Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name:
UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene namesi
Name:UCP1
Synonyms:SLC25A7, UCP
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9623Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei116 – 13217Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei178 – 19417Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei212 – 23120Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei266 – 28823Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 306305Mitochondrial brown fat uncoupling protein 1PRO_0000090661Add
BLAST

Expressioni

Tissue specificityi

Brown adipose tissue.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001977.

Structurei

3D structure databases

ProteinModelPortaliP14271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1Add
BLAST
Repeati110 – 20091Solcar 2Add
BLAST
Repeati209 – 29486Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni273 – 29523Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP14271.
KOiK08769.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGTTTTDVP PTMGVKIFSA GVAACLADVI TFPLDTAKVR QQIQGEFPIT
60 70 80 90 100
SGIRYKGVLG TITTLAKTEG PLKLYSGLPA GLQRQISFAS LRIGLYDTVQ
110 120 130 140 150
EFFTSGEETP SLGSKISAGL TTGGVAVFIG QPTEVVKVRL QAQSHLHGLK
160 170 180 190 200
PRYTGTYNAY RIIATTESLT SLWKGTTPNL LRNVIINCTE LVTYDLMKGA
210 220 230 240 250
LVRNEILADD VPCHFVSALI AGFCTTLLSS PVDVVKTRFI NSPPGQYASV
260 270 280 290 300
PNCAMTMFTK EGPTAFFKGF VPSFLRLGSW NVIMFVCFEK LKGELMRSRQ

TVDCAT
Length:306
Mass (Da):33,083
Last modified:January 1, 1990 - v1
Checksum:i58343CAD94C910F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14696 mRNA. Translation: CAA32826.1.
PIRiA32446.
RefSeqiNP_001164548.1. NM_001171077.1.
UniGeneiOcu.2093.

Genome annotation databases

GeneIDi100328618.
KEGGiocu:100328618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14696 mRNA. Translation: CAA32826.1.
PIRiA32446.
RefSeqiNP_001164548.1. NM_001171077.1.
UniGeneiOcu.2093.

3D structure databases

ProteinModelPortaliP14271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100328618.
KEGGiocu:100328618.

Organism-specific databases

CTDi7350.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP14271.
KOiK08769.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCP1_RABIT
AccessioniPrimary (citable) accession number: P14271
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 11, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.