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P14290 (ERBS_SACEN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Erythromycin biosynthesis sensory transduction protein eryC1
Gene names
Name:eryC1
Synonyms:eryCI
Ordered Locus Names:SACE_0734
OrganismSaccharopolyspora erythraea (strain NRRL 23338) [Complete proteome] [HAMAP]
Taxonomic identifier405948 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora ›

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sensor protein that transfers the signal of environmental stimuli to the regulatory region of target genes to activate or repress transcription of erythromycin biosynthesis genes Potential.

Subcellular location

Cell membrane; Peripheral membrane protein Potential.

Sequence similarities

Belongs to the DegT/DnrJ/EryC1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Erythromycin biosynthesis sensory transduction protein eryC1
PRO_0000110012

Regions

DNA binding160 – 17920H-T-H motif Potential
Region53 – 158106Hydrophobic

Amino acid modifications

Modified residue1861N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict691L → V in CAA33548. Ref.1
Sequence conflict92 – 954AVSR → GVP in CAA33548. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P14290 [UniParc].

Last modified February 22, 2012. Version 2.
Checksum: DAC755AB6890F279

FASTA36639,410
        10         20         30         40         50         60 
MDVPFLDLQA AYLELRSDID QACRRVLGSG WYLHGPENEA FEAEFAAYCE NAHCVTVGSG 

        70         80         90        100        110        120 
CDALELSLLA LGVGQGDEVI VPSHTFIATW LAVSRVGAVP VPVEPEGVSH TLDPALVEQA 

       130        140        150        160        170        180 
ITPRTAAILP VHLYGHPADL DALRAIADRH GLALVEDVAQ AVGARHRGHR VGAGSNAAAF 

       190        200        210        220        230        240 
SFYPGKNLGA LGDGGAVVTT DPALAERIRL LRNYGSKQKY VHEVRGTNAR LDELQAAVLR 

       250        260        270        280        290        300 
VKLRHLDDWN ARRTTLAQHY QTELKDVPGI TLPETHPWAD SAWHLFVLRC ENRDHLQRHL 

       310        320        330        340        350        360 
TDAGVQTLIH YPTPVHLSPA YADLGLPPGS FPVAESLAGE VLSLPIGPHL SREAADHVIA 


TLKAGA

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis."
Dhillon N., Hale R.S., Cortes J., Leadlay P.F.
Mol. Microbiol. 3:1405-1414(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NRRL 23338.
[2]"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338."
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F.
Nat. Biotechnol. 25:447-453(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NRRL 23338.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X15541 Genomic DNA. Translation: CAA33548.1.
AM420293 Genomic DNA. Translation: CAM00075.1.
PIRS06725.
RefSeqYP_001103001.1. NC_009142.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING405948.SACE_0734.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM00075; CAM00075; SACE_0734.
GeneID4940595.
KEGGsen:SACE_0734.
PATRIC23408856. VBISacEry28377_0748.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0399.
HOGENOMHOG000230164.
OMAAAYCEAK.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-17089.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000653. DegT/StrS_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF01041. DegT_DnrJ_EryC1. 1 hit.
[Graphical view]
PIRSFPIRSF000390. PLP_StrS. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNetSearch...

Entry information

Entry nameERBS_SACEN
AccessionPrimary (citable) accession number: P14290
Secondary accession number(s): A4F7Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 22, 2012
Last modified: May 29, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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