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Reviewed, UniProtKB/Swiss-Prot P14332 (6PGD_PIG)

Last modified November 24, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44
Gene names
Name: PGD
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length250 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Sequence caution

The sequence CAA34633.1 differs from that shown. Reason: Frameshift at positions 226 and 249.

Ontologies

Keywords
   Biological processPentose shunt
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP or NADPH binding

Inferred from electronic annotation. Source: InterPro

phosphogluconate dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 250›2506-phosphogluconate dehydrogenase, decarboxylating
PRO_0000090065

Amino acid modifications

Modified residue771N6-acetyllysine By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P14332-1 [UniParc].

Last modified October 10, 2003. Version 3.
Checksum: 8BBB0655D9A40C36

FASTA25027,806
        10         20         30         40         50         60 
IEITANILKF QDADGKHLLP KIRDSAGQKG TGKWTAISAL EYGVPVTLIG EAVFARCLSS 

        70         80         90        100        110        120 
LKDERVQASK KLKGPQKIQF SGDKKSFLED IRKALYASKI ISYTQGFMLL RQAAAEFGWS 

       130        140        150        160        170        180 
STTEHRLMWR GGCIIRSVFL GKIKDAFDRN PGLQNLLLDD FFKSAVEDCQ DSWRRAVSTG 

       190        200        210        220        230        240 
VQTGIPMPCF TTALSFYDGY RHEMLPANLI QAQRDYFGAH TYELLAKPGH FVHTNWTGHG 

       250 
GSVSSSSYNA 

« Hide

References

[1]"Isolation, characterization and chromosomal assignment of a partial cDNA for porcine 6-phosphogluconate dehydrogenase."
Harbitz I., Chowdhary B., Chowdhary R., Kran S., Frengen E., Gustavsson I., Davies W.
Hereditas 112:83-88(1990) [PubMed: 2361879] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Analysis of the gluconate (gnt) operon of Bacillus subtilis."
Reizer A., Deutscher J., Saier M.H. Jr., Reizer J.
Mol. Microbiol. 5:1081-1089(1991) [PubMed: 1659648] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16638 mRNA. Translation: CAA34633.1. Frameshift.
PIRA48325.
UniGeneSsc.36928

3D structure databases

SMRP14332. Positions 1-241.
ModBaseSearch...

Genome annotation databases

EnsemblENSSSCT00000003774; ENSSSCP00000003687; ENSSSCG00000003402; Sus scrofa. [Genome view]

Phylogenomic databases

HOVERGENP14332.

Enzyme and pathway databases

BRENDA1.1.1.44. 249.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006183. 6-phosphogluconate_DH.
IPR006114. 6PGDH_C.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF00393. 6PGD. 1 hit.
[Graphical view]
PRINTSPR00076. 6PGDHDRGNASE.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry name6PGD_PIG
AccessionPrimary (citable) accession number: P14332
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 10, 2003
Last modified: November 24, 2009
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents