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Protein

H-2 class I histocompatibility antigen, TLA(B) alpha chain

Gene

H2-T3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, TLA(B) alpha chain
Alternative name(s):
MHC thymus leukemia antigen
Gene namesi
Name:H2-T3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95959. H2-T3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 314288ExtracellularSequence analysisAdd
BLAST
Transmembranei315 – 33420HelicalSequence analysisAdd
BLAST
Topological domaini335 – 38450CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 384358H-2 class I histocompatibility antigen, TLA(B) alpha chainPRO_0000018937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 190PROSITE-ProRule annotation
Disulfide bondi229 ↔ 285PROSITE-ProRule annotation
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14432.
MaxQBiP14432.
PaxDbiP14432.
PRIDEiP14432.

PTM databases

PhosphoSiteiP14432.

Expressioni

Tissue specificityi

TL antigens are only expressed on thymocytes, activated T-lymphocytes and on some thymic leukemias.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099736.

Structurei

Secondary structure

1
384
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 3912Combined sources
Beta strandi48 – 547Combined sources
Beta strandi57 – 648Combined sources
Turni65 – 684Combined sources
Beta strandi70 – 734Combined sources
Helixi76 – 794Combined sources
Helixi83 – 10220Combined sources
Helixi104 – 1107Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi119 – 13012Combined sources
Turni131 – 1344Combined sources
Beta strandi135 – 14410Combined sources
Beta strandi147 – 1526Combined sources
Beta strandi159 – 1635Combined sources
Helixi164 – 17512Combined sources
Helixi178 – 18710Combined sources
Helixi189 – 20416Combined sources
Beta strandi212 – 2198Combined sources
Beta strandi223 – 23715Combined sources
Beta strandi240 – 2456Combined sources
Beta strandi253 – 2564Combined sources
Beta strandi263 – 2653Combined sources
Beta strandi267 – 2759Combined sources
Helixi280 – 2823Combined sources
Beta strandi283 – 2886Combined sources
Beta strandi292 – 2943Combined sources
Beta strandi296 – 2994Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NEZX-ray2.10A27-300[»]
ProteinModelPortaliP14432.
SMRiP14432. Positions 27-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini211 – 29989Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 11690Alpha-1Add
BLAST
Regioni117 – 20892Alpha-2Add
BLAST
Regioni209 – 30092Alpha-3Add
BLAST
Regioni301 – 31414Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP14432.
PhylomeDBiP14432.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMGTPVPGT LLILLAASQG QTQTCPGSHS LRYFYTALSR PAISEPWYIA
60 70 80 90 100
VGYLDDTQFV RFNSSGETAT YKLSAPWVEQ EGPEYWARET EIVTSNAQFF
110 120 130 140 150
RENLQTMLDY YNLSQNGSHT IQVMYGCEVE FFGSLFRAYE QHGYDGPDYI
160 170 180 190 200
ALNEDLKTWT AADTAAEITR SKWEQAGYTE LRRTYLEGPC KDSLLRYLEN
210 220 230 240 250
RKKTQECTDP PKTHVTHHPR PEGYVTLRCW ALRFYPADIT LTWQLNGEEL
260 270 280 290 300
IQDTELVETR PAGDGTFQKW AAVVVPLGKE QKYTCHVYHE GLPEPLTLRW
310 320 330 340 350
EPPQTSMPNR TTVRALLGAM IILGFMSGSV MMWMRKNNGG NGDDNTAAYQ
360 370 380
NEREHLSLDP RAESEALGVE AGMKDLPSAP PLVS
Length:384
Mass (Da):43,479
Last modified:November 1, 1997 - v2
Checksum:i305891FC35F41E76
GO

Sequence cautioni

The sequence CAA26586.1 differs from that shown. Reason: Frameshift at position 359. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61P → Q in CAA26586 (PubMed:3894562).Curated
Sequence conflicti9 – 91G → S in CAA26586 (PubMed:3894562).Curated
Sequence conflicti20 – 201G → V in CAA26586 (PubMed:3894562).Curated
Sequence conflicti60 – 601V → A in CAA26586 (PubMed:3894562).Curated
Sequence conflicti63 – 631N → D in CAA26586 (PubMed:3894562).Curated
Sequence conflicti65 – 651S → A in CAA26586 (PubMed:3894562).Curated
Sequence conflicti69 – 691A → G in CAA26586 (PubMed:3894562).Curated
Sequence conflicti147 – 1471P → Q in CAA26586 (PubMed:3894562).Curated
Sequence conflicti164 – 1641T → M in CAA26586 (PubMed:3894562).Curated
Sequence conflicti219 – 2191P → A in CAA26586 (PubMed:3894562).Curated
Sequence conflicti224 – 2241Y → D in CAA26586 (PubMed:3894562).Curated
Sequence conflicti233 – 2331R → G in CAA26586 (PubMed:3894562).Curated
Sequence conflicti238 – 2381D → H in CAA26586 (PubMed:3894562).Curated
Sequence conflicti277 – 2771L → S in CAA26586 (PubMed:3894562).Curated
Sequence conflicti279 – 2791K → E in CAA26586 (PubMed:3894562).Curated
Sequence conflicti302 – 3021P → L in AAA39692 (PubMed:2410925).Curated
Sequence conflicti305 – 3051T → S in CAA26586 (PubMed:3894562).Curated
Sequence conflicti359 – 3591D → T in AAA39692 (PubMed:2410925).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471P → R in haplotype T3B.
Natural varianti365 – 3651E → D in haplotype T3B.
Natural varianti381 – 3811P → H in haplotype T3B.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02817 Genomic DNA. Translation: CAA26586.1. Frameshift.
M13285 Genomic DNA. Translation: AAA39687.1.
M75875 Genomic DNA. Translation: AAA39658.1.
M11741, M11742 Genomic DNA. Translation: AAA39692.1.
CCDSiCCDS28718.1.
PIRiA25132.
A25148.
I48851.
I54499.
UniGeneiMm.426002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02817 Genomic DNA. Translation: CAA26586.1. Frameshift.
M13285 Genomic DNA. Translation: AAA39687.1.
M75875 Genomic DNA. Translation: AAA39658.1.
M11741, M11742 Genomic DNA. Translation: AAA39692.1.
CCDSiCCDS28718.1.
PIRiA25132.
A25148.
I48851.
I54499.
UniGeneiMm.426002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NEZX-ray2.10A27-300[»]
ProteinModelPortaliP14432.
SMRiP14432. Positions 27-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099736.

PTM databases

PhosphoSiteiP14432.

Proteomic databases

EPDiP14432.
MaxQBiP14432.
PaxDbiP14432.
PRIDEiP14432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95959. H2-T3.

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP14432.
PhylomeDBiP14432.

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

EvolutionaryTraceiP14432.
PROiP14432.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse."
    Fisher D.A., Hunt S.W. III, Hood L.E.
    J. Exp. Med. 162:528-545(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene."
    Pontarotti P.A., Mashimo H., Zeff R.A., Fisher D.A., Hood L., Mellor A., Flavell R.A., Nathenson S.G.
    Proc. Natl. Acad. Sci. U.S.A. 83:1782-1786(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-384.

Entry informationi

Entry nameiHA1T_MOUSE
AccessioniPrimary (citable) accession number: P14432
Secondary accession number(s): P14433, Q31194, Q31203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.