ID   RED1_YEAST              Reviewed;         827 AA.
AC   P14291; D6VYR0;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   24-JAN-2024, entry version 174.
DE   RecName: Full=Protein RED1;
DE   AltName: Full=Reductional division protein 1;
GN   Name=RED1; OrderedLocusNames=YLR263W; ORFNames=L8479.6;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2550770; DOI=10.1007/bf00331281;
RA   Thompson E.A., Roeder G.S.;
RT   "Expression and DNA sequence of RED1, a gene required for meiosis I
RT   chromosome segregation in yeast.";
RL   Mol. Gen. Genet. 218:293-301(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Probable constituent of the synaptonemal complex during
CC       meiosis. May interact with HOP1. Required for meiosis I chromosome
CC       segregation.
CC   -!- INTERACTION:
CC       P14291; P20050: HOP1; NbExp=3; IntAct=EBI-14909, EBI-3768303;
CC       P14291; P14291: RED1; NbExp=3; IntAct=EBI-14909, EBI-14909;
CC       P14291; Q12306: SMT3; NbExp=9; IntAct=EBI-14909, EBI-17490;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Meiosis-specific.
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DR   EMBL; X16183; CAA34306.1; -; Genomic_DNA.
DR   EMBL; U17244; AAB67376.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09576.1; -; Genomic_DNA.
DR   PIR; JQ0308; COBYD1.
DR   RefSeq; NP_013365.1; NM_001182150.1.
DR   AlphaFoldDB; P14291; -.
DR   SMR; P14291; -.
DR   BioGRID; 31531; 71.
DR   ComplexPortal; CPX-1387; Synaptonemal complex.
DR   DIP; DIP-2372N; -.
DR   IntAct; P14291; 13.
DR   MINT; P14291; -.
DR   STRING; 4932.YLR263W; -.
DR   iPTMnet; P14291; -.
DR   PaxDb; 4932-YLR263W; -.
DR   PeptideAtlas; P14291; -.
DR   EnsemblFungi; YLR263W_mRNA; YLR263W; YLR263W.
DR   GeneID; 850968; -.
DR   KEGG; sce:YLR263W; -.
DR   AGR; SGD:S000004253; -.
DR   SGD; S000004253; RED1.
DR   VEuPathDB; FungiDB:YLR263W; -.
DR   eggNOG; ENOG502QVW0; Eukaryota.
DR   HOGENOM; CLU_334647_0_0_1; -.
DR   InParanoid; P14291; -.
DR   OMA; MRRESTK; -.
DR   OrthoDB; 1978160at2759; -.
DR   BioCyc; YEAST:G3O-32363-MONOMER; -.
DR   BioGRID-ORCS; 850968; 6 hits in 10 CRISPR screens.
DR   PRO; PR:P14291; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; P14291; Protein.
DR   GO; GO:0000794; C:condensed nuclear chromosome; NAS:ComplexPortal.
DR   GO; GO:0000800; C:lateral element; IDA:SGD.
DR   GO; GO:0000795; C:synaptonemal complex; NAS:ComplexPortal.
DR   GO; GO:0031490; F:chromatin DNA binding; IDA:SGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0005198; F:structural molecule activity; IDA:SGD.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; NAS:ComplexPortal.
DR   GO; GO:0035825; P:homologous recombination; NAS:ComplexPortal.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; IMP:SGD.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; NAS:ComplexPortal.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IMP:SGD.
DR   InterPro; IPR012491; Red1/Rec10.
DR   Pfam; PF07964; Red1; 1.
DR   PIRSF; PIRSF001747; Rec10_Red1; 1.
PE   1: Evidence at protein level;
KW   Meiosis; Nucleus; Reference proteome; Sporulation.
FT   CHAIN           1..827
FT                   /note="Protein RED1"
FT                   /id="PRO_0000097234"
FT   REGION          364..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..392
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..586
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        615..655
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   827 AA;  95538 MW;  CA1A206F9A274C3F CRC64;
     MEGLKKKIFG VCLKNDLAQT RNETKGIHYG LMTLETSKQL QEFLHLLVIK REVIQNFELL
     FHIINVAVKI TDSNLPSDDI WHFILKLRFS SEINIDEDSK VLNYLLETGI AMENPVSWKC
     LAVISSILSS VPQSKKIITN LIETEHAKKI GQLFDNIQDL QQGNFLVEIL SNCFKKSASN
     SKKVEKIPQL WQSRSKNKFF FENEFYPFSS KNGSLQTCQF LCNNFMSTLS FTGILRQVSY
     SGSETLKNLR IFKKKDDENS YFIQCIYNKI YLWLDEKAPL EFERKKIRIT KNLKNKIQIK
     LRQPFHECVR TTADKTALLF NKTKGFQLEF EDEKLGETFF HNVNNIPKIS EVQNFLVLDY
     IEEEPENEGE EEEQIGRADE QKEDEEEESL DELSTPMVYP IKSSIPHNHN EKVQLVTPDR
     SVSIRSDEWD LKSNTEDEEG NVLADLKISS TKETKRQTDY VHIDSEDQSP VVSAQMRKMR
     RESTKTLEIL RQEFKDKDVQ NKEDQSEQIQ NPFVNTSSLV VGKSCLVNPK EKPNIDQTVV
     GITELKSNSS IKKRDINILD TIFGQPPSKK QKQFHKKEKK KQQKKLTNFK PIIDVPSQDK
     RNLRSNAPTK PKSIKVSKLR TDKKVTGEKS SPETAAEKVD DQTVRSNDEQ AMSRATKEKC
     FPDVNEGKEI TKDDAKVSLE SKKNNETFVD SSVVEKHTPP DKDCNNCNIT DILESTTVID
     LQSPHGLSAP GQNTFTNKLQ EQIYSSINHF SNELVRKISI INQELNKKIL KELSEKYQKL
     FSELQDNFQN DTNEMLKFMG EIKDMMNLPE DQLVHAIRTR KFDNNKR
//