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Reviewed, UniProtKB/Swiss-Prot P14335 (POLG_KUNJM)

Last modified June 16, 2009. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Genome polyprotein
Cleaved into the following 10 chains:
    1- Recommended name:
            Protein C
        Alternative name(s):
            Core protein
            Capsid protein
    2- Recommended name:
            Small envelope protein M
        Alternative name(s):
            Matrix protein
    3- Recommended name:
            Envelope protein E
    4- Recommended name:
            Non-structural protein 1
                Short name=NS1
    5- Recommended name:
            Non-structural protein 2A
                Short name=NS2A
    6- Recommended name:
            Flavivirin protease NS2B regulatory subunit
    7- Recommended name:
            Flavivirin protease NS3 catalytic subunit
              EC=3.4.21.91
    8- Recommended name:
            Non-structural protein 4A
                Short name=NS4A
    9- Recommended name:
            Non-structural protein 4B
                Short name=NS4B
    10- Recommended name:
            RNA-directed RNA polymerase
              EC=2.7.7.48
        Alternative name(s):
            NS5
OrganismKunjin virus (strain MRM61C) [Complete proteome]
Taxonomic identifier11078 [NCBI]
Taxonomic lineageViruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Flavivirus › Japanese encephalitis virus group
Virus hostCiconiiformes [TaxID: 8920]
Homo sapiens (Human) [TaxID: 9606]
Equus caballus (Horse) [TaxID: 9796]
Culex annulirostris (Common banded mosquito) [TaxID: 162997]

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Protein attributes

Sequence length3433 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein. Ref.3

Catalytic activity

Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

NS3 and NS2B form a heterodimer. NS3 is the catalytic subunit, whereas NS2B strongly stimulates the latter By similarity.

Subcellular location

Protein C: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Small envelope protein M: Virion Potential. Host membrane; Single-pass membrane protein Potential.

Envelope protein E: Virion Potential. Host membrane; Multi-pass membrane protein Potential.

Non-structural protein 4A: Host membrane; Single-pass membrane protein Potential.

Non-structural protein 4B: Host membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins By similarity.

Miscellaneous

The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E By similarity.

Sequence similarities

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 peptidase S7 domain.

Contains 1 RdRp catalytic domain.

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Ontologies

Keywords
   Biological processRNA replication
   Cellular componentCapsid protein
Core protein
Envelope protein
Membrane
Virion
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
Nucleotidyltransferase
RNA-directed RNA polymerase
Transferase
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processRNA metabolic process

Inferred from electronic annotation. Source: InterPro

methylation

Inferred from electronic annotation. Source: InterPro

transcription, RNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

viral genome replication

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

viral nucleocapsid

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

methyltransferase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host
Chain2 – 123122Protein C
PRO_0000037703
Propeptide124 – 21592
PRO_0000037704
Chain216 – 29075Small envelope protein M
PRO_0000037705
Chain291 – 791501Envelope protein E
PRO_0000037706
Chain792 – 1143352Non-structural protein 1
PRO_0000037707
Chain1144 – 1374231Non-structural protein 2A
PRO_0000037708
Chain1375 – 1505131Flavivirin protease NS2B regulatory subunit
PRO_0000037709
Chain1506 – 2124619Flavivirin protease NS3 catalytic subunit
PRO_0000037710
Chain2125 – 2273149Non-structural protein 4A
PRO_0000037711
Chain2274 – 2528255Non-structural protein 4B
PRO_0000037712
Chain2529 – 3433905RNA-directed RNA polymerase
PRO_0000037713

Regions

Transmembrane109 – 12921 Potential
Transmembrane249 – 26921 Potential
Transmembrane276 – 29217 Potential
Transmembrane744 – 76421 Potential
Transmembrane771 – 79121 Potential
Transmembrane1175 – 119521 Potential
Transmembrane1217 – 123721 Potential
Transmembrane1246 – 126823 Potential
Transmembrane1289 – 130921 Potential
Transmembrane1314 – 133118 Potential
Transmembrane1346 – 136621 Potential
Transmembrane1376 – 139621 Potential
Transmembrane1400 – 142021 Potential
Transmembrane1478 – 149821 Potential
Transmembrane2175 – 219521 Potential
Transmembrane2201 – 222121 Potential
Transmembrane2223 – 224321 Potential
Transmembrane2259 – 227921 Potential
Transmembrane2313 – 233321 Potential
Transmembrane2359 – 237921 Potential
Transmembrane2381 – 240121 Potential
Transmembrane2445 – 246521 Potential
Domain1512 – 1683172Peptidase S7
Domain1686 – 1842157Helicase ATP-binding
Domain1853 – 2018166Helicase C-terminal
Domain3058 – 3210153RdRp catalytic
Nucleotide binding1699 – 17068ATP Potential
Region388 – 40114Involved in fusion
Motif1790 – 17934DEAH box

Sites

Active site15561Charge relay system By similarity
Active site15801Charge relay system By similarity
Active site16401Charge relay system By similarity

Amino acid modifications

Glycosylation1381N-linked (GlcNAc...); by host Potential
Glycosylation9211N-linked (GlcNAc...); by host Potential
Glycosylation9661N-linked (GlcNAc...); by host Potential
Glycosylation9981N-linked (GlcNAc...); by host Potential
Disulfide bond293 ↔ 320 By similarity
Disulfide bond350 ↔ 406 By similarity
Disulfide bond364 ↔ 395 By similarity
Disulfide bond382 ↔ 411 By similarity
Disulfide bond480 ↔ 578 By similarity
Disulfide bond595 ↔ 626 By similarity

Natural variations

Natural variant1501P → T in strain: Infectious clone pAKUN and Infectious clone FLSDX.
Natural variant8201I → M in strain: Infectious clone pAKUNa and Infectious clone FLSDX.
Natural variant9431N → S in strain: Infectious clone pAKUN and Infectious clone FLSDX.
Natural variant10411P → L in strain: Infectious clone pAKUN and Infectious clone FLSDX.
Natural variant12021I → N in strain: Infectious clone pAKUN.
Natural variant13181R → K in strain: Infectious clone pAKUN.
Natural variant19671T → I in strain: Infectious clone pAKUN and Infectious clone FLSDX.
Natural variant19741A → V in strain: Infectious clone pAKUN and Infectious clone FLSDX.
Natural variant20231Y → H in strain: Infectious clone pAKUN.
Natural variant20621S → P in strain: Infectious clone pAKUN.
Natural variant23391T → N in strain: Infectious clone pAKUN and Infectious clone FLSDX.

Secondary structure

1 .............................................................................................................................................................................................. 3433
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P14335-1 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: EE4B888A7D040B99

FASTA3,433381,369
        10         20         30         40         50         60 
MSKKPGGPGK SRAVNMLKRG MPRVLSLTGL KRAMLSLIDG RGPTRFVLAL LAFFRFTAIA 

        70         80         90        100        110        120 
PTRAVLDRWR SVNKQTAMKH LLSFKKELGT LTSAINRRSS KQKKRGGKTG IAFMIGLIAG 

       130        140        150        160        170        180 
VGAVTLSNFQ GKVMMTVNAT DVTDIITIPP AAGKNLCIVR AMDVGHMCDD TITYECPVLS 

       190        200        210        220        230        240 
AGNDPEDIDC WCTKLAVYVR YGRCTKTRHS RRSRRSLTVQ THGESTLSNK KGAWMDSTKA 

       250        260        270        280        290        300 
TRYLVKTESW ILRNPGYALV AAVIGWMLGS NTMQRVVFAV LLLLVAPAYS FNCLGMSNRD 

       310        320        330        340        350        360 
FLEGVSGATW VDLVLEGDSC VTIMSKDKPT IDVKMMNMEA ANLAEVRSYC YLATVSELST 

       370        380        390        400        410        420 
KAACPTMGEA HNDKRADPSF VCKQGVVDRG WGNGCGLFGK GSIDTCAKFA CSTKATGRTI 

       430        440        450        460        470        480 
LKENIKYEVA IFVHGPTTVE SHGNYFTQTG AAQAGRFSIT PAAPSYTLKL GEYGEVTVDC 

       490        500        510        520        530        540 
EPRSGIDTSA YYVMTVGTKT FLVHREWFMD LNLPWSSAES NVWRNRETLM EFEEPHATKQ 

       550        560        570        580        590        600 
SVIALGSQEG ALHQALAGAI PVEFSSNTVK LTSGHLKCRV KMEKLQLKGT TYGVCSKAFR 

       610        620        630        640        650        660 
FLGTPADTGH GTVVLELQYT GTDGPCKIPI SSVASLNDLT PVGRLVTVNP FVSVSTANAK 

       670        680        690        700        710        720 
VLIELEPPFG DSYIVVGRGE QQINHHWHKS GSSIGKAFTA TLKGAQRLAA LGDTAWDFGS 

       730        740        750        760        770        780 
VGGVFTSVGK AVHQVFGGAF RSLFGGMSWI TQGLLGALLL WMGINARDRS IALTFLAVGG 

       790        800        810        820        830        840 
VLLFLSVNVH ADTGCAIDIS RQELRCGSGV FIHNDVEAWI DRYKYYPETP QGLAKIIQKA 

       850        860        870        880        890        900 
HKEGVCGLRS VSRLEHQMWE AVKDELNTLL KENGVDLSIV VEKQEGMYKS APRRLTATTE 

       910        920        930        940        950        960 
KLEIGWKAWG KSILFAPELA NNTFVIDGPE TKECPTQNRA WNNLEVEDFG FGLTSTRMFL 

       970        980        990       1000       1010       1020 
RVRESNTTEC DSKIIGTAVK NNLAIHSDLS YWIESRFNDT WKLERAVLGE VKSCTWPETH 

      1030       1040       1050       1060       1070       1080 
TLWGDGVLES DLIIPITLAG PRSNHNRRPG YKTQSQGPWD EGRVEIDFDY CPGTTVTLSE 

      1090       1100       1110       1120       1130       1140 
SCGHRGPATR TTTESGKLIT DWCCRSCTLP PLRYQTDNGC WYGMEIRPQR HDEKTLVQSQ 

      1150       1160       1170       1180       1190       1200 
VNAYNADMID PFQLGLLVVF LATQEVLRKR WTAKISMPAI LIALLVLVFG GITYTDVLRY 

      1210       1220       1230       1240       1250       1260 
VILVGAAFAE SNSGGDVVHL ALMATFKIQP VFMVASFLKA RWTNQENILL MLAAAFFQMA 

      1270       1280       1290       1300       1310       1320 
YYDARQILLW EMPDVLNSLA VAWMILRAIT FTTTSNVVVP LLALLTPGLR CLNLDVYRIL 

      1330       1340       1350       1360       1370       1380 
LLMVGIGSLI REKRSAAAKK KGASLLCLAL ASTGFFNPMI LAAGLVACDP NRKRGWPATE 

      1390       1400       1410       1420       1430       1440 
VMTAVGLMFA IVGGLAELDI DSMAIPMTIA GLMFAAFVIS GKSTDMWIER TADISWEGDA 

      1450       1460       1470       1480       1490       1500 
EITGSSERVD VRLDDDGNFQ LMNDPGAPWK IWMLRMACLA ISAYTPWAIL PSVVGFWITL 

      1510       1520       1530       1540       1550       1560 
QYTKRGGVLW DTPSPKEYKR GDTTTGVYRI MTRGLLGSYQ AGAGVMVEGV FHTLWHTTKG 

      1570       1580       1590       1600       1610       1620 
AALMSGEGRL DPYWGSVKED RLCYGGPWKL QHKWNGQDEV QMIVVEPGKN VKNVQTKPGV 

      1630       1640       1650       1660       1670       1680 
FKTPEGEIGA VTLDFPTGTS GSPIVDKNGD VIGLYGNGVI MPNGSYISAI VQGERMDEPV 

      1690       1700       1710       1720       1730       1740 
PAGFEPEMLR KKQITVLDLH PGAGKTRRIL PQIIKEAINR RLRTAVLAPT RVVAAEMAEA 

      1750       1760       1770       1780       1790       1800 
LRGLPIRYQT SAVAREHNGN EIVDVMCHAT LTHRLMSPHR VPNYNLFVMD EAHFTDPASI 

      1810       1820       1830       1840       1850       1860 
AARGYISTRV ELGEAAAIFM TATPPGTSDP FPESNAPISD LQTEIPDRAW NSGYEWITEY 

      1870       1880       1890       1900       1910       1920 
IGKTVWFVPS VKMGNEIALC LQRAGKKVIQ LNRKSYETEY PKCKNDDWDF VVTTDISEMG 

      1930       1940       1950       1960       1970       1980 
ANFKASRVID SRKSVKPTII TEGEGRVILG EPSAVTAASA AQRRGRTGRN PSQAGDEYCY 

      1990       2000       2010       2020       2030       2040 
GGHTNEDDSN CAHWTEARIM LDNINMPNGL IAQFYQPERE KVYTMDGEYR LRGEERKNFL 

      2050       2060       2070       2080       2090       2100 
ELLRTADLPV WLAYKVAAAG VSYHDRRWCF DGPRTNTILE DNNEVEVITK LGERKILRPR 

      2110       2120       2130       2140       2150       2160 
WIDARVYSDH QALKSFKDFA SGKRSQIGFI EVLGKMPEHF MGKTWEALDT MYVVATAEKG 

      2170       2180       2190       2200       2210       2220 
GRAHRMALEE LPDALQTIAL IALLSVMTMG VFFLLMQRKG IGKIGLGGVV LGAATFFCWM 

      2230       2240       2250       2260       2270       2280 
AEVPGTKIAG MLLLSLLLMI VLIPEPEKQR SQTDNQLAVF LICVLTLVGA VAANEMGWLD 

      2290       2300       2310       2320       2330       2340 
KTKSDISGLF GQRIETKENF SIGEFLLDLR PATAWSLYAV TTAVLTPLLK HLITSDYITT 

      2350       2360       2370       2380       2390       2400 
SLTSINVQAS ALFTLARGFP FVDVGVSALL LAAGCWGQVT LTVTVTSATL LFCHYAYMVP 

      2410       2420       2430       2440       2450       2460 
GWQAEAMRSA QRRTAAGIMK NAVVDGIVAT DVPELERTTP IMQKKVGQVM LILVSLAALV 

      2470       2480       2490       2500       2510       2520 
VNPSVKTVRE AGILITAAAV TLWENGASSV WNATTAIGLC HIMRGGWLSC LSITWTLVKN 

      2530       2540       2550       2560       2570       2580 
MEKPGLKRGG AKGRTLGEVW KERLNQMTKE EFIRYRKEAI TEVDRSAAKH ARKERNITGG 

      2590       2600       2610       2620       2630       2640 
HPVSRGTAKL RWLVERRFLE PVGKVIDLGC GRGGWCYYMA TQKRVQEVRG YTKGGPGHEE 

      2650       2660       2670       2680       2690       2700 
PQLVQSYGWN IVTMKSGVDV FYRPSECCDT LLCDIGESSS SAEVEEHRTL RVLEMVEDWL 

      2710       2720       2730       2740       2750       2760 
HRGPKEFCVK VLCPYMPKVI EKMELLQRRY GGGLVRNPLS RNSTHEMYWV SRASGNVVHS 

      2770       2780       2790       2800       2810       2820 
VNMTSQVLLG RMEKKTWKGP QYEEDVNLGS GTRAVGKPLL NSDTSKIKNR IERLRREYSS 

      2830       2840       2850       2860       2870       2880 
TWHHDENHPY RTWNYHGSYE VKPTGSASSL VNGVVRLLSK PWDTITNVTT MAMTDTTPFG 

      2890       2900       2910       2920       2930       2940 
QQRVFKEKVD TKAPEPPEGV KYVLNETTNW LWAFLAREKR PRMCSREEFI RKVNSNAALG 

      2950       2960       2970       2980       2990       3000 
AMFEEQNQWR SAREAVEDPK FWEMVDEERE AHLRGECHTC IYNMMGKREK KPGEFGKAKG 

      3010       3020       3030       3040       3050       3060 
SRAIWFMWLG ARFLEFEALG FLNEDHWLGR KNSGGGVEGL GLQKLGYILR EVGTRPGGRI 

      3070       3080       3090       3100       3110       3120 
YADDTAGWDT RITRADLENE AKVLELLDGE HRRLARAIIE LTYRHKVVKV MRPAADGRTV 

      3130       3140       3150       3160       3170       3180 
MDVISREDQR GSGQVVTYAL NTFTNLAVQL VRMMEGEGVI GPDDVEKLTK GKGPKVRTWL 

      3190       3200       3210       3220       3230       3240 
SENGEERLSR MAVSGDDCVV KPLDDRFATS LHFLNAMSKV RKDIQEWKPS TGWYDWQQVP 

      3250       3260       3270       3280       3290       3300 
FCSNHFTELI MKDGRTLVTP CRGQDELVGR ARISPGAGWN VRDTACLAKS YAQMWLLLYF 

      3310       3320       3330       3340       3350       3360 
HRRDLRLMAN AICSAVPVNW VPTGRTTWSI HAGGEWMTTE DMLEVWNRVW IEENEWMEDK 

      3370       3380       3390       3400       3410       3420 
TPVEKWSDVP YSGKREDIWC GSLIGTRARA TWAENIQVAI NQVRSIIGDE KYVDYMSSLK 

      3430 
RYEDTTLVED TVL

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References

[1]"Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins."
Coia G., Parker M.D., Speight G., Byrne M.E., Westaway E.G.
J. Gen. Virol. 69:1-21(1988) [PubMed: 2826659] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Molecular and functional analyses of Kunjin virus infectious cDNA clones demonstrate the essential role for NS2A in virus assembly and for a nonconservative residue in NS3 in RNA replication."
Liu W.J., Chen H.B., Khromykh A.A.
J. Virol. 77:7804-7813(2003) [PubMed: 12829820] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Infectious clone FLSDX and Infectious clone pAKUN.
[3]"Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A."
Mackenzie J.M., Khromykh A.A., Jones M.K., Westaway E.G.
Virology 245:203-215(1998) [PubMed: 9636360] [Abstract]
Cited for: FUNCTION OF NON-STRUCTURAL PROTEIN 2A, NON-STRUCTURAL PROTEIN 4A.
[4]"West Nile virus core protein; tetramer structure and ribbon formation."
Dokland T., Walsh M., Mackenzie J.M., Khromykh A.A., Ee K.H., Wang S.
Structure 12:1157-1163(2004) [PubMed: 15242592] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-98.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D00246 Genomic RNA. Translation: BAA00176.1.
AY274504 Genomic RNA. Translation: AAP78941.1.
AY274505 Genomic RNA. Translation: AAP78942.1.
PIRGNWVKV. A28697.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1SFKX-ray3.20A/B/C/D/E/F/G/H23-98[»]
2HCNX-ray2.35A2846-3433[»]
2HCSX-ray2.50A2846-3433[»]
2HFZX-ray3.00A2802-3433[»]
2OF6electron microscopy24.00A/B/C291-690[»]
2OY0X-ray2.80A/B2534-2795[»]
2QEQX-ray3.10A/B1691-2124[»]
SMRP14335. Positions 291-690, 1515-1683.
ModBaseSearch...

Protein family/group databases

MEROPSS07.001.

Family and domain databases

InterProIPR014001. DEAD-like_N.
IPR011492. DEAD_Flavivir.
IPR001650. DNA/RNA_helicase_C.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR000069. Env_glycoprot_M_flavivir.
IPR013756. Flav_glyE_cen_2.
IPR011999. Flav_glyE_cen_dm.
IPR013754. Flav_glyE_dim.
IPR001122. Flavi_capsidC.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flv_glyE_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR014021. Helicase_SF1/SF2_ATP-bd.
IPR001850. Peptidase_S7.
IPR000208. RNA_pol_flaviviral.
IPR007094. RNA_pol_PSvir.
IPR002877. rRNA_MeTrfase_RrmJ/FtsJ.
[Graphical view]
Gene3DG3DSA:3.30.67.10. Flav_glyE_cen_2. 1 hit.
G3DSA:2.60.98.10. Flav_glyE_dim. 1 hit.
G3DSA:2.60.40.350. Flv_glyE_Ig-like. 1 hit.
PfamPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
ProDomPD001496. Flavi_NS1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS00690. DEAH_ATP_HELICASE. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePOLG_KUNJM
AccessionPrimary (citable) accession number: P14335
Secondary accession number(s): Q7T4P4, Q7T4P5, Q82983
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 16, 2009
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents