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P14416

- DRD2_HUMAN

UniProt

P14416 - DRD2_HUMAN

Protein

D(2) dopamine receptor

Gene

DRD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 175 (01 Oct 2014)
      Sequence version 2 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141AgonistBy similarity
    Sitei194 – 1941Important for receptor activationBy similarity
    Sitei197 – 1971Important for receptor activationBy similarity

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
    3. drug binding Source: BHF-UCL
    4. identical protein binding Source: IntAct
    5. potassium channel regulator activity Source: BHF-UCL
    6. protein binding Source: BHF-UCL

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. adenohypophysis development Source: BHF-UCL
    3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
    4. adult walking behavior Source: BHF-UCL
    5. arachidonic acid secretion Source: BHF-UCL
    6. associative learning Source: BHF-UCL
    7. auditory behavior Source: Ensembl
    8. axonogenesis Source: BHF-UCL
    9. behavioral response to cocaine Source: BHF-UCL
    10. behavioral response to ethanol Source: BHF-UCL
    11. branching morphogenesis of a nerve Source: BHF-UCL
    12. cellular calcium ion homeostasis Source: BHF-UCL
    13. cerebral cortex GABAergic interneuron migration Source: BHF-UCL
    14. circadian regulation of gene expression Source: BHF-UCL
    15. dopamine metabolic process Source: BHF-UCL
    16. feeding behavior Source: Ensembl
    17. G-protein coupled receptor internalization Source: Ensembl
    18. grooming behavior Source: Ensembl
    19. intracellular signal transduction Source: BHF-UCL
    20. locomotory behavior Source: BHF-UCL
    21. long-term memory Source: Ensembl
    22. negative regulation of adenylate cyclase activity Source: BHF-UCL
    23. negative regulation of blood pressure Source: BHF-UCL
    24. negative regulation of cell migration Source: BHF-UCL
    25. negative regulation of cell proliferation Source: BHF-UCL
    26. negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
    27. negative regulation of cytosolic calcium ion concentration Source: Ensembl
    28. negative regulation of dopamine receptor signaling pathway Source: BHF-UCL
    29. negative regulation of dopamine secretion Source: Ensembl
    30. negative regulation of insulin secretion Source: Ensembl
    31. negative regulation of protein kinase B signaling Source: BHF-UCL
    32. negative regulation of protein secretion Source: BHF-UCL
    33. negative regulation of synaptic transmission, glutamatergic Source: BHF-UCL
    34. negative regulation of voltage-gated calcium channel activity Source: BHF-UCL
    35. neurological system process involved in regulation of systemic arterial blood pressure Source: BHF-UCL
    36. neuron-neuron synaptic transmission Source: BHF-UCL
    37. orbitofrontal cortex development Source: Ensembl
    38. peristalsis Source: BHF-UCL
    39. phosphatidylinositol metabolic process Source: BHF-UCL
    40. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
    41. pigmentation Source: Ensembl
    42. positive regulation of cytokinesis Source: UniProt
    43. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
    44. positive regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
    45. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    46. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    47. positive regulation of growth hormone secretion Source: BHF-UCL
    48. positive regulation of long-term synaptic potentiation Source: Ensembl
    49. positive regulation of multicellular organism growth Source: Ensembl
    50. positive regulation of neuroblast proliferation Source: BHF-UCL
    51. positive regulation of receptor internalization Source: Ensembl
    52. positive regulation of renal sodium excretion Source: Ensembl
    53. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    54. positive regulation of urine volume Source: Ensembl
    55. prepulse inhibition Source: BHF-UCL
    56. protein localization Source: BHF-UCL
    57. regulation of cAMP metabolic process Source: BHF-UCL
    58. regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
    59. regulation of heart rate Source: BHF-UCL
    60. regulation of locomotion involved in locomotory behavior Source: Ensembl
    61. regulation of long-term neuronal synaptic plasticity Source: BHF-UCL
    62. regulation of phosphoprotein phosphatase activity Source: Ensembl
    63. regulation of potassium ion transport Source: BHF-UCL
    64. regulation of sodium ion transport Source: BHF-UCL
    65. regulation of synapse structural plasticity Source: Ensembl
    66. regulation of synaptic transmission, GABAergic Source: BHF-UCL
    67. release of sequestered calcium ion into cytosol Source: BHF-UCL
    68. response to amphetamine Source: BHF-UCL
    69. response to axon injury Source: Ensembl
    70. response to cocaine Source: BHF-UCL
    71. response to drug Source: BHF-UCL
    72. response to histamine Source: BHF-UCL
    73. response to hypoxia Source: Ensembl
    74. response to inactivity Source: Ensembl
    75. response to iron ion Source: Ensembl
    76. response to light stimulus Source: BHF-UCL
    77. response to morphine Source: BHF-UCL
    78. response to nicotine Source: Ensembl
    79. response to toxic substance Source: Ensembl
    80. sensory perception of smell Source: BHF-UCL
    81. striatum development Source: Ensembl
    82. synapse assembly Source: BHF-UCL
    83. synaptic transmission, dopaminergic Source: Ensembl
    84. temperature homeostasis Source: BHF-UCL
    85. visual learning Source: BHF-UCL
    86. Wnt signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16968. Dopamine receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP14416.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D(2) dopamine receptor
    Alternative name(s):
    Dopamine D2 receptor
    Gene namesi
    Name:DRD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3023. DRD2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. axon Source: BHF-UCL
    3. axon terminus Source: Ensembl
    4. dendrite Source: BHF-UCL
    5. dendritic spine Source: Ensembl
    6. endocytic vesicle Source: Ensembl
    7. integral component of plasma membrane Source: BHF-UCL
    8. lateral plasma membrane Source: Ensembl
    9. perikaryon Source: Ensembl
    10. plasma membrane Source: Reactome
    11. postsynaptic density Source: Ensembl
    12. sperm flagellum Source: Ensembl
    13. synaptic vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.1 Publication
    Note: The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541V → I in DYT11; uncertain pathological significance; the mutation does not affect functional properties. 1 Publication
    Corresponds to variant rs104894220 [ dbSNP | Ensembl ].
    VAR_017143

    Keywords - Diseasei

    Disease mutation, Dystonia

    Organism-specific databases

    MIMi103780. phenotype.
    159900. phenotype.
    Orphaneti36899. Myoclonus-dystonia syndrome.
    PharmGKBiPA27478.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443D(2) dopamine receptorPRO_0000069387Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 182PROSITE-ProRule annotation
    Disulfide bondi399 ↔ 401PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP14416.
    PRIDEiP14416.

    PTM databases

    PhosphoSiteiP14416.

    Expressioni

    Gene expression databases

    ArrayExpressiP14416.
    BgeeiP14416.
    CleanExiHS_DRD2.
    GenevestigatoriP14416.

    Organism-specific databases

    HPAiHPA015691.

    Interactioni

    Subunit structurei

    Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 By similarity. Interacts with CADPS and CADPS2. Interacts with ARRB2 By similarity. Interacts with GNAI1. Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself4EBI-2928178,EBI-2928178
    ADORA2AP292742EBI-2928178,EBI-2902702
    SLC6A3Q019594EBI-2928178,EBI-6661445

    Protein-protein interaction databases

    BioGridi108147. 11 interactions.
    DIPiDIP-5977N.
    IntActiP14416. 4 interactions.
    MINTiMINT-201447.
    STRINGi9606.ENSP00000354859.

    Structurei

    Secondary structure

    1
    443
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi431 – 44212

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I15model-A34-58[»]
    B72-97[»]
    C108-129[»]
    D153-172[»]
    E190-210[»]
    F371-396[»]
    G403-426[»]
    2YOUX-ray2.19B/C430-443[»]
    ProteinModelPortaliP14416.
    SMRiP14416. Positions 37-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14416.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularBy similarityAdd
    BLAST
    Topological domaini61 – 7010CytoplasmicBy similarity
    Topological domaini94 – 10815ExtracellularBy similarityAdd
    BLAST
    Topological domaini131 – 15121CytoplasmicBy similarityAdd
    BLAST
    Topological domaini173 – 18816ExtracellularBy similarityAdd
    BLAST
    Topological domaini214 – 373160CytoplasmicBy similarityAdd
    BLAST
    Topological domaini396 – 40914ExtracellularBy similarityAdd
    BLAST
    Topological domaini432 – 44312CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 6023Helical; Name=1By similarityAdd
    BLAST
    Transmembranei71 – 9323Helical; Name=2By similarityAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3By similarityAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4By similarityAdd
    BLAST
    Transmembranei189 – 21325Helical; Name=5By similarityAdd
    BLAST
    Transmembranei374 – 39522Helical; Name=6By similarityAdd
    BLAST
    Transmembranei410 – 43122Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1978Agonist bindingBy similarity
    Regioni211 – 373163Interaction with PPP1R9BBy similarityAdd
    BLAST
    Regioni386 – 3949Agonist bindingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG309657.
    HOVERGENiHBG106962.
    KOiK04145.
    OMAiNSVKHSR.
    OrthoDBiEOG769ZMG.
    PhylomeDBiP14416.
    TreeFamiTF334382.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR001922. Dopamine_D2_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00567. DOPAMINED2R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P14416-1) [UniParc]FASTAAdd to Basket

    Also known as: D2(Long)

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF    50
    GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 100
    KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 150
    RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV 200
    PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM 250
    KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP 300
    SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK 350
    TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD 400
    CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC 443
    Length:443
    Mass (Da):50,619
    Last modified:April 1, 1990 - v2
    Checksum:i9BF8EA36C988A2E2
    GO
    Isoform 2 (identifier: P14416-2) [UniParc]FASTAAdd to Basket

    Also known as: D2(Short)

    The sequence of this isoform differs from the canonical sequence as follows:
         242-270: Missing.

    Show »
    Length:414
    Mass (Da):47,347
    Checksum:iBFC25AC601DFDC7F
    GO
    Isoform 3 (identifier: P14416-3) [UniParc]FASTAAdd to Basket

    Also known as: D2(Longer)

    The sequence of this isoform differs from the canonical sequence as follows:
         270-270: V → VVQ

    Show »
    Length:445
    Mass (Da):50,847
    Checksum:i111674E96E087FD6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401L → R in AAB26819. (PubMed:1363862)Curated

    Polymorphismi

    Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIMi:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541V → I in DYT11; uncertain pathological significance; the mutation does not affect functional properties. 1 Publication
    Corresponds to variant rs104894220 [ dbSNP | Ensembl ].
    VAR_017143
    Natural varianti310 – 3101P → S.
    Corresponds to variant rs1800496 [ dbSNP | Ensembl ].
    VAR_014674
    Natural varianti311 – 3111S → C May be associated with a higher risk for schizophrenia. 1 Publication
    Corresponds to variant rs1801028 [ dbSNP | Ensembl ].
    VAR_003462
    Natural varianti327 – 3271K → E.1 Publication
    Corresponds to variant rs71653614 [ dbSNP | Ensembl ].
    VAR_064579

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei242 – 27029Missing in isoform 2. 1 PublicationVSP_001870Add
    BLAST
    Alternative sequencei270 – 2701V → VVQ in isoform 3. 1 PublicationVSP_026455

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30625 mRNA. Translation: AAA88024.1.
    X51645 mRNA. Translation: CAB56463.1.
    X51646 Genomic DNA. Translation: CAB37869.1.
    X51362 mRNA. Translation: CAA35746.1.
    M29066 mRNA. Translation: AAA52761.1.
    S62137 mRNA. Translation: AAB26819.1.
    S69899 mRNA. Translation: AAB20571.1.
    S58589
    , S58577, S58584, S58586, S58588 Genomic DNA. Translation: AAB26274.1.
    AF176812 mRNA. Translation: AAF61479.1.
    AB065860 Genomic DNA. Translation: BAC06078.1.
    AF050737 Genomic DNA. Translation: AAC78779.1.
    BC021195 mRNA. Translation: AAH21195.1.
    CCDSiCCDS8361.1. [P14416-1]
    CCDS8362.1. [P14416-2]
    PIRiS08417. DYHUD2.
    RefSeqiNP_000786.1. NM_000795.3. [P14416-1]
    NP_057658.2. NM_016574.3. [P14416-2]
    XP_005271482.1. XM_005271425.2. [P14416-1]
    XP_006718837.1. XM_006718774.1. [P14416-2]
    UniGeneiHs.73893.

    Genome annotation databases

    EnsembliENST00000346454; ENSP00000278597; ENSG00000149295. [P14416-2]
    ENST00000362072; ENSP00000354859; ENSG00000149295. [P14416-1]
    ENST00000538967; ENSP00000438215; ENSG00000149295. [P14416-3]
    ENST00000542968; ENSP00000442172; ENSG00000149295. [P14416-1]
    GeneIDi1813.
    KEGGihsa:1813.
    UCSCiuc001pnz.3. human. [P14416-1]
    uc001pob.4. human. [P14416-2]

    Polymorphism databases

    DMDMi118206.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30625 mRNA. Translation: AAA88024.1 .
    X51645 mRNA. Translation: CAB56463.1 .
    X51646 Genomic DNA. Translation: CAB37869.1 .
    X51362 mRNA. Translation: CAA35746.1 .
    M29066 mRNA. Translation: AAA52761.1 .
    S62137 mRNA. Translation: AAB26819.1 .
    S69899 mRNA. Translation: AAB20571.1 .
    S58589
    , S58577 , S58584 , S58586 , S58588 Genomic DNA. Translation: AAB26274.1 .
    AF176812 mRNA. Translation: AAF61479.1 .
    AB065860 Genomic DNA. Translation: BAC06078.1 .
    AF050737 Genomic DNA. Translation: AAC78779.1 .
    BC021195 mRNA. Translation: AAH21195.1 .
    CCDSi CCDS8361.1. [P14416-1 ]
    CCDS8362.1. [P14416-2 ]
    PIRi S08417. DYHUD2.
    RefSeqi NP_000786.1. NM_000795.3. [P14416-1 ]
    NP_057658.2. NM_016574.3. [P14416-2 ]
    XP_005271482.1. XM_005271425.2. [P14416-1 ]
    XP_006718837.1. XM_006718774.1. [P14416-2 ]
    UniGenei Hs.73893.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I15 model - A 34-58 [» ]
    B 72-97 [» ]
    C 108-129 [» ]
    D 153-172 [» ]
    E 190-210 [» ]
    F 371-396 [» ]
    G 403-426 [» ]
    2YOU X-ray 2.19 B/C 430-443 [» ]
    ProteinModelPortali P14416.
    SMRi P14416. Positions 37-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108147. 11 interactions.
    DIPi DIP-5977N.
    IntActi P14416. 4 interactions.
    MINTi MINT-201447.
    STRINGi 9606.ENSP00000354859.

    Chemistry

    BindingDBi P14416.
    ChEMBLi CHEMBL2095169.
    DrugBanki DB01063. Acetophenazine.
    DB00915. Amantadine.
    DB00714. Apomorphine.
    DB01238. Aripiprazole.
    DB01200. Bromocriptine.
    DB00490. Buspirone.
    DB00248. Cabergoline.
    DB01038. Carphenazine.
    DB00477. Chlorpromazine.
    DB01239. Chlorprothixene.
    DB00568. Cinnarizine.
    DB00363. Clozapine.
    DB01184. Domperidone.
    DB00450. Droperidol.
    DB00696. Ergotamine.
    DB00875. Flupenthixol.
    DB00623. Fluphenazine.
    DB04842. Fluspirilene.
    DB00502. Haloperidol.
    DB01235. Levodopa.
    DB00589. Lisuride.
    DB00408. Loxapine.
    DB00933. Mesoridazine.
    DB01233. Metoclopramide.
    DB00805. Minaprine.
    DB01618. Molindone.
    DB00334. Olanzapine.
    DB01267. Paliperidone.
    DB01186. Pergolide.
    DB00850. Perphenazine.
    DB01100. Pimozide.
    DB00413. Pramipexole.
    DB00433. Prochlorperazine.
    DB00420. Promazine.
    DB01069. Promethazine.
    DB00777. Propiomazine.
    DB01224. Quetiapine.
    DB00409. Remoxipride.
    DB00734. Risperidone.
    DB00268. Ropinirole.
    DB06144. Sertindole.
    DB00391. Sulpiride.
    DB00372. Thiethylperazine.
    DB00679. Thioridazine.
    DB00752. Tranylcypromine.
    DB00831. Trifluoperazine.
    DB00508. Triflupromazine.
    DB00246. Ziprasidone.
    DB01624. Zuclopenthixol.
    GuidetoPHARMACOLOGYi 215.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P14416.

    Polymorphism databases

    DMDMi 118206.

    Proteomic databases

    PaxDbi P14416.
    PRIDEi P14416.

    Protocols and materials databases

    DNASUi 1813.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000346454 ; ENSP00000278597 ; ENSG00000149295 . [P14416-2 ]
    ENST00000362072 ; ENSP00000354859 ; ENSG00000149295 . [P14416-1 ]
    ENST00000538967 ; ENSP00000438215 ; ENSG00000149295 . [P14416-3 ]
    ENST00000542968 ; ENSP00000442172 ; ENSG00000149295 . [P14416-1 ]
    GeneIDi 1813.
    KEGGi hsa:1813.
    UCSCi uc001pnz.3. human. [P14416-1 ]
    uc001pob.4. human. [P14416-2 ]

    Organism-specific databases

    CTDi 1813.
    GeneCardsi GC11M113280.
    HGNCi HGNC:3023. DRD2.
    HPAi HPA015691.
    MIMi 103780. phenotype.
    126450. gene.
    159900. phenotype.
    neXtProti NX_P14416.
    Orphaneti 36899. Myoclonus-dystonia syndrome.
    PharmGKBi PA27478.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309657.
    HOVERGENi HBG106962.
    KOi K04145.
    OMAi NSVKHSR.
    OrthoDBi EOG769ZMG.
    PhylomeDBi P14416.
    TreeFami TF334382.

    Enzyme and pathway databases

    Reactomei REACT_16968. Dopamine receptors.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P14416.

    Miscellaneous databases

    EvolutionaryTracei P14416.
    GeneWikii Dopamine_receptor_D2.
    GenomeRNAii 1813.
    NextBioi 7389.
    PROi P14416.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14416.
    Bgeei P14416.
    CleanExi HS_DRD2.
    Genevestigatori P14416.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR001922. Dopamine_D2_rcpt.
    IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00567. DOPAMINED2R.
    PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The major dopamine D2 receptor: molecular analysis of the human D2A subtype."
      Selbie L.A., Hayes G., Shine J.
      DNA 8:683-689(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The dopamine D2 receptor: two molecular forms generated by alternative splicing."
      Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A., Shivers B.D., Seeburg P.H.
      EMBO J. 8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
    3. "Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region."
      Robakis N.K., Mohamadi M., Fu D.Y., Sambamurti K., Refolo L.M.
      Nucleic Acids Res. 18:1299-1299(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Molecular cloning and expression of a dopamine D2 receptor from human retina."
      Stormann T.M., Gdula D.C., Weiner D.M., Brann M.R.
      Mol. Pharmacol. 37:1-6(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    6. "DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype."
      Selbie L.A., Hayes G., Shine J.
      Adv. Second Messenger Phosphoprotein Res. 24:9-14(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    8. "D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA."
      Dearry A., Falardeau P., Shores C., Caron M.G.
      Cell. Mol. Neurobiol. 11:437-453(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    9. "Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2."
      Seeman P., Ohara K., Ulpian C., Seeman M.V., Jellinger K., Tol H.H., Niznik H.B.
      Neuropsychopharmacology 8:137-142(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Brain.
    10. "New dopamine receptor, D2(Longer), with unique TG splice site, in human brain."
      Seeman P., Nam D., Ulpian C., Liu I.S.C., Tallerico T.
      Brain Res. Mol. Brain Res. 76:132-141(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Corpus striatum.
    11. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
    12. Kidd K.K.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    14. "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."
      Binda A.V., Kabbani N., Levenson R.
      Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CADPS AND CADPS2.
    15. "Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool."
      Lopez-Aranda M.F., Acevedo M.J., Gutierrez A., Koulen P., Khan Z.U.
      J. Cell Sci. 120:2171-2178(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GNAI2.
    16. Cited for: HOMOOLIGOMERIZATION, INTERACTION WITH DRD4.
    17. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."
      Albizu L., Holloway T., Gonzalez-Maeso J., Sealfon S.C.
      Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTR2A, FUNCTION, SUBCELLULAR LOCATION.
    18. "Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity."
      Johnston C.A., Siderovski D.P.
      Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 208-226 IN COMPLEX WITH GNAI1, INTERACTION WITH GNAI1, FUNCTION.
    19. Cited for: RETRACTION.
    20. "A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys)."
      Itokawa M., Arinami T., Futamura N., Hamaguchi H., Toru M.
      Biochem. Biophys. Res. Commun. 196:1369-1375(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-311.
    21. Cited for: VARIANT DYT11 ILE-154.
    22. "Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics."
      Johann M., Putzhammer A., Eichhammer P., Wodarz N.
      Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
    23. Cited for: CHARACTERIZATION OF VARIANT DYT11 ILE-154.
    24. Cited for: VARIANT GLU-327.

    Entry informationi

    Entry nameiDRD2_HUMAN
    AccessioniPrimary (citable) accession number: P14416
    Secondary accession number(s): Q9NZR3, Q9UPA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 175 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3