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Protein

H-2 class II histocompatibility antigen, A beta chain

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein antigen binding Source: BHF-UCL
  • toxic substance binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  • antigen processing and presentation of peptide antigen Source: MGI
  • B cell affinity maturation Source: BHF-UCL
  • cellular response to interferon-gamma Source: BHF-UCL
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immune response Source: MGI
  • immunoglobulin production involved in immunoglobulin mediated immune response Source: MGI
  • positive regulation of alpha-beta T cell activation Source: BHF-UCL
  • positive regulation of antigen processing and presentation Source: BHF-UCL
  • positive regulation of T-helper 1 type immune response Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-389948. PD-1 signaling.
R-MMU-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A beta chain
Gene namesi
Name:H2-Ab1
Synonyms:H2-iabeta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 226ExtracellularSequence analysisAdd BLAST199
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 265CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • early endosome Source: MGI
  • external side of plasma membrane Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • multivesicular body Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000001899328 – 265H-2 class II histocompatibility antigen, A beta chainAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 106PROSITE-ProRule annotation
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 201PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP14483.
PaxDbiP14483.
PRIDEiP14483.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073421.
CleanExiMM_H2-AB1.
ExpressionAtlasiP14483. baseline and differential.
GenevisibleiP14483. MM.

Interactioni

GO - Molecular functioni

  • protein antigen binding Source: BHF-UCL
  • transcription factor binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi200147. 1 interactor.
IntActiP14483. 1 interactor.
MINTiMINT-257639.
STRINGi10090.ENSMUSP00000041008.

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 45Combined sources12
Turni46 – 49Combined sources4
Beta strandi50 – 59Combined sources10
Beta strandi62 – 68Combined sources7
Turni69 – 71Combined sources3
Beta strandi73 – 75Combined sources3
Helixi79 – 81Combined sources3
Helixi82 – 89Combined sources8
Helixi92 – 104Combined sources13
Helixi106 – 111Combined sources6
Helixi113 – 116Combined sources4
Helixi118 – 120Combined sources3
Beta strandi126 – 132Combined sources7
Turni137 – 139Combined sources3
Beta strandi142 – 153Combined sources12
Beta strandi156 – 161Combined sources6
Beta strandi164 – 166Combined sources3
Beta strandi170 – 172Combined sources3
Beta strandi179 – 181Combined sources3
Beta strandi183 – 190Combined sources8
Beta strandi199 – 204Combined sources6
Beta strandi212 – 216Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50B/D/F/H27-216[»]
1MUJX-ray2.15B28-216[»]
3C5ZX-ray2.55D/H30-216[»]
3C60X-ray3.05D/H30-216[»]
3C6LX-ray3.40D/H30-216[»]
3RDTX-ray2.70D30-218[»]
4P23X-ray2.25D31-219[»]
4P46X-ray2.85D31-219[»]
4P5TX-ray3.26D/H27-218[»]
ProteinModelPortaliP14483.
SMRiP14483.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 213Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 122Beta-1Add BLAST95
Regioni123 – 216Beta-2Add BLAST94
Regioni217 – 226Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
KOiK06752.
OMAiEMTPRRG.
OrthoDBiEOG091G0SXL.
PhylomeDBiP14483.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVYQFMG ECYFTNGTQR
60 70 80 90 100
IRYVTRYIYN REEYVRYDSD VGEHRAVTEL GRPDAEYWNS QPEILERTRA
110 120 130 140 150
ELDTVCRHNY EGPETHTSLR RLEQPNVVIS LSRTEALNHH NTLVCSVTDF
160 170 180 190 200
YPAKIKVRWF RNGQEETVGV SSTQLIRNGD WTFQVLVMLE MTPRRGEVYT
210 220 230 240 250
CHVEHPSLKS PITVEWRAQS ESAWSKMLSG IGGCVLGVIF LGLGLFIRHR
260
SQKGPRGPPP AGLLQ
Length:265
Mass (Da):30,128
Last modified:January 1, 1990 - v1
Checksum:iDA5118187D254BD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01527 Genomic DNA. Translation: CAA24768.1.
AF027865 Genomic DNA. Translation: AAB81531.1.
CCDSiCCDS37583.1.
PIRiI48656.
RefSeqiNP_996988.2. NM_207105.3.
UniGeneiMm.254067.

Genome annotation databases

EnsembliENSMUST00000040828; ENSMUSP00000041008; ENSMUSG00000073421.
GeneIDi14961.
KEGGimmu:14961.
UCSCiuc008ccb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01527 Genomic DNA. Translation: CAA24768.1.
AF027865 Genomic DNA. Translation: AAB81531.1.
CCDSiCCDS37583.1.
PIRiI48656.
RefSeqiNP_996988.2. NM_207105.3.
UniGeneiMm.254067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50B/D/F/H27-216[»]
1MUJX-ray2.15B28-216[»]
3C5ZX-ray2.55D/H30-216[»]
3C60X-ray3.05D/H30-216[»]
3C6LX-ray3.40D/H30-216[»]
3RDTX-ray2.70D30-218[»]
4P23X-ray2.25D31-219[»]
4P46X-ray2.85D31-219[»]
4P5TX-ray3.26D/H27-218[»]
ProteinModelPortaliP14483.
SMRiP14483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200147. 1 interactor.
IntActiP14483. 1 interactor.
MINTiMINT-257639.
STRINGi10090.ENSMUSP00000041008.

Proteomic databases

EPDiP14483.
PaxDbiP14483.
PRIDEiP14483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040828; ENSMUSP00000041008; ENSMUSG00000073421.
GeneIDi14961.
KEGGimmu:14961.
UCSCiuc008ccb.2. mouse.

Organism-specific databases

CTDi14961.
MGIiMGI:103070. H2-Ab1.

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
KOiK06752.
OMAiEMTPRRG.
OrthoDBiEOG091G0SXL.
PhylomeDBiP14483.
TreeFamiTF336626.

Enzyme and pathway databases

ReactomeiR-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-389948. PD-1 signaling.
R-MMU-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiP14483.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073421.
CleanExiMM_H2-AB1.
ExpressionAtlasiP14483. baseline and differential.
GenevisibleiP14483. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHB2A_MOUSE
AccessioniPrimary (citable) accession number: P14483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.