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Reviewed, UniProtKB/Swiss-Prot P14336 (POLG_TBEVW)

Last modified June 16, 2009. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Genome polyprotein
Cleaved into the following 10 chains:
    1- Recommended name:
            Protein C
        Alternative name(s):
            Core protein
            Capsid protein
    2- Recommended name:
            Small envelope protein M
        Alternative name(s):
            Matrix protein
    3- Recommended name:
            Envelope protein E
    4- Recommended name:
            Non-structural protein 1
                Short name=NS1
    5- Recommended name:
            Non-structural protein 2A
                Short name=NS2A
    6- Recommended name:
            Flavivirin protease NS2B regulatory subunit
    7- Recommended name:
            Flavivirin protease NS3 catalytic subunit
              EC=3.4.21.91
    8- Recommended name:
            Non-structural protein 4A
                Short name=NS4A
    9- Recommended name:
            Non-structural protein 4B
                Short name=NS4B
    10- Recommended name:
            RNA-directed RNA polymerase
              EC=2.7.7.48
        Alternative name(s):
            NS5
OrganismTick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus) [Complete proteome]
Taxonomic identifier11088 [NCBI]
Taxonomic lineageViruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Flavivirus › tick-borne encephalitis virus group
Virus hostIxodes ricinus (Sheep tick) [TaxID: 34613]
Ixodes persulcatus (Taiga tick) [TaxID: 34615]

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Protein attributes

Sequence length3414 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein.

Catalytic activity

Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

NS3 and NS2B form a heterodimer. NS3 is the catalytic subunit, whereas NS2B strongly stimulates the latter By similarity.

Subcellular location

Protein C: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Small envelope protein M: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Envelope protein E: Virion Potential. Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 4A: Host membrane; Single-pass membrane protein Potential.

Non-structural protein 4B: Host membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins By similarity.

Miscellaneous

The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E By similarity.

Sequence similarities

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 peptidase S7 domain.

Contains 1 RdRp catalytic domain.

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Ontologies

Keywords
   Biological processRNA replication
   Cellular componentCapsid protein
Core protein
Envelope protein
Membrane
Virion
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
Nucleotidyltransferase
RNA-directed RNA polymerase
Transferase
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processRNA metabolic process

Inferred from electronic annotation. Source: InterPro

methylation

Inferred from electronic annotation. Source: InterPro

transcription, RNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

viral genome replication

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

methyltransferase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host
Chain2 – 112111Protein C
PRO_0000037815
Propeptide113 – 20593
PRO_0000037816
Chain206 – 28075Small envelope protein M
PRO_0000037817
Chain281 – 776496Envelope protein E
PRO_0000037818
Chain777 – 1128352Non-structural protein 1
PRO_0000037819
Chain1129 – 1358230Non-structural protein 2A
PRO_0000037820
Chain1359 – 1489131Flavivirin protease NS2B regulatory subunit
PRO_0000037821
Chain1490 – 2110621Flavivirin protease NS3 catalytic subunit
PRO_0000037822
Chain2111 – 2259149Non-structural protein 4A
PRO_0000037823
Chain2260 – 2511252Non-structural protein 4B
PRO_0000037824
Chain2512 – 3414903RNA-directed RNA polymerase
PRO_0000037825

Regions

Transmembrane101 – 11212Hydrophobic signal sequence Potential
Transmembrane247 – 25913 Potential
Transmembrane266 – 28015 Potential
Transmembrane738 – 75114 Potential
Domain1496 – 1672177Peptidase S7
Domain1675 – 1831157Helicase ATP-binding
Domain1841 – 2000160Helicase C-terminal
Domain3040 – 3189150RdRp catalytic
Nucleotide binding1688 – 16958ATP Potential
Region378 – 39114Involved in fusion
Motif1779 – 17824DEAH box

Sites

Active site15431Charge relay system By similarity
Active site15671Charge relay system By similarity
Active site16271Charge relay system By similarity

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...); by host Potential
Glycosylation4341N-linked (GlcNAc...); by host Potential
Glycosylation8611N-linked (GlcNAc...); by host Potential
Glycosylation9831N-linked (GlcNAc...); by host Potential
Glycosylation9991N-linked (GlcNAc...); by host Potential
Glycosylation24471N-linked (GlcNAc...); by host Potential
Disulfide bond283 ↔ 310
Disulfide bond340 ↔ 396
Disulfide bond354 ↔ 385
Disulfide bond372 ↔ 401
Disulfide bond466 ↔ 570
Disulfide bond587 ↔ 618

Secondary structure

1 ......................................................................... 3414
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P14336-1 [UniParc].

Last modified May 30, 2000. Version 4.
Checksum: 35DBCE014B310B79

FASTA3,414378,322
        10         20         30         40         50         60 
MVKKAILKGK GGGPPRRVSK ETATKTRQPR VQMPNGLVLM RMMGILWHAV AGTARNPVLK 

        70         80         90        100        110        120 
AFWNSVPLKQ ATAALRKIKR TVSALMVGLQ KRGKRRSATD WMSWLLVITL LGMTLAATVR 

       130        140        150        160        170        180 
KERDGSTVIR AEGKDAATQV RVENGTCVIL ATDMGSWCDD SLSYECVTID QGEEPVDVDC 

       190        200        210        220        230        240 
FCRNVDGVYL EYGRCGKQEG SRTRRSVLIP SHAQGELTGR GHKWLEGDSL RTHLTRVEGW 

       250        260        270        280        290        300 
VWKNKLLALA MVTVVWLTLE SVVTRVAVLV VLLCLAPVYA SRCTHLENRD FVTGTQGTTR 

       310        320        330        340        350        360 
VTLVLELGGC VTITAEGKPS MDVWLDAIYQ ENPAKTREYC LHAKLSDTKV AARCPTMGPA 

       370        380        390        400        410        420 
TLAEEHQGGT VCKRDQSDRG WGNHCGLFGK GSIVACVKAA CEAKKKATGH VYDANKIVYT 

       430        440        450        460        470        480 
VKVEPHTGDY VAANETHSGR KTASFTISSE KTILTMGEYG DVSLLCRVAS GVDLAQTVIL 

       490        500        510        520        530        540 
ELDKTVEHLP TAWQVHRDWF NDLALPWKHE GAQNWNNAER LVEFGAPHAV KMDVYNLGDQ 

       550        560        570        580        590        600 
TGVLLKALAG VPVAHIEGTK YHLKSGHVTC EVGLEKLKMK GLTYTMCDKT KFTWKRAPTD 

       610        620        630        640        650        660 
SGHDTVVMEV TFSGTKPCRI PVRAVAHGSP DVNVAMLITP NPTIENNGGG FIEMQLPPGD 

       670        680        690        700        710        720 
NIIYVGELSH QWFQKGSSIG RVFQKTKKGI ERLTVIGEHA WDFGSAGGFL SSIGKAVHTV 

       730        740        750        760        770        780 
LGGAFNSIFG GVGFLPKLLL GVALAWLGLN MRNPTMSMSF LLAGGLVLAM TLGVGADVGC 

       790        800        810        820        830        840 
AVDTERMELR CGEGLVVWRE VSEWYDNYAY YPETPGALAS AIKETFEEGS CGVVPQNRLE 

       850        860        870        880        890        900 
MAMWRSSVTE LNLALAEGEA NLTVVVDKFD PTDYRGGVPG LLKKGKDIKV SWKSWGHSMI 

       910        920        930        940        950        960 
WSIPEAPRRF MVGTEGQSEC PLERRKTGVF TVAEFGVGLR TKVFLDFRQE PTHECDTGVM 

       970        980        990       1000       1010       1020 
GAAVKNGMAI HTDQSLWMRS MKNDTGTYIV ELLVTDLRNC SWPASHTIDN ADVVDSELFL 

      1030       1040       1050       1060       1070       1080 
PASLAGPRSW YNRIPGYSEQ VKGPWKYTPI RVIREECPGT TVTINAKCDK RGASVRSTTE 

      1090       1100       1110       1120       1130       1140 
SGKVIPEWCC RACTMPPVTF RTGTDCWYAM EIRPVHDQGG LVRSMVVADN GELLSEGGVP 

      1150       1160       1170       1180       1190       1200 
GIVALFVVLE YIIRRRPSTG TTVVWGGIVV LALLVTGMVR IESLVRYVVA VGITFHLELG 

      1210       1220       1230       1240       1250       1260 
PEIVALMLLQ AVFELRVGLL SAFALRRSLT VREMVTTYFL LLVLELGLPG ASLEEFWKWG 

      1270       1280       1290       1300       1310       1320 
DALAMGALIF RACTAEGKTG AGLLLMALMT QQDVVTVHHG LVCFLSVASA CSVWRLLKGH 

      1330       1340       1350       1360       1370       1380 
REQKGLTWVV PLAGLLGGEG SGIRLLAFWE LSAHRGRRSF SEPLTVVGVM LTLASGMMRH 

      1390       1400       1410       1420       1430       1440 
TSQEALCALA VASFLLLMLV LGTRKMQLVA EWSGCVEWYP ELVNEGGEVS LRVRQDAMGN 

      1450       1460       1470       1480       1490       1500 
FHLTELEKEE RMMAFWLIAG LAASAIHWSG ILGVMGLWTL TEMLRSSRRS DLVFSGQGGR 

      1510       1520       1530       1540       1550       1560 
ERGDRPFEVK DGVYRIFSPG LFWGQNQVGV GYGSKGVLHT MWHVTRGAAL SIDDAVAGPY 

      1570       1580       1590       1600       1610       1620 
WADVREDVVC YGGAWSLEEK WKGETVQVHA FPPGRAHEVH QCQPGELILD TGRKLGAIPI 

      1630       1640       1650       1660       1670       1680 
DLVKGTSGSP ILNAQGVVVG LYGNGLKTNE TYVSSIAQGE AEKSRPNLPQ AVVGTGWTSK 

      1690       1700       1710       1720       1730       1740 
GQITVLDMHP GSGKTHRVLP ELIRQCIDRR LRTLVLAPTR VVLKEMERAL NGKRVRFHSP 

      1750       1760       1770       1780       1790       1800 
AVSDQQAGGA IVDVMCHATY VNRRLLPQGR QNWEVAIMDE AHWTDPHSIA ARGHLYTLAK 

      1810       1820       1830       1840       1850       1860 
ENKCALVLMT ATPPGKSEPF PESNGAITSE ERQIPDGEWR DGFDWITEYE GRTAWFVPSI 

      1870       1880       1890       1900       1910       1920 
AKGGAIARTL RQKGKSVICL NSKTFEKDYS RVRDEKPDFV VTTDISEMGA NLDVSRVIDG 

      1930       1940       1950       1960       1970       1980 
RTNIKPEEVD GKVELTGTRR VTTASAAQRR GRVGRQDGRT DEYIYSGQCD DDDSGLVQWK 

      1990       2000       2010       2020       2030       2040 
EAQILLDNIT TLRGPVATFY GPEQDKMPEV AGHFRLTEEK RKHFRHLLTH CDFTPWLAWH 

      2050       2060       2070       2080       2090       2100 
VAANVSSVTD RSWTWEGPEA NAVDEASGDL VTFRSPNGAE RTLRPVWKDA RMFKEGRDIK 

      2110       2120       2130       2140       2150       2160 
EFVAYASGRR SFGDVLTGMS GVPELLRHRC VSALDVFYTL MHEEPGSRAM RMAERDAPEA 

      2170       2180       2190       2200       2210       2220 
FLTMVEMMVL GLATLGVIWC FVVRTSISRM MLGTLVLLAS LLLLWAGGVG YGNMAGVALI 

      2230       2240       2250       2260       2270       2280 
FYTLLTVLQP EAGKQRSSDD NKLAYFLLTL CSLAGLVAAN EMGFLEKTKA DLSTALWSER 

      2290       2300       2310       2320       2330       2340 
EEPRPWSEWT NVDIQPARSW GTYVLVVSLF TPYIIHQLQT KIQQLVNSAV ASGAQAMRDL 

      2350       2360       2370       2380       2390       2400 
GGGAPFFGVA GHVMTLGVVS LIGATPTSLM VGVGLAALHL AIVVSGLEAE LTQRAHKVFF 

      2410       2420       2430       2440       2450       2460 
SAMVRNPMVD GDVINPFGEG EAKPALYERK MSLVLATVLC LMSVVMNRTV ASITEASAVG 

      2470       2480       2490       2500       2510       2520 
LAAAGQLLRP EADTLWTMPV ACGMSGVVRG SLWGFLPLGH RLWLRASGGR RGGSEGDTLG 

      2530       2540       2550       2560       2570       2580 
DLWKRRLNNC TREEFFVYRR TGILETERDK ARELLRRGET NVGLAVSRGT AKLAWLEERG 

      2590       2600       2610       2620       2630       2640 
YATLKGEVVD LGCGRGGWSY YAASRPAVMS VRAYTIGGKG HEAPKMVTSL GWNLIKFRSG 

      2650       2660       2670       2680       2690       2700 
MDVFSMQPHR ADTVMCDIGE SSPDAAVEGE RTRKVILLME QWKNRNPTAA CVFKVLAPYR 

      2710       2720       2730       2740       2750       2760 
PEVIEALHRF QLQWGGGLVR TPFSRNSTHE MYYSTAVTGN IVNSVNVQSR KLLARFGDQR 

      2770       2780       2790       2800       2810       2820 
GPTKVPELDL GVGTRCVVLA EDKVKEQDVQ ERIRALREQY SETWHMDEEH PYRTWQYWGS 

      2830       2840       2850       2860       2870       2880 
YRTAPTGSAA SLINGVVKLL SWPWNAREDV VRMAMTDTTA FGQQRVFKDK VDTKAQEPQP 

      2890       2900       2910       2920       2930       2940 
GTRVIMRAVN DWILERLAQK SKPRMCSREE FIAKVKSNAA LGAWSDEQNR WASAREAVED 

      2950       2960       2970       2980       2990       3000 
PAFWRLVDEE RERHLMGRCA HCVYNMMGKR EKKLGEFGVA KGSRAIWYMW LGSRFLEFEA 

      3010       3020       3030       3040       3050       3060 
LGFLNEDHWA SRESSGAGVE GISLNYLGWH LKKLSTLNGG LFYADDTAGW DTKVTNADLE 

      3070       3080       3090       3100       3110       3120 
DEEQILRYME GEHKQLATTI MQKAYHAKVV KVARPSRDGG CIMDVITRRD QRGSGQVVTY 

      3130       3140       3150       3160       3170       3180 
ALNTLTNIKV QLIRMMEGEG VIEAADAHNP RLLRVERWLK EHGEERLGRM LVSGDDCVVR 

      3190       3200       3210       3220       3230       3240 
PLDDRFGKAL YFLNDMAKTR KDIGEWEHSA GFSSWEEVPF CSHHFHELVM KDGRTLVVPC 

      3250       3260       3270       3280       3290       3300 
RDQDELVGRA RISPGCGWSV RETACLSKAY GQMWLLSYFH RRDLRTLGLA INSAVPADWV 

      3310       3320       3330       3340       3350       3360 
PTGRTTWSIH ASGAWMTTED MLDVWNRVWI LDNPFMQNKE RVMEWRDVPY LPKAQDMLCS 

      3370       3380       3390       3400       3410 
SLVGRRERAE WAKNIWGAVE KVRKMIGPEK FKDYLSCMDR HDLHWELRLE SSII

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References

[1]"The flavivirus 3'-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus."
Wallner G., Mandl C.W., Kunz C., Heinz F.X.
Virology 213:169-178(1995) [PubMed: 7483260] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], SEQUENCE REVISION.
Strain: Neudoerfl.
[2]"Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses."
Mandl C.W., Heinz F.X., Kunz C.
Virology 166:197-205(1988) [PubMed: 3413985] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-779.
Strain: Neudoerfl.
[3]"Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses."
Mandl C.W., Heinz F.X., Stoeckl E., Kunz C.
Virology 173:291-301(1989) [PubMed: 2554575] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 767-3414.
Strain: Neudoerfl.
[4]"The envelope glycoprotein from tick-borne encephalitis virus at 2-A resolution."
Rey F.A., Heinz F.X., Mandl C.W., Kunz C., Harrison S.C.
Nature 375:291-298(1995) [PubMed: 7753193] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 281-680.
+Additional computationally mapped references.

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Web resources

Virus Particle ExploreR db

Icosahedral capsid structure

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Cross-references

Sequence databases

U27495 Genomic RNA. Translation: AAA86870.1.
PIRGNWVNE. A31052.
RefSeqNP_043135.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1N6Gelectron microscopy16.00A/B/C281-675[»]
1NA4electron microscopy-A/B/C281-675[»]
1SVBX-ray1.90A281-675[»]
1URZX-ray2.70A/B/C/D/E/F281-681[»]
SMRP14336. Positions 281-675.
ModBaseSearch...

Protein family/group databases

MEROPSS07.001.
TCDB1.H.3.1.1. viral pore-forming membrane fusion protein-3 (VMFP3) family.

Genome annotation databases

GeneID1489719.

Family and domain databases

InterProIPR014001. DEAD-like_N.
IPR011492. DEAD_Flavivir.
IPR001650. DNA/RNA_helicase_C.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR000069. Env_glycoprot_M_flavivir.
IPR011999. Flav_glyE_cen_dm.
IPR013754. Flav_glyE_dim.
IPR001122. Flavi_capsidC.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flv_glyE_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR014021. Helicase_SF1/SF2_ATP-bd.
IPR001850. Peptidase_S7.
IPR000208. RNA_pol_flaviviral.
IPR007094. RNA_pol_PSvir.
IPR002877. rRNA_MeTrfase_RrmJ/FtsJ.
[Graphical view]
Gene3DG3DSA:2.60.98.10. Flav_glyE_dim. 1 hit.
G3DSA:2.60.40.350. Flv_glyE_Ig-like. 1 hit.
PfamPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
ProDomPD001496. Flavi_NS1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS00690. DEAH_ATP_HELICASE. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePOLG_TBEVW
AccessionPrimary (citable) accession number: P14336
Secondary accession number(s): Q88493
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: May 30, 2000
Last modified: June 16, 2009
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents