P14429 (HA17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
H-2 class I histocompatibility antigen, Q7 alpha chain

Alternative name(s):
QA-2 antigen

Gene names

Name:

H2-Q7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Sequence caution	The sequence CAA28977.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

By similarity

Chain

22 – 334

313

H-2 class I histocompatibility antigen, Q7 alpha chain

PRO_0000018933

Regions

Topological domain

22 – 310

289

Extracellular Potential

Transmembrane

311 – 332

22

Helical; Potential

Domain

206 – 294

89

Ig-like C1-type

Region

22 – 111

90

Alpha-1

Region

112 – 203

92

Alpha-2

Region

204 – 295

92

Alpha-3

Region

296 – 310

15

Connecting peptide

Amino acid modifications

Glycosylation

107

1

N-linked (GlcNAc...) Potential

Glycosylation

277

1

N-linked (GlcNAc...) Potential

Disulfide bond

122 ↔ 185

By similarity

Disulfide bond

224 ↔ 280

By similarity

Experimental info

Sequence conflict

87

1

I → M Ref.3

Secondary structure

1

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334

Helix Strand Turn

Details...

Beta strand

24 – 33

10

Beta strand

42 – 49

8

Beta strand

52 – 58

7

Beta strand

61 – 63

3

Helix

71 – 73

3

Helix

77 – 105

29

Beta strand

115 – 124

10

Beta strand

128 – 139

12

Beta strand

142 – 147

6

Beta strand

154 – 156

3

Helix

159 – 170

12

Helix

173 – 182

10

Helix

184 – 195

12

Helix

197 – 200

4

Beta strand

207 – 214

8

Beta strand

216 – 232

17

Beta strand

235 – 240

6

Turn

246 – 248

3

Beta strand

249 – 251

3

Beta strand

258 – 260

3

Beta strand

262 – 271

10

Beta strand

278 – 283

6

Beta strand

287 – 289

3

Beta strand

291 – 293

3

Sequences

	Sequence		Length	Mass (Da)
	P14429 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 1E63FAFCCBD6763B	FASTA	334	37,924
	10 20 30 40 50 60 MALTMLLLLV AAALTLIETR AGQHSLQYFH TAVSRPGLGE PWFISVGYVD DTQFVRFDSD 70 80 90 100 110 120 AENPRMEPRA RWMEQEGPEY WERETQIAKG HEQSFRGSLR TAQSYYNQSK GGSHTLQWMY 130 140 150 160 170 180 GCDMGSDGRL LRGYLQFAYE GRDYIALNED LKTWTAVDMA AQITRRKWEQ AGIAEKDQAY 190 200 210 220 230 240 LEGTCMQSLR RYLQLGKETL LRTDPPKAHV THHPRSYGAV TLRCWALGFY PADITLTWQL 250 260 270 280 290 300 NGEELTQDME LVETRPAGDG TFQKWASVVV PLGKEQNYTC HVNHEGLPEP LTLRWGRWEP 310 320 330 PPYTVSNMAT IAVVVDLGAV AIIGAVVAFV MNRR

References

[1]	"Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison." Devlin J.J., Weiss E.H., Paulson M., Flavell R.A. EMBO J. 4:3203-3207(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/10.
[2]	"Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice." Waneck G.L., Sherman D.H., Calvin S., Allen H., Flavell R.A. J. Exp. Med. 165:1358-1370(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/10.
[3]	"A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains." Steinmetz M., Moore K.W., Frelinger J.G., Sher B.T., Shen F.W., Boyse E.A., Hood L. Cell 25:683-692(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen." Ulker N., Lewis K.D., Hood L.E., Stroynowski I. EMBO J. 9:3839-3847(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 292-334.
[5]	"Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse." Brorson K.A., Hunt S.W. III, Hunkapiller T., Sun Y.H., Cheroutre H., Nickerson D.A., Hood L. J. Exp. Med. 170:1837-1858(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 300-334.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X03210, X03441 Genomic DNA. Translation: CAA26954.1.
X05389 mRNA. Translation: CAA28977.1. Different initiation.
X57330 mRNA. Translation: CAA40606.1.

IPI

IPI00312980.

PIR

A24582.

RefSeq

NP_034524.3. NM_010394.4.

UniGene

Mm.431282.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1K8D	X-ray	2.30	A	22-295	[»]

ProteinModelPortal

P14429.

SMR

P14429. Positions 22-295.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-223453.

Proteomic databases

PaxDb

P14429.

PRIDE

P14429.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000071951; ENSMUSP00000071843; ENSMUSG00000060550.

GeneID

15018.

KEGG

mmu:15018.

UCSC

uc012arh.1. mouse.

Organism-specific databases

CTD

15018.

MGI

MGI:95936. H2-Q7.

Phylogenomic databases

eggNOG

NOG42056.

GeneTree

ENSGT00700000104216.

HOGENOM

HOG000296917.

HOVERGEN

HBG016709.

KO

K06751.

OMA

EENTRTI.

Enzyme and pathway databases

Reactome

REACT_102124. Immune System.
REACT_107772. Immune System.

Gene expression databases

ArrayExpress

P14429.

Bgee

P14429.

CleanEx

MM_H2-Q7.

Genevestigator

P14429.

GermOnline

ENSMUSG00000060550. Mus musculus.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]

PRINTS

PR01638. MHCCLASSI.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P14429.

NextBio

287426.

SOURCE

Search...

Entry information

Entry name

HA17_MOUSE

Accession

Primary (citable) accession number: P14429

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 29, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program