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P14543

- NID1_HUMAN

UniProt

P14543 - NID1_HUMAN

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Protein

Nidogen-1

Gene
NID1, NID
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. collagen binding Source: BHF-UCL
  3. laminin binding Source: BHF-UCL
  4. proteoglycan binding Source: BHF-UCL

GO - Biological processi

  1. basement membrane organization Source: BHF-UCL
  2. cell-matrix adhesion Source: Ensembl
  3. extracellular matrix disassembly Source: Reactome
  4. extracellular matrix organization Source: Reactome
  5. glomerular basement membrane development Source: Ensembl
  6. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_118572. Degradation of the extracellular matrix.
REACT_169262. Laminin interactions.

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Nidogen-1
Short name:
NID-1
Alternative name(s):
Entactin
Gene namesi
Name:NID1
Synonyms:NID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7821. NID1.

Subcellular locationi

GO - Cellular componenti

  1. basal lamina Source: Ensembl
  2. basement membrane Source: BHF-UCL
  3. cell periphery Source: Ensembl
  4. extracellular region Source: Reactome
  5. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 12471219Nidogen-1PRO_0000007669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891Sulfotyrosine Reviewed prediction
Modified residuei296 – 2961Sulfotyrosine Reviewed prediction
Disulfide bondi390 ↔ 403 By similarity
Disulfide bondi397 ↔ 412 By similarity
Disulfide bondi411 ↔ 618 By similarity
Disulfide bondi414 ↔ 425 By similarity
Disulfide bondi672 ↔ 685 By similarity
Disulfide bondi679 ↔ 695 By similarity
Disulfide bondi697 ↔ 708 By similarity
Disulfide bondi714 ↔ 727 By similarity
Disulfide bondi721 ↔ 736 By similarity
Disulfide bondi738 ↔ 750 By similarity
Disulfide bondi762 ↔ 777 By similarity
Disulfide bondi769 ↔ 787 By similarity
Disulfide bondi789 ↔ 800 By similarity
Disulfide bondi806 ↔ 817 By similarity
Disulfide bondi811 ↔ 826 By similarity
Disulfide bondi828 ↔ 839 By similarity
Disulfide bondi849 ↔ 878 By similarity
Disulfide bondi889 ↔ 896 By similarity
Disulfide bondi898 ↔ 919 By similarity
Glycosylationi1137 – 11371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1212 ↔ 1223 By similarity
Disulfide bondi1219 ↔ 1232 By similarity
Disulfide bondi1234 ↔ 1243 By similarity

Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

MaxQBiP14543.
PaxDbiP14543.
PRIDEiP14543.

PTM databases

PhosphoSiteiP14543.

Expressioni

Gene expression databases

BgeeiP14543.
CleanExiHS_NID1.
GenevestigatoriP14543.

Organism-specific databases

HPAiCAB010044.

Interactioni

Subunit structurei

Interacts with FBLN1 and LGALS3BP By similarity. Interacts with PLXDC1.1 Publication

Protein-protein interaction databases

BioGridi110876. 12 interactions.
IntActiP14543. 9 interactions.
MINTiMINT-1193369.
STRINGi9606.ENSP00000264187.

Structurei

Secondary structure

1
1247
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi945 – 9506
Beta strandi953 – 9586
Beta strandi971 – 9744
Beta strandi978 – 9858
Beta strandi989 – 9968
Beta strandi1001 – 10099
Beta strandi1012 – 10176
Beta strandi1023 – 10308
Turni1031 – 10333
Beta strandi1034 – 10396
Turni1040 – 10423
Beta strandi1045 – 10495
Turni1050 – 10534
Beta strandi1054 – 10585
Beta strandi1066 – 10716
Beta strandi1075 – 10828
Beta strandi1089 – 10946
Turni1095 – 10973
Beta strandi1100 – 11045
Beta strandi1111 – 11166
Beta strandi1123 – 11275
Helixi1128 – 11303
Beta strandi1132 – 11376
Turni1138 – 11414
Beta strandi1142 – 11476
Beta strandi1153 – 11575
Beta strandi1162 – 11676
Turni1168 – 11714
Beta strandi1172 – 11776
Turni1178 – 11814
Beta strandi1182 – 11876
Beta strandi1191 – 11933
Beta strandi1195 – 120410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
ProteinModelPortaliP14543.
SMRiP14543. Positions 389-661, 671-912, 914-1235.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 268163NIDOAdd
BLAST
Domaini386 – 42641EGF-like 1Add
BLAST
Domaini430 – 667238Nidogen G2 beta-barrelAdd
BLAST
Domaini668 – 70942EGF-like 2Add
BLAST
Domaini710 – 75142EGF-like 3; calcium-binding Reviewed predictionAdd
BLAST
Domaini758 – 80144EGF-like 4Add
BLAST
Domaini802 – 84039EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST
Domaini846 – 91974Thyroglobulin type-1Add
BLAST
Repeati990 – 103243LDL-receptor class B 1Add
BLAST
Repeati1033 – 107543LDL-receptor class B 2Add
BLAST
Repeati1076 – 112045LDL-receptor class B 3Add
BLAST
Repeati1121 – 116242LDL-receptor class B 4Add
BLAST
Domaini1208 – 124437EGF-like 6Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi702 – 7043Cell attachment site

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 1 NIDO domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG282695.
HOGENOMiHOG000072712.
HOVERGENiHBG006498.
InParanoidiP14543.
KOiK06826.
OMAiDYRPDYR.
OrthoDBiEOG7M0NQN.
PhylomeDBiP14543.
TreeFamiTF320666.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR003886. Nidogen_extracell_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 2 hits.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P14543-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD     50
DFVSPALELS GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT 100
FGAVAPFLAD LDTTDGLGKV YYREDLSPSI TQRAAECVHR GFPEISFQPS 150
SAVVVTWESV APYQGPSRDP DQKGKRNTFQ AVLASSDSSS YAIFLYPEDG 200
LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA NDRESVENLA 250
KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 300
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT 350
RSFQLAVETF HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH 400
AECRDYATGF CCSCVAGYTG NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP 450
IVFENTDLHS YVVMNHGRSY TAISTIPETV GYSLLPLAPV GGIIGWMFAV 500
EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI DEHGHLTIDT 550
ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 600
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR 650
YALSNSIGPV REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG 700
FRGDGRTCYD IDECSEQPSV CGSHTICNNH PGTFRCECVE GYQFSDEGTC 750
VAVVDQRPIN YCETGLHNCD IPQRAQCIYT GGSSYTCSCL PGFSGDGQAC 800
QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV PGEVEKTRCQ 850
HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD 900
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ 950
TGKIERLPLE GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP 1000
SIGRASLHGG EPTTIIRQDL GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL 1050
DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW TDWNRDNPKI ETSYMDGTNR 1100
RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ PSRRKALEGL 1150
QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT 1200
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK 1247
Length:1,247
Mass (Da):136,377
Last modified:July 7, 2009 - v3
Checksum:iFCC839416525CD48
GO
Isoform 2 (identifier: P14543-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Show »
Length:1,114
Mass (Da):122,017
Checksum:i177A25689611C3BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311R → L.
Corresponds to variant rs2071529 [ dbSNP | Ensembl ].
VAR_055760
Natural varianti60 – 601S → R.1 Publication
Corresponds to variant rs17857302 [ dbSNP | Ensembl ].
VAR_058123
Natural varianti246 – 2461V → I.4 Publications
Corresponds to variant rs10733133 [ dbSNP | Ensembl ].
VAR_024264
Natural varianti302 – 3021R → H.
Corresponds to variant rs16833183 [ dbSNP | Ensembl ].
VAR_055761
Natural varianti335 – 3351R → H.
Corresponds to variant rs34406281 [ dbSNP | Ensembl ].
VAR_055762
Natural varianti387 – 3871R → H.
Corresponds to variant rs16833154 [ dbSNP | Ensembl ].
VAR_055763
Natural varianti669 – 6691Q → R.
Corresponds to variant rs3738534 [ dbSNP | Ensembl ].
VAR_021904
Natural varianti807 – 8071Q → H.1 Publication
Corresponds to variant rs3738531 [ dbSNP | Ensembl ].
VAR_058124
Natural varianti970 – 9701K → E.
Corresponds to variant rs16833060 [ dbSNP | Ensembl ].
VAR_055764
Natural varianti1036 – 10361F → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035835
Natural varianti1163 – 11631L → V.
Corresponds to variant rs16833032 [ dbSNP | Ensembl ].
VAR_055765
Natural varianti1226 – 12261T → I.
Corresponds to variant rs6662744 [ dbSNP | Ensembl ].
VAR_055766
Natural varianti1246 – 12461Q → R.3 Publications
Corresponds to variant rs3213190 [ dbSNP | Ensembl ].
VAR_058125

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei710 – 842133Missing in isoform 2. VSP_017254Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 342EL → SS in CAA57709. 1 Publication
Sequence conflicti37 – 426FGPGQG → SAPDR in CAA57709. 1 Publication
Sequence conflicti653 – 6531L → F in AAA59932. 1 Publication
Sequence conflicti653 – 6531L → F in CAA57709. 1 Publication
Sequence conflicti1115 – 11151T → H in AAA59932. 1 Publication
Sequence conflicti1115 – 11151T → H in CAA57709. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30269 mRNA. Translation: AAA59932.1.
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.
CCDSiCCDS1608.1. [P14543-1]
PIRiA33322. MMHUND.
RefSeqiNP_002499.2. NM_002508.2. [P14543-1]
UniGeneiHs.356624.

Genome annotation databases

EnsembliENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
GeneIDi4811.
KEGGihsa:4811.
UCSCiuc001hxo.3. human. [P14543-1]
uc009xgd.3. human. [P14543-2]

Polymorphism databases

DMDMi251757450.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30269 mRNA. Translation: AAA59932.1 .
X82245
, X84819 , X84820 , X84821 , X84822 , X84823 , X84824 , X84825 , X84826 , X84827 , X84828 , X84829 , X84830 , X84831 , X84832 , X84833 , X84834 , X84835 , X84836 , X84837 Genomic DNA. Translation: CAA57709.1 .
AL122018 , AL139161 Genomic DNA. Translation: CAI22680.1 .
AL122018 , AL139161 Genomic DNA. Translation: CAI22681.1 .
AL139161 , AL122018 Genomic DNA. Translation: CAI23421.1 .
AL139161 , AL122018 Genomic DNA. Translation: CAI23422.1 .
BC045606 mRNA. Translation: AAH45606.1 .
AB209448 mRNA. Translation: BAD92685.1 .
M27445 mRNA. Translation: AAA57261.1 .
CCDSi CCDS1608.1. [P14543-1 ]
PIRi A33322. MMHUND.
RefSeqi NP_002499.2. NM_002508.2. [P14543-1 ]
UniGenei Hs.356624.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NDX model - A 941-1206 [» ]
ProteinModelPortali P14543.
SMRi P14543. Positions 389-661, 671-912, 914-1235.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110876. 12 interactions.
IntActi P14543. 9 interactions.
MINTi MINT-1193369.
STRINGi 9606.ENSP00000264187.

Chemistry

DrugBanki DB00102. Becaplermin.
DB00013. Urokinase.

Protein family/group databases

MEROPSi I63.001.

PTM databases

PhosphoSitei P14543.

Polymorphism databases

DMDMi 251757450.

Proteomic databases

MaxQBi P14543.
PaxDbi P14543.
PRIDEi P14543.

Protocols and materials databases

DNASUi 4811.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264187 ; ENSP00000264187 ; ENSG00000116962 . [P14543-1 ]
ENST00000366595 ; ENSP00000355554 ; ENSG00000116962 . [P14543-2 ]
GeneIDi 4811.
KEGGi hsa:4811.
UCSCi uc001hxo.3. human. [P14543-1 ]
uc009xgd.3. human. [P14543-2 ]

Organism-specific databases

CTDi 4811.
GeneCardsi GC01M236139.
H-InvDB HIX0023622.
HGNCi HGNC:7821. NID1.
HPAi CAB010044.
MIMi 131390. gene.
neXtProti NX_P14543.
PharmGKBi PA31625.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282695.
HOGENOMi HOG000072712.
HOVERGENi HBG006498.
InParanoidi P14543.
KOi K06826.
OMAi DYRPDYR.
OrthoDBi EOG7M0NQN.
PhylomeDBi P14543.
TreeFami TF320666.

Enzyme and pathway databases

Reactomei REACT_118572. Degradation of the extracellular matrix.
REACT_169262. Laminin interactions.

Miscellaneous databases

ChiTaRSi NID1. human.
GeneWikii Entactin.
GenomeRNAii 4811.
NextBioi 18544.
PROi P14543.
SOURCEi Search...

Gene expression databases

Bgeei P14543.
CleanExi HS_NID1.
Genevestigatori P14543.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR003886. Nidogen_extracell_dom.
IPR000716. Thyroglobulin_1.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF12947. EGF_3. 2 hits.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene."
    Nagayoshi T., Sanborn D., Hickok N.J., Olsen D.R., Fazio M.J., Chu M.-L., Knowlton R., Mann K., Deutzmann R., Timpl R., Uitto J.
    DNA 8:581-594(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-246 AND ARG-1246.
  2. "Genomic sequences and structural organization of the human nidogen gene (NID)."
    Zimmermann K., Hoischen S., Hafner M., Nischt R.
    Genomics 27:245-250(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-246 AND ARG-1246.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-60 AND ILE-246.
    Tissue: Testis.
  5. "Human nidogen gene: structural and functional characterization of the 5'-flanking region."
    Fazio M.J., O'Leary J., Kahari V.M., Chen Y.Q., Saitta B., Uitto J.
    J. Invest. Dermatol. 97:281-285(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1247 (ISOFORM 2), VARIANTS ILE-246 AND HIS-807.
    Tissue: Brain.
  7. "Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43."
    Olsen D.R., Nagayoshi T., Fazio M., Mattei M.-G., Passage E., Weil D., Timpl R., Chu M.-L., Uitto J.
    Am. J. Hum. Genet. 44:876-885(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-1247 (ISOFORM 1), VARIANT ARG-1246.
    Tissue: Placenta.
  8. "Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."
    Lee H.K., Seo I.A., Park H.K., Park H.T.
    FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXDC1.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1036.

Entry informationi

Entry nameiNID1_HUMAN
AccessioniPrimary (citable) accession number: P14543
Secondary accession number(s): Q14942
, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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