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P14288

- BGAL_SULAC

UniProt

P14288 - BGAL_SULAC

Protein

Beta-galactosidase

Gene

bgaS

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Temperature dependencei

    Thermostable.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei209 – 2091Proton donorSequence Analysis
    Active sitei389 – 3891NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciSACI330779:GH9J-1818-MONOMER.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Short name:
    Lactase
    Gene namesi
    Name:bgaS
    Ordered Locus Names:Saci_1849
    OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
    Taxonomic identifieri330779 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001018: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Beta-galactosidasePRO_0000063866Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi330779.Saci_1849.

    Structurei

    3D structure databases

    ProteinModelPortaliP14288.
    SMRiP14288. Positions 1-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG2723.
    HOGENOMiHOG000088630.
    KOiK01190.
    OMAiGEYTEMG.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 2 hits.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14288-1 [UniParc]FASTAAdd to Basket

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    MLSFPKGFKF GWSQSGFQSE MGTPGSEDPN SDWHVWVHDR ENIVSQVVSG    50
    DLPENGPGYW GNYKRFHDEA EKIGLNAVRI NVEWSRIFPR PLPKPEMQTG 100
    TDKENSPVIS VDLNESKLRE MDNYANHEAL SHYRQILEDL RNRGFHIVLN 150
    MYHWTLPIWL HDPIRVRRGD FTGPTGWLNS RTVYEFARFS AYVAWKLDDL 200
    ASEYATMNEP NVVWGAGYAF PRAGFPPNYL SFRLSEIAKW NIIQAHARAY 250
    DAIKSVSKKS VGIIYANTSY YPLRPQDNEA VEIAERLNRW SFFDSIIKGE 300
    ITSEGQNVRE DLRNRLDWIG VNYYTRTVVT KAESGYLTLP GYGDRCERNS 350
    LSLANLPTSD FGWEFFPEGL YDVLLKYWNR YGLPLYVMEN GIADDADYQR 400
    PYYLVSHIYQ VHRALNEGVD VRGYLHWSLA DNYEWSSGFS MRFGLLKVDY 450
    LTKRLYWRPS ALVYREITRS NGIPEELEHL NRVPPIKPLR H 491
    Length:491
    Mass (Da):57,143
    Last modified:August 30, 2005 - v2
    Checksum:iA7FF7F4DEEC1C189
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351Q → H in CAA34074. (PubMed:2508066)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15950 Genomic DNA. Translation: CAA34074.1.
    CP000077 Genomic DNA. Translation: AAY81155.1.
    RefSeqiYP_256448.1. NC_007181.1.

    Genome annotation databases

    EnsemblBacteriaiAAY81155; AAY81155; Saci_1849.
    GeneIDi3474772.
    KEGGisai:Saci_1849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15950 Genomic DNA. Translation: CAA34074.1 .
    CP000077 Genomic DNA. Translation: AAY81155.1 .
    RefSeqi YP_256448.1. NC_007181.1.

    3D structure databases

    ProteinModelPortali P14288.
    SMRi P14288. Positions 1-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 330779.Saci_1849.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY81155 ; AAY81155 ; Saci_1849 .
    GeneIDi 3474772.
    KEGGi sai:Saci_1849.

    Phylogenomic databases

    eggNOGi COG2723.
    HOGENOMi HOG000088630.
    KOi K01190.
    OMAi GEYTEMG.

    Enzyme and pathway databases

    BioCyci SACI330779:GH9J-1818-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a thermostable beta-galactosidase from Sulfolobus solfataricus."
      Little S., Cartwright P., Campbell C., Prenneta A., McChesney J., Mountain A., Robinson M.
      Nucleic Acids Res. 17:7980-7980(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
      Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
      J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

    Entry informationi

    Entry nameiBGAL_SULAC
    AccessioniPrimary (citable) accession number: P14288
    Secondary accession number(s): Q4J7S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to originate from S.solfataricus strain P1, but the culture was contaminated with S.acidocaldarius.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3