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Reviewed, UniProtKB/Swiss-Prot P14383 (P5CR1_BACSU)

Last modified June 16, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pyrroline-5-carboxylate reductase 1
      Short name=P5C reductase 1
      Short name=P5CR 1
    EC=1.5.1.2
Gene names
Name: proH
Synonyms: proC, yoxE
Ordered Locus Names: BSU18480
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

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Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

proline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

pyrroline-5-carboxylate reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Pyrroline-5-carboxylate reductase 1
PRO_0000187285

Natural variations

Natural variant581T → A in strain: W23.
Natural variant701L → S in strain: W23.
Natural variant741L → I in strain: W23.
Natural variant931N → S in strain: W23.
Natural variant1001S → T in strain: W23.
Natural variant1271E → Q in strain: W23.
Natural variant1591K → Q in strain: W23.
Natural variant2361H → Q in strain: W23.
Natural variant2391I → V in strain: W23.

Experimental info

Sequence conflict2561Q → E Ref.3

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Sequences

Sequence LengthMass (Da)Tools
P14383-1 [UniParc].

Last modified September 26, 2001. Version 5.
Checksum: F4DC7E6F84C6ED42

FASTA29732,031
        10         20         30         40         50         60 
MRTKKRTKEM LPIFDQKKVA FIGAGSMAEG MISGIVRANK IPKQNICVTN RSNTERLTEL 

        70         80         90        100        110        120 
ELQYGIKGAL PNQLCIEDMD VLILAMKPKD AENALSSLKS RIQPHQLILS VLAGITTSFI 

       130        140        150        160        170        180 
EQSLLNEQPV VRVMPNTSSM IGASATAIAL GKYVSEDLKK LAEALLGCMG EVYTIQENQM 

       190        200        210        220        230        240 
DIFTGIAGSG PAYFYYLMEF IEKTGEEAGL DKQLSRSIGA QTLLGAAKML METGEHPEIL 

       250        260        270        280        290 
RDNITSPNGT TAAGLQALKK SGGGEAISQA IKHAAKRSKE ISEDIEKTAA PLSGVIK

« Hide

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References

« Hide 'large scale' references
[1]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[2]"Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence."
Medigue C., Rose M., Viari A., Danchin A.
Genome Res. 9:1116-1127(1999) [PubMed: 10568751] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Variations and coding features of the sequence spanning the replication terminus of Bacillus subtilis 168 and W23 chromosomes."
Ahn K.S., Wake R.G.
Gene 98:107-112(1991) [PubMed: 1849493] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-256.
Strain: 168 and W23.
[4]"DNA and protein sequence conservation at the replication terminus in Bacillus subtilis 168 and W23."
Lewis P.J., Wake R.G.
J. Bacteriol. 171:1402-1408(1989) [PubMed: 2493444] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-200.
Strain: W23.
[5]"Multiple genes for the last step of proline biosynthesis in Bacillus subtilis."
Belitsky B.R., Brill J., Bremer E., Sonenshein A.L.
J. Bacteriol. 183:4389-4392(2001) [PubMed: 11418582] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-297, FUNCTION.
Strain: 168 / SMY.

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Cross-references

Sequence databases

AL009126 Genomic DNA. Translation: CAB13741.2.
M24523 Genomic DNA. Translation: AAA22722.1.
AF006720 Genomic DNA. Translation: AAB62697.1.
PIRE69682.
RefSeqNP_389730.2.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID940035.
GenomeReviewsGene locus BSU18480 in contig AL009126_GR.
KEGGbsu:BSU18480.

Organism-specific databases

SubtiListBG11049. proH. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP14383.
OMAP14383. APSGHSK.

Enzyme and pathway databases

BioCycBSUB224308:BSU1848-MON.
BRENDA1.5.1.2. 150.

Family and domain databases

InterProIPR004455. NADP_OxRdtase_F420.
IPR000304. P5CR.
[Graphical view]
PANTHERPTHR11645. P5CR. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMsTIGR00112. proC. 1 hit.
PROSITEPS00521. P5CR. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameP5CR1_BACSU
AccessionPrimary (citable) accession number: P14383
Secondary accession number(s): O07508, O31828
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: September 26, 2001
Last modified: June 16, 2009
This is version 79 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents