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P14359 (SNA3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SNA3
Gene names
Name:SNA3
Ordered Locus Names:YJL151C
ORF Names:J0630
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Vacuole lumen. Cytoplasmic vesicle membrane; Multi-pass membrane protein Potential. Note: Sorted via late endosomes to the vacuolar lumen in a ubiquitin-independent manner. Ref.6 Ref.7

Miscellaneous

Present with 12500 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the UPF0057 (PMP3) family.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RSP5P399402EBI-26122,EBI-16219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 133133Protein SNA3
PRO_0000193990

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 4811Lumenal Potential
Transmembrane49 – 6921Helical; Potential
Topological domain70 – 13364Cytoplasmic Potential

Amino acid modifications

Cross-link125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9

Sequences

Sequence LengthMass (Da)Tools
P14359 [UniParc].

Last modified April 18, 2006. Version 3.
Checksum: DBA26AF5B769C02A

FASTA13315,199
        10         20         30         40         50         60 
MDRDHINDHD HRMSYSINKD DLLLMVLAVF IPPVAVWKRK GMFNRDTLLN LLLFLLLFFP 

        70         80         90        100        110        120 
AIIHACYVVY ETSSERSYDL SRRHATAPAV DRDLEAHPAE ESQAQPPAYD EDDEAGADVP 

       130 
LMDNKQQLSS GRT 

« Hide

References

« Hide 'large scale' references
[1]"Biosynthesis of inositol in yeast. Primary structure of myo-inositol-1-phosphate synthase (EC 5.5.1.4) and functional analysis of its structural gene, the INO1 locus."
Dean-Johnson M., Henry S.A.
J. Biol. Chem. 264:1274-1283(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI."
Katsoulou C., Tzermia M., Tavernarakis N., Alexandraki D.
Yeast 12:787-797(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting."
Reggiori F., Pelham H.R.B.
EMBO J. 20:5176-5186(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-125.
[10]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[11]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04453 Genomic DNA. Translation: AAA66309.1.
Z49427 Genomic DNA. Translation: CAA89447.1.
X87371 Genomic DNA. Translation: CAA60804.1.
AY692894 Genomic DNA. Translation: AAT92913.1.
BK006943 Genomic DNA. Translation: DAA08651.1.
PIRB30902. A32209.
RefSeqNP_012384.1. NM_001181584.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4LCDX-ray3.10C/D104-127[»]
ProteinModelPortalP14359.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33608. 68 interactions.
DIPDIP-1730N.
IntActP14359. 49 interactions.
MINTMINT-409887.
STRING4932.YJL151C.

Protein family/group databases

TCDB9.B.12.3.1. the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family.

Proteomic databases

MaxQBP14359.
PaxDbP14359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL151C; YJL151C; YJL151C.
GeneID853290.
KEGGsce:YJL151C.

Organism-specific databases

CYGDYJL151c.
SGDS000003687. SNA3.

Phylogenomic databases

eggNOGCOG0401.
HOGENOMHOG000154356.
OMAAGARICF.
OrthoDBEOG70CRMF.

Enzyme and pathway databases

BioCycYEAST:G3O-31594-MONOMER.

Gene expression databases

GenevestigatorP14359.

Family and domain databases

InterProIPR000612. PMP3.
[Graphical view]
PANTHERPTHR21659. PTHR21659. 1 hit.
PfamPF01679. Pmp3. 1 hit.
[Graphical view]
PROSITEPS01309. UPF0057. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973594.

Entry information

Entry nameSNA3_YEAST
AccessionPrimary (citable) accession number: P14359
Secondary accession number(s): D6VW35, Q6B236
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 18, 2006
Last modified: June 11, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references