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P14292

- PMPA_CANBO

UniProt

P14292 - PMPA_CANBO

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Protein
Putative peroxiredoxin-A
Gene
PMPA
Organism
Candida boidinii (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Its function is very likely to be related to the metabolism of methanol.

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

GO - Molecular functioni

  1. peroxidase activity Source: UniProtKB-KW
  2. peroxiredoxin activity Source: UniProtKB-EC

GO - Biological processi

  1. methanol metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Methanol utilization

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peroxiredoxin-A (EC:1.11.1.15)
Alternative name(s):
PMP20
Peroxisomal membrane protein A
Thioredoxin reductase
Allergen: Cand b 2
Gene namesi
Name:PMPA
OrganismiCandida boidinii (Yeast)
Taxonomic identifieri5477 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

GO - Cellular componenti

  1. peroxisomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Asp f 3 of Aspergillus fumigatus.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei178. Cand b 2.
3175. Cand b 2.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 167166Putative peroxiredoxin-A
PRO_0000056604Add
BLAST

Expressioni

Inductioni

By methanol.

Structurei

3D structure databases

ProteinModelPortaliP14292.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 167164Thioredoxin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi165 – 1673Microbody targeting signal

Sequence similaritiesi

Belongs to the peroxiredoxin 2 family.
Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14292-1 [UniParc]FASTAAdd to Basket

« Hide

MAPIKRGDRF PTTDDVYYIP PEGGEPGPLE LSKFVKTKKF VVVSVPGAFT    50
PPCTEQHLPG YIKNLPRILS KGVDFVLVIS QNDPFVLKGW KKELGAADAK 100
KLVFVSDPNL KLTKKLGSTI DLSAIGLGTR SGRLALIVNR SGIVEYAAIE 150
NGGEVDVSTA QKIIAKL 167
Length:167
Mass (Da):18,004
Last modified:January 23, 2007 - v3
Checksum:iBB6474B84834D0D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04984 Genomic DNA. Translation: AAA34357.1.
PIRiA32646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04984 Genomic DNA. Translation: AAA34357.1 .
PIRi A32646.

3D structure databases

ProteinModelPortali P14292.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 178. Cand b 2.
3175. Cand b 2.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF08534. Redoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii."
    Garrard L.J., Goodman J.M.
    J. Biol. Chem. 264:13929-13937(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
    Strain: ATCC 32195.
  2. "Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes."
    Hemmann S., Blaser K., Crameri R.
    Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CROSS-REACTIVITY WITH ASP F 3.

Entry informationi

Entry nameiPMPA_CANBO
AccessioniPrimary (citable) accession number: P14292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 22, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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