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P14292

- PMPA_CANBO

UniProt

P14292 - PMPA_CANBO

Protein

Putative peroxiredoxin-A

Gene

PMPA

Organism
Candida boidinii (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Its function is very likely to be related to the metabolism of methanol.

    Catalytic activityi

    2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

    GO - Molecular functioni

    1. peroxidase activity Source: UniProtKB-KW
    2. peroxiredoxin activity Source: UniProtKB-EC

    GO - Biological processi

    1. methanol metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Methanol utilization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative peroxiredoxin-A (EC:1.11.1.15)
    Alternative name(s):
    PMP20
    Peroxisomal membrane protein A
    Thioredoxin reductase
    Allergen: Cand b 2
    Gene namesi
    Name:PMPA
    OrganismiCandida boidinii (Yeast)
    Taxonomic identifieri5477 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    GO - Cellular componenti

    1. peroxisomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Peroxisome

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Asp f 3 of Aspergillus fumigatus.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei178. Cand b 2.
    3175. Cand b 2.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 167166Putative peroxiredoxin-APRO_0000056604Add
    BLAST

    Expressioni

    Inductioni

    By methanol.

    Structurei

    3D structure databases

    ProteinModelPortaliP14292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 167164ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi165 – 1673Microbody targeting signal

    Sequence similaritiesi

    Belongs to the peroxiredoxin 2 family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR013740. Redoxin.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF08534. Redoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14292-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPIKRGDRF PTTDDVYYIP PEGGEPGPLE LSKFVKTKKF VVVSVPGAFT    50
    PPCTEQHLPG YIKNLPRILS KGVDFVLVIS QNDPFVLKGW KKELGAADAK 100
    KLVFVSDPNL KLTKKLGSTI DLSAIGLGTR SGRLALIVNR SGIVEYAAIE 150
    NGGEVDVSTA QKIIAKL 167
    Length:167
    Mass (Da):18,004
    Last modified:January 23, 2007 - v3
    Checksum:iBB6474B84834D0D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04984 Genomic DNA. Translation: AAA34357.1.
    PIRiA32646.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04984 Genomic DNA. Translation: AAA34357.1 .
    PIRi A32646.

    3D structure databases

    ProteinModelPortali P14292.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 178. Cand b 2.
    3175. Cand b 2.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR013740. Redoxin.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF08534. Redoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii."
      Garrard L.J., Goodman J.M.
      J. Biol. Chem. 264:13929-13937(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
      Strain: ATCC 32195.
    2. "Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes."
      Hemmann S., Blaser K., Crameri R.
      Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: CROSS-REACTIVITY WITH ASP F 3.

    Entry informationi

    Entry nameiPMPA_CANBO
    AccessioniPrimary (citable) accession number: P14292
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3