Reviewed, UniProtKB/Swiss-Prot P14465 (FIBB_ANTAM)

Names and origin

Protein names

Recommended name:
    Fibrinogen beta chain
Cleaved into the following chain:
    1- Recommended name:
            Fibrinopeptide B

Gene names

Name:

FGB

Organism

Antilocapra americana (Pronghorn)

Taxonomic identifier

9891 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Antilocapridae › Antilocapra

Protein attributes

Sequence length	21 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
Subunit structure	Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain By similarity.
Subcellular location	Secreted.
Domain	A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Post-translational modification	Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot.

Ontologies

Keywords
Biological process	Blood coagulation
Cellular component	Secreted
Domain	Coiled coil
PTM	Disulfide bond Pyrrolidone carboxylic acid Sulfation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	blood coagulation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 21	21	Fibrinopeptide B		PRO_0000009053
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid
	Modified residue	6	1	Sulfotyrosine
Experimental info
	Non-terminal residue	21	1

Sequences

	Sequence		Length	Mass (Da)
	P14465-1 [UniParc]. Last modified February 1, 1994. Version 2. Checksum: FCE6183BE1F31627	FASTA	21	2,585
	10 20 QPSYDYDEEE DDRAKLRLDA R

References

[1]	"Amino acid sequence studies on artiodacty fibrinopeptides." Mross G.A., Doolittle R.F. Arch. Biochem. Biophys. 122:674-684(1967) Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P14465.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FIBB_ANTAM

Accession

Primary (citable) accession number: P14465

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)