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P14416

- DRD2_HUMAN

UniProt

P14416 - DRD2_HUMAN

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Protein

D(2) dopamine receptor

Gene

DRD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141AgonistBy similarity
Sitei194 – 1941Important for receptor activationBy similarity
Sitei197 – 1971Important for receptor activationBy similarity

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  3. drug binding Source: BHF-UCL
  4. identical protein binding Source: IntAct
  5. potassium channel regulator activity Source: BHF-UCL

GO - Biological processi

  1. activation of protein kinase activity Source: Ensembl
  2. adenohypophysis development Source: BHF-UCL
  3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
  4. adult walking behavior Source: BHF-UCL
  5. arachidonic acid secretion Source: BHF-UCL
  6. associative learning Source: BHF-UCL
  7. auditory behavior Source: Ensembl
  8. axonogenesis Source: BHF-UCL
  9. behavioral response to cocaine Source: BHF-UCL
  10. behavioral response to ethanol Source: BHF-UCL
  11. branching morphogenesis of a nerve Source: BHF-UCL
  12. cellular calcium ion homeostasis Source: BHF-UCL
  13. cerebral cortex GABAergic interneuron migration Source: BHF-UCL
  14. circadian regulation of gene expression Source: BHF-UCL
  15. dopamine metabolic process Source: BHF-UCL
  16. feeding behavior Source: Ensembl
  17. G-protein coupled receptor internalization Source: Ensembl
  18. grooming behavior Source: Ensembl
  19. intracellular signal transduction Source: BHF-UCL
  20. locomotory behavior Source: BHF-UCL
  21. long-term memory Source: Ensembl
  22. negative regulation of adenylate cyclase activity Source: BHF-UCL
  23. negative regulation of blood pressure Source: BHF-UCL
  24. negative regulation of cell migration Source: BHF-UCL
  25. negative regulation of cell proliferation Source: BHF-UCL
  26. negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
  27. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  28. negative regulation of dopamine receptor signaling pathway Source: BHF-UCL
  29. negative regulation of dopamine secretion Source: Ensembl
  30. negative regulation of insulin secretion Source: Ensembl
  31. negative regulation of protein kinase B signaling Source: BHF-UCL
  32. negative regulation of protein secretion Source: BHF-UCL
  33. negative regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  34. negative regulation of voltage-gated calcium channel activity Source: BHF-UCL
  35. neurological system process involved in regulation of systemic arterial blood pressure Source: BHF-UCL
  36. neuron-neuron synaptic transmission Source: BHF-UCL
  37. orbitofrontal cortex development Source: Ensembl
  38. peristalsis Source: BHF-UCL
  39. phosphatidylinositol metabolic process Source: BHF-UCL
  40. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  41. pigmentation Source: Ensembl
  42. positive regulation of cytokinesis Source: UniProt
  43. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
  44. positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
  45. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  46. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  47. positive regulation of growth hormone secretion Source: BHF-UCL
  48. positive regulation of long-term synaptic potentiation Source: Ensembl
  49. positive regulation of multicellular organism growth Source: Ensembl
  50. positive regulation of neuroblast proliferation Source: BHF-UCL
  51. positive regulation of receptor internalization Source: Ensembl
  52. positive regulation of renal sodium excretion Source: Ensembl
  53. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  54. positive regulation of urine volume Source: Ensembl
  55. prepulse inhibition Source: BHF-UCL
  56. protein localization Source: BHF-UCL
  57. regulation of cAMP metabolic process Source: BHF-UCL
  58. regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
  59. regulation of heart rate Source: BHF-UCL
  60. regulation of locomotion involved in locomotory behavior Source: Ensembl
  61. regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
  62. regulation of phosphoprotein phosphatase activity Source: Ensembl
  63. regulation of potassium ion transport Source: BHF-UCL
  64. regulation of sodium ion transport Source: BHF-UCL
  65. regulation of synapse structural plasticity Source: Ensembl
  66. regulation of synaptic transmission, GABAergic Source: BHF-UCL
  67. release of sequestered calcium ion into cytosol Source: BHF-UCL
  68. response to amphetamine Source: BHF-UCL
  69. response to axon injury Source: Ensembl
  70. response to cocaine Source: BHF-UCL
  71. response to drug Source: BHF-UCL
  72. response to histamine Source: BHF-UCL
  73. response to hypoxia Source: Ensembl
  74. response to inactivity Source: Ensembl
  75. response to iron ion Source: Ensembl
  76. response to light stimulus Source: BHF-UCL
  77. response to morphine Source: BHF-UCL
  78. response to nicotine Source: Ensembl
  79. response to toxic substance Source: Ensembl
  80. sensory perception of smell Source: BHF-UCL
  81. striatum development Source: Ensembl
  82. synapse assembly Source: BHF-UCL
  83. synaptic transmission, dopaminergic Source: Ensembl
  84. temperature homeostasis Source: BHF-UCL
  85. visual learning Source: BHF-UCL
  86. Wnt signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16968. Dopamine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP14416.

Names & Taxonomyi

Protein namesi
Recommended name:
D(2) dopamine receptor
Alternative name(s):
Dopamine D2 receptor
Gene namesi
Name:DRD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3023. DRD2.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularBy similarityAdd
BLAST
Transmembranei38 – 6023Helical; Name=1By similarityAdd
BLAST
Topological domaini61 – 7010CytoplasmicBy similarity
Transmembranei71 – 9323Helical; Name=2By similarityAdd
BLAST
Topological domaini94 – 10815ExtracellularBy similarityAdd
BLAST
Transmembranei109 – 13022Helical; Name=3By similarityAdd
BLAST
Topological domaini131 – 15121CytoplasmicBy similarityAdd
BLAST
Transmembranei152 – 17221Helical; Name=4By similarityAdd
BLAST
Topological domaini173 – 18816ExtracellularBy similarityAdd
BLAST
Transmembranei189 – 21325Helical; Name=5By similarityAdd
BLAST
Topological domaini214 – 373160CytoplasmicBy similarityAdd
BLAST
Transmembranei374 – 39522Helical; Name=6By similarityAdd
BLAST
Topological domaini396 – 40914ExtracellularBy similarityAdd
BLAST
Transmembranei410 – 43122Helical; Name=7By similarityAdd
BLAST
Topological domaini432 – 44312CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. axon Source: BHF-UCL
  3. axon terminus Source: Ensembl
  4. dendrite Source: BHF-UCL
  5. dendritic spine Source: Ensembl
  6. endocytic vesicle Source: Ensembl
  7. integral component of plasma membrane Source: BHF-UCL
  8. lateral plasma membrane Source: Ensembl
  9. perikaryon Source: Ensembl
  10. plasma membrane Source: Reactome
  11. postsynaptic density Source: Ensembl
  12. sperm flagellum Source: Ensembl
  13. synaptic vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.1 Publication
Note: The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541V → I in DYT11; uncertain pathological significance; the mutation does not affect functional properties. 1 Publication
Corresponds to variant rs104894220 [ dbSNP | Ensembl ].
VAR_017143

Keywords - Diseasei

Disease mutation, Dystonia

Organism-specific databases

MIMi103780. phenotype.
159900. phenotype.
Orphaneti36899. Myoclonus-dystonia syndrome.
PharmGKBiPA27478.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443D(2) dopamine receptorPRO_0000069387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 182PROSITE-ProRule annotation
Disulfide bondi399 ↔ 401PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14416.
PRIDEiP14416.

PTM databases

PhosphoSiteiP14416.

Expressioni

Gene expression databases

BgeeiP14416.
CleanExiHS_DRD2.
ExpressionAtlasiP14416. baseline and differential.
GenevestigatoriP14416.

Organism-specific databases

HPAiHPA015691.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with GNAI1. Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2928178,EBI-2928178
ADORA2AP292742EBI-2928178,EBI-2902702
SLC6A3Q019594EBI-2928178,EBI-6661445

Protein-protein interaction databases

BioGridi108147. 11 interactions.
DIPiDIP-5977N.
IntActiP14416. 4 interactions.
MINTiMINT-201447.
STRINGi9606.ENSP00000354859.

Structurei

Secondary structure

1
443
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi431 – 44212Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I15model-A34-58[»]
B72-97[»]
C108-129[»]
D153-172[»]
E190-210[»]
F371-396[»]
G403-426[»]
2YOUX-ray2.19B/C430-443[»]
ProteinModelPortaliP14416.
SMRiP14416. Positions 37-443.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14416.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1978Agonist bindingBy similarity
Regioni211 – 373163Interaction with PPP1R9BBy similarityAdd
BLAST
Regioni386 – 3949Agonist bindingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG309657.
GeneTreeiENSGT00770000120457.
HOVERGENiHBG106962.
InParanoidiP14416.
KOiK04145.
OMAiNSVKHSR.
OrthoDBiEOG769ZMG.
PhylomeDBiP14416.
TreeFamiTF334382.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P14416-1) [UniParc]FASTAAdd to Basket

Also known as: D2(Long)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF
60 70 80 90 100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW
110 120 130 140 150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR
160 170 180 190 200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV
210 220 230 240 250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM
260 270 280 290 300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP
310 320 330 340 350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK
360 370 380 390 400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD
410 420 430 440
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC
Length:443
Mass (Da):50,619
Last modified:April 1, 1990 - v2
Checksum:i9BF8EA36C988A2E2
GO
Isoform 2 (identifier: P14416-2) [UniParc]FASTAAdd to Basket

Also known as: D2(Short)

The sequence of this isoform differs from the canonical sequence as follows:
     242-270: Missing.

Show »
Length:414
Mass (Da):47,347
Checksum:iBFC25AC601DFDC7F
GO
Isoform 3 (identifier: P14416-3) [UniParc]FASTAAdd to Basket

Also known as: D2(Longer)

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: V → VVQ

Show »
Length:445
Mass (Da):50,847
Checksum:i111674E96E087FD6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401L → R in AAB26819. (PubMed:1363862)Curated

Polymorphismi

Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIMi:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541V → I in DYT11; uncertain pathological significance; the mutation does not affect functional properties. 1 Publication
Corresponds to variant rs104894220 [ dbSNP | Ensembl ].
VAR_017143
Natural varianti310 – 3101P → S.
Corresponds to variant rs1800496 [ dbSNP | Ensembl ].
VAR_014674
Natural varianti311 – 3111S → C May be associated with a higher risk for schizophrenia. 1 Publication
Corresponds to variant rs1801028 [ dbSNP | Ensembl ].
VAR_003462
Natural varianti327 – 3271K → E.1 Publication
Corresponds to variant rs71653614 [ dbSNP | Ensembl ].
VAR_064579

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei242 – 27029Missing in isoform 2. 1 PublicationVSP_001870Add
BLAST
Alternative sequencei270 – 2701V → VVQ in isoform 3. 1 PublicationVSP_026455

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30625 mRNA. Translation: AAA88024.1.
X51645 mRNA. Translation: CAB56463.1.
X51646 Genomic DNA. Translation: CAB37869.1.
X51362 mRNA. Translation: CAA35746.1.
M29066 mRNA. Translation: AAA52761.1.
S62137 mRNA. Translation: AAB26819.1.
S69899 mRNA. Translation: AAB20571.1.
S58589
, S58577, S58584, S58586, S58588 Genomic DNA. Translation: AAB26274.1.
AF176812 mRNA. Translation: AAF61479.1.
AB065860 Genomic DNA. Translation: BAC06078.1.
AF050737 Genomic DNA. Translation: AAC78779.1.
BC021195 mRNA. Translation: AAH21195.1.
CCDSiCCDS8361.1. [P14416-1]
CCDS8362.1. [P14416-2]
PIRiS08417. DYHUD2.
RefSeqiNP_000786.1. NM_000795.3. [P14416-1]
NP_057658.2. NM_016574.3. [P14416-2]
XP_005271482.1. XM_005271425.2. [P14416-1]
XP_006718837.1. XM_006718774.1. [P14416-2]
UniGeneiHs.73893.

Genome annotation databases

EnsembliENST00000346454; ENSP00000278597; ENSG00000149295. [P14416-2]
ENST00000362072; ENSP00000354859; ENSG00000149295. [P14416-1]
ENST00000538967; ENSP00000438215; ENSG00000149295. [P14416-3]
ENST00000542968; ENSP00000442172; ENSG00000149295. [P14416-1]
GeneIDi1813.
KEGGihsa:1813.
UCSCiuc001pnz.3. human. [P14416-1]
uc001pob.4. human. [P14416-2]

Polymorphism databases

DMDMi118206.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30625 mRNA. Translation: AAA88024.1 .
X51645 mRNA. Translation: CAB56463.1 .
X51646 Genomic DNA. Translation: CAB37869.1 .
X51362 mRNA. Translation: CAA35746.1 .
M29066 mRNA. Translation: AAA52761.1 .
S62137 mRNA. Translation: AAB26819.1 .
S69899 mRNA. Translation: AAB20571.1 .
S58589
, S58577 , S58584 , S58586 , S58588 Genomic DNA. Translation: AAB26274.1 .
AF176812 mRNA. Translation: AAF61479.1 .
AB065860 Genomic DNA. Translation: BAC06078.1 .
AF050737 Genomic DNA. Translation: AAC78779.1 .
BC021195 mRNA. Translation: AAH21195.1 .
CCDSi CCDS8361.1. [P14416-1 ]
CCDS8362.1. [P14416-2 ]
PIRi S08417. DYHUD2.
RefSeqi NP_000786.1. NM_000795.3. [P14416-1 ]
NP_057658.2. NM_016574.3. [P14416-2 ]
XP_005271482.1. XM_005271425.2. [P14416-1 ]
XP_006718837.1. XM_006718774.1. [P14416-2 ]
UniGenei Hs.73893.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1I15 model - A 34-58 [» ]
B 72-97 [» ]
C 108-129 [» ]
D 153-172 [» ]
E 190-210 [» ]
F 371-396 [» ]
G 403-426 [» ]
2YOU X-ray 2.19 B/C 430-443 [» ]
ProteinModelPortali P14416.
SMRi P14416. Positions 37-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108147. 11 interactions.
DIPi DIP-5977N.
IntActi P14416. 4 interactions.
MINTi MINT-201447.
STRINGi 9606.ENSP00000354859.

Chemistry

BindingDBi P14416.
ChEMBLi CHEMBL2095396.
DrugBanki DB01614. Acepromazine.
DB01063. Acetophenazine.
DB01425. Alizapride.
DB00915. Amantadine.
DB06288. Amisulpride.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB01200. Bromocriptine.
DB00490. Buspirone.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB01151. Desipramine.
DB01184. Domperidone.
DB00988. Dopamine.
DB01142. Doxepin.
DB00450. Droperidol.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB04842. Fluspirilene.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01221. Ketamine.
DB01235. L-DOPA.
DB00589. Lisuride.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00934. Maprotiline.
DB01043. Memantine.
DB00933. Mesoridazine.
DB01403. Methotrimeprazine.
DB01233. Metoclopramide.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB01618. Molindone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB01100. Pimozide.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00433. Prochlorperazine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB06144. Sertindole.
DB00391. Sulpiride.
DB04844. Tetrabenazine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00831. Trifluoperazine.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB01392. Yohimbine.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi 215.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P14416.

Polymorphism databases

DMDMi 118206.

Proteomic databases

PaxDbi P14416.
PRIDEi P14416.

Protocols and materials databases

DNASUi 1813.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346454 ; ENSP00000278597 ; ENSG00000149295 . [P14416-2 ]
ENST00000362072 ; ENSP00000354859 ; ENSG00000149295 . [P14416-1 ]
ENST00000538967 ; ENSP00000438215 ; ENSG00000149295 . [P14416-3 ]
ENST00000542968 ; ENSP00000442172 ; ENSG00000149295 . [P14416-1 ]
GeneIDi 1813.
KEGGi hsa:1813.
UCSCi uc001pnz.3. human. [P14416-1 ]
uc001pob.4. human. [P14416-2 ]

Organism-specific databases

CTDi 1813.
GeneCardsi GC11M113280.
HGNCi HGNC:3023. DRD2.
HPAi HPA015691.
MIMi 103780. phenotype.
126450. gene.
159900. phenotype.
neXtProti NX_P14416.
Orphaneti 36899. Myoclonus-dystonia syndrome.
PharmGKBi PA27478.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309657.
GeneTreei ENSGT00770000120457.
HOVERGENi HBG106962.
InParanoidi P14416.
KOi K04145.
OMAi NSVKHSR.
OrthoDBi EOG769ZMG.
PhylomeDBi P14416.
TreeFami TF334382.

Enzyme and pathway databases

Reactomei REACT_16968. Dopamine receptors.
REACT_19231. G alpha (i) signalling events.
SignaLinki P14416.

Miscellaneous databases

EvolutionaryTracei P14416.
GeneWikii Dopamine_receptor_D2.
GenomeRNAii 1813.
NextBioi 7389.
PROi P14416.
SOURCEi Search...

Gene expression databases

Bgeei P14416.
CleanExi HS_DRD2.
ExpressionAtlasi P14416. baseline and differential.
Genevestigatori P14416.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
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Publicationsi

« Hide 'large scale' publications
  1. "The major dopamine D2 receptor: molecular analysis of the human D2A subtype."
    Selbie L.A., Hayes G., Shine J.
    DNA 8:683-689(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The dopamine D2 receptor: two molecular forms generated by alternative splicing."
    Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A., Shivers B.D., Seeburg P.H.
    EMBO J. 8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
  3. "Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region."
    Robakis N.K., Mohamadi M., Fu D.Y., Sambamurti K., Refolo L.M.
    Nucleic Acids Res. 18:1299-1299(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Molecular cloning and expression of a dopamine D2 receptor from human retina."
    Stormann T.M., Gdula D.C., Weiner D.M., Brann M.R.
    Mol. Pharmacol. 37:1-6(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  6. "DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype."
    Selbie L.A., Hayes G., Shine J.
    Adv. Second Messenger Phosphoprotein Res. 24:9-14(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  8. "D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA."
    Dearry A., Falardeau P., Shores C., Caron M.G.
    Cell. Mol. Neurobiol. 11:437-453(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  9. "Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2."
    Seeman P., Ohara K., Ulpian C., Seeman M.V., Jellinger K., Tol H.H., Niznik H.B.
    Neuropsychopharmacology 8:137-142(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Brain.
  10. "New dopamine receptor, D2(Longer), with unique TG splice site, in human brain."
    Seeman P., Nam D., Ulpian C., Liu I.S.C., Tallerico T.
    Brain Res. Mol. Brain Res. 76:132-141(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Corpus striatum.
  11. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
  12. Kidd K.K.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  14. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."
    Binda A.V., Kabbani N., Levenson R.
    Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CADPS AND CADPS2.
  15. "Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool."
    Lopez-Aranda M.F., Acevedo M.J., Gutierrez A., Koulen P., Khan Z.U.
    J. Cell Sci. 120:2171-2178(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GNAI2.
  16. Cited for: HOMOOLIGOMERIZATION, INTERACTION WITH DRD4.
  17. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."
    Albizu L., Holloway T., Gonzalez-Maeso J., Sealfon S.C.
    Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTR2A, FUNCTION, SUBCELLULAR LOCATION.
  18. "Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity."
    Johnston C.A., Siderovski D.P.
    Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 208-226 IN COMPLEX WITH GNAI1, INTERACTION WITH GNAI1, FUNCTION.
  19. Cited for: RETRACTION.
  20. "A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys)."
    Itokawa M., Arinami T., Futamura N., Hamaguchi H., Toru M.
    Biochem. Biophys. Res. Commun. 196:1369-1375(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYS-311.
  21. Cited for: VARIANT DYT11 ILE-154.
  22. "Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics."
    Johann M., Putzhammer A., Eichhammer P., Wodarz N.
    Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
  23. Cited for: CHARACTERIZATION OF VARIANT DYT11 ILE-154.
  24. Cited for: VARIANT GLU-327.

Entry informationi

Entry nameiDRD2_HUMAN
AccessioniPrimary (citable) accession number: P14416
Secondary accession number(s): Q9NZR3, Q9UPA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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