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P14315 (CAPZB_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
F-actin-capping protein subunit beta isoforms 1 and 2
Alternative name(s):
Beta-actinin subunit II
CapZ 36/32
CapZ B1 and B2
Gene names
Name:CAPZB
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.

Subunit structure

Heterodimer of an alpha and a beta subunit. Component of the WASH complex By similarity. Isoform 2 also is a component of dynactin complex from brain, which contains the actin-related protein ARP1.

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Tissue specificity

Isoform 2 is the predominant isoform of nonmuscle tissues and isoform 1 is the predominant isoform of muscle tissues. In cardiac muscle, isoform 1 is located at Z-disks of sarcomeres while isoform 2 is enriched at intercalated disks.

Sequence similarities

Belongs to the F-actin-capping protein beta subunit family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P14315-1)

Also known as: Beta-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P14315-2)

Also known as: Beta-2;

The sequence of this isoform differs from the canonical sequence as follows:
     246-277: IDAIPDNQKYKQLQRELSQVLTQRQIYIQPDN → VQTFADKSKQEALKNDLVEALKRKQQS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 277276F-actin-capping protein subunit beta isoforms 1 and 2
PRO_0000204636

Amino acid modifications

Modified residue21N-acetylserine By similarity

Natural variations

Alternative sequence246 – 27732IDAIP…IQPDN → VQTFADKSKQEALKNDLVEA LKRKQQS in isoform 2.
VSP_000769

Secondary structure

1 ........................................ 277
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Beta-1) [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 55E5271EDA5454D6

FASTA27731,364
        10         20         30         40         50         60 
MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA RDKVVGKDYL 

        70         80         90        100        110        120 
LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA NNAFDQYRDL YFEGGVSSVY 

       130        140        150        160        170        180 
LWDLDHGFAG VILIKKAGDG SKKIKGCWDS IHVVEVQEKS SGRTAHYKLT STVMLWLQTN 

       190        200        210        220        230        240 
KTGSGTMNLG GSLTRQMEKD ETVSDSSPHI ANIGRLVEDM ENKIRSTLNE IYFGKTKDIV 

       250        260        270 
NGLRSIDAIP DNQKYKQLQR ELSQVLTQRQ IYIQPDN

« Hide

Isoform 2 (Beta-2) [UniParc].

Checksum: B8567604B64E23D7
Show »

FASTA27230,611

References

[1]"cDNAs encoding the beta subunit of cap Z, the actin-capping protein of the Z line of muscle."
Caldwell J.E., Waddle J.A., Cooper J.A., Hollands J.A., Casella S.J., Casella J.F.
J. Biol. Chem. 264:12648-12652(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates."
Schafer D.A., Korshunova Y.O., Schroer T.A., Cooper J.A.
J. Cell Biol. 127:453-465(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Beta-actinin is equivalent to Cap Z protein."
Maruyama K., Kurokawa H., Oosawa M., Shimaoka S., Yamamoto H., Ito M., Maruyama K.
J. Biol. Chem. 265:8712-8715(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 160-168 AND 182-198.
Tissue: Muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J04959 mRNA. Translation: AAA49144.1.
U07826 mRNA. Translation: AAA52222.1.
IPIIPI00571469.
IPI00591422.
PIRA34335.
A54819.
RefSeqNP_001167000.1. NM_001173529.1.
NP_990768.1. NM_205437.2.
UniGeneGga.4050.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IZNX-ray2.10B/D1-277[»]
2KXPNMR-B2-271[»]
2KZ7NMR-B1-277[»]
3AA0X-ray1.70B1-244[»]
3AA1X-ray1.90B1-244[»]
3AA6X-ray1.90B1-244[»]
3AA7X-ray1.90B1-244[»]
3AAAX-ray2.20B1-277[»]
3AAEX-ray3.30B/D/F/H/J1-277[»]
3LK2X-ray2.20B1-243[»]
3LK3X-ray2.68B1-277[»]
3LK4X-ray1.992/5/8/B/E/H/K/N/Q/T/W/Z1-277[»]
ProteinModelPortalP14315.
SMRP14315. Positions 2-271.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-35365N.
IntActP14315. 1 interaction.
MINTMINT-3390662.
STRING9031.ENSGALP00000006415.

Proteomic databases

PaxDbP14315.
PRIDEP14315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000006424; ENSGALP00000006414; ENSGALG00000004034.
GeneID396418.
KEGGgga:396418.

Organism-specific databases

CTD832.

Phylogenomic databases

eggNOGNOG291067.
GeneTreeENSGT00390000017957.
HOGENOMHOG000041208.
HOVERGENHBG050789.
InParanoidP14315.
KOK10365.
OMANLLQEVY.

Enzyme and pathway databases

ReactomeREACT_96458. Hemostasis.

Family and domain databases

InterProIPR019771. F-actin_capping_bsu_CS.
IPR001698. WASH_F-actin_cap_beta.
[Graphical view]
PANTHERPTHR10619. PTHR10619. 1 hit.
PfamPF01115. F_actin_cap_B. 1 hit.
[Graphical view]
PRINTSPR00192. FACTINCAPB.
PROSITEPS00231. F_ACTIN_CAPPING_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP14315.
NextBio20816459.

Entry information

Entry nameCAPZB_CHICK
AccessionPrimary (citable) accession number: P14315
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents