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Protein

Putative peroxiredoxin-A

Gene

PMPA

Organism
Candida boidinii (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Its function is very likely to be related to the metabolism of methanol.

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

GO - Molecular functioni

  1. peroxidase activity Source: UniProtKB-KW
  2. peroxiredoxin activity Source: UniProtKB-EC

GO - Biological processi

  1. methanol metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Methanol utilization

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peroxiredoxin-A (EC:1.11.1.15)
Alternative name(s):
PMP20
Peroxisomal membrane protein A
Thioredoxin reductase
Allergen: Cand b 2
Gene namesi
Name:PMPA
OrganismiCandida boidinii (Yeast)
Taxonomic identifieri5477 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataeaOgataea/Candida clade

Subcellular locationi

GO - Cellular componenti

  1. peroxisomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Asp f 3 of Aspergillus fumigatus.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei178. Cand b 2.
3175. Cand b 2.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 167166Putative peroxiredoxin-APRO_0000056604Add
BLAST

Expressioni

Inductioni

By methanol.

Structurei

3D structure databases

ProteinModelPortaliP14292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 167164ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi165 – 1673Microbody targeting signal

Sequence similaritiesi

Belongs to the peroxiredoxin 2 family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPIKRGDRF PTTDDVYYIP PEGGEPGPLE LSKFVKTKKF VVVSVPGAFT
60 70 80 90 100
PPCTEQHLPG YIKNLPRILS KGVDFVLVIS QNDPFVLKGW KKELGAADAK
110 120 130 140 150
KLVFVSDPNL KLTKKLGSTI DLSAIGLGTR SGRLALIVNR SGIVEYAAIE
160
NGGEVDVSTA QKIIAKL
Length:167
Mass (Da):18,004
Last modified:January 22, 2007 - v3
Checksum:iBB6474B84834D0D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04984 Genomic DNA. Translation: AAA34357.1.
PIRiA32646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04984 Genomic DNA. Translation: AAA34357.1.
PIRiA32646.

3D structure databases

ProteinModelPortaliP14292.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei178. Cand b 2.
3175. Cand b 2.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii."
    Garrard L.J., Goodman J.M.
    J. Biol. Chem. 264:13929-13937(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
    Strain: ATCC 32195.
  2. "Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes."
    Hemmann S., Blaser K., Crameri R.
    Am. J. Respir. Crit. Care Med. 156:1956-1962(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CROSS-REACTIVITY WITH ASP F 3.

Entry informationi

Entry nameiPMPA_CANBO
AccessioniPrimary (citable) accession number: P14292
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 31, 1989
Last sequence update: January 22, 2007
Last modified: January 6, 2015
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.