P14290 (ERBS_SACEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Erythromycin biosynthesis sensory transduction protein eryC1

Gene names

Name:

eryC1

Organism

Saccharopolyspora erythraea (strain NRRL 23338)

Taxonomic identifier

405948 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Saccharopolyspora

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sensor protein that transfers the signal of environmental stimuli to the regulatory region of target genes to activate or repress transcription of erythromycin biosynthesis genes Potential.
Subcellular location	Cell membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the degT/dnrJ/eryC1 family.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis Transcription Transcription regulation Two-component regulatory system
Cellular component	Cell membrane Membrane
Ligand	DNA-binding Pyridoxal phosphate
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW two-component signal transduction system (phosphorelay) Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW catalytic activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Erythromycin biosynthesis sensory transduction protein eryC1		PRO_0000110012
Regions
	DNA binding	159 – 178	20	H-T-H motif Potential
	Region	53 – 157	105	Hydrophobic
Amino acid modifications
	Modified residue	185	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P14290 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 0DCD732F020FFD03	FASTA	365	39,235
	10 20 30 40 50 60 MDVPFLDLQA AYLELRSDID QACRRVLGSG WYLHGPENEA FEAEFAAYCE NAHCVTVGSG 70 80 90 100 110 120 CDALELSLVA LGVGQGDEVI VPSHTFIATW LGVPVGAVPV PVEPEGVSHT LDPALVEQAI 130 140 150 160 170 180 TPRTAAILPV HLYGHPADLD ALRAIADRHG LALVEDVAQA VGARHRGHRV GAGSNAAAFS 190 200 210 220 230 240 FYPGKNLGAL GDGGAVVTTD PALAERIRLL RNYGSKQKYV HEVRGTNARL DELQAAVLRV 250 260 270 280 290 300 KLRHLDDWNA RRTTLAQHYQ TELKDVPGIT LPETHPWADS AWHLFVLRCE NRDHLQRHLT 310 320 330 340 350 360 DAGVQTLIHY PTPVHLSPAY ADLGLPPGSF PVAESLAGEV LSLPIGPHLS REAADHVIAT LKAGA

References

[1]	"Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis." Dhillon N., Hale R.S., Cortes J., Leadlay P.F. Mol. Microbiol. 3:1405-1414(1989) [PubMed: 2575703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15541 Genomic DNA. Translation: CAA33548.1.
PIR	S06725.
3D structure databases
ProteinModelPortal	P14290.
SMR	P14290. Positions 3-365.
ModBase	Search...
Protein-protein interaction databases
STRING	P14290.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000653. DegT/StrS_aminotransferase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF01041. DegT_DnrJ_EryC1. 1 hit. [Graphical view]
PIRSF	PIRSF000390. PLP_StrS. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ERBS_SACEN

Accession

Primary (citable) accession number: P14290

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 31, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program