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Protein

Beta-galactosidase

Gene

bgaS

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Temperature dependencei

Thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei209Proton donorSequence analysis1
Active sitei389NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.B34. 6160.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Lactase
Gene namesi
Name:bgaS
Ordered Locus Names:Saci_1849
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000638661 – 491Beta-galactosidaseAdd BLAST491

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1849.

Structurei

3D structure databases

ProteinModelPortaliP14288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Phylogenomic databases

eggNOGiarCOG05412. Archaea.
COG2723. LUCA.
HOGENOMiHOG000088630.
KOiK01190.
OMAiDVERCKF.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 2 hits.
PfamiPF00232. Glyco_hydro_1. 2 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFPKGFKF GWSQSGFQSE MGTPGSEDPN SDWHVWVHDR ENIVSQVVSG
60 70 80 90 100
DLPENGPGYW GNYKRFHDEA EKIGLNAVRI NVEWSRIFPR PLPKPEMQTG
110 120 130 140 150
TDKENSPVIS VDLNESKLRE MDNYANHEAL SHYRQILEDL RNRGFHIVLN
160 170 180 190 200
MYHWTLPIWL HDPIRVRRGD FTGPTGWLNS RTVYEFARFS AYVAWKLDDL
210 220 230 240 250
ASEYATMNEP NVVWGAGYAF PRAGFPPNYL SFRLSEIAKW NIIQAHARAY
260 270 280 290 300
DAIKSVSKKS VGIIYANTSY YPLRPQDNEA VEIAERLNRW SFFDSIIKGE
310 320 330 340 350
ITSEGQNVRE DLRNRLDWIG VNYYTRTVVT KAESGYLTLP GYGDRCERNS
360 370 380 390 400
LSLANLPTSD FGWEFFPEGL YDVLLKYWNR YGLPLYVMEN GIADDADYQR
410 420 430 440 450
PYYLVSHIYQ VHRALNEGVD VRGYLHWSLA DNYEWSSGFS MRFGLLKVDY
460 470 480 490
LTKRLYWRPS ALVYREITRS NGIPEELEHL NRVPPIKPLR H
Length:491
Mass (Da):57,143
Last modified:August 30, 2005 - v2
Checksum:iA7FF7F4DEEC1C189
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135Q → H in CAA34074 (PubMed:2508066).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15950 Genomic DNA. Translation: CAA34074.1.
CP000077 Genomic DNA. Translation: AAY81155.1.
RefSeqiWP_011278657.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY81155; AAY81155; Saci_1849.
GeneIDi3474772.
KEGGisai:Saci_1849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15950 Genomic DNA. Translation: CAA34074.1.
CP000077 Genomic DNA. Translation: AAY81155.1.
RefSeqiWP_011278657.1. NC_007181.1.

3D structure databases

ProteinModelPortaliP14288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_1849.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY81155; AAY81155; Saci_1849.
GeneIDi3474772.
KEGGisai:Saci_1849.

Phylogenomic databases

eggNOGiarCOG05412. Archaea.
COG2723. LUCA.
HOGENOMiHOG000088630.
KOiK01190.
OMAiDVERCKF.

Enzyme and pathway databases

BRENDAi3.2.1.B34. 6160.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR033132. Glyco_hydro_1_N_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 2 hits.
PfamiPF00232. Glyco_hydro_1. 2 hits.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBGAL_SULAC
AccessioniPrimary (citable) accession number: P14288
Secondary accession number(s): Q4J7S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 30, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from S.solfataricus strain P1, but the culture was contaminated with S.acidocaldarius.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.