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Reviewed, UniProtKB/Swiss-Prot P14483 (HB2A_MOUSE)

Last modified July 13, 2010. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
H-2 class II histocompatibility antigen, A beta chain
Gene names
Name:H2-Ab1
Synonyms:H2-iabeta
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus
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Protein attributesHide

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.
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General annotation (Comments)Hide

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727
Chain28 – 265238H-2 class II histocompatibility antigen, A beta chain
PRO_0000018993

Regions

Topological domain28 – 226199Extracellular Potential
Transmembrane227 – 24721Helical; Potential
Topological domain248 – 26518Cytoplasmic Potential
Domain125 – 21389Ig-like C1-type
Region28 – 12295Beta-1
Region123 – 21694Beta-2
Region217 – 22610Connecting peptide

Amino acid modifications

Glycosylation461N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 106 By similarity
Disulfide bond145 ↔ 201 By similarity

Secondary structure

1 ......................................... 265
Helix Strand Turn

Details...

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SequencesHide

Sequence LengthMass (Da)Tools
P14483-1 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: DA5118187D254BD6

FASTA26530,128
        10         20         30         40         50         60 
MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVYQFMG ECYFTNGTQR IRYVTRYIYN 

        70         80         90        100        110        120 
REEYVRYDSD VGEHRAVTEL GRPDAEYWNS QPEILERTRA ELDTVCRHNY EGPETHTSLR 

       130        140        150        160        170        180 
RLEQPNVVIS LSRTEALNHH NTLVCSVTDF YPAKIKVRWF RNGQEETVGV SSTQLIRNGD 

       190        200        210        220        230        240 
WTFQVLVMLE MTPRRGEVYT CHVEHPSLKS PITVEWRAQS ESAWSKMLSG IGGCVLGVIF 

       250        260 
LGLGLFIRHR SQKGPRGPPP AGLLQ

« Hide

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ReferencesHide

[1]"Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon."
Larhammar D., Hammerling U., Denaro M., Lund T., Flavell R.A., Rask L., Peterson P.A.
Cell 34:179-188(1983) [PubMed: 6411350] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G., Hood L.E.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ		V01527 Genomic DNA. Translation: CAA24768.1.
AF027865 Genomic DNA. Translation: AAB81531.1.
IPIIPI00126585.
PIRI48656.
RefSeqNP_996988.2.
UniGeneMm.254067

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50B/D/F/H30-216[»]
1MUJX-ray2.15B28-216[»]
3C5ZX-ray2.55D/H30-216[»]
3C60X-ray3.05D/H30-216[»]
3C6LX-ray3.40D/H30-216[»]
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-257639.
STRINGP14483.

Proteomic databases

PRIDEP14483.

Genome annotation databases

EnsemblENSMUST00000040828; ENSMUSP00000041008; ENSMUSG00000073421; Mus musculus. [Genome view]
GeneID14961.

Organism-specific databases

MGIMGI:103070. H2-Ab1.

Phylogenomic databases

HOGENOMHBG283835.
HOVERGENHBG012730.
InParanoidP14483.
OMAWKKALRI.
PhylomeDBP14483.

Gene expression databases

ArrayExpressP14483.
BgeeP14483.
CleanExMM_H2-AB1.
GenevestigatorP14483.
GermOnlineENSMUSG00000073421. Mus musculus.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000353. MHC_II_b_N.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...
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Entry informationHide

Entry nameHB2A_MOUSE
AccessionPrimary (citable) accession number: P14483
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 13, 2010
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
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Relevant documentsHide

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents