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P14543 (NID1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 166. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nidogen-1

Short name=NID-1
Alternative name(s):
Entactin
Gene names
Name:NID1
Synonyms:NID
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

Subunit structure

Interacts with FBLN1 and LGALS3BP By similarity. Interacts with PLXDC1. Ref.8

Subcellular location

Secretedextracellular spaceextracellular matrixbasement membrane.

Post-translational modification

N- and O-glycosylated.

Sequence similarities

Contains 6 EGF-like domains.

Contains 4 LDL-receptor class B repeats.

Contains 1 NIDO domain.

Contains 1 nidogen G2 beta-barrel domain.

Contains 1 thyroglobulin type-1 domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentBasement membrane
Extracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
Sulfation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbasement membrane organization

Traceable author statement PubMed 22952693. Source: BHF-UCL

cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

extracellular matrix disassembly

Traceable author statement. Source: Reactome

extracellular matrix organization

Traceable author statement. Source: Reactome

glomerular basement membrane development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell-substrate adhesion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentbasal lamina

Inferred from electronic annotation. Source: Ensembl

basement membrane

Inferred from direct assay PubMed 22952693. Source: BHF-UCL

cell periphery

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

collagen binding

Inferred from direct assay PubMed 22952693. Source: BHF-UCL

laminin binding

Inferred from direct assay PubMed 22952693. Source: BHF-UCL

proteoglycan binding

Inferred from physical interaction PubMed 22952693. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P14543-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P14543-2)

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828
Chain29 – 12471219Nidogen-1
PRO_0000007669

Regions

Domain106 – 268163NIDO
Domain386 – 42641EGF-like 1
Domain430 – 667238Nidogen G2 beta-barrel
Domain668 – 70942EGF-like 2
Domain710 – 75142EGF-like 3; calcium-binding Potential
Domain758 – 80144EGF-like 4
Domain802 – 84039EGF-like 5; calcium-binding Potential
Domain846 – 91974Thyroglobulin type-1
Repeat990 – 103243LDL-receptor class B 1
Repeat1033 – 107543LDL-receptor class B 2
Repeat1076 – 112045LDL-receptor class B 3
Repeat1121 – 116242LDL-receptor class B 4
Domain1208 – 124437EGF-like 6
Motif702 – 7043Cell attachment site

Amino acid modifications

Modified residue2891Sulfotyrosine Potential
Modified residue2961Sulfotyrosine Potential
Glycosylation11371N-linked (GlcNAc...) Potential
Disulfide bond390 ↔ 403 By similarity
Disulfide bond397 ↔ 412 By similarity
Disulfide bond411 ↔ 618 By similarity
Disulfide bond414 ↔ 425 By similarity
Disulfide bond672 ↔ 685 By similarity
Disulfide bond679 ↔ 695 By similarity
Disulfide bond697 ↔ 708 By similarity
Disulfide bond714 ↔ 727 By similarity
Disulfide bond721 ↔ 736 By similarity
Disulfide bond738 ↔ 750 By similarity
Disulfide bond762 ↔ 777 By similarity
Disulfide bond769 ↔ 787 By similarity
Disulfide bond789 ↔ 800 By similarity
Disulfide bond806 ↔ 817 By similarity
Disulfide bond811 ↔ 826 By similarity
Disulfide bond828 ↔ 839 By similarity
Disulfide bond849 ↔ 878 By similarity
Disulfide bond889 ↔ 896 By similarity
Disulfide bond898 ↔ 919 By similarity
Disulfide bond1212 ↔ 1223 By similarity
Disulfide bond1219 ↔ 1232 By similarity
Disulfide bond1234 ↔ 1243 By similarity

Natural variations

Alternative sequence710 – 842133Missing in isoform 2.
VSP_017254
Natural variant311R → L.
Corresponds to variant rs2071529 [ dbSNP | Ensembl ].
VAR_055760
Natural variant601S → R. Ref.4
Corresponds to variant rs17857302 [ dbSNP | Ensembl ].
VAR_058123
Natural variant2461V → I. Ref.1 Ref.2 Ref.4 Ref.6
Corresponds to variant rs10733133 [ dbSNP | Ensembl ].
VAR_024264
Natural variant3021R → H.
Corresponds to variant rs16833183 [ dbSNP | Ensembl ].
VAR_055761
Natural variant3351R → H.
Corresponds to variant rs34406281 [ dbSNP | Ensembl ].
VAR_055762
Natural variant3871R → H.
Corresponds to variant rs16833154 [ dbSNP | Ensembl ].
VAR_055763
Natural variant6691Q → R.
Corresponds to variant rs3738534 [ dbSNP | Ensembl ].
VAR_021904
Natural variant8071Q → H. Ref.6
Corresponds to variant rs3738531 [ dbSNP | Ensembl ].
VAR_058124
Natural variant9701K → E.
Corresponds to variant rs16833060 [ dbSNP | Ensembl ].
VAR_055764
Natural variant10361F → S in a colorectal cancer sample; somatic mutation. Ref.9
VAR_035835
Natural variant11631L → V.
Corresponds to variant rs16833032 [ dbSNP | Ensembl ].
VAR_055765
Natural variant12261T → I.
Corresponds to variant rs6662744 [ dbSNP | Ensembl ].
VAR_055766
Natural variant12461Q → R. Ref.1 Ref.2 Ref.7
Corresponds to variant rs3213190 [ dbSNP | Ensembl ].
VAR_058125

Experimental info

Sequence conflict33 – 342EL → SS in CAA57709. Ref.2
Sequence conflict37 – 426FGPGQG → SAPDR in CAA57709. Ref.2
Sequence conflict6531L → F in AAA59932. Ref.1
Sequence conflict6531L → F in CAA57709. Ref.2
Sequence conflict11151T → H in AAA59932. Ref.1
Sequence conflict11151T → H in CAA57709. Ref.2

Secondary structure

...................................................... 1247
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 7, 2009. Version 3.
Checksum: FCC839416525CD48

FASTA1,247136,377
        10         20         30         40         50         60 
MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD DFVSPALELS 

        70         80         90        100        110        120 
GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT FGAVAPFLAD LDTTDGLGKV 

       130        140        150        160        170        180 
YYREDLSPSI TQRAAECVHR GFPEISFQPS SAVVVTWESV APYQGPSRDP DQKGKRNTFQ 

       190        200        210        220        230        240 
AVLASSDSSS YAIFLYPEDG LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA 

       250        260        270        280        290        300 
NDRESVENLA KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 

       310        320        330        340        350        360 
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT RSFQLAVETF 

       370        380        390        400        410        420 
HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH AECRDYATGF CCSCVAGYTG 

       430        440        450        460        470        480 
NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP IVFENTDLHS YVVMNHGRSY TAISTIPETV 

       490        500        510        520        530        540 
GYSLLPLAPV GGIIGWMFAV EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI 

       550        560        570        580        590        600 
DEHGHLTIDT ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 

       610        620        630        640        650        660 
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR YALSNSIGPV 

       670        680        690        700        710        720 
REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG FRGDGRTCYD IDECSEQPSV 

       730        740        750        760        770        780 
CGSHTICNNH PGTFRCECVE GYQFSDEGTC VAVVDQRPIN YCETGLHNCD IPQRAQCIYT 

       790        800        810        820        830        840 
GGSSYTCSCL PGFSGDGQAC QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV 

       850        860        870        880        890        900 
PGEVEKTRCQ HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD 

       910        920        930        940        950        960 
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ TGKIERLPLE 

       970        980        990       1000       1010       1020 
GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP SIGRASLHGG EPTTIIRQDL 

      1030       1040       1050       1060       1070       1080 
GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW 

      1090       1100       1110       1120       1130       1140 
TDWNRDNPKI ETSYMDGTNR RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ 

      1150       1160       1170       1180       1190       1200 
PSRRKALEGL QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT 

      1210       1220       1230       1240 
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK 

« Hide

Isoform 2 [UniParc].

Checksum: 177A25689611C3BD
Show »

FASTA1,114122,017

References

« Hide 'large scale' references
[1]"Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene."
Nagayoshi T., Sanborn D., Hickok N.J., Olsen D.R., Fazio M.J., Chu M.-L., Knowlton R., Mann K., Deutzmann R., Timpl R., Uitto J.
DNA 8:581-594(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-246 AND ARG-1246.
[2]"Genomic sequences and structural organization of the human nidogen gene (NID)."
Zimmermann K., Hoischen S., Hafner M., Nischt R.
Genomics 27:245-250(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-246 AND ARG-1246.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-60 AND ILE-246.
Tissue: Testis.
[5]"Human nidogen gene: structural and functional characterization of the 5'-flanking region."
Fazio M.J., O'Leary J., Kahari V.M., Chen Y.Q., Saitta B., Uitto J.
J. Invest. Dermatol. 97:281-285(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1247 (ISOFORM 2), VARIANTS ILE-246 AND HIS-807.
Tissue: Brain.
[7]"Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43."
Olsen D.R., Nagayoshi T., Fazio M., Mattei M.-G., Passage E., Weil D., Timpl R., Chu M.-L., Uitto J.
Am. J. Hum. Genet. 44:876-885(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-1247 (ISOFORM 1), VARIANT ARG-1246.
Tissue: Placenta.
[8]"Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
Lee H.K., Seo I.A., Park H.K., Park H.T.
FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PLXDC1.
[9]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1036.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30269 mRNA. Translation: AAA59932.1.
X82245 expand/collapse EMBL AC list , X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.
CCDSCCDS1608.1. [P14543-1]
PIRMMHUND. A33322.
RefSeqNP_002499.2. NM_002508.2. [P14543-1]
UniGeneHs.356624.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
ProteinModelPortalP14543.
SMRP14543. Positions 389-661, 671-912, 914-1235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110876. 12 interactions.
IntActP14543. 9 interactions.
MINTMINT-1193369.
STRING9606.ENSP00000264187.

Chemistry

DrugBankDB00102. Becaplermin.
DB00013. Urokinase.

Protein family/group databases

MEROPSI63.001.

PTM databases

PhosphoSiteP14543.

Polymorphism databases

DMDM251757450.

Proteomic databases

MaxQBP14543.
PaxDbP14543.
PRIDEP14543.

Protocols and materials databases

DNASU4811.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
GeneID4811.
KEGGhsa:4811.
UCSCuc001hxo.3. human. [P14543-1]
uc009xgd.3. human. [P14543-2]

Organism-specific databases

CTD4811.
GeneCardsGC01M236139.
H-InvDBHIX0023622.
HGNCHGNC:7821. NID1.
HPACAB010044.
MIM131390. gene.
neXtProtNX_P14543.
PharmGKBPA31625.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282695.
HOGENOMHOG000072712.
HOVERGENHBG006498.
InParanoidP14543.
KOK06826.
OMADYRPDYR.
OrthoDBEOG7M0NQN.
PhylomeDBP14543.
TreeFamTF320666.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

BgeeP14543.
CleanExHS_NID1.
GenevestigatorP14543.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR003886. Nidogen_extracell_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamPF12662. cEGF. 1 hit.
PF12947. EGF_3. 2 hits.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNID1. human.
GeneWikiEntactin.
GenomeRNAi4811.
NextBio18544.
PROP14543.
SOURCESearch...

Entry information

Entry nameNID1_HUMAN
AccessionPrimary (citable) accession number: P14543
Secondary accession number(s): Q14942 expand/collapse secondary AC list , Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM