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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Otolemur crassicaudatus (Brown greater galago) (Galago crassicaudatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Short name:
Alpha-I
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiOtolemur crassicaudatus (Brown greater galago) (Galago crassicaudatus)
Taxonomic identifieri9463 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLorisiformesGalagidaeOtolemur

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000526381 – 142Hemoglobin subunit alpha-AAdd BLAST142

Proteomic databases

PRIDEiP14259.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP14259.
SMRiP14259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like_sf.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P14259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSPTDKSI VKAAWEKVGA HAGDYGAEAL ERMFLSFPTT KTYFPQFDLS
60 70 80 90 100
HGSAQVKGHG KKVADALTNA VLHVDDMPSA LSALSDLHAH KLTVDPVNFK
110 120 130 140
LLSHCLLVTL ACHLPAEFTP AVHASLDKFM ASVSTVLTSK YR
Length:142
Mass (Da):15,332
Last modified:January 23, 2007 - v2
Checksum:iBC4F46BB70D139EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29742 Genomic DNA. Translation: AAA35448.1.
PIRiA25597.

Similar proteinsi

Entry informationi

Entry nameiHBA1_OTOCR
AccessioniPrimary (citable) accession number: P14259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families