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Protein

Beta-lactamase OXA-10

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes both carbenicillin and oxacillin.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Acyl-ester intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Enzyme and pathway databases

BRENDAi3.5.2.6 5087

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-10 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase PSE-2
Gene namesi
Name:bla
Synonyms:oxa10, pse2
Encoded oniPlasmid pMON2340 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5482
DrugBankiDB02122 4-iodo-acetamido phenylboronic acid
DB04342 7-((Carboxy(4-Hydroxyphenyl)Acetyl)Amino)-7-Methoxy-(3-((1-Methyl-1h-Tetrazol-5-Yl)Thio)Methyl)-8-Oxo-5-Oxa-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
DB03801 Lysine Nz-Carboxylic Acid
DB00760 Meropenem

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001703021 – 266Beta-lactamase OXA-10Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 51
Modified residuei70N6-carboxylysine1 Publication1

Keywords - PTMi

Disulfide bond

Interactioni

Chemistry databases

BindingDBiP14489

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 24Combined sources4
Helixi26 – 29Combined sources4
Helixi30 – 33Combined sources4
Turni34 – 36Combined sources3
Beta strandi39 – 45Combined sources7
Turni46 – 49Combined sources4
Beta strandi50 – 54Combined sources5
Helixi56 – 59Combined sources4
Helixi66 – 69Combined sources4
Helixi70 – 79Combined sources10
Beta strandi81 – 83Combined sources3
Helixi100 – 102Combined sources3
Helixi108 – 113Combined sources6
Helixi117 – 127Combined sources11
Helixi129 – 138Combined sources10
Turni150 – 155Combined sources6
Beta strandi156 – 158Combined sources3
Helixi163 – 174Combined sources12
Beta strandi178 – 180Combined sources3
Helixi182 – 192Combined sources11
Beta strandi193 – 197Combined sources5
Beta strandi200 – 208Combined sources9
Beta strandi214 – 216Combined sources3
Beta strandi218 – 228Combined sources11
Beta strandi231 – 242Combined sources12
Helixi244 – 248Combined sources5
Helixi249 – 260Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E3UX-ray1.66A/B/C/D21-266[»]
1E4DX-ray1.80A/B/C/D21-266[»]
1EWZX-ray2.40A/B/C/D21-266[»]
1FOFX-ray2.00A/B20-265[»]
1K4EX-ray2.00A/B20-266[»]
1K4FX-ray1.60A/B20-266[»]
1K54X-ray1.70A/B/C/D21-266[»]
1K55X-ray1.39A/B/C/D21-266[»]
1K56X-ray1.70A/B/C/D21-266[»]
1K57X-ray1.90A/B/C/D21-266[»]
1K6RX-ray2.30A/B20-266[»]
1K6SX-ray2.03A/B20-266[»]
2HP5X-ray2.70A/B/C/D20-266[»]
2HP6X-ray2.20A/B20-266[»]
2HP9X-ray2.50A/B20-266[»]
2HPBX-ray2.05A/B20-266[»]
2RL3X-ray1.90A/B20-266[»]
2WGIX-ray2.85A/B21-266[»]
2WGVX-ray1.80A/B20-266[»]
2WGWX-ray1.80A/B20-266[»]
2WKHX-ray1.79A/B20-266[»]
2WKIX-ray2.10A/B20-266[»]
2X01X-ray1.90A/B20-266[»]
2X02X-ray1.35A/B20-266[»]
3LCEX-ray2.00A/B/C/D21-266[»]
4S2OX-ray1.70A/B20-265[»]
4WZ5X-ray1.60A/B/C/D20-266[»]
5FQ9X-ray1.50A/B20-266[»]
5MMYX-ray1.88A/B20-264[»]
5MNUX-ray1.56A/B20-265[»]
5MOXX-ray1.41A/B20-265[»]
5MOZX-ray1.34A/B20-265[»]
ProteinModelPortaliP14489
SMRiP14489
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14489

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni205 – 207Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK18792

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR002137 Beta-lactam_class-D_AS
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00337 BETA_LACTAMASE_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFAAYVII ACLSSTALAG SITENTSWNK EFSAEAVNGV FVLCKSSSKS
60 70 80 90 100
CATNDLARAS KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK
110 120 130 140 150
QWERDLTLRG AIQVSAVPVF QQIAREVGEV RMQKYLKKFS YGNQNISGGI
160 170 180 190 200
DKFWLEGQLR ISAVNQVEFL ESLYLNKLSA SKENQLIVKE ALVTEAAPEY
210 220 230 240 250
LVHSKTGFSG VGTESNPGVA WWVGWVEKET EVYFFAFNMD IDNESKLPLR
260
KSIPTKIMES EGIIGG
Length:266
Mass (Da):29,507
Last modified:January 1, 1990 - v1
Checksum:i9ABFF429D028F240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37105 Genomic DNA Translation: AAB60534.1
J03427 Genomic DNA Translation: AAA25648.1
PIRiS06462
RefSeqiWP_000846390.1, NZ_NXHS01000023.1

Genome annotation databases

KEGGiag:AAB60534

Similar proteinsi

Entry informationi

Entry nameiBLO10_PSEAI
AccessioniPrimary (citable) accession number: P14489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid, Transposable element
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Main funding by: National Institutes of Health