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Protein

Endoglucanase 3

Gene

cel-3

Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits both endoglucanase and cellobiosidase activities.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei448Proton donorBy similarity1
Active sitei597NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciFSUC59374:G1GMS-2655-MONOMER

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 3 (EC:3.2.1.4)
Alternative name(s):
Cellulase 3
Endo-1,4-beta-glucanase 3
Short name:
EG3
Gene namesi
Name:cel-3
Ordered Locus Names:Fisuc_2230, FSU_2772
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
Proteomesi
  • UP000000517 Componenti: Chromosome

Subcellular locationi

  • Membrane Curated; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
PropeptideiPRO_000000786124 – 2651 PublicationAdd BLAST242
ChainiPRO_0000007862266 – 658Endoglucanase 3Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1

Post-translational modificationi

May be a lipoprotein and may be glycosylated.

Keywords - PTMi

Lipoprotein, Palmitate, Zymogen

Proteomic databases

PRIDEiP14250

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi59374.Fisuc_2230

Structurei

3D structure databases

ProteinModelPortaliP14250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 277CBM11Sequence analysisAdd BLAST191

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2730 LUCA
KOiK01179
OMAiPDEANGH

Family and domain databases

InterProiView protein in InterPro
IPR005087 CBM_fam11
IPR008979 Galactose-bd-like_sf
IPR001547 Glyco_hydro_5
IPR018087 Glyco_hydro_5_CS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF03425 CBM_11, 1 hit
PF00150 Cellulase, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 2 hits
PROSITEiView protein in PROSITE
PS00659 GLYCOSYL_HYDROL_F5, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLKNFYPKM SVLGIATVMA LTACGDENTQ ALFANNPVPG AENQVPVSSS
60 70 80 90 100
DMSPTSSDAV IDPTSSSAAV VDPSTLPAEG PITMPEGLGT LVDDFEDGDN
110 120 130 140 150
LSKIGDYWYT YNDNDNGGAS IITTPLNEEE NIIPGRVNNG SNYALQVNYT
160 170 180 190 200
LDRGDYEYDP YVGWGVQVAP DEANGHFGGL TYWYKGGAHE VHIEITDVED
210 220 230 240 250
YDVHLAKFPA SRTWKQAVVR FKDLVQGGWG KEIPFDAKHI MAISFQAKGN
260 270 280 290 300
KSKLVTDSLF IDNIYLQDSS EVEKDQPDME IKDPVIPVVE FTEAEITVTN
310 320 330 340 350
PLQEKAMKYL NKGVNFTNWL ENADGKFKSF ELGESDVKIL ADNGFKSLRL
360 370 380 390 400
PIDLDLYATN RDAFIAGTDT ELKFDDDTLF LVLDSFVEWT AKYNMSFVID
410 420 430 440 450
YHEYDNSYNT TSAKDPNYIK MMAETWKHVA AHYAESPRED LFFELLNEPD
460 470 480 490 500
MSDGKVTAAT WTTAAQAMID AIRTVDTKHT ILFGDAQWYS ITLLAKRTPF
510 520 530 540 550
TDDNIIYVIH TYEPFAFTHQ GGSWTDYATI HDIPFPYDPA KWSTVSGDFG
560 570 580 590 600
VNKSTKSYVK TNIKNYYKTG SKEAILEQIL KAKKWAATNN VPVIINEFGA
610 620 630 640 650
LNLRSTAESR LNYLTAMREI CDTLQIPWTH WGYTGNFSVI ENGKLIEGLD

KALGVGSK
Length:658
Mass (Da):73,424
Last modified:February 1, 1996 - v2
Checksum:i1C96E64C3F7109A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29047 Genomic DNA Translation: AAA24893.1
CP001792 Genomic DNA Translation: ACX75816.1
CP002158 Genomic DNA Translation: ADL25000.1
PIRiA33598
RefSeqiWP_014546871.1, NC_017448.1

Genome annotation databases

EnsemblBacteriaiACX75816; ACX75816; Fisuc_2230
ADL25000; ADL25000; FSU_2772
GeneIDi34756578
KEGGifsc:FSU_2772
fsu:Fisuc_2230
PATRICifig|59374.8.peg.2655

Similar proteinsi

Entry informationi

Entry nameiGUN3_FIBSS
AccessioniPrimary (citable) accession number: P14250
Secondary accession number(s): C9RK83, D9S6Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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