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Protein

DNA-directed RNA polymerase subunit A''

Gene

rpoA2

Organism
Methanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMVAN406327:GI04-685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A'' (EC:2.7.7.6)
Gene namesi
Name:rpoA2
Ordered Locus Names:Mevan_0674
OrganismiMethanococcus vannielii (strain SB / ATCC 35089 / DSM 1224)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386DNA-directed RNA polymerase subunit A''PRO_0000074019Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_0674.

Structurei

3D structure databases

ProteinModelPortaliP14247.
SMRiP14247. Positions 57-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Family and domain databases

HAMAPiMF_00411. RNApol_arch_A.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.

Sequencei

Sequence statusi: Complete.

P14247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMADLEKKL ENSVLPPLLR RELSEKILKE NINEEYIVDE IIQETIRAYS
60 70 80 90 100
RTVIEPGEAV GVIAAQSIGE PGTQMTMRTF HYAGVAELNV TLGLPRMIEI
110 120 130 140 150
VDARKEPSTP TMSIYLRGDY KYDRESAAIV SKNIESTTVE SVSEDISVDL
160 170 180 190 200
VNECITIVLD VQQLESRQLT VNNVVEAIKS KMKLKIEENE NILSLKIKTP
210 220 230 240 250
SLKALRKRLP KVREIHLKGV PNIKRVIIRK EIDEYVLYSE GSNLKEVFEI
260 270 280 290 300
DGVDTTKTTT NNIVEIQDVL GVEAARNAII REMDATLGNQ GLTVDKRHLM
310 320 330 340 350
MVADLMTTDG VVKPIGRHGI GGEKASVLAR AAFEETVKHL YSASMRGYVD
360 370 380
DLSGVVENII VGKPISMGTG CINVCIKKEY EEGKEL
Length:386
Mass (Da):42,983
Last modified:November 1, 1995 - v2
Checksum:i0D26292FB45BA6A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73293 Genomic DNA. Translation: CAA51729.1.
CP000742 Genomic DNA. Translation: ABR54580.1.
X15970 Genomic DNA. Translation: CAA34086.1.
PIRiS47163.
RefSeqiWP_011972482.1. NC_009634.1.

Genome annotation databases

EnsemblBacteriaiABR54580; ABR54580; Mevan_0674.
GeneIDi5325061.
KEGGimvn:Mevan_0674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73293 Genomic DNA. Translation: CAA51729.1.
CP000742 Genomic DNA. Translation: ABR54580.1.
X15970 Genomic DNA. Translation: CAA34086.1.
PIRiS47163.
RefSeqiWP_011972482.1. NC_009634.1.

3D structure databases

ProteinModelPortaliP14247.
SMRiP14247. Positions 57-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi406327.Mevan_0674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR54580; ABR54580; Mevan_0674.
GeneIDi5325061.
KEGGimvn:Mevan_0674.

Phylogenomic databases

eggNOGiarCOG04256. Archaea.
COG0086. LUCA.
HOGENOMiHOG000222986.
KOiK03042.
OMAiRPIGRHG.

Enzyme and pathway databases

BioCyciMVAN406327:GI04-685-MONOMER.

Family and domain databases

HAMAPiMF_00411. RNApol_arch_A.
InterProiIPR007081. RNA_pol_Rpb1_5.
IPR012757. RNAP_A2.
[Graphical view]
PfamiPF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02389. RNA_pol_rpoA2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of the genes of the large subunits of the DNA dependent RNA-polymerase of Methanococcus vannielii."
    Palm P., Arnold-Ammer I., Lechner K.A., Zillig W.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB / ATCC 35089 / DSM 1224.
  3. "Organization and nucleotide sequence of a transcriptional unit of Methanococcus vannielii comprising genes for protein synthesis elongation factors and ribosomal proteins."
    Lechner K., Heller G., Boeck A.
    J. Mol. Evol. 29:20-27(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 171-386.

Entry informationi

Entry nameiRPOA2_METVS
AccessioniPrimary (citable) accession number: P14247
Secondary accession number(s): A6UQ08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.