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Protein

Muscle-specific protein 20

Gene

Mp20

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

  • cell adhesion Source: FlyBase
  • myoblast fusion Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of myoblast fusion Source: FlyBase

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle-specific protein 20
Gene namesi
Name:Mp20
Synonyms:Tpn
ORF Names:CG4696
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002789. Mp20.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047791 – 184Muscle-specific protein 20Add BLAST184

Proteomic databases

PaxDbiP14318.
PRIDEiP14318.

Expressioni

Tissue specificityi

Found in synchronous muscle; not found in asynchronous indirect flight muscle.1 Publication

Gene expression databases

BgeeiFBgn0002789.
GenevisibleiP14318. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi62231. 6 interactors.
DIPiDIP-18096N.
IntActiP14318. 3 interactors.
MINTiMINT-942840.
STRINGi7227.FBpp0086858.

Structurei

3D structure databases

ProteinModelPortaliP14318.
SMRiP14318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 122CHPROSITE-ProRule annotationAdd BLAST106
Repeati157 – 181Calponin-likeAdd BLAST25

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
InParanoidiP14318.
KOiK20526.
OrthoDBiEOG091G0LY2.
PhylomeDBiP14318.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
PRINTSiPR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.

Sequencei

Sequence statusi: Complete.

P14318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLERAVRAK IASKRNPEMD KEAQEWIEAI IAEKFPAGQS YEDVLKDGQV
60 70 80 90 100
LCKLINVLSP NAVPKVNSSG GQFKFMENIN NFQKALKEYG VPDIDVFQTV
110 120 130 140 150
DLYEKKDIAN VTNTIFALGR ATYKHADFKG PFLGPKPADE CKRDFTEEQL
160 170 180
KAGQTIVGLQ AGSNKGATQA GQNLGAGRKI LLGK
Length:184
Mass (Da):20,190
Last modified:August 2, 2002 - v2
Checksum:iB291ACA92AED3873
GO

Sequence cautioni

The sequence ABE01209 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13S → G in CAA68746 (PubMed:2537318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00795 Genomic DNA. Translation: CAA68746.1.
AE013599 Genomic DNA. Translation: AAF58396.1.
AE013599 Genomic DNA. Translation: AAM68603.1.
AY071496 mRNA. Translation: AAL49118.1.
BT024979 mRNA. Translation: ABE01209.1. Different initiation.
PIRiA30128.
RefSeqiNP_001014522.2. NM_001014522.2.
NP_476643.1. NM_057295.4.
UniGeneiDm.596.

Genome annotation databases

EnsemblMetazoaiFBtr0087745; FBpp0086858; FBgn0002789.
GeneIDi36468.
KEGGidme:Dmel_CG4696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00795 Genomic DNA. Translation: CAA68746.1.
AE013599 Genomic DNA. Translation: AAF58396.1.
AE013599 Genomic DNA. Translation: AAM68603.1.
AY071496 mRNA. Translation: AAL49118.1.
BT024979 mRNA. Translation: ABE01209.1. Different initiation.
PIRiA30128.
RefSeqiNP_001014522.2. NM_001014522.2.
NP_476643.1. NM_057295.4.
UniGeneiDm.596.

3D structure databases

ProteinModelPortaliP14318.
SMRiP14318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62231. 6 interactors.
DIPiDIP-18096N.
IntActiP14318. 3 interactors.
MINTiMINT-942840.
STRINGi7227.FBpp0086858.

Proteomic databases

PaxDbiP14318.
PRIDEiP14318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087745; FBpp0086858; FBgn0002789.
GeneIDi36468.
KEGGidme:Dmel_CG4696.

Organism-specific databases

CTDi36468.
FlyBaseiFBgn0002789. Mp20.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
InParanoidiP14318.
KOiK20526.
OrthoDBiEOG091G0LY2.
PhylomeDBiP14318.

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiMp20. fly.
GenomeRNAii36468.
PROiP14318.

Gene expression databases

BgeeiFBgn0002789.
GenevisibleiP14318. DM.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
PRINTSiPR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMP20_DROME
AccessioniPrimary (citable) accession number: P14318
Secondary accession number(s): A4UZF7, Q1WWC7, Q9V6M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 2, 2002
Last modified: March 15, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.