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P14483

- HB2A_MOUSE

UniProt

P14483 - HB2A_MOUSE

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Protein
H-2 class II histocompatibility antigen, A beta chain
Gene
H2-Ab1, H2-iabeta
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. peptide antigen binding Source: MGI
  2. protein binding Source: MGI
  3. repressing transcription factor binding Source: BHF-UCL
  4. toxic substance binding Source: BHF-UCL
  5. transcription factor binding Source: BHF-UCL
  6. ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  1. B cell affinity maturation Source: BHF-UCL
  2. antigen processing and presentation Source: MGI
  3. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  4. antigen processing and presentation of peptide antigen Source: MGI
  5. cellular response to interferon-gamma Source: BHF-UCL
  6. immune response Source: MGI
  7. positive regulation of T-helper 1 type immune response Source: BHF-UCL
  8. positive regulation of alpha-beta T cell activation Source: BHF-UCL
  9. positive regulation of antigen processing and presentation Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_198660. Interferon gamma signaling.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A beta chain
Gene namesi
Name:H2-Ab1
Synonyms:H2-iabeta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 226199Extracellular Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Topological domaini248 – 26518Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. MHC class II protein complex Source: MGI
  3. early endosome Source: MGI
  4. external side of plasma membrane Source: MGI
  5. integral component of membrane Source: MGI
  6. intracellular Source: MGI
  7. multivesicular body Source: MGI
  8. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727
Add
BLAST
Chaini28 – 265238H-2 class II histocompatibility antigen, A beta chain
PRO_0000018993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 106 By similarity
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi145 ↔ 201 By similarity

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP14483.
PaxDbiP14483.
PRIDEiP14483.

Expressioni

Gene expression databases

ArrayExpressiP14483.
BgeeiP14483.
CleanExiMM_H2-AB1.
GenevestigatoriP14483.

Interactioni

Protein-protein interaction databases

BioGridi200147. 1 interaction.
IntActiP14483. 1 interaction.
MINTiMINT-257639.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 4512
Turni46 – 494
Beta strandi50 – 5910
Beta strandi62 – 687
Turni69 – 713
Beta strandi73 – 753
Helixi79 – 813
Helixi82 – 898
Helixi92 – 10413
Helixi106 – 1116
Helixi113 – 1164
Helixi118 – 1203
Beta strandi126 – 1327
Turni137 – 1393
Beta strandi142 – 15312
Beta strandi156 – 1616
Beta strandi164 – 1663
Beta strandi170 – 1723
Beta strandi179 – 1813
Beta strandi183 – 1908
Beta strandi199 – 2046
Beta strandi212 – 2165

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50B/D/F/H27-216[»]
1MUJX-ray2.15B28-216[»]
3C5ZX-ray2.55D/H30-216[»]
3C60X-ray3.05D/H30-216[»]
3C6LX-ray3.40D/H30-216[»]
3RDTX-ray2.70D30-218[»]
4P23X-ray2.25D31-219[»]
4P46X-ray2.85D31-219[»]
4P5TX-ray3.26D/H27-218[»]
ProteinModelPortaliP14483.
SMRiP14483. Positions 33-218.

Miscellaneous databases

EvolutionaryTraceiP14483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 21389Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 12295Beta-1
Add
BLAST
Regioni123 – 21694Beta-2
Add
BLAST
Regioni217 – 22610Connecting peptide

Sequence similaritiesi

Belongs to the MHC class II family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68200.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
InParanoidiP14483.
KOiK06752.
OMAiRQRSQKG.
OrthoDBiEOG7PS1GV.
PhylomeDBiP14483.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14483-1 [UniParc]FASTAAdd to Basket

« Hide

MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVYQFMG ECYFTNGTQR    50
IRYVTRYIYN REEYVRYDSD VGEHRAVTEL GRPDAEYWNS QPEILERTRA 100
ELDTVCRHNY EGPETHTSLR RLEQPNVVIS LSRTEALNHH NTLVCSVTDF 150
YPAKIKVRWF RNGQEETVGV SSTQLIRNGD WTFQVLVMLE MTPRRGEVYT 200
CHVEHPSLKS PITVEWRAQS ESAWSKMLSG IGGCVLGVIF LGLGLFIRHR 250
SQKGPRGPPP AGLLQ 265
Length:265
Mass (Da):30,128
Last modified:January 1, 1990 - v1
Checksum:iDA5118187D254BD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01527 Genomic DNA. Translation: CAA24768.1.
AF027865 Genomic DNA. Translation: AAB81531.1.
CCDSiCCDS37583.1.
PIRiI48656.
RefSeqiNP_996988.2. NM_207105.3.
UniGeneiMm.254067.

Genome annotation databases

EnsembliENSMUST00000040828; ENSMUSP00000041008; ENSMUSG00000073421.
GeneIDi14961.
KEGGimmu:14961.
UCSCiuc008ccb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01527 Genomic DNA. Translation: CAA24768.1 .
AF027865 Genomic DNA. Translation: AAB81531.1 .
CCDSi CCDS37583.1.
PIRi I48656.
RefSeqi NP_996988.2. NM_207105.3.
UniGenei Mm.254067.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LNU X-ray 2.50 B/D/F/H 27-216 [» ]
1MUJ X-ray 2.15 B 28-216 [» ]
3C5Z X-ray 2.55 D/H 30-216 [» ]
3C60 X-ray 3.05 D/H 30-216 [» ]
3C6L X-ray 3.40 D/H 30-216 [» ]
3RDT X-ray 2.70 D 30-218 [» ]
4P23 X-ray 2.25 D 31-219 [» ]
4P46 X-ray 2.85 D 31-219 [» ]
4P5T X-ray 3.26 D/H 27-218 [» ]
ProteinModelPortali P14483.
SMRi P14483. Positions 33-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200147. 1 interaction.
IntActi P14483. 1 interaction.
MINTi MINT-257639.

Proteomic databases

MaxQBi P14483.
PaxDbi P14483.
PRIDEi P14483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040828 ; ENSMUSP00000041008 ; ENSMUSG00000073421 .
GeneIDi 14961.
KEGGi mmu:14961.
UCSCi uc008ccb.2. mouse.

Organism-specific databases

CTDi 14961.
MGIi MGI:103070. H2-Ab1.

Phylogenomic databases

eggNOGi NOG68200.
HOGENOMi HOG000100909.
HOVERGENi HBG012730.
InParanoidi P14483.
KOi K06752.
OMAi RQRSQKG.
OrthoDBi EOG7PS1GV.
PhylomeDBi P14483.
TreeFami TF336626.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_198660. Interferon gamma signaling.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Miscellaneous databases

EvolutionaryTracei P14483.
NextBioi 287310.
PROi P14483.
SOURCEi Search...

Gene expression databases

ArrayExpressi P14483.
Bgeei P14483.
CleanExi MM_H2-AB1.
Genevestigatori P14483.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon."
    Larhammar D., Hammerling U., Denaro M., Lund T., Flavell R.A., Rask L., Peterson P.A.
    Cell 34:179-188(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G., Hood L.E.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination."
    van Niel G., Wubbolts R., Ten Broeke T., Buschow S.I., Ossendorp F.A., Melief C.J., Raposo G., van Balkom B.W., Stoorvogel W.
    Immunity 25:885-894(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  4. "Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination."
    Shin J.S., Ebersold M., Pypaert M., Delamarre L., Hartley A., Mellman I.
    Nature 444:115-118(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.

Entry informationi

Entry nameiHB2A_MOUSE
AccessioniPrimary (citable) accession number: P14483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi