P14292 (PMPA_CANBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative peroxiredoxin-A
EC=1.11.1.15

Alternative name(s):
PMP20
Peroxisomal membrane protein A
Thioredoxin reductase
Allergen=Cand b 2

Gene names

Name:

PMPA

Organism

Candida boidinii (Yeast)

Taxonomic identifier

5477 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Its function is very likely to be related to the metabolism of methanol.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subcellular location	Peroxisome membrane; Peripheral membrane protein.
Induction	By methanol.
Allergenic properties	Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Asp f 3 of Aspergillus fumigatus.
Sequence similarities	Belongs to the peroxiredoxin 2 family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Biological process	Methanol utilization
Cellular component	Membrane Peroxisome
Disease	Allergen
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	methanol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	peroxisomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 167	166	Putative peroxiredoxin-A		PRO_0000056604
Regions
	Domain	4 – 167	164	Thioredoxin
	Motif	165 – 167	3	Microbody targeting signal

Sequences

	Sequence		Length	Mass (Da)
	P14292 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: BB6474B84834D0D5	FASTA	167	18,004
	10 20 30 40 50 60 MAPIKRGDRF PTTDDVYYIP PEGGEPGPLE LSKFVKTKKF VVVSVPGAFT PPCTEQHLPG 70 80 90 100 110 120 YIKNLPRILS KGVDFVLVIS QNDPFVLKGW KKELGAADAK KLVFVSDPNL KLTKKLGSTI 130 140 150 160 DLSAIGLGTR SGRLALIVNR SGIVEYAAIE NGGEVDVSTA QKIIAKL

References

[1]	"Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii." Garrard L.J., Goodman J.M. J. Biol. Chem. 264:13929-13937(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26. Strain: ATCC 32195.
[2]	"Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes." Hemmann S., Blaser K., Crameri R. Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed] [Europe PMC] [Abstract] Cited for: CROSS-REACTIVITY WITH ASP F 3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04984 Genomic DNA. Translation: AAA34357.1.
PIR	A32646.
3D structure databases
ProteinModelPortal	P14292.
ModBase	Search...
Protein family/group databases
Allergome	178. Cand b 2. 3175. Cand b 2.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR013740. Redoxin. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF08534. Redoxin. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PMPA_CANBO

Accession

Primary (citable) accession number: P14292

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program