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Protein

H-2 class II histocompatibility antigen, A-B alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  • antigen processing and presentation of peptide antigen Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • response to interferon-gamma Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-389948. PD-1 signaling.
R-MMU-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-B alpha chain
Short name:
IAalpha
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 218ExtracellularSequence analysisAdd BLAST195
Transmembranei219 – 244HelicalSequence analysisAdd BLAST26
Topological domaini245 – 256CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001897524 – 256H-2 class II histocompatibility antigen, A-B alpha chainAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi134 ↔ 190PROSITE-ProRule annotation1 Publication
Glycosylationi145N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14434.
MaxQBiP14434.
PaxDbiP14434.
PeptideAtlasiP14434.
PRIDEiP14434.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036594.
CleanExiMM_H2-AA.
ExpressionAtlasiP14434. baseline and differential.
GenevisibleiP14434. MM.

Interactioni

Protein-protein interaction databases

BioGridi200146. 1 interactor.
IntActiP14434. 1 interactor.
MINTiMINT-257614.
STRINGi10090.ENSMUSP00000046105.

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 42Combined sources13
Turni43 – 45Combined sources3
Beta strandi46 – 53Combined sources8
Beta strandi56 – 62Combined sources7
Turni63 – 66Combined sources4
Beta strandi67 – 72Combined sources6
Helixi73 – 76Combined sources4
Helixi83 – 103Combined sources21
Turni104 – 106Combined sources3
Beta strandi115 – 122Combined sources8
Beta strandi126 – 128Combined sources3
Beta strandi130 – 139Combined sources10
Beta strandi145 – 154Combined sources10
Beta strandi157 – 161Combined sources5
Beta strandi165 – 167Combined sources3
Turni168 – 170Combined sources3
Beta strandi172 – 180Combined sources9
Beta strandi188 – 193Combined sources6
Beta strandi197 – 199Combined sources3
Beta strandi201 – 205Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50A/C/E/G27-208[»]
1MUJX-ray2.15A24-205[»]
3C5ZX-ray2.55C/G27-208[»]
3C60X-ray3.05C/G27-208[»]
3C6LX-ray3.40C/G27-208[»]
3RDTX-ray2.70C27-208[»]
4P23X-ray2.25C27-205[»]
4P46X-ray2.85C27-205[»]
4P5TX-ray3.26C/G27-208[»]
ProteinModelPortaliP14434.
SMRiP14434.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 206Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 111Alpha-1Add BLAST88
Regioni112 – 205Alpha-2Add BLAST94
Regioni206 – 218Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000112076.
HOVERGENiHBG006862.
KOiK06752.
OMAiSKSDHAF.
OrthoDBiEOG091G0IC9.
PhylomeDBiP14434.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSRALILG VLALTTMLSL CGGEDDIEAD HVGTYGISVY QSPGDIGQYT
60 70 80 90 100
FEFDGDELFY VDLDKKETVW MLPEFGQLAS FDPQGGLQNI AVVKHNLGVL
110 120 130 140 150
TKRSNSTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR
160 170 180 190 200
NSKSVADGVY ETSFFVNRDY SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP
210 220 230 240 250
VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS

RHPGPL
Length:256
Mass (Da):28,093
Last modified:May 30, 2000 - v2
Checksum:iC9DD084F6179B41F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027865 Genomic DNA. Translation: AAB81529.1.
AF050157 Genomic DNA. Translation: AAC05285.1.
BC019721 mRNA. Translation: AAH19721.1.
BC031711 mRNA. Translation: AAH31711.1.
K01922 mRNA. Translation: AAA39614.1.
CCDSiCCDS28645.1.
RefSeqiNP_034508.2. NM_010378.2.
UniGeneiMm.235338.

Genome annotation databases

EnsembliENSMUST00000040655; ENSMUSP00000046105; ENSMUSG00000036594.
GeneIDi14960.
KEGGimmu:14960.
UCSCiuc008ccd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027865 Genomic DNA. Translation: AAB81529.1.
AF050157 Genomic DNA. Translation: AAC05285.1.
BC019721 mRNA. Translation: AAH19721.1.
BC031711 mRNA. Translation: AAH31711.1.
K01922 mRNA. Translation: AAA39614.1.
CCDSiCCDS28645.1.
RefSeqiNP_034508.2. NM_010378.2.
UniGeneiMm.235338.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LNUX-ray2.50A/C/E/G27-208[»]
1MUJX-ray2.15A24-205[»]
3C5ZX-ray2.55C/G27-208[»]
3C60X-ray3.05C/G27-208[»]
3C6LX-ray3.40C/G27-208[»]
3RDTX-ray2.70C27-208[»]
4P23X-ray2.25C27-205[»]
4P46X-ray2.85C27-205[»]
4P5TX-ray3.26C/G27-208[»]
ProteinModelPortaliP14434.
SMRiP14434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200146. 1 interactor.
IntActiP14434. 1 interactor.
MINTiMINT-257614.
STRINGi10090.ENSMUSP00000046105.

Proteomic databases

EPDiP14434.
MaxQBiP14434.
PaxDbiP14434.
PeptideAtlasiP14434.
PRIDEiP14434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040655; ENSMUSP00000046105; ENSMUSG00000036594.
GeneIDi14960.
KEGGimmu:14960.
UCSCiuc008ccd.1. mouse.

Organism-specific databases

CTDi14960.
MGIiMGI:95895. H2-Aa.

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000112076.
HOVERGENiHBG006862.
KOiK06752.
OMAiSKSDHAF.
OrthoDBiEOG091G0IC9.
PhylomeDBiP14434.
TreeFamiTF333797.

Enzyme and pathway databases

ReactomeiR-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-2132295. MHC class II antigen presentation.
R-MMU-389948. PD-1 signaling.
R-MMU-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiP14434.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036594.
CleanExiMM_H2-AA.
ExpressionAtlasiP14434. baseline and differential.
GenevisibleiP14434. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA2B_MOUSE
AccessioniPrimary (citable) accession number: P14434
Secondary accession number(s): O78195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.