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P14434

- HA2B_MOUSE

UniProt

P14434 - HA2B_MOUSE

Protein

H-2 class II histocompatibility antigen, A-B alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
    3. antigen processing and presentation of peptide antigen Source: MGI
    4. positive regulation of T cell differentiation Source: MGI
    5. response to interferon-gamma Source: BHF-UCL

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_198660. Interferon gamma signaling.
    REACT_215414. Translocation of ZAP-70 to Immunological synapse.
    REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
    REACT_225145. Downstream TCR signaling.
    REACT_225768. Generation of second messenger molecules.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H-2 class II histocompatibility antigen, A-B alpha chain
    Short name:
    IAalpha
    Gene namesi
    Name:H2-Aa
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:95895. H2-Aa.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosome Source: MGI
    4. MHC class II protein complex Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane, MHC II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 256233H-2 class II histocompatibility antigen, A-B alpha chainPRO_0000018975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi134 ↔ 1901 PublicationPROSITE-ProRule annotation
    Glycosylationi145 – 1451N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP14434.
    PaxDbiP14434.
    PRIDEiP14434.

    Expressioni

    Gene expression databases

    ArrayExpressiP14434.
    BgeeiP14434.
    CleanExiMM_H2-AA.
    GenevestigatoriP14434.

    Interactioni

    Protein-protein interaction databases

    BioGridi200146. 1 interaction.
    IntActiP14434. 1 interaction.
    MINTiMINT-257614.

    Structurei

    Secondary structure

    1
    256
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 4213
    Turni43 – 453
    Beta strandi46 – 538
    Beta strandi56 – 627
    Turni63 – 664
    Beta strandi67 – 726
    Helixi73 – 764
    Helixi83 – 10321
    Turni104 – 1063
    Beta strandi115 – 1228
    Beta strandi126 – 1283
    Beta strandi130 – 13910
    Beta strandi145 – 15410
    Beta strandi157 – 1615
    Beta strandi165 – 1673
    Turni168 – 1703
    Beta strandi172 – 1809
    Beta strandi188 – 1936
    Beta strandi197 – 1993
    Beta strandi201 – 2055

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LNUX-ray2.50A/C/E/G27-208[»]
    1MUJX-ray2.15A24-205[»]
    3C5ZX-ray2.55C/G27-208[»]
    3C60X-ray3.05C/G27-208[»]
    3C6LX-ray3.40C/G27-208[»]
    3RDTX-ray2.70C27-208[»]
    4P23X-ray2.25C27-205[»]
    4P46X-ray2.85C27-205[»]
    4P5TX-ray3.26C/G27-208[»]
    ProteinModelPortaliP14434.
    SMRiP14434. Positions 26-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14434.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 218195ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 25612CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei219 – 24426HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 20693Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 11188Alpha-1Add
    BLAST
    Regioni112 – 20594Alpha-2Add
    BLAST
    Regioni206 – 21813Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26577.
    GeneTreeiENSGT00560000076735.
    HOGENOMiHOG000112076.
    HOVERGENiHBG006862.
    InParanoidiP14434.
    KOiK06752.
    OMAiSYGVNVY.
    OrthoDBiEOG7C2R26.
    PhylomeDBiP14434.
    TreeFamiTF333797.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14434-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSRALILG VLALTTMLSL CGGEDDIEAD HVGTYGISVY QSPGDIGQYT    50
    FEFDGDELFY VDLDKKETVW MLPEFGQLAS FDPQGGLQNI AVVKHNLGVL 100
    TKRSNSTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR 150
    NSKSVADGVY ETSFFVNRDY SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP 200
    VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS 250
    RHPGPL 256
    Length:256
    Mass (Da):28,093
    Last modified:May 30, 2000 - v2
    Checksum:iC9DD084F6179B41F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027865 Genomic DNA. Translation: AAB81529.1.
    AF050157 Genomic DNA. Translation: AAC05285.1.
    BC019721 mRNA. Translation: AAH19721.1.
    BC031711 mRNA. Translation: AAH31711.1.
    K01922 mRNA. Translation: AAA39614.1.
    CCDSiCCDS28645.1.
    RefSeqiNP_034508.2. NM_010378.2.
    UniGeneiMm.235338.

    Genome annotation databases

    EnsembliENSMUST00000040655; ENSMUSP00000046105; ENSMUSG00000036594.
    GeneIDi14960.
    KEGGimmu:14960.
    UCSCiuc008ccd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027865 Genomic DNA. Translation: AAB81529.1 .
    AF050157 Genomic DNA. Translation: AAC05285.1 .
    BC019721 mRNA. Translation: AAH19721.1 .
    BC031711 mRNA. Translation: AAH31711.1 .
    K01922 mRNA. Translation: AAA39614.1 .
    CCDSi CCDS28645.1.
    RefSeqi NP_034508.2. NM_010378.2.
    UniGenei Mm.235338.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LNU X-ray 2.50 A/C/E/G 27-208 [» ]
    1MUJ X-ray 2.15 A 24-205 [» ]
    3C5Z X-ray 2.55 C/G 27-208 [» ]
    3C60 X-ray 3.05 C/G 27-208 [» ]
    3C6L X-ray 3.40 C/G 27-208 [» ]
    3RDT X-ray 2.70 C 27-208 [» ]
    4P23 X-ray 2.25 C 27-205 [» ]
    4P46 X-ray 2.85 C 27-205 [» ]
    4P5T X-ray 3.26 C/G 27-208 [» ]
    ProteinModelPortali P14434.
    SMRi P14434. Positions 26-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200146. 1 interaction.
    IntActi P14434. 1 interaction.
    MINTi MINT-257614.

    Proteomic databases

    MaxQBi P14434.
    PaxDbi P14434.
    PRIDEi P14434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040655 ; ENSMUSP00000046105 ; ENSMUSG00000036594 .
    GeneIDi 14960.
    KEGGi mmu:14960.
    UCSCi uc008ccd.1. mouse.

    Organism-specific databases

    CTDi 14960.
    MGIi MGI:95895. H2-Aa.

    Phylogenomic databases

    eggNOGi NOG26577.
    GeneTreei ENSGT00560000076735.
    HOGENOMi HOG000112076.
    HOVERGENi HBG006862.
    InParanoidi P14434.
    KOi K06752.
    OMAi SYGVNVY.
    OrthoDBi EOG7C2R26.
    PhylomeDBi P14434.
    TreeFami TF333797.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_198660. Interferon gamma signaling.
    REACT_215414. Translocation of ZAP-70 to Immunological synapse.
    REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
    REACT_225145. Downstream TCR signaling.
    REACT_225768. Generation of second messenger molecules.

    Miscellaneous databases

    EvolutionaryTracei P14434.
    NextBioi 287306.
    PROi P14434.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14434.
    Bgeei P14434.
    CleanExi MM_H2-AA.
    Genevestigatori P14434.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the mouse major histocompatibility locus class II region."
      Rowen L., Qin S., Ahearn M.E., Loretz C., Faust J., Lasky S., Mahairas G., Hood L.E.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Sequence of the mouse major histocompatibility class II region."
      Rowen L., Qin S., Loretz C., Mix L., Lasky S., Madan A., Hood L.E.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "Regions of allelic hypervariability in the murine A alpha immune response gene."
      Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
      Cell 34:169-177(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-256.
    5. "Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif."
      Zhu Y., Rudensky A.Y., Corper A.L., Teyton L., Wilson I.A.
      J. Mol. Biol. 326:1157-1174(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 24-205 IN COMPLEX WITH HUMAN CLIP PEPTIDE, GLYCOSYLATION AT ASN-145, DISULFIDE BONDS.

    Entry informationi

    Entry nameiHA2B_MOUSE
    AccessioniPrimary (citable) accession number: P14434
    Secondary accession number(s): O78195
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3