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Protein

Nidogen-1

Gene

NID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • collagen binding Source: BHF-UCL
  • laminin binding Source: BHF-UCL
  • proteoglycan binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116962-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-3000157. Laminin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Nidogen-1
Short name:
NID-1
Alternative name(s):
Entactin
Gene namesi
Name:NID1
Synonyms:NID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7821. NID1.

Subcellular locationi

GO - Cellular componenti

  • basal lamina Source: Ensembl
  • basement membrane Source: BHF-UCL
  • cell periphery Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: UniProtKB
  • extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4811.
OpenTargetsiENSG00000116962.
PharmGKBiPA31625.

Chemistry databases

DrugBankiDB00013. Urokinase.

Polymorphism and mutation databases

BioMutaiNID1.
DMDMi251757450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000000766929 – 1247Nidogen-1Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289SulfotyrosineSequence analysis1
Modified residuei296SulfotyrosineSequence analysis1
Disulfide bondi390 ↔ 403By similarity
Disulfide bondi397 ↔ 412By similarity
Disulfide bondi411 ↔ 618By similarity
Disulfide bondi414 ↔ 425By similarity
Disulfide bondi672 ↔ 685By similarity
Disulfide bondi679 ↔ 695By similarity
Disulfide bondi697 ↔ 708By similarity
Disulfide bondi714 ↔ 727By similarity
Disulfide bondi721 ↔ 736By similarity
Disulfide bondi738 ↔ 750By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi769 ↔ 787By similarity
Disulfide bondi789 ↔ 800By similarity
Disulfide bondi806 ↔ 817By similarity
Disulfide bondi811 ↔ 826By similarity
Disulfide bondi828 ↔ 839By similarity
Disulfide bondi849 ↔ 878By similarity
Disulfide bondi889 ↔ 896By similarity
Disulfide bondi898 ↔ 919By similarity
Glycosylationi1137N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1212 ↔ 1223By similarity
Disulfide bondi1219 ↔ 1232By similarity
Disulfide bondi1234 ↔ 1243By similarity

Post-translational modificationi

N- and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

EPDiP14543.
MaxQBiP14543.
PaxDbiP14543.
PeptideAtlasiP14543.
PRIDEiP14543.

PTM databases

iPTMnetiP14543.
PhosphoSitePlusiP14543.

Expressioni

Gene expression databases

BgeeiENSG00000116962.
CleanExiHS_NID1.
GenevisibleiP14543. HS.

Organism-specific databases

HPAiCAB010044.

Interactioni

Subunit structurei

Interacts with FBLN1 and LGALS3BP (By similarity). Interacts with PLXDC1.By similarity1 Publication

GO - Molecular functioni

  • collagen binding Source: BHF-UCL
  • laminin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi110876. 17 interactors.
IntActiP14543. 9 interactors.
MINTiMINT-1193369.
STRINGi9606.ENSP00000264187.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
ProteinModelPortaliP14543.
SMRiP14543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 268NIDOPROSITE-ProRule annotationAdd BLAST163
Domaini386 – 426EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini430 – 667Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST238
Domaini668 – 709EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini710 – 751EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini758 – 801EGF-like 4PROSITE-ProRule annotationAdd BLAST44
Domaini802 – 840EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini846 – 919Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST74
Repeati990 – 1032LDL-receptor class B 1Add BLAST43
Repeati1033 – 1075LDL-receptor class B 2Add BLAST43
Repeati1076 – 1120LDL-receptor class B 3Add BLAST45
Repeati1121 – 1162LDL-receptor class B 4Add BLAST42
Domaini1208 – 1244EGF-like 6PROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi702 – 704Cell attachment site3

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 4 LDL-receptor class B repeats.PROSITE-ProRule annotation
Contains 1 NIDO domain.PROSITE-ProRule annotation
Contains 1 nidogen G2 beta-barrel domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1214. Eukaryota.
ENOG410XR8N. LUCA.
GeneTreeiENSGT00860000133769.
HOGENOMiHOG000072712.
HOVERGENiHBG006498.
InParanoidiP14543.
KOiK06826.
OMAiLHNCDIP.
OrthoDBiEOG091G030P.
PhylomeDBiP14543.
TreeFamiTF320666.

Family and domain databases

CDDicd00255. nidG2. 1 hit.
Gene3Di2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR000033. LDLR_classB_rpt.
IPR003886. NIDO_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14543-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD
60 70 80 90 100
DFVSPALELS GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT
110 120 130 140 150
FGAVAPFLAD LDTTDGLGKV YYREDLSPSI TQRAAECVHR GFPEISFQPS
160 170 180 190 200
SAVVVTWESV APYQGPSRDP DQKGKRNTFQ AVLASSDSSS YAIFLYPEDG
210 220 230 240 250
LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA NDRESVENLA
260 270 280 290 300
KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT
310 320 330 340 350
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT
360 370 380 390 400
RSFQLAVETF HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH
410 420 430 440 450
AECRDYATGF CCSCVAGYTG NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP
460 470 480 490 500
IVFENTDLHS YVVMNHGRSY TAISTIPETV GYSLLPLAPV GGIIGWMFAV
510 520 530 540 550
EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI DEHGHLTIDT
560 570 580 590 600
ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS
610 620 630 640 650
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR
660 670 680 690 700
YALSNSIGPV REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG
710 720 730 740 750
FRGDGRTCYD IDECSEQPSV CGSHTICNNH PGTFRCECVE GYQFSDEGTC
760 770 780 790 800
VAVVDQRPIN YCETGLHNCD IPQRAQCIYT GGSSYTCSCL PGFSGDGQAC
810 820 830 840 850
QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV PGEVEKTRCQ
860 870 880 890 900
HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD
910 920 930 940 950
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ
960 970 980 990 1000
TGKIERLPLE GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP
1010 1020 1030 1040 1050
SIGRASLHGG EPTTIIRQDL GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL
1060 1070 1080 1090 1100
DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW TDWNRDNPKI ETSYMDGTNR
1110 1120 1130 1140 1150
RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ PSRRKALEGL
1160 1170 1180 1190 1200
QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT
1210 1220 1230 1240
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK
Length:1,247
Mass (Da):136,377
Last modified:July 7, 2009 - v3
Checksum:iFCC839416525CD48
GO
Isoform 2 (identifier: P14543-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-842: Missing.

Show »
Length:1,114
Mass (Da):122,017
Checksum:i177A25689611C3BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 34EL → SS in CAA57709 (PubMed:7557988).Curated2
Sequence conflicti37 – 42FGPGQG → SAPDR in CAA57709 (PubMed:7557988).Curated6
Sequence conflicti653L → F in AAA59932 (PubMed:2574658).Curated1
Sequence conflicti653L → F in CAA57709 (PubMed:7557988).Curated1
Sequence conflicti1115T → H in AAA59932 (PubMed:2574658).Curated1
Sequence conflicti1115T → H in CAA57709 (PubMed:7557988).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05576031R → L.Corresponds to variant rs2071529dbSNPEnsembl.1
Natural variantiVAR_05812360S → R.1 PublicationCorresponds to variant rs17857302dbSNPEnsembl.1
Natural variantiVAR_024264246V → I.4 PublicationsCorresponds to variant rs10733133dbSNPEnsembl.1
Natural variantiVAR_055761302R → H.Corresponds to variant rs16833183dbSNPEnsembl.1
Natural variantiVAR_055762335R → H.Corresponds to variant rs34406281dbSNPEnsembl.1
Natural variantiVAR_055763387R → H.Corresponds to variant rs16833154dbSNPEnsembl.1
Natural variantiVAR_021904669Q → R.Corresponds to variant rs3738534dbSNPEnsembl.1
Natural variantiVAR_058124807Q → H.1 PublicationCorresponds to variant rs3738531dbSNPEnsembl.1
Natural variantiVAR_055764970K → E.Corresponds to variant rs16833060dbSNPEnsembl.1
Natural variantiVAR_0358351036F → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0557651163L → V.Corresponds to variant rs16833032dbSNPEnsembl.1
Natural variantiVAR_0557661226T → I.Corresponds to variant rs6662744dbSNPEnsembl.1
Natural variantiVAR_0581251246Q → R.3 PublicationsCorresponds to variant rs3213190dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017254710 – 842Missing in isoform 2. 2 PublicationsAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30269 mRNA. Translation: AAA59932.1.
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.
CCDSiCCDS1608.1. [P14543-1]
PIRiA33322. MMHUND.
RefSeqiNP_002499.2. NM_002508.2. [P14543-1]
UniGeneiHs.356624.

Genome annotation databases

EnsembliENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
GeneIDi4811.
KEGGihsa:4811.
UCSCiuc001hxo.4. human. [P14543-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30269 mRNA. Translation: AAA59932.1.
X82245
, X84819, X84820, X84821, X84822, X84823, X84824, X84825, X84826, X84827, X84828, X84829, X84830, X84831, X84832, X84833, X84834, X84835, X84836, X84837 Genomic DNA. Translation: CAA57709.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22680.1.
AL122018, AL139161 Genomic DNA. Translation: CAI22681.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23421.1.
AL139161, AL122018 Genomic DNA. Translation: CAI23422.1.
BC045606 mRNA. Translation: AAH45606.1.
AB209448 mRNA. Translation: BAD92685.1.
M27445 mRNA. Translation: AAA57261.1.
CCDSiCCDS1608.1. [P14543-1]
PIRiA33322. MMHUND.
RefSeqiNP_002499.2. NM_002508.2. [P14543-1]
UniGeneiHs.356624.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NDXmodel-A941-1206[»]
ProteinModelPortaliP14543.
SMRiP14543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110876. 17 interactors.
IntActiP14543. 9 interactors.
MINTiMINT-1193369.
STRINGi9606.ENSP00000264187.

Chemistry databases

DrugBankiDB00013. Urokinase.

PTM databases

iPTMnetiP14543.
PhosphoSitePlusiP14543.

Polymorphism and mutation databases

BioMutaiNID1.
DMDMi251757450.

Proteomic databases

EPDiP14543.
MaxQBiP14543.
PaxDbiP14543.
PeptideAtlasiP14543.
PRIDEiP14543.

Protocols and materials databases

DNASUi4811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264187; ENSP00000264187; ENSG00000116962. [P14543-1]
ENST00000366595; ENSP00000355554; ENSG00000116962. [P14543-2]
GeneIDi4811.
KEGGihsa:4811.
UCSCiuc001hxo.4. human. [P14543-1]

Organism-specific databases

CTDi4811.
DisGeNETi4811.
GeneCardsiNID1.
H-InvDBHIX0023622.
HGNCiHGNC:7821. NID1.
HPAiCAB010044.
MIMi131390. gene.
neXtProtiNX_P14543.
OpenTargetsiENSG00000116962.
PharmGKBiPA31625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1214. Eukaryota.
ENOG410XR8N. LUCA.
GeneTreeiENSGT00860000133769.
HOGENOMiHOG000072712.
HOVERGENiHBG006498.
InParanoidiP14543.
KOiK06826.
OMAiLHNCDIP.
OrthoDBiEOG091G030P.
PhylomeDBiP14543.
TreeFamiTF320666.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116962-MONOMER.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
R-HSA-3000157. Laminin interactions.

Miscellaneous databases

ChiTaRSiNID1. human.
GeneWikiiEntactin.
GenomeRNAii4811.
PROiP14543.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116962.
CleanExiHS_NID1.
GenevisibleiP14543. HS.

Family and domain databases

CDDicd00255. nidG2. 1 hit.
Gene3Di2.120.10.30. 1 hit.
2.40.155.10. 2 hits.
4.10.800.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom.
IPR006605. G2_nidogen/fibulin_G2F.
IPR009017. GFP.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR000033. LDLR_classB_rpt.
IPR003886. NIDO_dom.
IPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07474. G2F. 1 hit.
PF00058. Ldl_recept_b. 3 hits.
PF06119. NIDO. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SM00682. G2F. 1 hit.
SM00135. LY. 5 hits.
SM00539. NIDO. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF54511. SSF54511. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 4 hits.
PS51220. NIDO. 1 hit.
PS50993. NIDOGEN_G2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNID1_HUMAN
AccessioniPrimary (citable) accession number: P14543
Secondary accession number(s): Q14942
, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 7, 2009
Last modified: November 30, 2016
This is version 190 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.