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Protein

Pupal cuticle protein

Gene

Pcp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the cuticle of the pupa of fruit fly.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pupal cuticle protein
Gene namesi
Name:Pcp
ORF Names:CG3440
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003046. Pcp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 184169Pupal cuticle proteinPRO_0000006397Add
BLAST

Proteomic databases

PaxDbiP14484.
PRIDEiP14484.

Expressioni

Developmental stagei

Expressed throughout both the fourth and the fifth larval instars.

Gene expression databases

BgeeiP14484.
GenevisibleiP14484. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079016.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10362Chitin-binding type R&RPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chitin-binding type R&R domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KC0S. Eukaryota.
ENOG4110MQM. LUCA.
GeneTreeiENSGT00840000130268.
InParanoidiP14484.
OMAiYLTHPPT.
OrthoDBiEOG75J0Q6.
PhylomeDBiP14484.

Family and domain databases

InterProiIPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PRINTSiPR00947. CUTICLE.
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLLVNFIVA LAVLQVQAGS SYIPDSDRNT RTLQNDLQVE RDGKYRYAYE
60 70 80 90 100
TSNGISASQE GLGGVAVQGG SSYTSPEGEV ISVNYVADEF GYHPVGAHIP
110 120 130 140 150
QVPDYILRSL EYIRTHPYQI KDYYTGELKT VEHDAAAFNV YTRNIQDHTI
160 170 180
PQSRPSTTPK TIYLTHPPTT TSRPLRQRRA LPTH
Length:184
Mass (Da):20,633
Last modified:January 1, 1990 - v1
Checksum:i4493B893F61329C2
GO

Sequence cautioni

The sequence ABX00770.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → LQ in AAA28564 (PubMed:3079672).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02527 Genomic DNA. Translation: AAA28564.1.
AE014134 Genomic DNA. Translation: AAF52475.1.
BT031148 mRNA. Translation: ABX00770.1. Different initiation.
PIRiB24787. UCFFPM.
RefSeqiNP_476673.1. NM_057325.3.

Genome annotation databases

EnsemblMetazoaiFBtr0079388; FBpp0079016; FBgn0003046.
GeneIDi33985.
KEGGidme:Dmel_CG3440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02527 Genomic DNA. Translation: AAA28564.1.
AE014134 Genomic DNA. Translation: AAF52475.1.
BT031148 mRNA. Translation: ABX00770.1. Different initiation.
PIRiB24787. UCFFPM.
RefSeqiNP_476673.1. NM_057325.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079016.

Proteomic databases

PaxDbiP14484.
PRIDEiP14484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079388; FBpp0079016; FBgn0003046.
GeneIDi33985.
KEGGidme:Dmel_CG3440.

Organism-specific databases

CTDi18543.
FlyBaseiFBgn0003046. Pcp.

Phylogenomic databases

eggNOGiENOG410KC0S. Eukaryota.
ENOG4110MQM. LUCA.
GeneTreeiENSGT00840000130268.
InParanoidiP14484.
OMAiYLTHPPT.
OrthoDBiEOG75J0Q6.
PhylomeDBiP14484.

Miscellaneous databases

GenomeRNAii33985.
PROiP14484.

Gene expression databases

BgeeiP14484.
GenevisibleiP14484. DM.

Family and domain databases

InterProiIPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PRINTSiPR00947. CUTICLE.
PROSITEiPS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands."
    Henikoff S., Keene M.A., Fechtel K., Fristrom J.W.
    Cell 44:33-42(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conserved arrangement of nested genes at the Drosophila Gart locus."
    Henikoff S., Eghtedarzadeh M.K.
    Genetics 117:711-725(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Larva and Pupae.

Entry informationi

Entry nameiCUPP_DROME
AccessioniPrimary (citable) accession number: P14484
Secondary accession number(s): A8WHK2, Q9VM52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.