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P14292 (PMPA_CANBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative peroxiredoxin-A

EC=1.11.1.15
Alternative name(s):
PMP20
Peroxisomal membrane protein A
Thioredoxin reductase
Allergen=Cand b 2
Gene names
Name:PMPA
OrganismCandida boidinii (Yeast)
Taxonomic identifier5477 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Its function is very likely to be related to the metabolism of methanol.

Catalytic activity

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Subcellular location

Peroxisome membrane; Peripheral membrane protein.

Induction

By methanol.

Allergenic properties

Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Asp f 3 of Aspergillus fumigatus.

Sequence similarities

Belongs to the peroxiredoxin 2 family.

Contains 1 thioredoxin domain.

Ontologies

Keywords
   Biological processMethanol utilization
   Cellular componentMembrane
Peroxisome
   DiseaseAllergen
   DomainRedox-active center
   Molecular functionOxidoreductase
Peroxidase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processmethanol metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionperoxidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

peroxiredoxin activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 167166Putative peroxiredoxin-A
PRO_0000056604

Regions

Domain4 – 167164Thioredoxin
Motif165 – 1673Microbody targeting signal

Sequences

Sequence LengthMass (Da)Tools
P14292 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: BB6474B84834D0D5

FASTA16718,004
        10         20         30         40         50         60 
MAPIKRGDRF PTTDDVYYIP PEGGEPGPLE LSKFVKTKKF VVVSVPGAFT PPCTEQHLPG 

        70         80         90        100        110        120 
YIKNLPRILS KGVDFVLVIS QNDPFVLKGW KKELGAADAK KLVFVSDPNL KLTKKLGSTI 

       130        140        150        160 
DLSAIGLGTR SGRLALIVNR SGIVEYAAIE NGGEVDVSTA QKIIAKL 

« Hide

References

[1]"Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii."
Garrard L.J., Goodman J.M.
J. Biol. Chem. 264:13929-13937(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
Strain: ATCC 32195.
[2]"Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes."
Hemmann S., Blaser K., Crameri R.
Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: CROSS-REACTIVITY WITH ASP F 3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04984 Genomic DNA. Translation: AAA34357.1.
PIRA32646.

3D structure databases

ProteinModelPortalP14292.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome178. Cand b 2.
3175. Cand b 2.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMPA_CANBO
AccessionPrimary (citable) accession number: P14292
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 22, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries