P14416 (DRD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D(2) dopamine receptor

Alternative name(s):
Dopamine D2 receptor

Gene names

Name:

DRD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase By similarity. Ref.17
Subunit structure	Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 By similarity. Interacts with CADPS and CADPS2. Interacts with ARRB2 By similarity. Interacts with GNAI1. Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Ref.14 Ref.15 Ref.16 Ref.17
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.
Involvement in disease	Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Note: The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (Ref.22). Ref.20 Ref.22
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Dystonia
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor internalization Inferred from electronic annotation. Source: Compara Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara activation of protein kinase activity Inferred from electronic annotation. Source: Compara adenohypophysis development Inferred from sequence or structural similarity. Source: BHF-UCL adenylate cyclase-inhibiting dopamine receptor signaling pathway Inferred from direct assay PubMed 1331329Ref.2PubMed 1331329. Source: BHF-UCL adult walking behavior Inferred from sequence or structural similarity. Source: BHF-UCL arachidonic acid secretion Inferred from direct assay PubMed 8301582. Source: BHF-UCL auditory behavior Inferred from electronic annotation. Source: Compara axonogenesis Inferred from sequence or structural similarity. Source: BHF-UCL behavioral response to cocaine Inferred from sequence or structural similarity. Source: BHF-UCL behavioral response to ethanol Inferred from sequence or structural similarity. Source: BHF-UCL branching morphogenesis of a nerve Inferred from sequence or structural similarity. Source: BHF-UCL cerebral cortex GABAergic interneuron migration Inferred from sequence or structural similarity. Source: BHF-UCL circadian regulation of gene expression Inferred from sequence or structural similarity. Source: BHF-UCL dopamine metabolic process Inferred by curator PubMed 8301582. Source: BHF-UCL elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from direct assay PubMed 1331329PubMed 1331329. Source: BHF-UCL feeding behavior Inferred from electronic annotation. Source: Compara grooming behavior Inferred from electronic annotation. Source: Compara intracellular protein kinase cascade Inferred from direct assay PubMed 1331329PubMed 1331329. Source: BHF-UCL long-term memory Inferred from electronic annotation. Source: Compara negative regulation of adenylate cyclase activity Inferred from direct assay Ref.2. Source: BHF-UCL negative regulation of blood pressure Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell migration Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell proliferation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of circadian sleep/wake cycle, sleep Inferred from electronic annotation. Source: Compara negative regulation of dopamine receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of insulin secretion Inferred from electronic annotation. Source: Compara negative regulation of protein kinase B signaling cascade Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of protein secretion Inferred from direct assay PubMed 16839358. Source: BHF-UCL negative regulation of synaptic transmission, glutamatergic Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of voltage-gated calcium channel activity Inferred from direct assay PubMed 7921596. Source: BHF-UCL neurological system process involved in regulation of systemic arterial blood pressure Inferred from sequence or structural similarity. Source: BHF-UCL neuron-neuron synaptic transmission Inferred from sequence or structural similarity. Source: BHF-UCL peristalsis Inferred from sequence or structural similarity. Source: BHF-UCL phosphatidylinositol metabolic process Inferred from sequence or structural similarity. Source: BHF-UCL phospholipase C-activating dopamine receptor signaling pathway Inferred from genetic interaction PubMed 17194762. Source: MGI pigmentation Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of dopamine uptake involved in synaptic transmission Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of growth hormone secretion Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara positive regulation of neuroblast proliferation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of receptor internalization Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of urine volume Inferred from electronic annotation. Source: Compara prepulse inhibition Inferred from sequence or structural similarity. Source: BHF-UCL protein localization Inferred from sequence or structural similarity. Source: BHF-UCL reduction of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara regulation of cAMP metabolic process Inferred from direct assay PubMed 8666994. Source: BHF-UCL regulation of dopamine secretion Inferred from electronic annotation. Source: Compara regulation of heart rate Inferred from sequence or structural similarity. Source: BHF-UCL regulation of long-term neuronal synaptic plasticity Inferred from sequence or structural similarity. Source: BHF-UCL regulation of phosphoprotein phosphatase activity Inferred from electronic annotation. Source: Compara regulation of potassium ion transport Inferred from sequence or structural similarity. Source: BHF-UCL regulation of sodium ion transport Inferred from sequence or structural similarity. Source: BHF-UCL regulation of synaptic transmission, GABAergic Inferred from sequence or structural similarity. Source: BHF-UCL release of sequestered calcium ion into cytosol Inferred from sequence or structural similarity. Source: BHF-UCL response to amphetamine Inferred from sequence or structural similarity. Source: BHF-UCL response to axon injury Inferred from electronic annotation. Source: Compara response to drug Inferred from sequence or structural similarity. Source: BHF-UCL response to histamine Inferred from direct assay PubMed 16839358. Source: BHF-UCL response to hypoxia Inferred from electronic annotation. Source: Compara response to inactivity Inferred from electronic annotation. Source: Compara response to iron ion Inferred from electronic annotation. Source: Compara response to morphine Inferred from sequence or structural similarity. Source: BHF-UCL response to nicotine Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara sensory perception of smell Inferred from sequence or structural similarity. Source: BHF-UCL synapse assembly Inferred from sequence or structural similarity. Source: BHF-UCL synaptic transmission, dopaminergic Inferred from electronic annotation. Source: Compara temperature homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL visual learning Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara axon Inferred from sequence or structural similarity. Source: BHF-UCL axon terminus Inferred from electronic annotation. Source: Compara dendrite Inferred from sequence or structural similarity. Source: BHF-UCL endocytic vesicle Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred by curator Ref.2. Source: BHF-UCL lateral plasma membrane Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara synaptic vesicle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	dopamine binding Inferred from electronic annotation. Source: Compara dopamine neurotransmitter receptor activity, coupled via Gi/Go Inferred from direct assay PubMed 8301582Ref.2. Source: BHF-UCL drug binding Inferred from direct assay PubMed 8413587. Source: BHF-UCL potassium channel regulator activity Non-traceable author statement PubMed 12297500. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ADORA2A	P29274	2	EBI-2928178,EBI-2902702

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P14416-1)

Also known as: D2(Long);

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P14416-2)

Also known as: D2(Short);

The sequence of this isoform differs from the canonical sequence as follows:
     242-270: Missing.

Isoform 3 (identifier: P14416-3)

Also known as: D2(Longer);

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: V → VVQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	D(2) dopamine receptor		PRO_0000069387
Regions
	Topological domain	1 – 37	37	Extracellular By similarity
	Transmembrane	38 – 60	23	Helical; Name=1; By similarity
	Topological domain	61 – 70	10	Cytoplasmic By similarity
	Transmembrane	71 – 93	23	Helical; Name=2; By similarity
	Topological domain	94 – 108	15	Extracellular By similarity
	Transmembrane	109 – 130	22	Helical; Name=3; By similarity
	Topological domain	131 – 151	21	Cytoplasmic By similarity
	Transmembrane	152 – 172	21	Helical; Name=4; By similarity
	Topological domain	173 – 188	16	Extracellular By similarity
	Transmembrane	189 – 213	25	Helical; Name=5; By similarity
	Topological domain	214 – 373	160	Cytoplasmic By similarity
	Transmembrane	374 – 395	22	Helical; Name=6; By similarity
	Topological domain	396 – 409	14	Extracellular By similarity
	Transmembrane	410 – 431	22	Helical; Name=7; By similarity
	Topological domain	432 – 443	12	Cytoplasmic By similarity
	Region	190 – 197	8	Agonist binding By similarity
	Region	211 – 373	163	Interaction with PPP1R9B By similarity
	Region	386 – 394	9	Agonist binding By similarity
Sites
	Binding site	114	1	Agonist By similarity
	Site	194	1	Important for receptor activation By similarity
	Site	197	1	Important for receptor activation By similarity
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	23	1	N-linked (GlcNAc...) Potential
	Disulfide bond	107 ↔ 182		By similarity
	Disulfide bond	399 ↔ 401		By similarity
Natural variations
	Alternative sequence	242 – 270	29	Missing in isoform 2.		VSP_001870
	Alternative sequence	270	1	V → VVQ in isoform 3.		VSP_026455
	Natural variant	154	1	V → I in DYT11; uncertain pathological significance; the mutation does not affect functional properties. Ref.20 Ref.22 Corresponds to variant rs104894220 [ dbSNP | Ensembl ].		VAR_017143
	Natural variant	310	1	P → S. Corresponds to variant rs1800496 [ dbSNP | Ensembl ].		VAR_014674
	Natural variant	311	1	S → C May be associated with a higher risk for schizophrenia. Ref.19 Corresponds to variant rs1801028 [ dbSNP | Ensembl ].		VAR_003462
	Natural variant	327	1	K → E. Ref.23 Corresponds to variant rs71653614 [ dbSNP | Ensembl ].		VAR_064579
Experimental info
	Sequence conflict	40	1	L → R in AAB26819. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (D2(Long)) [UniParc]. Last modified April 1, 1990. Version 2. Checksum: 9BF8EA36C988A2E2	FASTA	443	50,619
	10 20 30 40 50 60 MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS 70 80 90 100 110 120 REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 130 140 150 160 170 180 SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN 190 200 210 220 230 240 ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL 250 260 270 280 290 300 KGNCTHPEDM KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP 310 320 330 340 350 360 SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK TRTSLKTMSR 370 380 390 400 410 420 RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD CNIPPVLYSA FTWLGYVNSA 430 440 VNPIIYTTFN IEFRKAFLKI LHC
	Isoform 2 (D2(Short)) [UniParc]. Checksum: BFC25AC601DFDC7F	FASTA	414	47,347
	10 20 30 40 50 60 MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS 70 80 90 100 110 120 REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 130 140 150 160 170 180 SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN 190 200 210 220 230 240 ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL 250 260 270 280 290 300 KEAARRAQEL EMEMLSSTSP PERTRYSPIP PSHHQLTLPD PSHHGLHSTP DSPAKPEKNG 310 320 330 340 350 360 HAKDHPKIAK IFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF 370 380 390 400 410 FITHILNIHC DCNIPPVLYS AFTWLGYVNS AVNPIIYTTF NIEFRKAFLK ILHC
	Isoform 3 (D2(Longer)) [UniParc]. Checksum: 111674E96E087FD6	FASTA	445	50,847
	10 20 30 40 50 60 MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS 70 80 90 100 110 120 REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 130 140 150 160 170 180 SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNADQN 190 200 210 220 230 240 ECIIANPAFV VYSSIVSFYV PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL 250 260 270 280 290 300 KGNCTHPEDM KLCTVIMKSN GSFPVNRRRV VQEAARRAQE LEMEMLSSTS PPERTRYSPI 310 320 330 340 350 360 PPSHHQLTLP DPSHHGLHST PDSPAKPEKN GHAKDHPKIA KIFEIQTMPN GKTRTSLKTM 370 380 390 400 410 420 SRRKLSQQKE KKATQMLAIV LGVFIICWLP FFITHILNIH CDCNIPPVLY SAFTWLGYVN 430 440 SAVNPIIYTT FNIEFRKAFL KILHC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The major dopamine D2 receptor: molecular analysis of the human D2A subtype." Selbie L.A., Hayes G., Shine J. DNA 8:683-689(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The dopamine D2 receptor: two molecular forms generated by alternative splicing." Dal-Toso R., Sommer B., Ewert M., Herb A., Pritchett D.B., Bach A., Shivers B.D., Seeburg P.H. EMBO J. 8:4025-4034(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
[3]	"Human retina D2 receptor cDNAs have multiple polyadenylation sites and differ from a pituitary clone at the 5' non-coding region." Robakis N.K., Mohamadi M., Fu D.Y., Sambamurti K., Refolo L.M. Nucleic Acids Res. 18:1299-1299(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[4]	"Cloning of the cDNA and gene for a human D2 dopamine receptor." Grandy D.K., Marchionni M.A., Makam H., Stofko R.E., Alfano M., Frothingham L., Fischer J.B., Burke-Howie K.J., Bunzow J.R., Server A.C., Civelli O. Proc. Natl. Acad. Sci. U.S.A. 86:9762-9766(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]	"Molecular cloning and expression of a dopamine D2 receptor from human retina." Stormann T.M., Gdula D.C., Weiner D.M., Brann M.R. Mol. Pharmacol. 37:1-6(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[6]	"DNA homology screening: isolation and characterization of the human D2A dopamine receptor subtype." Selbie L.A., Hayes G., Shine J. Adv. Second Messenger Phosphoprotein Res. 24:9-14(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[7]	"Structure and expression of human and rat D2 dopamine receptor genes." Araki K., Kuwano R., Morii K., Hayashi S., Minoshima S., Shimizu N., Katagiri T., Usui H., Kumanishi T., Takahashi Y. Neurochem. Int. 21:91-98(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[8]	"D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA." Dearry A., Falardeau P., Shores C., Caron M.G. Cell. Mol. Neurobiol. 11:437-453(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[9]	"Schizophrenia: normal sequence in the dopamine D2 receptor region that couples to G-proteins. DNA polymorphisms in D2." Seeman P., Ohara K., Ulpian C., Seeman M.V., Jellinger K., Tol H.H., Niznik H.B. Neuropsychopharmacology 8:137-142(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Brain.
[10]	"New dopamine receptor, D2(Longer), with unique TG splice site, in human brain." Seeman P., Nam D., Ulpian C., Liu I.S.C., Tallerico T. Brain Res. Mol. Brain Res. 76:132-141(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Corpus striatum.
[11]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
[12]	Kidd K.K. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[13]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[14]	"Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)." Binda A.V., Kabbani N., Levenson R. Biochem. Pharmacol. 69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CADPS AND CADPS2.
[15]	"Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool." Lopez-Aranda M.F., Acevedo M.J., Gutierrez A., Koulen P., Khan Z.U. J. Cell Sci. 120:2171-2178(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GNAI2.
[16]	"Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions." Borroto-Escuela D.O., Van Craenenbroeck K., Romero-Fernandez W., Guidolin D., Woods A.S., Rivera A., Haegeman G., Agnati L.F., Tarakanov A.O., Fuxe K. Biochem. Biophys. Res. Commun. 404:928-934(2011) [PubMed] [Europe PMC] [Abstract] Cited for: HOMOOLIGOMERIZATION, INTERACTION WITH DRD4.
[17]	"Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity." Johnston C.A., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 208-226 IN COMPLEX WITH GNAI1, INTERACTION WITH GNAI1, FUNCTION.
[18]	Erratum Johnston C.A., Siderovski D.P. Proc. Natl. Acad. Sci. U.S.A. 109:1808-1808(2012) [PubMed] [Europe PMC] [Abstract] Cited for: RETRACTION.
[19]	"A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys)." Itokawa M., Arinami T., Futamura N., Hamaguchi H., Toru M. Biochem. Biophys. Res. Commun. 196:1369-1375(1993) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CYS-311.
[20]	"Association of a missense change in the D2 dopamine receptor with myoclonus dystonia." Klein C., Brin M.F., Kramer P., Sena-Esteves M., de Leon D., Doheny D., Bressman S., Fahn S., Breakefield X.O., Ozelius L.J. Proc. Natl. Acad. Sci. U.S.A. 96:5173-5176(1999) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT DYT11 ILE-154.
[21]	"Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics." Johann M., Putzhammer A., Eichhammer P., Wodarz N. Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM.
[22]	"Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia." Klein C., Gurvich N., Sena-Esteves M., Bressman S., Brin M.F., Ebersole B.J., Fink S., Forsgren L., Friedman J., Grimes D., Holmgren G., Kyllerman M., Lang A.E., de Leon D., Leung J., Prioleau C., Raymond D., Sanner G. , Saunders-Pullman R., Vieregge P., Wahlstrom J., Breakefield X.O., Kramer P.L., Ozelius L.J., Sealfon S.C. Ann. Neurol. 47:369-373(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT DYT11 ILE-154.
[23]	"A population-specific HTR2B stop codon predisposes to severe impulsivity." Bevilacqua L., Doly S., Kaprio J., Yuan Q., Tikkanen R., Paunio T., Zhou Z., Wedenoja J., Maroteaux L., Diaz S., Belmer A., Hodgkinson C.A., Dell'osso L., Suvisaari J., Coccaro E., Rose R.J., Peltonen L., Virkkunen M., Goldman D. Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLU-327.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M30625 mRNA. Translation: AAA88024.1.
X51645 mRNA. Translation: CAB56463.1.
X51646 Genomic DNA. Translation: CAB37869.1.
X51362 mRNA. Translation: CAA35746.1.
M29066 mRNA. Translation: AAA52761.1.
S62137 mRNA. Translation: AAB26819.1.
S69899 mRNA. Translation: AAB20571.1.
S58589 , S58577, S58584, S58586, S58588 Genomic DNA. Translation: AAB26274.1.
AF176812 mRNA. Translation: AAF61479.1.
AB065860 Genomic DNA. Translation: BAC06078.1.
AF050737 Genomic DNA. Translation: AAC78779.1.
BC021195 mRNA. Translation: AAH21195.1.

IPI

IPI00026590.
IPI00219367.
IPI00375079.

PIR

DYHUD2. S08417.

RefSeq

NP_000786.1. NM_000795.3.
NP_057658.2. NM_016574.3.

UniGene

Hs.73893.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1I15	model	-	A	34-58	[»]
			B	72-97	[»]
			C	108-129	[»]
			D	153-172	[»]
			E	190-210	[»]
			F	371-396	[»]
			G	403-426	[»]

ProteinModelPortal

P14416.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5977N.

IntAct

P14416. 2 interactions.

MINT

MINT-201447.

STRING

9606.ENSP00000354859.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

P14416.

Polymorphism databases

DMDM

118206.

Proteomic databases

PaxDb

P14416.

PRIDE

P14416.

Protocols and materials databases

DNASU

1813.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000346454; ENSP00000278597; ENSG00000149295.
ENST00000355319; ENSP00000347474; ENSG00000149295.
ENST00000362072; ENSP00000354859; ENSG00000149295.
ENST00000538967; ENSP00000438215; ENSG00000149295.
ENST00000542968; ENSP00000442172; ENSG00000149295.

GeneID

1813.

KEGG

hsa:1813.

UCSC

uc001pnz.3. human.
uc001pob.4. human.

Organism-specific databases

CTD

1813.

GeneCards

GC11M113280.

HGNC

HGNC:3023. DRD2.

HPA

HPA015691.

MIM

103780. phenotype.
126450. gene.
159900. phenotype.

neXtProt

NX_P14416.

Orphanet

36899. Myoclonic dystonia.

PharmGKB

PA27478.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG309657.

HOVERGEN

HBG106962.

KO

K04145.

OMA

WYDDDLE.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P14416.

Bgee

P14416.

CleanEx

HS_DRD2.

Genevestigator

P14416.

GermOnline

ENSG00000149295. Homo sapiens.

Family and domain databases

InterPro

IPR001922. Dopa_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P14416.

ChEMBL

CHEMBL217.

DrugBank

DB01063. Acetophenazine.
DB00915. Amantadine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB01200. Bromocriptine.
DB00490. Buspirone.
DB00248. Cabergoline.
DB01038. Carphenazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB01184. Domperidone.
DB00450. Droperidol.
DB00696. Ergotamine.
DB00875. Flupenthixol.
DB00623. Fluphenazine.
DB04842. Fluspirilene.
DB00502. Haloperidol.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB00933. Mesoridazine.
DB01233. Metoclopramide.
DB00805. Minaprine.
DB01618. Molindone.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB01100. Pimozide.
DB00413. Pramipexole.
DB00433. Prochlorperazine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB06144. Sertindole.
DB00391. Sulpiride.
DB00372. Thiethylperazine.
DB00679. Thioridazine.
DB00752. Tranylcypromine.
DB00831. Trifluoperazine.
DB00508. Triflupromazine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.

EvolutionaryTrace

P14416.

GenomeRNAi

1813.

NextBio

7389.

SOURCE

Search...

Entry information

Entry name

DRD2_HUMAN

Accession

Primary (citable) accession number: P14416
Secondary accession number(s): Q9NZR3, Q9UPA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 160 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.