylation

1137

1

N-linked (GlcNAc...) Potential

Disulfide bond

390 ↔ 403

By similarity

Disulfide bond

397 ↔ 412

By similarity

Disulfide bond

411 ↔ 618

By similarity

Disulfide bond

414 ↔ 425

By similarity

Disulfide bond

672 ↔ 685

By similarity

Disulfide bond

679 ↔ 695

By similarity

Disulfide bond

697 ↔ 708

By similarity

Disulfide bond

714 ↔ 727

By similarity

Disulfide bond

721 ↔ 736

By similarity

Disulfide bond

738 ↔ 750

By similarity

Disulfide bond

762 ↔ 777

By similarity

Disulfide bond

769 ↔ 787

By similarity

Disulfide bond

789 ↔ 800

By similarity

Disulfide bond

806 ↔ 817

By similarity

Disulfide bond

811 ↔ 826

By similarity

Disulfide bond

828 ↔ 839

By similarity

Disulfide bond

849 ↔ 878

By similarity

Disulfide bond

889 ↔ 896

By similarity

Disulfide bond

898 ↔ 919

By similarity

Disulfide bond

1212 ↔ 1223

By similarity

Disulfide bond

1219 ↔ 1232

By similarity

Disulfide bond

1234 ↔ 1243

By similarity

Natural variations

Alternative sequence

710 – 842

133

Missing in isoform 2.

VSP_017254

Natural variant

31

1

R → L.
Corresponds to variant rs2071529 [ dbSNP | Ensembl ].

VAR_055760

Natural variant

60

1

S → R. Ref.4
Corresponds to variant rs17857302 [ dbSNP | Ensembl ].

VAR_058123

Natural variant

246

1

V → I. Ref.1 Ref.2 Ref.4 Ref.6
Corresponds to variant rs10733133 [ dbSNP | Ensembl ].

VAR_024264

Natural variant

302

1

R → H.
Corresponds to variant rs16833183 [ dbSNP | Ensembl ].

VAR_055761

Natural variant

335

1

R → H.
Corresponds to variant rs34406281 [ dbSNP | Ensembl ].

VAR_055762

Natural variant

387

1

R → H.
Corresponds to variant rs16833154 [ dbSNP | Ensembl ].

VAR_055763

Natural variant

669

1

Q → R.
Corresponds to variant rs3738534 [ dbSNP | Ensembl ].

VAR_021904

Natural variant

807

1

Q → H. Ref.6
Corresponds to variant rs3738531 [ dbSNP | Ensembl ].

VAR_058124

Natural variant

970

1

K → E.
Corresponds to variant rs16833060 [ dbSNP | Ensembl ].

VAR_055764

Natural variant

1036

1

F → S in a colorectal cancer sample; somatic mutation. Ref.9

VAR_035835

Natural variant

1163

1

L → V.
Corresponds to variant rs16833032 [ dbSNP | Ensembl ].

VAR_055765

Natural variant

1226

1

T → I.
Corresponds to variant rs6662744 [ dbSNP | Ensembl ].

VAR_055766

Natural variant

1246

1

Q → R. Ref.1 Ref.2 Ref.7
Corresponds to variant rs3213190 [ dbSNP | Ensembl ].

VAR_058125

Experimental info

Sequence conflict

33 – 34

2

EL → SS in CAA57709. Ref.2

Sequence conflict

37 – 42

6

FGPGQG → SAPDR in CAA57709. Ref.2

Sequence conflict

653

1

L → F in AAA59932. Ref.1

Sequence conflict

653

1

L → F in CAA57709. Ref.2

Sequence conflict

1115

1

T → H in AAA59932. Ref.1

Sequence conflict

1115

1

T → H in CAA57709. Ref.2

Secondary structure

1

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1247

Helix Strand Turn

Details...

Beta strand

945 – 950

6

Beta strand

953 – 958

6

Beta strand

971 – 974

4

Beta strand

978 – 985

8

Beta strand

989 – 996

8

Beta strand

1001 – 1009

9

Beta strand

1012 – 1017

6

Beta strand

1023 – 1030

8

Turn

1031 – 1033

3

Beta strand

1034 – 1039

6

Turn

1040 – 1042

3

Beta strand

1045 – 1049

5

Turn

1050 – 1053

4

Beta strand

1054 – 1058

5

Beta strand

1066 – 1071

6

Beta strand

1075 – 1082

8

Beta strand

1089 – 1094

6

Turn

1095 – 1097

3

Beta strand

1100 – 1104

5

Beta strand

1111 – 1116

6

Beta strand

1123 – 1127

5

Helix

1128 – 1130

3

Beta strand

1132 – 1137

6

Turn

1138 – 1141

4

Beta strand

1142 – 1147

6

Beta strand

1153 – 1157

5

Beta strand

1162 – 1167

6

Turn

1168 – 1171

4

Beta strand

1172 – 1177

6

Turn

1178 – 1181

4

Beta strand

1182 – 1187

6

Beta strand

1191 – 1193

3

Beta strand

1195 – 1204

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 7, 2009. Version 3. Checksum: FCC839416525CD48	FASTA	1,247	136,377
	10 20 30 40 50 60 MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD DFVSPALELS 70 80 90 100 110 120 GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT FGAVAPFLAD LDTTDGLGKV 130 140 150 160 170 180 YYREDLSPSI TQRAAECVHR GFPEISFQPS SAVVVTWESV APYQGPSRDP DQKGKRNTFQ 190 200 210 220 230 240 AVLASSDSSS YAIFLYPEDG LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA 250 260 270 280 290 300 NDRESVENLA KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 310 320 330 340 350 360 TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT RSFQLAVETF 370 380 390 400 410 420 HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH AECRDYATGF CCSCVAGYTG 430 440 450 460 470 480 NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP IVFENTDLHS YVVMNHGRSY TAISTIPETV 490 500 510 520 530 540 GYSLLPLAPV GGIIGWMFAV EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI 550 560 570 580 590 600 DEHGHLTIDT ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 610 620 630 640 650 660 PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR YALSNSIGPV 670 680 690 700 710 720 REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG FRGDGRTCYD IDECSEQPSV 730 740 750 760 770 780 CGSHTICNNH PGTFRCECVE GYQFSDEGTC VAVVDQRPIN YCETGLHNCD IPQRAQCIYT 790 800 810 820 830 840 GGSSYTCSCL PGFSGDGQAC QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV 850 860 870 880 890 900 PGEVEKTRCQ HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD 910 920 930 940 950 960 RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ TGKIERLPLE 970 980 990 1000 1010 1020 GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP SIGRASLHGG EPTTIIRQDL 1030 1040 1050 1060 1070 1080 GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW 1090 1100 1110 1120 1130 1140 TDWNRDNPKI ETSYMDGTNR RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ 1150 1160 1170 1180 1190 1200 PSRRKALEGL QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT 1210 1220 1230 1240 ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK
	Isoform 2 [UniParc]. Checksum: 177A25689611C3BD	FASTA	1,114	122,017
	10 20 30 40 50 60 MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD DFVSPALELS 70 80 90 100 110 120 GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT FGAVAPFLAD LDTTDGLGKV 130 140 150 160 170 180 YYREDLSPSI TQRAAECVHR GFPEISFQPS SAVVVTWESV APYQGPSRDP DQKGKRNTFQ 190 200 210 220 230 240 AVLASSDSSS YAIFLYPEDG LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA 250 260 270 280 290 300 NDRESVENLA KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 310 320 330 340 350 360 TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT RSFQLAVETF 370 380 390 400 410 420 HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH AECRDYATGF CCSCVAGYTG 430 440 450 460 470 480 NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP IVFENTDLHS YVVMNHGRSY TAISTIPETV 490 500 510 520 530 540 GYSLLPLAPV GGIIGWMFAV EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI 550 560 570 580 590 600 DEHGHLTIDT ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 610 620 630 640 650 660 PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR YALSNSIGPV 670 680 690 700 710 720 REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG FRGDGRTCYE VEKTRCQHER 730 740 750 760 770 780 EHILGAAGAT DPQRPIPPGL FVPECDAHGH YAPTQCHGST GYCWCVDRDG REVEGTRTRP 790 800 810 820 830 840 GMTPPCLSTV APPIHQGPAV PTAVIPLPPG THLLFAQTGK IERLPLEGNT MRKTEAKAFL 850 860 870 880 890 900 HVPAKVIIGL AFDCVDKMVY WTDITEPSIG RASLHGGEPT TIIRQDLGSP EGIAVDHLGR 910 920 930 940 950 960 NIFWTDSNLD RIEVAKLDGT QRRVLFETDL VNPRGIVTDS VRGNLYWTDW NRDNPKIETS 970 980 990 1000 1010 1020 YMDGTNRRIL VQDDLGLPNG LTFDAFSSQL CWVDAGTNRA ECLNPSQPSR RKALEGLQYP 1030 1040 1050 1060 1070 1080 FAVTSYGKNL YFTDWKMNSV VALDLAISKE TDAFQPHKQT RLYGITTALS QCPQGHNYCS 1090 1100 1110 VNNGGCTHLC LATPGSRTCR CPDNTLGVDC IEQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene." Nagayoshi T., Sanborn D., Hickok N.J., Olsen D.R., Fazio M.J., Chu M.-L., Knowlton R., Mann K., Deutzmann R., Timpl R., Uitto J. DNA 8:581-594(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-246 AND ARG-1246.
[2]	"Genomic sequences and structural organization of the human nidogen gene (NID)." Zimmermann K., Hoischen S., Hafner M., Nischt R. Genomics 27:245-250(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-246 AND ARG-1246.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-60 AND ILE-246. Tissue: Testis.
[5]	"Human nidogen gene: structural and functional characterization of the 5'-flanking region." Fazio M.J., O'Leary J., Kahari V.M., Chen Y.Q., Saitta B., Uitto J. J. Invest. Dermatol. 97:281-285(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
[6]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1247 (ISOFORM 2), VARIANTS ILE-246 AND HIS-807. Tissue: Brain.
[7]	"Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43." Olsen D.R., Nagayoshi T., Fazio M., Mattei M.-G., Passage E., Weil D., Timpl R., Chu M.-L., Uitto J. Am. J. Hum. Genet. 44:876-885(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-1247 (ISOFORM 1), VARIANT ARG-1246. Tissue: Placenta.
[8]	"Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo." Lee H.K., Seo I.A., Park H.K., Park H.T. FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLXDC1.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1036.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M30269 mRNA. Translation: AAA59932.1.
X82245 , X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.

IPI

IPI00026944.
IPI00384542.

PIR

MMHUND. A33322.

RefSeq

NP_002499.2. NM_002508.2.

UniGene

Hs.356624.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NDX	model	-	A	941-1206	[»]

ProteinModelPortal

P14543.

ModBase

Search...

Protein-protein interaction databases

IntAct

P14543. 5 interactions.

MINT

MINT-1193369.

STRING

9606.ENSP00000264187.

PTM databases

PhosphoSite

P14543.

Polymorphism databases

DMDM

251757450.

Proteomic databases

PaxDb

P14543.

PRIDE

P14543.

Protocols and materials databases

DNASU

4811.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000264187; ENSP00000264187; ENSG00000116962.
ENST00000366595; ENSP00000355554; ENSG00000116962.

GeneID

4811.

KEGG

hsa:4811.

UCSC

uc001hxo.3. human.
uc009xgd.3. human.

Organism-specific databases

CTD

4811.

GeneCards

GC01M236139.

H-InvDB

HIX0023622.

HGNC

HGNC:7821. NID1.

HPA

CAB010044.

MIM

131390. gene.

neXtProt

NX_P14543.

PharmGKB

PA31625.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG282695.

HOGENOM

HOG000072712.

HOVERGEN

HBG006498.

InParanoid

P14543.

KO

K06826.

OMA

DYRPDYR.

OrthoDB

EOG4BCDM4.

PhylomeDB

P14543.

Gene expression databases

Bgee

P14543.

CleanEx

HS_NID1.

Genevestigator

P14543.

GermOnline

ENSG00000116962. Homo sapiens.

Family and domain databases

Gene3D

2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.

InterPro

IPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR000033. LDLR_classB_rpt.
IPR003886. Nidogen_extracell_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]

Pfam

PF12662. cEGF. 1 hit.
PF12947. EGF_3. 2 hits.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]

SMART

SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]

SUPFAM

SSF54511. GFP_like. 1 hit.
SSF57610. Thyroglobulin_1. 1 hit.

PROSITE

PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NID1. human.

DrugBank

DB00102. Becaplermin.
DB00013. Urokinase.

GenomeRNAi

4811.

NextBio

18544.

SOURCE

Search...

Entry information

Entry name

NID1_HUMAN

Accession

Primary (citable) accession number: P14543
Secondary accession number(s): Q14942 , Q59FL2, Q5TAF2, Q5TAF3, Q86XD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 154 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.