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Protein

H-2 class II histocompatibility antigen, A-U alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-U alpha chain
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 189›189ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21526HelicalSequence analysisAdd
BLAST
Topological domaini216 – 22712CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 227›227H-2 class II histocompatibility antigen, A-U alpha chainPRO_0000080749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi105 ↔ 161PROSITE-ProRule annotation
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14438.
MaxQBiP14438.
PaxDbiP14438.
PRIDEiP14438.

Expressioni

Gene expression databases

CleanExiMM_H2-AA.

Interactioni

Protein-protein interaction databases

MINTiMINT-243446.
STRINGi10090.ENSMUSP00000046105.

Structurei

Secondary structure

227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 1313Combined sources
Turni14 – 163Combined sources
Beta strandi17 – 248Combined sources
Beta strandi27 – 337Combined sources
Turni34 – 374Combined sources
Beta strandi38 – 436Combined sources
Helixi46 – 483Combined sources
Helixi55 – 7420Combined sources
Turni75 – 773Combined sources
Beta strandi86 – 938Combined sources
Beta strandi101 – 11010Combined sources
Beta strandi116 – 1216Combined sources
Beta strandi124 – 1263Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi143 – 1519Combined sources
Beta strandi159 – 1646Combined sources
Beta strandi172 – 1765Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K2DX-ray2.20A1-179[»]
1U3HX-ray2.42C/G1-179[»]
2P24X-ray2.15A1-190[»]
2PXYX-ray2.23C1-178[»]
2Z31X-ray2.70C1-178[»]
ProteinModelPortaliP14438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14438.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17793Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni‹1 – 82›82Alpha-1Add
BLAST
Regioni83 – 17694Alpha-2Add
BLAST
Regioni177 – 18913Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P14438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DHVGSYGIVV YQSPGDIGQY TFEFDGDELF YVDLDKKETI WMLPEFAQLR
60 70 80 90 100
SFDPQGGLQN IATGKHNLGV LTKRSNSTPA TNEAPQATVF PKSPVLLGQP
110 120 130 140 150
NTLICFVDNI FPPVINITWL RNSKSVADGV YETSFFVNRD YSFHKLSYLT
160 170 180 190 200
FIPSDDDIYD CKVEHWGLEE PVLKHWEPEI PAPMSELTET VVCALGLSVG
210 220
LVGIVVGTIF IIQGLRSGGT SRHPGPL
Length:227
Mass (Da):25,136
Last modified:January 1, 1990 - v1
Checksum:iD1B7FDF1B390C877
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01926 mRNA. Translation: AAA39623.1.
PIRiPL0125.
UniGeneiMm.235338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01926 mRNA. Translation: AAA39623.1.
PIRiPL0125.
UniGeneiMm.235338.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K2DX-ray2.20A1-179[»]
1U3HX-ray2.42C/G1-179[»]
2P24X-ray2.15A1-190[»]
2PXYX-ray2.23C1-178[»]
2Z31X-ray2.70C1-178[»]
ProteinModelPortaliP14438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-243446.
STRINGi10090.ENSMUSP00000046105.

Proteomic databases

EPDiP14438.
MaxQBiP14438.
PaxDbiP14438.
PRIDEiP14438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
HOVERGENiHBG006862.

Miscellaneous databases

EvolutionaryTraceiP14438.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AA.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regions of allelic hypervariability in the murine A alpha immune response gene."
    Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
    Cell 34:169-177(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Lung and Spleen.

Entry informationi

Entry nameiHA2U_MOUSE
AccessioniPrimary (citable) accession number: P14438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 11, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.