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Reviewed, UniProtKB/Swiss-Prot P14359 (SNA3_YEAST)

Last modified November 24, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein SNA3
Gene names
Name: SNA3
Ordered Locus Names: YJL151C
ORF Names: J0630
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Vacuole lumen. Cytoplasmic vesicle membrane; Multi-pass membrane protein Potential. Note: Sorted via late endosomes to the vacuolar lumen in a ubiquitin-independent manner.

Miscellaneous

Present with 12500 molecules/cell in log phase SD medium. Ref.7

Sequence similarities

Belongs to the UPF0057 (PMP3) family.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-26122,EBI-26122
P253611EBI-26122,EBI-21909
P283211EBI-26122,EBI-26790
P286251EBI-26122,EBI-27313
P388451EBI-26122,EBI-24770
ACF2Q121681EBI-26122,EBI-32973
AGP1P253761EBI-26122,EBI-2357
ARF1P110761EBI-26122,EBI-2816
ARO8P530901EBI-26122,EBI-2042933
AYR1P404711EBI-26122,EBI-25213
COG3P400941EBI-26122,EBI-16605
CYS4P325821EBI-26122,EBI-4167
EHT1P382951EBI-26122,EBI-20890
ERG1P324761EBI-26122,EBI-6545
ERG27Q124521EBI-26122,EBI-38132
ERG7P386041EBI-26122,EBI-6572
FAT1P382251EBI-26122,EBI-6819
GAP1P191451EBI-26122,EBI-7314
GCS1P351971EBI-26122,EBI-7475
GLN1P322881EBI-26122,EBI-7665
GTT1P405821EBI-26122,EBI-7941
HSP30P256191EBI-26122,EBI-8563
HXT1P324651EBI-26122,EBI-8759
HXT3P324661EBI-26122,EBI-8770
HXT7P390041EBI-26122,EBI-8790
IPP1P008171EBI-26122,EBI-9338
KES1P358441EBI-26122,EBI-9648
KRE27P405401EBI-26122,EBI-24977
LCB1P250451EBI-26122,EBI-10059
LSB3P436031EBI-26122,EBI-22980
MEH1Q022051EBI-26122,EBI-27062
MID2P360271EBI-26122,EBI-10901
MUP1P502761EBI-26122,EBI-11624
PDR12Q027851EBI-26122,EBI-13065
PLM2Q043831EBI-26122,EBI-2079237
PMP2P409751EBI-26122,EBI-2043041
PMP3P872841EBI-26122,EBI-13555
RER2P351961EBI-26122,EBI-14943
RET2P436211EBI-26122,EBI-4876
RSP5P399401EBI-26122,EBI-16219
RTN1Q049471EBI-26122,EBI-38020
SEC21P320741EBI-26122,EBI-4891
SEC26P418101EBI-26122,EBI-4869
SEC27P418111EBI-26122,EBI-4898
SEL1Q042281EBI-26122,EBI-27730
SLC1P333331EBI-26122,EBI-13494
SLY1P222131EBI-26122,EBI-17387
SPF1P399861EBI-26122,EBI-3128
TGL1P341631EBI-26122,EBI-19177
TPO2P532831EBI-26122,EBI-2044753
TSC10P383421EBI-26122,EBI-21124
VAC8P399681EBI-26122,EBI-20212
VAS1P07806-11EBI-26122,EBI-1009942
VMA13P418071EBI-26122,EBI-20281
VMA4P222031EBI-26122,EBI-20268
VMA7P391111EBI-26122,EBI-20272
VMA8P326101EBI-26122,EBI-20264
VPS35P341101EBI-26122,EBI-20415
VPS66Q065081EBI-26122,EBI-36961
YEH1Q078041EBI-26122,EBI-36254

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 133133Protein SNA3
PRO_0000193990

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721 Potential
Topological domain38 – 4811Lumenal Potential
Transmembrane49 – 6921 Potential
Topological domain70 – 13364Cytoplasmic Potential

Amino acid modifications

Modified residue861Phosphothreonine Ref.10
Cross-link125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.8

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Sequences

Sequence LengthMass (Da)Tools
P14359-1 [UniParc].

Last modified April 18, 2006. Version 3.
Checksum: DBA26AF5B769C02A

FASTA13315,199
        10         20         30         40         50         60 
MDRDHINDHD HRMSYSINKD DLLLMVLAVF IPPVAVWKRK GMFNRDTLLN LLLFLLLFFP 

        70         80         90        100        110        120 
AIIHACYVVY ETSSERSYDL SRRHATAPAV DRDLEAHPAE ESQAQPPAYD EDDEAGADVP 

       130 
LMDNKQQLSS GRT

« Hide

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References

« Hide 'large scale' references
[1]"Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus."
Dean-Johnson M., Henry S.A.
J. Biol. Chem. 264:1274-1283(1989) [PubMed: 2642902] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
Yeast 12:787-797(1996) [PubMed: 8813765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting."
Reggiori F., Pelham H.R.B.
EMBO J. 20:5176-5186(2001) [PubMed: 11566881] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed: 14557538] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-125, MASS SPECTROMETRY.
[9]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[10]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

J04453 Genomic DNA. Translation: AAA66309.1.
Z49427 Genomic DNA. Translation: CAA89447.1.
X87371 Genomic DNA. Translation: CAA60804.1.
AY692894 Genomic DNA. Translation: AAT92913.1.
PIRB30902. A32209.
RefSeqNP_012384.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1730N.
IntActP14359. 75 interactions.
STRINGP14359.

Protein family/group databases

TCDB9.B.12.3.1. (Salt or low Temperature) stress-induced hydrophobic peptide (SHP) family.

Genome annotation databases

EnsemblYJL151C; YJL151C; YJL151C; Saccharomyces cerevisiae. [Genome view]
GeneID853290.
KEGGsce:YJL151C.
NMPDRfig|4932.3.peg.3349.

Organism-specific databases

CYGDYJL151c.
SGDS000003687. SNA3.

Phylogenomic databases

OrthoDBEOG93XWKN

Gene expression databases

ArrayExpressP14359.
GenevestigatorP14359.
GermOnlineYJL151C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000612. UPF0057.
[Graphical view]
PANTHERPTHR21659. UPF0057. 1 hit.
PfamPF01679. UPF0057. 1 hit.
[Graphical view]
PROSITEPS01309. UPF0057. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio973594.

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Entry information

Entry nameSNA3_YEAST
AccessionPrimary (citable) accession number: P14359
Secondary accession number(s): Q6B236
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 18, 2006
Last modified: November 24, 2009
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents