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P14359

- SNA3_YEAST

UniProt

P14359 - SNA3_YEAST

Protein

Protein SNA3

Gene

SNA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitin protein ligase binding Source: SGD

    GO - Biological processi

    1. cellular protein catabolic process Source: SGD
    2. endosome transport via multivesicular body sorting pathway Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31594-MONOMER.

    Protein family/group databases

    TCDBi9.B.12.3.1. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SNA3
    Gene namesi
    Name:SNA3
    Ordered Locus Names:YJL151C
    ORF Names:J0630
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL151c.
    SGDiS000003687. SNA3.

    Subcellular locationi

    Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Vacuole lumen. Cytoplasmic vesicle membrane Curated; Multi-pass membrane protein Curated
    Note: Sorted via late endosomes to the vacuolar lumen in a ubiquitin-independent manner.

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. fungal-type vacuole Source: SGD
    3. fungal-type vacuole lumen Source: SGD
    4. integral component of membrane Source: SGD
    5. late endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 133133Protein SNA3PRO_0000193990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki125 – 125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP14359.
    PaxDbiP14359.

    Expressioni

    Gene expression databases

    GenevestigatoriP14359.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RSP5P399402EBI-26122,EBI-16219

    Protein-protein interaction databases

    BioGridi33608. 68 interactions.
    DIPiDIP-1730N.
    IntActiP14359. 49 interactions.
    MINTiMINT-409887.
    STRINGi4932.YJL151C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LCDX-ray3.10C/D104-127[»]
    ProteinModelPortaliP14359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 4811LumenalSequence AnalysisAdd
    BLAST
    Topological domaini70 – 13364CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0057 (PMP3) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0401.
    HOGENOMiHOG000154356.
    OMAiAGARICF.
    OrthoDBiEOG70CRMF.

    Family and domain databases

    InterProiIPR000612. PMP3.
    [Graphical view]
    PANTHERiPTHR21659. PTHR21659. 1 hit.
    PfamiPF01679. Pmp3. 1 hit.
    [Graphical view]
    PROSITEiPS01309. UPF0057. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRDHINDHD HRMSYSINKD DLLLMVLAVF IPPVAVWKRK GMFNRDTLLN    50
    LLLFLLLFFP AIIHACYVVY ETSSERSYDL SRRHATAPAV DRDLEAHPAE 100
    ESQAQPPAYD EDDEAGADVP LMDNKQQLSS GRT 133
    Length:133
    Mass (Da):15,199
    Last modified:April 18, 2006 - v3
    Checksum:iDBA26AF5B769C02A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04453 Genomic DNA. Translation: AAA66309.1.
    Z49427 Genomic DNA. Translation: CAA89447.1.
    X87371 Genomic DNA. Translation: CAA60804.1.
    AY692894 Genomic DNA. Translation: AAT92913.1.
    BK006943 Genomic DNA. Translation: DAA08651.1.
    PIRiA32209. B30902.
    RefSeqiNP_012384.1. NM_001181584.1.

    Genome annotation databases

    EnsemblFungiiYJL151C; YJL151C; YJL151C.
    GeneIDi853290.
    KEGGisce:YJL151C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04453 Genomic DNA. Translation: AAA66309.1 .
    Z49427 Genomic DNA. Translation: CAA89447.1 .
    X87371 Genomic DNA. Translation: CAA60804.1 .
    AY692894 Genomic DNA. Translation: AAT92913.1 .
    BK006943 Genomic DNA. Translation: DAA08651.1 .
    PIRi A32209. B30902.
    RefSeqi NP_012384.1. NM_001181584.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LCD X-ray 3.10 C/D 104-127 [» ]
    ProteinModelPortali P14359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33608. 68 interactions.
    DIPi DIP-1730N.
    IntActi P14359. 49 interactions.
    MINTi MINT-409887.
    STRINGi 4932.YJL151C.

    Protein family/group databases

    TCDBi 9.B.12.3.1. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

    Proteomic databases

    MaxQBi P14359.
    PaxDbi P14359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL151C ; YJL151C ; YJL151C .
    GeneIDi 853290.
    KEGGi sce:YJL151C.

    Organism-specific databases

    CYGDi YJL151c.
    SGDi S000003687. SNA3.

    Phylogenomic databases

    eggNOGi COG0401.
    HOGENOMi HOG000154356.
    OMAi AGARICF.
    OrthoDBi EOG70CRMF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31594-MONOMER.

    Miscellaneous databases

    NextBioi 973594.

    Gene expression databases

    Genevestigatori P14359.

    Family and domain databases

    InterProi IPR000612. PMP3.
    [Graphical view ]
    PANTHERi PTHR21659. PTHR21659. 1 hit.
    Pfami PF01679. Pmp3. 1 hit.
    [Graphical view ]
    PROSITEi PS01309. UPF0057. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus."
      Dean-Johnson M., Henry S.A.
      J. Biol. Chem. 264:1274-1283(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
      Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
      Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting."
      Reggiori F., Pelham H.R.B.
      EMBO J. 20:5176-5186(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
      Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
      Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-125.
    10. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    11. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNA3_YEAST
    AccessioniPrimary (citable) accession number: P14359
    Secondary accession number(s): D6VW35, Q6B236
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 12500 molecules/cell in log phase SD medium.1 Publication

    Caution

    It is uncertain whether Met-1 or Met-13 is the initiator.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3