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Protein

Muscle-specific protein 20

Gene

Mp20

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

  • myoblast fusion Source: FlyBase
  • regulation of myoblast fusion Source: FlyBase

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Muscle-specific protein 20
Gene namesi
Name:Mp20
Synonyms:Tpn
ORF Names:CG4696
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002789 Mp20

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047791 – 184Muscle-specific protein 20Add BLAST184

Proteomic databases

PaxDbiP14318
PRIDEiP14318

Expressioni

Tissue specificityi

Found in synchronous muscle; not found in asynchronous indirect flight muscle.1 Publication

Gene expression databases

BgeeiFBgn0002789
GenevisibleiP14318 DM

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi62231, 8 interactors
DIPiDIP-18096N
IntActiP14318, 3 interactors
STRINGi7227.FBpp0086858

Structurei

3D structure databases

ProteinModelPortaliP14318
SMRiP14318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 122Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106
Repeati157 – 181Calponin-likeAdd BLAST25

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
InParanoidiP14318
KOiK20526
OMAiGRACYKH
OrthoDBiEOG091G0LY2
PhylomeDBiP14318

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

Sequencei

Sequence statusi: Complete.

P14318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLERAVRAK IASKRNPEMD KEAQEWIEAI IAEKFPAGQS YEDVLKDGQV
60 70 80 90 100
LCKLINVLSP NAVPKVNSSG GQFKFMENIN NFQKALKEYG VPDIDVFQTV
110 120 130 140 150
DLYEKKDIAN VTNTIFALGR ATYKHADFKG PFLGPKPADE CKRDFTEEQL
160 170 180
KAGQTIVGLQ AGSNKGATQA GQNLGAGRKI LLGK
Length:184
Mass (Da):20,190
Last modified:August 2, 2002 - v2
Checksum:iB291ACA92AED3873
GO

Sequence cautioni

The sequence ABE01209 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13S → G in CAA68746 (PubMed:2537318).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00795 Genomic DNA Translation: CAA68746.1
AE013599 Genomic DNA Translation: AAF58396.1
AE013599 Genomic DNA Translation: AAM68603.1
AY071496 mRNA Translation: AAL49118.1
BT024979 mRNA Translation: ABE01209.1 Different initiation.
PIRiA30128
RefSeqiNP_001014522.2, NM_001014522.2
NP_476643.1, NM_057295.4
UniGeneiDm.596

Genome annotation databases

EnsemblMetazoaiFBtr0087745; FBpp0086858; FBgn0002789
FBtr0345532; FBpp0311634; FBgn0002789
GeneIDi36468
KEGGidme:Dmel_CG4696

Similar proteinsi

Entry informationi

Entry nameiMP20_DROME
AccessioniPrimary (citable) accession number: P14318
Secondary accession number(s): A4UZF7, Q1WWC7, Q9V6M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 2, 2002
Last modified: May 23, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health