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P14483 (HB2A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H-2 class II histocompatibility antigen, A beta chain
Gene names
Name:H2-Ab1
Synonyms:H2-iabeta
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II. Ref.3 Ref.4

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentMembrane
MHC II
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell affinity maturation

Inferred from direct assay PubMed 1378867. Source: BHF-UCL

antigen processing and presentation

Inferred from direct assay PubMed 9432982. Source: MGI

antigen processing and presentation of exogenous peptide antigen via MHC class II

Inferred from direct assay PubMed 11027433PubMed 11069069PubMed 11714799PubMed 7679955PubMed 8598040PubMed 8598041PubMed 9432982PubMed 9492004. Source: MGI

antigen processing and presentation of peptide antigen

Inferred from direct assay PubMed 11069069. Source: MGI

cellular response to interferon-gamma

Inferred from direct assay PubMed 1845803PubMed 2493384PubMed 2502420PubMed 7691725PubMed 9244347. Source: BHF-UCL

immune response

Inferred from mutant phenotype PubMed 1909605. Source: MGI

positive regulation of T-helper 1 type immune response

Inferred from direct assay PubMed 14607905. Source: BHF-UCL

positive regulation of alpha-beta T cell activation

Inferred from direct assay PubMed 14607905. Source: BHF-UCL

positive regulation of antigen processing and presentation

Inferred from direct assay PubMed 14607905. Source: BHF-UCL

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 7679955. Source: MGI

MHC class II protein complex

Inferred from direct assay PubMed 11148202PubMed 7679955PubMed 7985028PubMed 8598040PubMed 8598041PubMed 8638109PubMed 9432982PubMed 9492004. Source: MGI

early endosome

Inferred from direct assay PubMed 11854359. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 11148202PubMed 12801066PubMed 14643301PubMed 7679955PubMed 8598040PubMed 8598041PubMed 8638109PubMed 9432982PubMed 9492004. Source: MGI

integral component of membrane

Inferred from direct assay PubMed 7584146. Source: MGI

intracellular

Inferred from direct assay PubMed 8890155. Source: MGI

multivesicular body

Inferred from direct assay PubMed 11854359. Source: MGI

plasma membrane

Inferred from direct assay PubMed 11854359PubMed 7679955PubMed 7985028PubMed 8638109PubMed 8890155. Source: MGI

   Molecular_functionpeptide antigen binding

Inferred from direct assay PubMed 11069069PubMed 9432982. Source: MGI

repressing transcription factor binding

Inferred from physical interaction PubMed 7592651. Source: BHF-UCL

toxic substance binding

Inferred from physical interaction PubMed 2159298. Source: BHF-UCL

transcription factor binding

Inferred from direct assay PubMed 8611149. Source: BHF-UCL

ubiquitin protein ligase binding

Inferred from physical interaction PubMed 16785530. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727
Chain28 – 265238H-2 class II histocompatibility antigen, A beta chain
PRO_0000018993

Regions

Topological domain28 – 226199Extracellular Potential
Transmembrane227 – 24721Helical; Potential
Topological domain248 – 26518Cytoplasmic Potential
Domain125 – 21389Ig-like C1-type
Region28 – 12295Beta-1
Region123 – 21694Beta-2
Region217 – 22610Connecting peptide

Amino acid modifications

Glycosylation461N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 106 By similarity
Disulfide bond145 ↔ 201 By similarity

Secondary structure

......................................... 265
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P14483 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: DA5118187D254BD6

FASTA26530,128
        10         20         30         40         50         60 
MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVYQFMG ECYFTNGTQR IRYVTRYIYN 

        70         80         90        100        110        120 
REEYVRYDSD VGEHRAVTEL GRPDAEYWNS QPEILERTRA ELDTVCRHNY EGPETHTSLR 

       130        140        150        160        170        180 
RLEQPNVVIS LSRTEALNHH NTLVCSVTDF YPAKIKVRWF RNGQEETVGV SSTQLIRNGD 

       190        200        210        220        230        240 
WTFQVLVMLE MTPRRGEVYT CHVEHPSLKS PITVEWRAQS ESAWSKMLSG IGGCVLGVIF 

       250        260 
LGLGLFIRHR SQKGPRGPPP AGLLQ 

« Hide

References

[1]"Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon."
Larhammar D., Hammerling U., Denaro M., Lund T., Flavell R.A., Rask L., Peterson P.A.
Cell 34:179-188(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G., Hood L.E.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination."
van Niel G., Wubbolts R., Ten Broeke T., Buschow S.I., Ossendorp F.A., Melief C.J., Raposo G., van Balkom B.W., Stoorvogel W.
Immunity 25:885-894(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION.
[4]"Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination."
Shin J.S., Ebersold M., Pypaert M., Delamarre L., Hartley A., Mellman I.
Nature 444:115-118(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V01527 Genomic DNA. Translation: CAA24768.1.
AF027865 Genomic DNA. Translation: AAB81531.1.
PIRI48656.
RefSeqNP_996988.2. NM_207105.3.
UniGeneMm.254067.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50B/D/F/H30-216[»]
1MUJX-ray2.15B28-216[»]
3C5ZX-ray2.55D/H30-216[»]
3C60X-ray3.05D/H30-216[»]
3C6LX-ray3.40D/H30-216[»]
3RDTX-ray2.70D27-218[»]
ProteinModelPortalP14483.
SMRP14483. Positions 33-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200147. 1 interaction.
IntActP14483. 1 interaction.
MINTMINT-257639.

Proteomic databases

PaxDbP14483.
PRIDEP14483.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040828; ENSMUSP00000041008; ENSMUSG00000073421.
GeneID14961.
KEGGmmu:14961.
UCSCuc008ccb.2. mouse.

Organism-specific databases

CTD14961.
MGIMGI:103070. H2-Ab1.

Phylogenomic databases

eggNOGNOG68200.
HOGENOMHOG000100909.
HOVERGENHBG012730.
InParanoidP14483.
KOK06752.
OMARQRSQKG.
OrthoDBEOG7PS1GV.
PhylomeDBP14483.
TreeFamTF336626.

Gene expression databases

ArrayExpressP14483.
BgeeP14483.
CleanExMM_H2-AB1.
GenevestigatorP14483.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP14483.
NextBio287310.
PROP14483.
SOURCESearch...

Entry information

Entry nameHB2A_MOUSE
AccessionPrimary (citable) accession number: P14483
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot