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Protein

H-2 class II histocompatibility antigen, A-U alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-U alpha chain
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 189ExtracellularSequence analysisAdd BLAST›189
Transmembranei190 – 215HelicalSequence analysisAdd BLAST26
Topological domaini216 – 227CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000080749‹1 – 227H-2 class II histocompatibility antigen, A-U alpha chainAdd BLAST›227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 161PROSITE-ProRule annotation
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP14438.
PaxDbiP14438.
PeptideAtlasiP14438.
PRIDEiP14438.

Expressioni

Gene expression databases

CleanExiMM_H2-AA.

Interactioni

Protein-protein interaction databases

MINTiMINT-243446.
STRINGi10090.ENSMUSP00000046105.

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 13Combined sources13
Turni14 – 16Combined sources3
Beta strandi17 – 24Combined sources8
Beta strandi27 – 33Combined sources7
Turni34 – 37Combined sources4
Beta strandi38 – 43Combined sources6
Helixi46 – 48Combined sources3
Helixi55 – 74Combined sources20
Turni75 – 77Combined sources3
Beta strandi86 – 93Combined sources8
Beta strandi101 – 110Combined sources10
Beta strandi116 – 121Combined sources6
Beta strandi124 – 126Combined sources3
Beta strandi130 – 132Combined sources3
Beta strandi143 – 151Combined sources9
Beta strandi159 – 164Combined sources6
Beta strandi172 – 176Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K2DX-ray2.20A1-179[»]
1U3HX-ray2.42C/G1-179[»]
2P24X-ray2.15A1-190[»]
2PXYX-ray2.23C1-178[»]
2Z31X-ray2.70C1-178[»]
ProteinModelPortaliP14438.
SMRiP14438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14438.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 177Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹1 – 82Alpha-1Add BLAST›82
Regioni83 – 176Alpha-2Add BLAST94
Regioni177 – 189Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P14438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DHVGSYGIVV YQSPGDIGQY TFEFDGDELF YVDLDKKETI WMLPEFAQLR
60 70 80 90 100
SFDPQGGLQN IATGKHNLGV LTKRSNSTPA TNEAPQATVF PKSPVLLGQP
110 120 130 140 150
NTLICFVDNI FPPVINITWL RNSKSVADGV YETSFFVNRD YSFHKLSYLT
160 170 180 190 200
FIPSDDDIYD CKVEHWGLEE PVLKHWEPEI PAPMSELTET VVCALGLSVG
210 220
LVGIVVGTIF IIQGLRSGGT SRHPGPL
Length:227
Mass (Da):25,136
Last modified:January 1, 1990 - v1
Checksum:iD1B7FDF1B390C877
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01926 mRNA. Translation: AAA39623.1.
PIRiPL0125.
UniGeneiMm.235338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01926 mRNA. Translation: AAA39623.1.
PIRiPL0125.
UniGeneiMm.235338.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K2DX-ray2.20A1-179[»]
1U3HX-ray2.42C/G1-179[»]
2P24X-ray2.15A1-190[»]
2PXYX-ray2.23C1-178[»]
2Z31X-ray2.70C1-178[»]
ProteinModelPortaliP14438.
SMRiP14438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-243446.
STRINGi10090.ENSMUSP00000046105.

Proteomic databases

MaxQBiP14438.
PaxDbiP14438.
PeptideAtlasiP14438.
PRIDEiP14438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
HOVERGENiHBG006862.

Miscellaneous databases

EvolutionaryTraceiP14438.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AA.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA2U_MOUSE
AccessioniPrimary (citable) accession number: P14438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.