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P14406

- CX7A2_HUMAN

UniProt

P14406 - CX7A2_HUMAN

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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

COX7A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Short name:
Cytochrome c oxidase subunit VIIaL
Gene namesi
Name:COX7A2
Synonyms:COX7AL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2288. COX7A2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrial respiratory chain Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323Mitochondrion1 PublicationAdd
BLAST
Chaini24 – 8360Cytochrome c oxidase subunit 7A2, mitochondrialPRO_0000006145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP14406.
PRIDEiP14406.

PTM databases

PhosphoSiteiP14406.

Expressioni

Gene expression databases

BgeeiP14406.
CleanExiHS_COX7A2.
ExpressionAtlasiP14406. baseline and differential.
GenevestigatoriP14406.

Interactioni

Subunit structurei

Interacts with PET100.1 Publication

Protein-protein interaction databases

BioGridi107740. 5 interactions.
IntActiP14406. 2 interactions.
STRINGi9606.ENSP00000230459.

Structurei

3D structure databases

ProteinModelPortaliP14406.
SMRiP14406. Positions 24-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP14406.
KOiK02270.
OrthoDBiEOG7BGHNV.
PhylomeDBiP14406.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PfamiPF02238. COX7a. 1 hit.
[Graphical view]
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14406-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRNLLALRQ IGQRTISTAS RRHFKNKVPE KQKLFQEDDE IPLYLKGGVA
60 70 80
DALLYRATMI LTVGGTAYAI YELAVASFPK KQE
Length:83
Mass (Da):9,396
Last modified:January 1, 1990 - v1
Checksum:i490F45059CAF971F
GO

Sequence cautioni

The sequence CAI19899.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401E → D.1 Publication
VAR_012319

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15822 mRNA. Translation: CAA33820.1.
AF134406 Genomic DNA. Translation: AAF61396.1.
CR407646 mRNA. Translation: CAG28574.1.
CR542125 mRNA. Translation: CAG46922.1.
AK312154 mRNA. Translation: BAG35088.1.
AL080250 Genomic DNA. Translation: CAI19899.1. Different initiation.
BC101826 mRNA. Translation: AAI01827.1.
BC101828 mRNA. Translation: AAI01829.1.
PIRiS06897. OSHU7L.
RefSeqiNP_001856.2. NM_001865.3.
UniGeneiHs.70312.

Genome annotation databases

EnsembliENST00000230459; ENSP00000230459; ENSG00000112695.
GeneIDi1347.
KEGGihsa:1347.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15822 mRNA. Translation: CAA33820.1 .
AF134406 Genomic DNA. Translation: AAF61396.1 .
CR407646 mRNA. Translation: CAG28574.1 .
CR542125 mRNA. Translation: CAG46922.1 .
AK312154 mRNA. Translation: BAG35088.1 .
AL080250 Genomic DNA. Translation: CAI19899.1 . Different initiation.
BC101826 mRNA. Translation: AAI01827.1 .
BC101828 mRNA. Translation: AAI01829.1 .
PIRi S06897. OSHU7L.
RefSeqi NP_001856.2. NM_001865.3.
UniGenei Hs.70312.

3D structure databases

ProteinModelPortali P14406.
SMRi P14406. Positions 24-81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107740. 5 interactions.
IntActi P14406. 2 interactions.
STRINGi 9606.ENSP00000230459.

Protein family/group databases

TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSitei P14406.

Proteomic databases

MaxQBi P14406.
PRIDEi P14406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000230459 ; ENSP00000230459 ; ENSG00000112695 .
GeneIDi 1347.
KEGGi hsa:1347.

Organism-specific databases

CTDi 1347.
GeneCardsi GC06M075947.
H-InvDB HIX0200919.
HGNCi HGNC:2288. COX7A2.
MIMi 123996. gene.
neXtProti NX_P14406.
PharmGKBi PA26806.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000264231.
HOVERGENi HBG051095.
InParanoidi P14406.
KOi K02270.
OrthoDBi EOG7BGHNV.
PhylomeDBi P14406.

Miscellaneous databases

ChiTaRSi COX7A2. human.
GeneWikii COX7A2.
GenomeRNAii 1347.
NextBioi 5461.
PROi P14406.
SOURCEi Search...

Gene expression databases

Bgeei P14406.
CleanExi HS_COX7A2.
ExpressionAtlasi P14406. baseline and differential.
Genevestigatori P14406.

Family and domain databases

Gene3Di 4.10.91.10. 1 hit.
InterProi IPR003177. Cyt_c_oxidase_su7a.
[Graphical view ]
PANTHERi PTHR10510. PTHR10510. 1 hit.
Pfami PF02238. COX7a. 1 hit.
[Graphical view ]
SUPFAMi SSF81419. SSF81419. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase."
    Fabrizi G.M., Rizzuto R., Nakase H., Mita S., Lomax M.I., Grossman L.I., Schon E.A.
    Nucleic Acids Res. 17:7107-7107(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Endothelial cell.
  2. "Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene."
    Huettemann M., Muehlenbein N., Schmidt T.R., Grossman L.I., Kadenbach B.
    Biochim. Biophys. Acta 1492:252-258(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart."
    van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.
    Eur. J. Biochem. 203:193-199(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-53.
    Tissue: Heart and Liver.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase."
    Szklarczyk R., Wanschers B.F., Cuypers T.D., Esseling J.J., Riemersma M., van den Brand M.A., Gloerich J., Lasonder E., van den Heuvel L.P., Nijtmans L.G., Huynen M.A.
    Genome Biol. 13:RESEARCH0012.1-RESEARCH0012.14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PET100.
  11. Devreese B.
    Submitted (DEC-2001) to UniProtKB
    Cited for: VARIANT ASP-40.

Entry informationi

Entry nameiCX7A2_HUMAN
AccessioniPrimary (citable) accession number: P14406
Secondary accession number(s): B2R5E1
, Q3MIH5, Q5TF59, Q6FGI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3