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Protein

H-2 class I histocompatibility antigen, TLA(B) alpha chain

Gene

H2-T3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, TLA(B) alpha chain
Alternative name(s):
MHC thymus leukemia antigen
Gene namesi
Name:H2-T3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95959. H2-T3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 314ExtracellularSequence analysisAdd BLAST288
Transmembranei315 – 334HelicalSequence analysisAdd BLAST20
Topological domaini335 – 384CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001893727 – 384H-2 class I histocompatibility antigen, TLA(B) alpha chainAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 190PROSITE-ProRule annotation
Disulfide bondi229 ↔ 285PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP14432.
PaxDbiP14432.
PeptideAtlasiP14432.
PRIDEiP14432.

Expressioni

Tissue specificityi

TL antigens are only expressed on thymocytes, activated T-lymphocytes and on some thymic leukemias.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099736.

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 39Combined sources12
Beta strandi48 – 54Combined sources7
Beta strandi57 – 64Combined sources8
Turni65 – 68Combined sources4
Beta strandi70 – 73Combined sources4
Helixi76 – 79Combined sources4
Helixi83 – 102Combined sources20
Helixi104 – 110Combined sources7
Beta strandi115 – 117Combined sources3
Beta strandi119 – 130Combined sources12
Turni131 – 134Combined sources4
Beta strandi135 – 144Combined sources10
Beta strandi147 – 152Combined sources6
Beta strandi159 – 163Combined sources5
Helixi164 – 175Combined sources12
Helixi178 – 187Combined sources10
Helixi189 – 204Combined sources16
Beta strandi212 – 219Combined sources8
Beta strandi223 – 237Combined sources15
Beta strandi240 – 245Combined sources6
Beta strandi253 – 256Combined sources4
Beta strandi263 – 265Combined sources3
Beta strandi267 – 275Combined sources9
Helixi280 – 282Combined sources3
Beta strandi283 – 288Combined sources6
Beta strandi292 – 294Combined sources3
Beta strandi296 – 299Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEZX-ray2.10A27-300[»]
ProteinModelPortaliP14432.
SMRiP14432.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 299Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 116Alpha-1Add BLAST90
Regioni117 – 208Alpha-2Add BLAST92
Regioni209 – 300Alpha-3Add BLAST92
Regioni301 – 314Connecting peptideAdd BLAST14

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP14432.
PhylomeDBiP14432.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMGTPVPGT LLILLAASQG QTQTCPGSHS LRYFYTALSR PAISEPWYIA
60 70 80 90 100
VGYLDDTQFV RFNSSGETAT YKLSAPWVEQ EGPEYWARET EIVTSNAQFF
110 120 130 140 150
RENLQTMLDY YNLSQNGSHT IQVMYGCEVE FFGSLFRAYE QHGYDGPDYI
160 170 180 190 200
ALNEDLKTWT AADTAAEITR SKWEQAGYTE LRRTYLEGPC KDSLLRYLEN
210 220 230 240 250
RKKTQECTDP PKTHVTHHPR PEGYVTLRCW ALRFYPADIT LTWQLNGEEL
260 270 280 290 300
IQDTELVETR PAGDGTFQKW AAVVVPLGKE QKYTCHVYHE GLPEPLTLRW
310 320 330 340 350
EPPQTSMPNR TTVRALLGAM IILGFMSGSV MMWMRKNNGG NGDDNTAAYQ
360 370 380
NEREHLSLDP RAESEALGVE AGMKDLPSAP PLVS
Length:384
Mass (Da):43,479
Last modified:November 1, 1997 - v2
Checksum:i305891FC35F41E76
GO

Sequence cautioni

The sequence CAA26586 differs from that shown. Reason: Frameshift at position 359.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6P → Q in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti9G → S in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti20G → V in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti60V → A in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti63N → D in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti65S → A in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti69A → G in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti147P → Q in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti164T → M in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti219P → A in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti224Y → D in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti233R → G in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti238D → H in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti277L → S in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti279K → E in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti302P → L in AAA39692 (PubMed:2410925).Curated1
Sequence conflicti305T → S in CAA26586 (PubMed:3894562).Curated1
Sequence conflicti359D → T in AAA39692 (PubMed:2410925).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti147P → R in haplotype T3B. 1
Natural varianti365E → D in haplotype T3B. 1
Natural varianti381P → H in haplotype T3B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02817 Genomic DNA. Translation: CAA26586.1. Frameshift.
M13285 Genomic DNA. Translation: AAA39687.1.
M75875 Genomic DNA. Translation: AAA39658.1.
M11741, M11742 Genomic DNA. Translation: AAA39692.1.
CCDSiCCDS28718.1.
PIRiA25132.
A25148.
I48851.
I54499.
UniGeneiMm.426002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02817 Genomic DNA. Translation: CAA26586.1. Frameshift.
M13285 Genomic DNA. Translation: AAA39687.1.
M75875 Genomic DNA. Translation: AAA39658.1.
M11741, M11742 Genomic DNA. Translation: AAA39692.1.
CCDSiCCDS28718.1.
PIRiA25132.
A25148.
I48851.
I54499.
UniGeneiMm.426002.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEZX-ray2.10A27-300[»]
ProteinModelPortaliP14432.
SMRiP14432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099736.

Proteomic databases

MaxQBiP14432.
PaxDbiP14432.
PeptideAtlasiP14432.
PRIDEiP14432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95959. H2-T3.

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP14432.
PhylomeDBiP14432.

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

EvolutionaryTraceiP14432.
PROiP14432.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA1T_MOUSE
AccessioniPrimary (citable) accession number: P14432
Secondary accession number(s): P14433, Q31194, Q31203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.