Reviewed, UniProtKB/Swiss-Prot P14291 (RED1_YEAST)

Names and origin

Protein names

Recommended name:
    Protein RED1
Alternative name(s):
    Reductional division protein 1

Gene names

Name:	RED1
Ordered Locus Names:	YLR263W
ORF Names:	L8479.6

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable constituent of the synaptonemal complex during meiosis. May interact with HOP1. Required for meiosis I chromosome segregation.
Subcellular location	Nucleus.
Developmental stage	Meiosis-specific.

Ontologies

Keywords
Biological process	Meiosis Sporulation
Cellular component	Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromosome segregation Inferred from electronic annotation. Source: InterPro meiotic recombination checkpoint Inferred from mutant phenotype. Source: SGD positive regulation of catalytic activity Inferred from direct assay. Source: SGD reciprocal meiotic recombination Inferred from electronic annotation. Source: InterPro sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW synaptonemal complex assembly Ref.1 Inferred from mutant phenotype. Source: SGD
Cellular component	lateral element Inferred from direct assay. Source: SGD
Molecular function	chromatin DNA binding Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SEC7	P11075	1	EBI-14909,EBI-16882
SMT3	Q12306	1	EBI-14909,EBI-17490

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 827	827	Protein RED1		PRO_0000097234

Sequences

	Sequence		Length	Mass (Da)
	P14291-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: CA1A206F9A274C3F	FASTA	827	95,538
	10 20 30 40 50 60 MEGLKKKIFG VCLKNDLAQT RNETKGIHYG LMTLETSKQL QEFLHLLVIK REVIQNFELL 70 80 90 100 110 120 FHIINVAVKI TDSNLPSDDI WHFILKLRFS SEINIDEDSK VLNYLLETGI AMENPVSWKC 130 140 150 160 170 180 LAVISSILSS VPQSKKIITN LIETEHAKKI GQLFDNIQDL QQGNFLVEIL SNCFKKSASN 190 200 210 220 230 240 SKKVEKIPQL WQSRSKNKFF FENEFYPFSS KNGSLQTCQF LCNNFMSTLS FTGILRQVSY 250 260 270 280 290 300 SGSETLKNLR IFKKKDDENS YFIQCIYNKI YLWLDEKAPL EFERKKIRIT KNLKNKIQIK 310 320 330 340 350 360 LRQPFHECVR TTADKTALLF NKTKGFQLEF EDEKLGETFF HNVNNIPKIS EVQNFLVLDY 370 380 390 400 410 420 IEEEPENEGE EEEQIGRADE QKEDEEEESL DELSTPMVYP IKSSIPHNHN EKVQLVTPDR 430 440 450 460 470 480 SVSIRSDEWD LKSNTEDEEG NVLADLKISS TKETKRQTDY VHIDSEDQSP VVSAQMRKMR 490 500 510 520 530 540 RESTKTLEIL RQEFKDKDVQ NKEDQSEQIQ NPFVNTSSLV VGKSCLVNPK EKPNIDQTVV 550 560 570 580 590 600 GITELKSNSS IKKRDINILD TIFGQPPSKK QKQFHKKEKK KQQKKLTNFK PIIDVPSQDK 610 620 630 640 650 660 RNLRSNAPTK PKSIKVSKLR TDKKVTGEKS SPETAAEKVD DQTVRSNDEQ AMSRATKEKC 670 680 690 700 710 720 FPDVNEGKEI TKDDAKVSLE SKKNNETFVD SSVVEKHTPP DKDCNNCNIT DILESTTVID 730 740 750 760 770 780 LQSPHGLSAP GQNTFTNKLQ EQIYSSINHF SNELVRKISI INQELNKKIL KELSEKYQKL 790 800 810 820 FSELQDNFQN DTNEMLKFMG EIKDMMNLPE DQLVHAIRTR KFDNNKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and DNA sequence of RED1, a gene required for meiosis I chromosome segregation in yeast." Thompson E.A., Roeder G.S. Mol. Gen. Genet. 218:293-301(1989) [PubMed: 2550770] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16183 Genomic DNA. Translation: CAA34306.1. U17244 Genomic DNA. Translation: AAB67376.1.
PIR	COBYD1. JQ0308.
RefSeq	NP_013365.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:2372N.
IntAct	P14291. 4 interactions.
Proteomic databases
PRIDE	P14291.
Genome annotation databases
Ensembl	YLR263W. Saccharomyces cerevisiae. [Contig view]
GeneID	850968.
GenomeReviews	Gene locus YLR263W in contig Y13138_GR.
KEGG	sce:YLR263W.
NMPDR	fig|4932.3.peg.4379.
Organism-specific databases
CYGD	YLR263w.
SGD	S000004253. RED1.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P14291.
OMA	P14291. MESTTIV.
Gene expression databases
ArrayExpress	P14291.
GermOnline	YLR263W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012491. Rec10_Red1. [Graphical view]
Pfam	PF07964. Red1. 1 hit. [Graphical view]
PIRSF	PIRSF001747. Rec10_Red1. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	967460.

Entry information

Entry name

RED1_YEAST

Accession

Primary (citable) accession number: P14291

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)