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Protein

Sodium/potassium-transporting ATPase subunit beta-2

Gene

ATP1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.By similarity

GO - Molecular functioni

  • ATPase activator activity Source: BHF-UCL
  • ATPase binding Source: BHF-UCL
  • sodium:potassium-exchanging ATPase activity Source: BHF-UCL

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • cellular potassium ion homeostasis Source: BHF-UCL
  • cellular sodium ion homeostasis Source: BHF-UCL
  • ion transmembrane transport Source: Reactome
  • leukocyte migration Source: Reactome
  • membrane repolarization Source: BHF-UCL
  • positive regulation of ATPase activity Source: BHF-UCL
  • positive regulation of potassium ion import Source: BHF-UCL
  • positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
  • positive regulation of sodium ion export from cell Source: BHF-UCL
  • potassium ion import Source: BHF-UCL
  • protein stabilization Source: BHF-UCL
  • regulation of cardiac conduction Source: Reactome
  • sodium ion export from cell Source: BHF-UCL
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

BioCyciZFISH:HS05260-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-2
Alternative name(s):
Adhesion molecule in glia
Short name:
AMOG
Sodium/potassium-dependent ATPase subunit beta-2
Gene namesi
Name:ATP1B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:805. ATP1B2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 67Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini68 – 290ExtracellularSequence analysisAdd BLAST223

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi482.
OpenTargetsiENSG00000129244.
PharmGKBiPA67.

Chemistry databases

ChEMBLiCHEMBL2095186.

Polymorphism and mutation databases

BioMutaiATP1B2.
DMDMi125987795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191041 – 290Sodium/potassium-transporting ATPase subunit beta-2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 150By similarity
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 177By similarity
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi200 ↔ 261By similarity
Glycosylationi238N-linked (GlcNAc...)1 Publication1
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14415.
MaxQBiP14415.
PaxDbiP14415.
PeptideAtlasiP14415.
PRIDEiP14415.

PTM databases

iPTMnetiP14415.
PhosphoSitePlusiP14415.

Expressioni

Gene expression databases

BgeeiENSG00000129244.
CleanExiHS_ATP1B2.
ExpressionAtlasiP14415. baseline and differential.
GenevisibleiP14415. HS.

Organism-specific databases

HPAiHPA010698.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106972. 8 interactors.
IntActiP14415. 1 interactor.
STRINGi9606.ENSP00000250111.

Structurei

3D structure databases

ProteinModelPortaliP14415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 290immunoglobulin-likeAdd BLAST98

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP14415.
KOiK01540.
OMAiTESWDLY.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP14415.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF
60 70 80 90 100
LTAMFTLTMW VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT
110 120 130 140 150
ESWDQHVQKL NKFLEPYNDS IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC
160 170 180 190 200
QFNRTQLGNC SGIGDSTHYG YSTGQPCVFI KMNRVINFYA GANQSMNVTC
210 220 230 240 250
AGKRDEDAEN LGNFVMFPAN GNIDLMYFPY YGKKFHVNYT QPLVAVKFLN
260 270 280 290
VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
Length:290
Mass (Da):33,367
Last modified:February 6, 2007 - v3
Checksum:iCC5BFBB6D01347F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51L → P in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti51L → P no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti121I → M in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti121I → M no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti148R → L in AAA51805 (PubMed:8305453).Curated1
Sequence conflicti148R → L no nucleotide entry (PubMed:15489334).Curated1
Sequence conflicti248F → L in AAC50873 (PubMed:8918259).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061031124Q → L.Corresponds to variant rs34745087dbSNPEnsembl.1
Natural variantiVAR_030339199T → A.Corresponds to variant rs2227866dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81181 mRNA. Translation: AAA51805.1.
U45945 mRNA. Translation: AAC50873.1.
AF007876 Genomic DNA. Translation: AAC39686.1.
AK290143 mRNA. Translation: BAF82832.1.
CH471108 Genomic DNA. Translation: EAW90148.1.
BC126175 mRNA. Translation: AAI26176.1.
CCDSiCCDS32550.1.
PIRiB32459.
JC5107.
RefSeqiNP_001290192.1. NM_001303263.1.
NP_001669.3. NM_001678.4.
UniGeneiHs.643540.

Genome annotation databases

EnsembliENST00000250111; ENSP00000250111; ENSG00000129244.
GeneIDi482.
KEGGihsa:482.
UCSCiuc002gif.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81181 mRNA. Translation: AAA51805.1.
U45945 mRNA. Translation: AAC50873.1.
AF007876 Genomic DNA. Translation: AAC39686.1.
AK290143 mRNA. Translation: BAF82832.1.
CH471108 Genomic DNA. Translation: EAW90148.1.
BC126175 mRNA. Translation: AAI26176.1.
CCDSiCCDS32550.1.
PIRiB32459.
JC5107.
RefSeqiNP_001290192.1. NM_001303263.1.
NP_001669.3. NM_001678.4.
UniGeneiHs.643540.

3D structure databases

ProteinModelPortaliP14415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106972. 8 interactors.
IntActiP14415. 1 interactor.
STRINGi9606.ENSP00000250111.

Chemistry databases

ChEMBLiCHEMBL2095186.

PTM databases

iPTMnetiP14415.
PhosphoSitePlusiP14415.

Polymorphism and mutation databases

BioMutaiATP1B2.
DMDMi125987795.

Proteomic databases

EPDiP14415.
MaxQBiP14415.
PaxDbiP14415.
PeptideAtlasiP14415.
PRIDEiP14415.

Protocols and materials databases

DNASUi482.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250111; ENSP00000250111; ENSG00000129244.
GeneIDi482.
KEGGihsa:482.
UCSCiuc002gif.2. human.

Organism-specific databases

CTDi482.
DisGeNETi482.
GeneCardsiATP1B2.
HGNCiHGNC:805. ATP1B2.
HPAiHPA010698.
MIMi182331. gene.
neXtProtiNX_P14415.
OpenTargetsiENSG00000129244.
PharmGKBiPA67.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP14415.
KOiK01540.
OMAiTESWDLY.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP14415.
TreeFamiTF314618.

Enzyme and pathway databases

BioCyciZFISH:HS05260-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-5578775. Ion homeostasis.
R-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP1B2. human.
GenomeRNAii482.
PROiP14415.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129244.
CleanExiHS_ATP1B2.
ExpressionAtlasiP14415. baseline and differential.
GenevisibleiP14415. HS.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B2_HUMAN
AccessioniPrimary (citable) accession number: P14415
Secondary accession number(s): A0AV17
, A8K278, D3DTQ2, O60444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.