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Protein

Sodium/potassium-transporting ATPase subunit beta-2

Gene

ATP1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.By similarity

GO - Molecular functioni

  • ATPase activator activity Source: BHF-UCL
  • ATPase binding Source: BHF-UCL
  • sodium:potassium-exchanging ATPase activity Source: BHF-UCL

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • cellular potassium ion homeostasis Source: BHF-UCL
  • cellular sodium ion homeostasis Source: BHF-UCL
  • ion transmembrane transport Source: Reactome
  • leukocyte migration Source: Reactome
  • membrane repolarization Source: BHF-UCL
  • positive regulation of ATPase activity Source: BHF-UCL
  • positive regulation of potassium ion import Source: BHF-UCL
  • positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
  • positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
  • potassium ion import Source: BHF-UCL
  • protein stabilization Source: BHF-UCL
  • regulation of cardiac conduction Source: Reactome
  • sodium ion export across plasma membrane Source: BHF-UCL

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-210991 Basigin interactions
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-2
Alternative name(s):
Adhesion molecule in glia
Short name:
AMOG
Sodium/potassium-dependent ATPase subunit beta-2
Gene namesi
Name:ATP1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129244.8
HGNCiHGNC:805 ATP1B2
MIMi182331 gene
neXtProtiNX_P14415

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 67Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini68 – 290ExtracellularSequence analysisAdd BLAST223

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi482
OpenTargetsiENSG00000129244
PharmGKBiPA67

Chemistry databases

ChEMBLiCHEMBL2095186
DrugBankiDB09479 Rubidium chloride Rb-82

Polymorphism and mutation databases

BioMutaiATP1B2
DMDMi125987795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191041 – 290Sodium/potassium-transporting ATPase subunit beta-2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 150By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 177By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 261By similarity
Glycosylationi238N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14415
MaxQBiP14415
PaxDbiP14415
PeptideAtlasiP14415
PRIDEiP14415

PTM databases

iPTMnetiP14415
PhosphoSitePlusiP14415

Expressioni

Gene expression databases

BgeeiENSG00000129244
CleanExiHS_ATP1B2
ExpressionAtlasiP14415 baseline and differential
GenevisibleiP14415 HS

Organism-specific databases

HPAiHPA010698

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106972, 9 interactors
IntActiP14415, 1 interactor
STRINGi9606.ENSP00000250111

Structurei

3D structure databases

ProteinModelPortaliP14415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 290immunoglobulin-likeAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP14415
KOiK01540
OMAiHKLNTIW
OrthoDBiEOG091G0DJ4
PhylomeDBiP14415
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P14415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF
60 70 80 90 100
LTAMFTLTMW VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT
110 120 130 140 150
ESWDQHVQKL NKFLEPYNDS IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC
160 170 180 190 200
QFNRTQLGNC SGIGDSTHYG YSTGQPCVFI KMNRVINFYA GANQSMNVTC
210 220 230 240 250
AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT QPLVAVKFLN
260 270 280 290
VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
Length:290
Mass (Da):33,367
Last modified:February 6, 2007 - v3
Checksum:iCC5BFBB6D01347F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51L → P in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti51L → P no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti121I → M in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti121I → M no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti148R → L in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti148R → L no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti248F → L in AAC50873 (PubMed:8918259).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061031124Q → L. Corresponds to variant dbSNP:rs34745087Ensembl.1
Natural variantiVAR_030339199T → A. Corresponds to variant dbSNP:rs2227866Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81181 mRNA Translation: AAA51805.1
U45945 mRNA Translation: AAC50873.1
AF007876 Genomic DNA Translation: AAC39686.1
AK290143 mRNA Translation: BAF82832.1
CH471108 Genomic DNA Translation: EAW90148.1
BC126175 mRNA Translation: AAI26176.1
CCDSiCCDS32550.1
PIRiB32459
JC5107
RefSeqiNP_001290192.1, NM_001303263.1
NP_001669.3, NM_001678.4
UniGeneiHs.643540

Genome annotation databases

EnsembliENST00000250111; ENSP00000250111; ENSG00000129244
GeneIDi482
KEGGihsa:482
UCSCiuc002gif.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAT1B2_HUMAN
AccessioniPrimary (citable) accession number: P14415
Secondary accession number(s): A0AV17
, A8K278, D3DTQ2, O60444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health