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P14483

- HB2A_MOUSE

UniProt

P14483 - HB2A_MOUSE

Protein

H-2 class II histocompatibility antigen, A beta chain

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI
    2. protein binding Source: MGI
    3. repressing transcription factor binding Source: BHF-UCL
    4. toxic substance binding Source: BHF-UCL
    5. transcription factor binding Source: BHF-UCL
    6. ubiquitin protein ligase binding Source: BHF-UCL

    GO - Biological processi

    1. antigen processing and presentation Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
    3. antigen processing and presentation of peptide antigen Source: MGI
    4. B cell affinity maturation Source: BHF-UCL
    5. cellular response to interferon-gamma Source: BHF-UCL
    6. immune response Source: MGI
    7. positive regulation of alpha-beta T cell activation Source: BHF-UCL
    8. positive regulation of antigen processing and presentation Source: BHF-UCL
    9. positive regulation of T-helper 1 type immune response Source: BHF-UCL

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_198660. Interferon gamma signaling.
    REACT_215414. Translocation of ZAP-70 to Immunological synapse.
    REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
    REACT_225145. Downstream TCR signaling.
    REACT_225768. Generation of second messenger molecules.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H-2 class II histocompatibility antigen, A beta chain
    Gene namesi
    Name:H2-Ab1
    Synonyms:H2-iabeta
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:103070. H2-Ab1.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: MGI
    2. external side of plasma membrane Source: MGI
    3. Golgi apparatus Source: MGI
    4. integral component of membrane Source: MGI
    5. intracellular Source: MGI
    6. MHC class II protein complex Source: MGI
    7. multivesicular body Source: MGI
    8. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane, MHC II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Add
    BLAST
    Chaini28 – 265238H-2 class II histocompatibility antigen, A beta chainPRO_0000018993Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 106PROSITE-ProRule annotation
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 201PROSITE-ProRule annotation

    Post-translational modificationi

    Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP14483.
    PaxDbiP14483.
    PRIDEiP14483.

    Expressioni

    Gene expression databases

    ArrayExpressiP14483.
    BgeeiP14483.
    CleanExiMM_H2-AB1.
    GenevestigatoriP14483.

    Interactioni

    Protein-protein interaction databases

    BioGridi200147. 1 interaction.
    IntActiP14483. 1 interaction.
    MINTiMINT-257639.

    Structurei

    Secondary structure

    1
    265
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 4512
    Turni46 – 494
    Beta strandi50 – 5910
    Beta strandi62 – 687
    Turni69 – 713
    Beta strandi73 – 753
    Helixi79 – 813
    Helixi82 – 898
    Helixi92 – 10413
    Helixi106 – 1116
    Helixi113 – 1164
    Helixi118 – 1203
    Beta strandi126 – 1327
    Turni137 – 1393
    Beta strandi142 – 15312
    Beta strandi156 – 1616
    Beta strandi164 – 1663
    Beta strandi170 – 1723
    Beta strandi179 – 1813
    Beta strandi183 – 1908
    Beta strandi199 – 2046
    Beta strandi212 – 2165

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LNUX-ray2.50B/D/F/H27-216[»]
    1MUJX-ray2.15B28-216[»]
    3C5ZX-ray2.55D/H30-216[»]
    3C60X-ray3.05D/H30-216[»]
    3C6LX-ray3.40D/H30-216[»]
    3RDTX-ray2.70D30-218[»]
    4P23X-ray2.25D31-219[»]
    4P46X-ray2.85D31-219[»]
    4P5TX-ray3.26D/H27-218[»]
    ProteinModelPortaliP14483.
    SMRiP14483. Positions 33-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14483.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 226199ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26518CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 21389Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 12295Beta-1Add
    BLAST
    Regioni123 – 21694Beta-2Add
    BLAST
    Regioni217 – 22610Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68200.
    HOGENOMiHOG000100909.
    HOVERGENiHBG012730.
    InParanoidiP14483.
    KOiK06752.
    OMAiRQRSQKG.
    OrthoDBiEOG7PS1GV.
    PhylomeDBiP14483.
    TreeFamiTF336626.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVYQFMG ECYFTNGTQR    50
    IRYVTRYIYN REEYVRYDSD VGEHRAVTEL GRPDAEYWNS QPEILERTRA 100
    ELDTVCRHNY EGPETHTSLR RLEQPNVVIS LSRTEALNHH NTLVCSVTDF 150
    YPAKIKVRWF RNGQEETVGV SSTQLIRNGD WTFQVLVMLE MTPRRGEVYT 200
    CHVEHPSLKS PITVEWRAQS ESAWSKMLSG IGGCVLGVIF LGLGLFIRHR 250
    SQKGPRGPPP AGLLQ 265
    Length:265
    Mass (Da):30,128
    Last modified:January 1, 1990 - v1
    Checksum:iDA5118187D254BD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01527 Genomic DNA. Translation: CAA24768.1.
    AF027865 Genomic DNA. Translation: AAB81531.1.
    CCDSiCCDS37583.1.
    PIRiI48656.
    RefSeqiNP_996988.2. NM_207105.3.
    UniGeneiMm.254067.

    Genome annotation databases

    EnsembliENSMUST00000040828; ENSMUSP00000041008; ENSMUSG00000073421.
    GeneIDi14961.
    KEGGimmu:14961.
    UCSCiuc008ccb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01527 Genomic DNA. Translation: CAA24768.1 .
    AF027865 Genomic DNA. Translation: AAB81531.1 .
    CCDSi CCDS37583.1.
    PIRi I48656.
    RefSeqi NP_996988.2. NM_207105.3.
    UniGenei Mm.254067.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LNU X-ray 2.50 B/D/F/H 27-216 [» ]
    1MUJ X-ray 2.15 B 28-216 [» ]
    3C5Z X-ray 2.55 D/H 30-216 [» ]
    3C60 X-ray 3.05 D/H 30-216 [» ]
    3C6L X-ray 3.40 D/H 30-216 [» ]
    3RDT X-ray 2.70 D 30-218 [» ]
    4P23 X-ray 2.25 D 31-219 [» ]
    4P46 X-ray 2.85 D 31-219 [» ]
    4P5T X-ray 3.26 D/H 27-218 [» ]
    ProteinModelPortali P14483.
    SMRi P14483. Positions 33-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200147. 1 interaction.
    IntActi P14483. 1 interaction.
    MINTi MINT-257639.

    Proteomic databases

    MaxQBi P14483.
    PaxDbi P14483.
    PRIDEi P14483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040828 ; ENSMUSP00000041008 ; ENSMUSG00000073421 .
    GeneIDi 14961.
    KEGGi mmu:14961.
    UCSCi uc008ccb.2. mouse.

    Organism-specific databases

    CTDi 14961.
    MGIi MGI:103070. H2-Ab1.

    Phylogenomic databases

    eggNOGi NOG68200.
    HOGENOMi HOG000100909.
    HOVERGENi HBG012730.
    InParanoidi P14483.
    KOi K06752.
    OMAi RQRSQKG.
    OrthoDBi EOG7PS1GV.
    PhylomeDBi P14483.
    TreeFami TF336626.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_198660. Interferon gamma signaling.
    REACT_215414. Translocation of ZAP-70 to Immunological synapse.
    REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
    REACT_225145. Downstream TCR signaling.
    REACT_225768. Generation of second messenger molecules.

    Miscellaneous databases

    EvolutionaryTracei P14483.
    NextBioi 287310.
    PROi P14483.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14483.
    Bgeei P14483.
    CleanExi MM_H2-AB1.
    Genevestigatori P14483.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon."
      Larhammar D., Hammerling U., Denaro M., Lund T., Flavell R.A., Rask L., Peterson P.A.
      Cell 34:179-188(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G., Hood L.E.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination."
      van Niel G., Wubbolts R., Ten Broeke T., Buschow S.I., Ossendorp F.A., Melief C.J., Raposo G., van Balkom B.W., Stoorvogel W.
      Immunity 25:885-894(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION.
    4. "Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination."
      Shin J.S., Ebersold M., Pypaert M., Delamarre L., Hartley A., Mellman I.
      Nature 444:115-118(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION.

    Entry informationi

    Entry nameiHB2A_MOUSE
    AccessioniPrimary (citable) accession number: P14483
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3