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P14434

- HA2B_MOUSE

UniProt

P14434 - HA2B_MOUSE

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Protein

H-2 class II histocompatibility antigen, A-B alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. peptide antigen binding Source: MGI

GO - Biological processi

  1. antigen processing and presentation Source: MGI
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  3. antigen processing and presentation of peptide antigen Source: MGI
  4. positive regulation of T cell differentiation Source: MGI
  5. response to interferon-gamma Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_198660. Interferon gamma signaling.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-B alpha chain
Short name:
IAalpha
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: MGI
  4. MHC class II protein complex Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 256233H-2 class II histocompatibility antigen, A-B alpha chainPRO_0000018975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi134 ↔ 1901 PublicationPROSITE-ProRule annotation
Glycosylationi145 – 1451N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP14434.
PaxDbiP14434.
PRIDEiP14434.

Expressioni

Gene expression databases

BgeeiP14434.
CleanExiMM_H2-AA.
ExpressionAtlasiP14434. baseline and differential.
GenevestigatoriP14434.

Interactioni

Protein-protein interaction databases

BioGridi200146. 1 interaction.
IntActiP14434. 1 interaction.
MINTiMINT-257614.

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 4213
Turni43 – 453
Beta strandi46 – 538
Beta strandi56 – 627
Turni63 – 664
Beta strandi67 – 726
Helixi73 – 764
Helixi83 – 10321
Turni104 – 1063
Beta strandi115 – 1228
Beta strandi126 – 1283
Beta strandi130 – 13910
Beta strandi145 – 15410
Beta strandi157 – 1615
Beta strandi165 – 1673
Turni168 – 1703
Beta strandi172 – 1809
Beta strandi188 – 1936
Beta strandi197 – 1993
Beta strandi201 – 2055

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50A/C/E/G27-208[»]
1MUJX-ray2.15A24-205[»]
3C5ZX-ray2.55C/G27-208[»]
3C60X-ray3.05C/G27-208[»]
3C6LX-ray3.40C/G27-208[»]
3RDTX-ray2.70C27-208[»]
4P23X-ray2.25C27-205[»]
4P46X-ray2.85C27-205[»]
4P5TX-ray3.26C/G27-208[»]
ProteinModelPortaliP14434.
SMRiP14434. Positions 26-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14434.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 218195ExtracellularSequence AnalysisAdd
BLAST
Topological domaini245 – 25612CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei219 – 24426HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 20693Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 11188Alpha-1Add
BLAST
Regioni112 – 20594Alpha-2Add
BLAST
Regioni206 – 21813Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26577.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000112076.
HOVERGENiHBG006862.
KOiK06752.
OMAiSYGVNVY.
OrthoDBiEOG7C2R26.
PhylomeDBiP14434.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14434 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRSRALILG VLALTTMLSL CGGEDDIEAD HVGTYGISVY QSPGDIGQYT
60 70 80 90 100
FEFDGDELFY VDLDKKETVW MLPEFGQLAS FDPQGGLQNI AVVKHNLGVL
110 120 130 140 150
TKRSNSTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR
160 170 180 190 200
NSKSVADGVY ETSFFVNRDY SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP
210 220 230 240 250
VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS

RHPGPL
Length:256
Mass (Da):28,093
Last modified:May 30, 2000 - v2
Checksum:iC9DD084F6179B41F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027865 Genomic DNA. Translation: AAB81529.1.
AF050157 Genomic DNA. Translation: AAC05285.1.
BC019721 mRNA. Translation: AAH19721.1.
BC031711 mRNA. Translation: AAH31711.1.
K01922 mRNA. Translation: AAA39614.1.
CCDSiCCDS28645.1.
RefSeqiNP_034508.2. NM_010378.2.
UniGeneiMm.235338.

Genome annotation databases

EnsembliENSMUST00000040655; ENSMUSP00000046105; ENSMUSG00000036594.
GeneIDi14960.
KEGGimmu:14960.
UCSCiuc008ccd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027865 Genomic DNA. Translation: AAB81529.1 .
AF050157 Genomic DNA. Translation: AAC05285.1 .
BC019721 mRNA. Translation: AAH19721.1 .
BC031711 mRNA. Translation: AAH31711.1 .
K01922 mRNA. Translation: AAA39614.1 .
CCDSi CCDS28645.1.
RefSeqi NP_034508.2. NM_010378.2.
UniGenei Mm.235338.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LNU X-ray 2.50 A/C/E/G 27-208 [» ]
1MUJ X-ray 2.15 A 24-205 [» ]
3C5Z X-ray 2.55 C/G 27-208 [» ]
3C60 X-ray 3.05 C/G 27-208 [» ]
3C6L X-ray 3.40 C/G 27-208 [» ]
3RDT X-ray 2.70 C 27-208 [» ]
4P23 X-ray 2.25 C 27-205 [» ]
4P46 X-ray 2.85 C 27-205 [» ]
4P5T X-ray 3.26 C/G 27-208 [» ]
ProteinModelPortali P14434.
SMRi P14434. Positions 26-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200146. 1 interaction.
IntActi P14434. 1 interaction.
MINTi MINT-257614.

Proteomic databases

MaxQBi P14434.
PaxDbi P14434.
PRIDEi P14434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040655 ; ENSMUSP00000046105 ; ENSMUSG00000036594 .
GeneIDi 14960.
KEGGi mmu:14960.
UCSCi uc008ccd.1. mouse.

Organism-specific databases

CTDi 14960.
MGIi MGI:95895. H2-Aa.

Phylogenomic databases

eggNOGi NOG26577.
GeneTreei ENSGT00760000118970.
HOGENOMi HOG000112076.
HOVERGENi HBG006862.
KOi K06752.
OMAi SYGVNVY.
OrthoDBi EOG7C2R26.
PhylomeDBi P14434.
TreeFami TF333797.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_198660. Interferon gamma signaling.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Miscellaneous databases

EvolutionaryTracei P14434.
NextBioi 287306.
PROi P14434.
SOURCEi Search...

Gene expression databases

Bgeei P14434.
CleanExi MM_H2-AA.
ExpressionAtlasi P14434. baseline and differential.
Genevestigatori P14434.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the mouse major histocompatibility locus class II region."
    Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G., Hood L.E.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Sequence of the mouse major histocompatibility class II region."
    Rowen L., Qin S., Loretz C., Mix L., Lasky S., Madan A., Hood L.E.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "Regions of allelic hypervariability in the murine A alpha immune response gene."
    Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
    Cell 34:169-177(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-256.
  5. "Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif."
    Zhu Y., Rudensky A.Y., Corper A.L., Teyton L., Wilson I.A.
    J. Mol. Biol. 326:1157-1174(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 24-205 IN COMPLEX WITH HUMAN CLIP PEPTIDE, GLYCOSYLATION AT ASN-145, DISULFIDE BONDS.

Entry informationi

Entry nameiHA2B_MOUSE
AccessioniPrimary (citable) accession number: P14434
Secondary accession number(s): O78195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3