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P14288

- BGAL_SULAC

UniProt

P14288 - BGAL_SULAC

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Protein

Beta-galactosidase

Gene
bgaS, Saci_1849
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Temperature dependencei

Thermostable.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei209 – 2091Proton donor Reviewed prediction
Active sitei389 – 3891Nucleophile By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1818-MONOMER.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Lactase
Gene namesi
Name:bgaS
Ordered Locus Names:Saci_1849
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Beta-galactosidasePRO_0000063866Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1849.

Structurei

3D structure databases

ProteinModelPortaliP14288.
SMRiP14288. Positions 1-491.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088630.
KOiK01190.
OMAiGEYTEMG.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 2 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14288-1 [UniParc]FASTAAdd to Basket

« Hide

MLSFPKGFKF GWSQSGFQSE MGTPGSEDPN SDWHVWVHDR ENIVSQVVSG    50
DLPENGPGYW GNYKRFHDEA EKIGLNAVRI NVEWSRIFPR PLPKPEMQTG 100
TDKENSPVIS VDLNESKLRE MDNYANHEAL SHYRQILEDL RNRGFHIVLN 150
MYHWTLPIWL HDPIRVRRGD FTGPTGWLNS RTVYEFARFS AYVAWKLDDL 200
ASEYATMNEP NVVWGAGYAF PRAGFPPNYL SFRLSEIAKW NIIQAHARAY 250
DAIKSVSKKS VGIIYANTSY YPLRPQDNEA VEIAERLNRW SFFDSIIKGE 300
ITSEGQNVRE DLRNRLDWIG VNYYTRTVVT KAESGYLTLP GYGDRCERNS 350
LSLANLPTSD FGWEFFPEGL YDVLLKYWNR YGLPLYVMEN GIADDADYQR 400
PYYLVSHIYQ VHRALNEGVD VRGYLHWSLA DNYEWSSGFS MRFGLLKVDY 450
LTKRLYWRPS ALVYREITRS NGIPEELEHL NRVPPIKPLR H 491
Length:491
Mass (Da):57,143
Last modified:August 30, 2005 - v2
Checksum:iA7FF7F4DEEC1C189
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351Q → H in CAA34074. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15950 Genomic DNA. Translation: CAA34074.1.
CP000077 Genomic DNA. Translation: AAY81155.1.
RefSeqiYP_256448.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY81155; AAY81155; Saci_1849.
GeneIDi3474772.
KEGGisai:Saci_1849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15950 Genomic DNA. Translation: CAA34074.1 .
CP000077 Genomic DNA. Translation: AAY81155.1 .
RefSeqi YP_256448.1. NC_007181.1.

3D structure databases

ProteinModelPortali P14288.
SMRi P14288. Positions 1-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 330779.Saci_1849.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY81155 ; AAY81155 ; Saci_1849 .
GeneIDi 3474772.
KEGGi sai:Saci_1849.

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088630.
KOi K01190.
OMAi GEYTEMG.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-1818-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 2 hits.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a thermostable beta-galactosidase from Sulfolobus solfataricus."
    Little S., Cartwright P., Campbell C., Prenneta A., McChesney J., Mountain A., Robinson M.
    Nucleic Acids Res. 17:7980-7980(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiBGAL_SULAC
AccessioniPrimary (citable) accession number: P14288
Secondary accession number(s): Q4J7S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 30, 2005
Last modified: May 14, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to originate from S.solfataricus strain P1, but the culture was contaminated with S.acidocaldarius.

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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