Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P14406

- CX7A2_HUMAN

UniProt

P14406 - CX7A2_HUMAN

Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

COX7A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    Protein family/group databases

    TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7A2, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase subunit VIIa-liver/heart
    Short name:
    Cytochrome c oxidase subunit VIIa-L
    Short name:
    Cytochrome c oxidase subunit VIIaL
    Gene namesi
    Name:COX7A2
    Synonyms:COX7AL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:2288. COX7A2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial respiratory chain Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26806.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2323Mitochondrion1 PublicationAdd
    BLAST
    Chaini24 – 8360Cytochrome c oxidase subunit 7A2, mitochondrialPRO_0000006145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP14406.
    PRIDEiP14406.

    PTM databases

    PhosphoSiteiP14406.

    Expressioni

    Gene expression databases

    ArrayExpressiP14406.
    BgeeiP14406.
    CleanExiHS_COX7A2.
    GenevestigatoriP14406.

    Interactioni

    Subunit structurei

    Interacts with PET100.1 Publication

    Protein-protein interaction databases

    BioGridi107740. 3 interactions.
    IntActiP14406. 2 interactions.
    STRINGi9606.ENSP00000230459.

    Structurei

    3D structure databases

    ProteinModelPortaliP14406.
    SMRiP14406. Positions 24-81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIa family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000264231.
    HOVERGENiHBG051095.
    InParanoidiP14406.
    KOiK02270.
    OrthoDBiEOG7BGHNV.
    PhylomeDBiP14406.

    Family and domain databases

    Gene3Di4.10.91.10. 1 hit.
    InterProiIPR003177. Cyt_c_oxidase_su7a.
    [Graphical view]
    PANTHERiPTHR10510. PTHR10510. 1 hit.
    PfamiPF02238. COX7a. 1 hit.
    [Graphical view]
    SUPFAMiSSF81419. SSF81419. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA   50
    DALLYRATMI LTVGGTAYAI YELAVASFPK KQE 83
    Length:83
    Mass (Da):9,396
    Last modified:January 1, 1990 - v1
    Checksum:i490F45059CAF971F
    GO

    Sequence cautioni

    The sequence CAI19899.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401E → D.1 Publication
    VAR_012319

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15822 mRNA. Translation: CAA33820.1.
    AF134406 Genomic DNA. Translation: AAF61396.1.
    CR407646 mRNA. Translation: CAG28574.1.
    CR542125 mRNA. Translation: CAG46922.1.
    AK312154 mRNA. Translation: BAG35088.1.
    AL080250 Genomic DNA. Translation: CAI19899.1. Different initiation.
    BC101826 mRNA. Translation: AAI01827.1.
    BC101828 mRNA. Translation: AAI01829.1.
    PIRiS06897. OSHU7L.
    RefSeqiNP_001856.2. NM_001865.3.
    UniGeneiHs.70312.

    Genome annotation databases

    EnsembliENST00000230459; ENSP00000230459; ENSG00000112695.
    GeneIDi1347.
    KEGGihsa:1347.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15822 mRNA. Translation: CAA33820.1 .
    AF134406 Genomic DNA. Translation: AAF61396.1 .
    CR407646 mRNA. Translation: CAG28574.1 .
    CR542125 mRNA. Translation: CAG46922.1 .
    AK312154 mRNA. Translation: BAG35088.1 .
    AL080250 Genomic DNA. Translation: CAI19899.1 . Different initiation.
    BC101826 mRNA. Translation: AAI01827.1 .
    BC101828 mRNA. Translation: AAI01829.1 .
    PIRi S06897. OSHU7L.
    RefSeqi NP_001856.2. NM_001865.3.
    UniGenei Hs.70312.

    3D structure databases

    ProteinModelPortali P14406.
    SMRi P14406. Positions 24-81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107740. 3 interactions.
    IntActi P14406. 2 interactions.
    STRINGi 9606.ENSP00000230459.

    Protein family/group databases

    TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    PTM databases

    PhosphoSitei P14406.

    Proteomic databases

    MaxQBi P14406.
    PRIDEi P14406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230459 ; ENSP00000230459 ; ENSG00000112695 .
    GeneIDi 1347.
    KEGGi hsa:1347.

    Organism-specific databases

    CTDi 1347.
    GeneCardsi GC06M075947.
    H-InvDB HIX0200919.
    HGNCi HGNC:2288. COX7A2.
    MIMi 123996. gene.
    neXtProti NX_P14406.
    PharmGKBi PA26806.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000264231.
    HOVERGENi HBG051095.
    InParanoidi P14406.
    KOi K02270.
    OrthoDBi EOG7BGHNV.
    PhylomeDBi P14406.

    Miscellaneous databases

    ChiTaRSi COX7A2. human.
    GeneWikii COX7A2.
    GenomeRNAii 1347.
    NextBioi 5461.
    PROi P14406.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14406.
    Bgeei P14406.
    CleanExi HS_COX7A2.
    Genevestigatori P14406.

    Family and domain databases

    Gene3Di 4.10.91.10. 1 hit.
    InterProi IPR003177. Cyt_c_oxidase_su7a.
    [Graphical view ]
    PANTHERi PTHR10510. PTHR10510. 1 hit.
    Pfami PF02238. COX7a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81419. SSF81419. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase."
      Fabrizi G.M., Rizzuto R., Nakase H., Mita S., Lomax M.I., Grossman L.I., Schon E.A.
      Nucleic Acids Res. 17:7107-7107(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Endothelial cell.
    2. "Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene."
      Huettemann M., Muehlenbein N., Schmidt T.R., Grossman L.I., Kadenbach B.
      Biochim. Biophys. Acta 1492:252-258(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart."
      van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.
      Eur. J. Biochem. 203:193-199(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-53.
      Tissue: Heart and Liver.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."
      Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M., van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P., Nijtmans L.G., Huynen M.A.
      Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PET100.
    11. Devreese B.
      Submitted (DEC-2001) to UniProtKB
      Cited for: VARIANT ASP-40.

    Entry informationi

    Entry nameiCX7A2_HUMAN
    AccessioniPrimary (citable) accession number: P14406
    Secondary accession number(s): B2R5E1
    , Q3MIH5, Q5TF59, Q6FGI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3