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Protein

D(2) dopamine receptor

Gene

DRD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114AgonistBy similarity1
Sitei194Important for receptor activationBy similarity1
Sitei197Important for receptor activationBy similarity1

GO - Molecular functioni

  • dopamine binding Source: GO_Central
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  • drug binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • potassium channel regulator activity Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149295-MONOMER.
ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP14416.
SIGNORiP14416.

Protein family/group databases

TCDBi9.A.14.3.10. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
D(2) dopamine receptor
Alternative name(s):
Dopamine D2 receptor
Gene namesi
Name:DRD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3023. DRD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularBy similarityAdd BLAST37
Transmembranei38 – 60Helical; Name=1By similarityAdd BLAST23
Topological domaini61 – 70CytoplasmicBy similarity10
Transmembranei71 – 93Helical; Name=2By similarityAdd BLAST23
Topological domaini94 – 108ExtracellularBy similarityAdd BLAST15
Transmembranei109 – 130Helical; Name=3By similarityAdd BLAST22
Topological domaini131 – 151CytoplasmicBy similarityAdd BLAST21
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 188ExtracellularBy similarityAdd BLAST16
Transmembranei189 – 213Helical; Name=5By similarityAdd BLAST25
Topological domaini214 – 373CytoplasmicBy similarityAdd BLAST160
Transmembranei374 – 395Helical; Name=6By similarityAdd BLAST22
Topological domaini396 – 409ExtracellularBy similarityAdd BLAST14
Transmembranei410 – 431Helical; Name=7By similarityAdd BLAST22
Topological domaini432 – 443CytoplasmicBy similarityAdd BLAST12

GO - Cellular componenti

  • acrosomal vesicle Source: Ensembl
  • axon Source: BHF-UCL
  • axon terminus Source: Ensembl
  • ciliary membrane Source: SYSCILIA_CCNET
  • dendrite Source: BHF-UCL
  • dendritic spine Source: Ensembl
  • endocytic vesicle Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • intracellular Source: GOC
  • lateral plasma membrane Source: Ensembl
  • non-motile cilium Source: SYSCILIA_CCNET
  • perikaryon Source: Ensembl
  • plasma membrane Source: WormBase
  • postsynaptic density Source: Ensembl
  • sperm flagellum Source: Ensembl
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1813.
MalaCardsiDRD2.
MIMi103780. phenotype.
OpenTargetsiENSG00000149295.
Orphaneti36899. Myoclonus-dystonia syndrome.
PharmGKBiPA27478.

Chemistry databases

ChEMBLiCHEMBL217.
DrugBankiDB01614. Acepromazine.
DB01063. Acetophenazine.
DB01425. Alizapride.
DB00915. Amantadine.
DB06288. Amisulpride.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB09128. Brexpiprazole.
DB01200. Bromocriptine.
DB09018. Bromopride.
DB00490. Buspirone.
DB00248. Cabergoline.
DB06016. Cariprazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB01151. Desipramine.
DB01184. Domperidone.
DB00988. Dopamine.
DB01142. Doxepin.
DB00450. Droperidol.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB04842. Fluspirilene.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01221. Ketamine.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00934. Maprotiline.
DB01043. Memantine.
DB00933. Mesoridazine.
DB01403. Methotrimeprazine.
DB01233. Metoclopramide.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB01618. Molindone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB01100. Pimozide.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00433. Prochlorperazine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB06144. Sertindole.
DB00391. Sulpiride.
DB04844. Tetrabenazine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00831. Trifluoperazine.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB01392. Yohimbine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi215.

Polymorphism and mutation databases

BioMutaiDRD2.
DMDMi118206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693871 – 443D(2) dopamine receptorAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 182PROSITE-ProRule annotation
Disulfide bondi399 ↔ 401PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14416.
PeptideAtlasiP14416.
PRIDEiP14416.

PTM databases

iPTMnetiP14416.
PhosphoSitePlusiP14416.
SwissPalmiP14416.

Expressioni

Gene expression databases

BgeeiENSG00000149295.
CleanExiHS_DRD2.
ExpressionAtlasiP14416. baseline and differential.
GenevisibleiP14416. HS.

Organism-specific databases

HPAiHPA015691.

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-2928178,EBI-2928178
ADORA2AP292742EBI-2928178,EBI-2902702
DRD4P219174EBI-11686358,EBI-8592297
SLC6A3Q019594EBI-2928178,EBI-6661445

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi108147. 17 interactors.
DIPiDIP-5977N.
IntActiP14416. 6 interactors.
MINTiMINT-201447.
STRINGi9606.ENSP00000354859.

Chemistry databases

BindingDBiP14416.

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi431 – 442Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I15model-A34-58[»]
B72-97[»]
C108-129[»]
D153-172[»]
E190-210[»]
F371-396[»]
G403-426[»]
5AERX-ray2.19B/C430-443[»]
ProteinModelPortaliP14416.
SMRiP14416.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14416.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni190 – 197Agonist bindingBy similarity8
Regioni211 – 373Interaction with PPP1R9BBy similarityAdd BLAST163
Regioni386 – 394Agonist bindingBy similarity9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP14416.
KOiK04145.
OMAiNSVKHSR.
OrthoDBiEOG091G06VI.
PhylomeDBiP14416.
TreeFamiTF334382.

Family and domain databases

InterProiIPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14416-1) [UniParc]FASTAAdd to basket
Also known as: D2(Long)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF
60 70 80 90 100
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW
110 120 130 140 150
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR
160 170 180 190 200
RVTVMISIVW VLSFTISCPL LFGLNNADQN ECIIANPAFV VYSSIVSFYV
210 220 230 240 250
PFIVTLLVYI KIYIVLRRRR KRVNTKRSSR AFRAHLRAPL KGNCTHPEDM
260 270 280 290 300
KLCTVIMKSN GSFPVNRRRV EAARRAQELE MEMLSSTSPP ERTRYSPIPP
310 320 330 340 350
SHHQLTLPDP SHHGLHSTPD SPAKPEKNGH AKDHPKIAKI FEIQTMPNGK
360 370 380 390 400
TRTSLKTMSR RKLSQQKEKK ATQMLAIVLG VFIICWLPFF ITHILNIHCD
410 420 430 440
CNIPPVLYSA FTWLGYVNSA VNPIIYTTFN IEFRKAFLKI LHC
Length:443
Mass (Da):50,619
Last modified:April 1, 1990 - v2
Checksum:i9BF8EA36C988A2E2
GO
Isoform 2 (identifier: P14416-2) [UniParc]FASTAAdd to basket
Also known as: D2(Short)

The sequence of this isoform differs from the canonical sequence as follows:
     242-270: Missing.

Show »
Length:414
Mass (Da):47,347
Checksum:iBFC25AC601DFDC7F
GO
Isoform 3 (identifier: P14416-3) [UniParc]FASTAAdd to basket
Also known as: D2(Longer)

The sequence of this isoform differs from the canonical sequence as follows:
     270-270: V → VVQ

Show »
Length:445
Mass (Da):50,847
Checksum:i111674E96E087FD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40L → R in AAB26819 (PubMed:1363862).Curated1

Polymorphismi

Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism [MIMi:103780]. Genetic variations in DRD2 might be a protective factor against the development of withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in alcoholics.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017143154V → I Found in patients with alcohol-responsive myoclonus-dystonia; unknown pathological significance; the mutation does not affect functional properties. 2 PublicationsCorresponds to variant rs104894220dbSNPEnsembl.1
Natural variantiVAR_014674310P → S.Corresponds to variant rs1800496dbSNPEnsembl.1
Natural variantiVAR_003462311S → C May be associated with a higher risk for schizophrenia. 1 PublicationCorresponds to variant rs1801028dbSNPEnsembl.1
Natural variantiVAR_064579327K → E.1 PublicationCorresponds to variant rs71653614dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001870242 – 270Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_026455270V → VVQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30625 mRNA. Translation: AAA88024.1.
X51645 mRNA. Translation: CAB56463.1.
X51646 Genomic DNA. Translation: CAB37869.1.
X51362 mRNA. Translation: CAA35746.1.
M29066 mRNA. Translation: AAA52761.1.
S62137 mRNA. Translation: AAB26819.1.
S69899 mRNA. Translation: AAB20571.1.
S58589
, S58577, S58584, S58586, S58588 Genomic DNA. Translation: AAB26274.1.
AF176812 mRNA. Translation: AAF61479.1.
AB065860 Genomic DNA. Translation: BAC06078.1.
AF050737 Genomic DNA. Translation: AAC78779.1.
BC021195 mRNA. Translation: AAH21195.1.
CCDSiCCDS8361.1. [P14416-1]
CCDS8362.1. [P14416-2]
PIRiS08417. DYHUD2.
RefSeqiNP_000786.1. NM_000795.3. [P14416-1]
NP_057658.2. NM_016574.3. [P14416-2]
XP_016872785.1. XM_017017296.1. [P14416-1]
UniGeneiHs.73893.

Genome annotation databases

EnsembliENST00000346454; ENSP00000278597; ENSG00000149295. [P14416-2]
ENST00000362072; ENSP00000354859; ENSG00000149295. [P14416-1]
ENST00000538967; ENSP00000438215; ENSG00000149295. [P14416-3]
ENST00000542968; ENSP00000442172; ENSG00000149295. [P14416-1]
GeneIDi1813.
KEGGihsa:1813.
UCSCiuc001pnz.4. human. [P14416-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30625 mRNA. Translation: AAA88024.1.
X51645 mRNA. Translation: CAB56463.1.
X51646 Genomic DNA. Translation: CAB37869.1.
X51362 mRNA. Translation: CAA35746.1.
M29066 mRNA. Translation: AAA52761.1.
S62137 mRNA. Translation: AAB26819.1.
S69899 mRNA. Translation: AAB20571.1.
S58589
, S58577, S58584, S58586, S58588 Genomic DNA. Translation: AAB26274.1.
AF176812 mRNA. Translation: AAF61479.1.
AB065860 Genomic DNA. Translation: BAC06078.1.
AF050737 Genomic DNA. Translation: AAC78779.1.
BC021195 mRNA. Translation: AAH21195.1.
CCDSiCCDS8361.1. [P14416-1]
CCDS8362.1. [P14416-2]
PIRiS08417. DYHUD2.
RefSeqiNP_000786.1. NM_000795.3. [P14416-1]
NP_057658.2. NM_016574.3. [P14416-2]
XP_016872785.1. XM_017017296.1. [P14416-1]
UniGeneiHs.73893.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I15model-A34-58[»]
B72-97[»]
C108-129[»]
D153-172[»]
E190-210[»]
F371-396[»]
G403-426[»]
5AERX-ray2.19B/C430-443[»]
ProteinModelPortaliP14416.
SMRiP14416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108147. 17 interactors.
DIPiDIP-5977N.
IntActiP14416. 6 interactors.
MINTiMINT-201447.
STRINGi9606.ENSP00000354859.

Chemistry databases

BindingDBiP14416.
ChEMBLiCHEMBL217.
DrugBankiDB01614. Acepromazine.
DB01063. Acetophenazine.
DB01425. Alizapride.
DB00915. Amantadine.
DB06288. Amisulpride.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB09128. Brexpiprazole.
DB01200. Bromocriptine.
DB09018. Bromopride.
DB00490. Buspirone.
DB00248. Cabergoline.
DB06016. Cariprazine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00363. Clozapine.
DB01151. Desipramine.
DB01184. Domperidone.
DB00988. Dopamine.
DB01142. Doxepin.
DB00450. Droperidol.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00875. Flupentixol.
DB00623. Fluphenazine.
DB04842. Fluspirilene.
DB00502. Haloperidol.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01221. Ketamine.
DB01235. Levodopa.
DB00589. Lisuride.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00934. Maprotiline.
DB01043. Memantine.
DB00933. Mesoridazine.
DB01403. Methotrimeprazine.
DB01233. Metoclopramide.
DB06148. Mianserin.
DB00805. Minaprine.
DB00370. Mirtazapine.
DB01618. Molindone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB01267. Paliperidone.
DB01186. Pergolide.
DB00850. Perphenazine.
DB01100. Pimozide.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00433. Prochlorperazine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00409. Remoxipride.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB06144. Sertindole.
DB00391. Sulpiride.
DB04844. Tetrabenazine.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB01623. Thiothixene.
DB00831. Trifluoperazine.
DB00508. Triflupromazine.
DB00726. Trimipramine.
DB01392. Yohimbine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi215.

Protein family/group databases

TCDBi9.A.14.3.10. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP14416.
PhosphoSitePlusiP14416.
SwissPalmiP14416.

Polymorphism and mutation databases

BioMutaiDRD2.
DMDMi118206.

Proteomic databases

PaxDbiP14416.
PeptideAtlasiP14416.
PRIDEiP14416.

Protocols and materials databases

DNASUi1813.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346454; ENSP00000278597; ENSG00000149295. [P14416-2]
ENST00000362072; ENSP00000354859; ENSG00000149295. [P14416-1]
ENST00000538967; ENSP00000438215; ENSG00000149295. [P14416-3]
ENST00000542968; ENSP00000442172; ENSG00000149295. [P14416-1]
GeneIDi1813.
KEGGihsa:1813.
UCSCiuc001pnz.4. human. [P14416-1]

Organism-specific databases

CTDi1813.
DisGeNETi1813.
GeneCardsiDRD2.
HGNCiHGNC:3023. DRD2.
HPAiHPA015691.
MalaCardsiDRD2.
MIMi103780. phenotype.
126450. gene.
neXtProtiNX_P14416.
OpenTargetsiENSG00000149295.
Orphaneti36899. Myoclonus-dystonia syndrome.
PharmGKBiPA27478.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOVERGENiHBG106962.
InParanoidiP14416.
KOiK04145.
OMAiNSVKHSR.
OrthoDBiEOG091G06VI.
PhylomeDBiP14416.
TreeFamiTF334382.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149295-MONOMER.
ReactomeiR-HSA-390651. Dopamine receptors.
R-HSA-418594. G alpha (i) signalling events.
SignaLinkiP14416.
SIGNORiP14416.

Miscellaneous databases

EvolutionaryTraceiP14416.
GeneWikiiDopamine_receptor_D2.
GenomeRNAii1813.
PROiP14416.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149295.
CleanExiHS_DRD2.
ExpressionAtlasiP14416. baseline and differential.
GenevisibleiP14416. HS.

Family and domain databases

InterProiIPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD2_HUMAN
AccessioniPrimary (citable) accession number: P14416
Secondary accession number(s): Q9NZR3, Q9UPA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 199 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.