Reviewed, UniProtKB/Swiss-Prot P14332 (6PGD_PIG)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:

PGD

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	250 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.
Sequence caution	The sequence CAA34633.1 differs from that shown. Reason: Frameshift at positions 226 and 249.

Ontologies

Keywords
Biological process	Pentose shunt
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 250	›250	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090065
Amino acid modifications
	Modified residue	77	1	N6-acetyllysine By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P14332-1 [UniParc]. Last modified October 10, 2003. Version 3. Checksum: 8BBB0655D9A40C36	FASTA	250	27,806
	10 20 30 40 50 60 IEITANILKF QDADGKHLLP KIRDSAGQKG TGKWTAISAL EYGVPVTLIG EAVFARCLSS 70 80 90 100 110 120 LKDERVQASK KLKGPQKIQF SGDKKSFLED IRKALYASKI ISYTQGFMLL RQAAAEFGWS 130 140 150 160 170 180 STTEHRLMWR GGCIIRSVFL GKIKDAFDRN PGLQNLLLDD FFKSAVEDCQ DSWRRAVSTG 190 200 210 220 230 240 VQTGIPMPCF TTALSFYDGY RHEMLPANLI QAQRDYFGAH TYELLAKPGH FVHTNWTGHG 250 GSVSSSSYNA

References

[1]	"Isolation, characterization and chromosomal assignment of a partial cDNA for porcine 6-phosphogluconate dehydrogenase." Harbitz I., Chowdhary B., Chowdhary R., Kran S., Frengen E., Gustavsson I., Davies W. Hereditas 112:83-88(1990) [PubMed: 2361879] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Analysis of the gluconate (gnt) operon of Bacillus subtilis." Reizer A., Deutscher J., Saier M.H. Jr., Reizer J. Mol. Microbiol. 5:1081-1089(1991) [PubMed: 1659648] [Abstract] Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16638 mRNA. Translation: CAA34633.1. Frameshift.
PIR	A48325.
UniGene	Ssc.36928
3D structure databases
SMR	P14332. Positions 1-241.
ModBase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000003774; ENSSSCP00000003687; ENSSSCG00000003402; Sus scrofa. [Genome view]
Phylogenomic databases
HOVERGEN	P14332.
Enzyme and pathway databases
BRENDA	1.1.1.44. 249.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_PIG

Accession

Primary (citable) accession number: P14332

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	October 10, 2003
Last modified:	November 24, 2009
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)