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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

COX7A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS03606-MONOMER.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Short name:
Cytochrome c oxidase subunit VIIaL
Gene namesi
Name:COX7A2
Synonyms:COX7AL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2288. COX7A2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial respiratory chain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1347.
PharmGKBiPA26806.

Polymorphism and mutation databases

BioMutaiCOX7A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23Mitochondrion1 PublicationAdd BLAST23
ChainiPRO_000000614524 – 83Cytochrome c oxidase subunit 7A2, mitochondrialAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP14406.
MaxQBiP14406.
PaxDbiP14406.
PeptideAtlasiP14406.
PRIDEiP14406.
TopDownProteomicsiP14406.

PTM databases

iPTMnetiP14406.
PhosphoSitePlusiP14406.

Expressioni

Gene expression databases

BgeeiENSG00000112695.
CleanExiHS_COX7A2.

Interactioni

Subunit structurei

Interacts with PET100.1 Publication

Protein-protein interaction databases

BioGridi107740. 19 interactors.
IntActiP14406. 4 interactors.
STRINGi9606.ENSP00000359098.

Structurei

3D structure databases

ProteinModelPortaliP14406.
SMRiP14406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP14406.
KOiK02270.
PhylomeDBiP14406.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA
60 70 80
DALLYRATMI LTVGGTAYAI YELAVASFPK KQE
Length:83
Mass (Da):9,396
Last modified:January 1, 1990 - v1
Checksum:i490F45059CAF971F
GO

Sequence cautioni

The sequence CAI19899 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01231940E → D.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15822 mRNA. Translation: CAA33820.1.
AF134406 Genomic DNA. Translation: AAF61396.1.
CR407646 mRNA. Translation: CAG28574.1.
CR542125 mRNA. Translation: CAG46922.1.
AK312154 mRNA. Translation: BAG35088.1.
AL080250 Genomic DNA. Translation: CAI19899.1. Different initiation.
BC101826 mRNA. Translation: AAI01827.1.
BC101828 mRNA. Translation: AAI01829.1.
PIRiS06897. OSHU7L.
RefSeqiNP_001856.2. NM_001865.3.
UniGeneiHs.70312.

Genome annotation databases

EnsembliENST00000230459; ENSP00000230459; ENSG00000112695.
GeneIDi1347.
KEGGihsa:1347.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15822 mRNA. Translation: CAA33820.1.
AF134406 Genomic DNA. Translation: AAF61396.1.
CR407646 mRNA. Translation: CAG28574.1.
CR542125 mRNA. Translation: CAG46922.1.
AK312154 mRNA. Translation: BAG35088.1.
AL080250 Genomic DNA. Translation: CAI19899.1. Different initiation.
BC101826 mRNA. Translation: AAI01827.1.
BC101828 mRNA. Translation: AAI01829.1.
PIRiS06897. OSHU7L.
RefSeqiNP_001856.2. NM_001865.3.
UniGeneiHs.70312.

3D structure databases

ProteinModelPortaliP14406.
SMRiP14406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107740. 19 interactors.
IntActiP14406. 4 interactors.
STRINGi9606.ENSP00000359098.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiP14406.
PhosphoSitePlusiP14406.

Polymorphism and mutation databases

BioMutaiCOX7A2.

Proteomic databases

EPDiP14406.
MaxQBiP14406.
PaxDbiP14406.
PeptideAtlasiP14406.
PRIDEiP14406.
TopDownProteomicsiP14406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230459; ENSP00000230459; ENSG00000112695.
GeneIDi1347.
KEGGihsa:1347.

Organism-specific databases

CTDi1347.
DisGeNETi1347.
GeneCardsiCOX7A2.
H-InvDBHIX0200919.
HGNCiHGNC:2288. COX7A2.
MIMi123996. gene.
neXtProtiNX_P14406.
PharmGKBiPA26806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP14406.
KOiK02270.
PhylomeDBiP14406.

Enzyme and pathway databases

BioCyciZFISH:HS03606-MONOMER.

Miscellaneous databases

ChiTaRSiCOX7A2. human.
GeneWikiiCOX7A2.
GenomeRNAii1347.
PROiP14406.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112695.
CleanExiHS_COX7A2.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX7A2_HUMAN
AccessioniPrimary (citable) accession number: P14406
Secondary accession number(s): B2R5E1
, Q3MIH5, Q5TF59, Q6FGI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.