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P14359

- SNA3_YEAST

UniProt

P14359 - SNA3_YEAST

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Protein

Protein SNA3

Gene

SNA3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  1. cellular protein catabolic process Source: SGD
  2. endosome transport via multivesicular body sorting pathway Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31594-MONOMER.

Protein family/group databases

TCDBi9.B.12.3.1. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SNA3
Gene namesi
Name:SNA3
Ordered Locus Names:YJL151C
ORF Names:J0630
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL151c.
SGDiS000003687. SNA3.

Subcellular locationi

Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Vacuole lumen. Cytoplasmic vesicle membrane Curated; Multi-pass membrane protein Curated
Note: Sorted via late endosomes to the vacuolar lumen in a ubiquitin-independent manner.

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. endosome Source: UniProtKB-KW
  3. fungal-type vacuole Source: SGD
  4. fungal-type vacuole lumen Source: SGD
  5. integral component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Protein SNA3PRO_0000193990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki125 – 125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP14359.
PaxDbiP14359.

Expressioni

Gene expression databases

GenevestigatoriP14359.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-26122,EBI-16219

Protein-protein interaction databases

BioGridi33608. 68 interactions.
DIPiDIP-1730N.
IntActiP14359. 49 interactions.
MINTiMINT-409887.
STRINGi4932.YJL151C.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LCDX-ray3.10C/D104-127[»]
ProteinModelPortaliP14359.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini38 – 4811LumenalSequence AnalysisAdd
BLAST
Topological domaini70 – 13364CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0057 (PMP3) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0401.
HOGENOMiHOG000154356.
InParanoidiP14359.
OMAiAGARICF.
OrthoDBiEOG70CRMF.

Family and domain databases

InterProiIPR000612. PMP3.
[Graphical view]
PANTHERiPTHR21659. PTHR21659. 1 hit.
PfamiPF01679. Pmp3. 1 hit.
[Graphical view]
PROSITEiPS01309. UPF0057. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14359-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRDHINDHD HRMSYSINKD DLLLMVLAVF IPPVAVWKRK GMFNRDTLLN
60 70 80 90 100
LLLFLLLFFP AIIHACYVVY ETSSERSYDL SRRHATAPAV DRDLEAHPAE
110 120 130
ESQAQPPAYD EDDEAGADVP LMDNKQQLSS GRT
Length:133
Mass (Da):15,199
Last modified:April 18, 2006 - v3
Checksum:iDBA26AF5B769C02A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04453 Genomic DNA. Translation: AAA66309.1.
Z49427 Genomic DNA. Translation: CAA89447.1.
X87371 Genomic DNA. Translation: CAA60804.1.
AY692894 Genomic DNA. Translation: AAT92913.1.
BK006943 Genomic DNA. Translation: DAA08651.1.
PIRiA32209. B30902.
RefSeqiNP_012384.1. NM_001181584.1.

Genome annotation databases

EnsemblFungiiYJL151C; YJL151C; YJL151C.
GeneIDi853290.
KEGGisce:YJL151C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04453 Genomic DNA. Translation: AAA66309.1 .
Z49427 Genomic DNA. Translation: CAA89447.1 .
X87371 Genomic DNA. Translation: CAA60804.1 .
AY692894 Genomic DNA. Translation: AAT92913.1 .
BK006943 Genomic DNA. Translation: DAA08651.1 .
PIRi A32209. B30902.
RefSeqi NP_012384.1. NM_001181584.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LCD X-ray 3.10 C/D 104-127 [» ]
ProteinModelPortali P14359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33608. 68 interactions.
DIPi DIP-1730N.
IntActi P14359. 49 interactions.
MINTi MINT-409887.
STRINGi 4932.YJL151C.

Protein family/group databases

TCDBi 9.B.12.3.1. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

Proteomic databases

MaxQBi P14359.
PaxDbi P14359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL151C ; YJL151C ; YJL151C .
GeneIDi 853290.
KEGGi sce:YJL151C.

Organism-specific databases

CYGDi YJL151c.
SGDi S000003687. SNA3.

Phylogenomic databases

eggNOGi COG0401.
HOGENOMi HOG000154356.
InParanoidi P14359.
OMAi AGARICF.
OrthoDBi EOG70CRMF.

Enzyme and pathway databases

BioCyci YEAST:G3O-31594-MONOMER.

Miscellaneous databases

NextBioi 973594.

Gene expression databases

Genevestigatori P14359.

Family and domain databases

InterProi IPR000612. PMP3.
[Graphical view ]
PANTHERi PTHR21659. PTHR21659. 1 hit.
Pfami PF01679. Pmp3. 1 hit.
[Graphical view ]
PROSITEi PS01309. UPF0057. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus."
    Dean-Johnson M., Henry S.A.
    J. Biol. Chem. 264:1274-1283(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
    Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
    Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting."
    Reggiori F., Pelham H.R.B.
    EMBO J. 20:5176-5186(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
    Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-125.
  10. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  11. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNA3_YEAST
AccessioniPrimary (citable) accession number: P14359
Secondary accession number(s): D6VW35, Q6B236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 12500 molecules/cell in log phase SD medium.1 Publication

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3