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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

Slc2a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei348 – 3481MonosaccharideBy similarity
Binding sitei419 – 4191MonosaccharideBy similarity

GO - Molecular functioni

  • dehydroascorbic acid transporter activity Source: UniProtKB
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: MGI

GO - Biological processi

  • carbohydrate transport Source: MGI
  • carbohydrate utilization Source: Ensembl
  • dehydroascorbic acid transport Source: UniProtKB
  • endocrine pancreas development Source: Reactome
  • fructose transport Source: Ensembl
  • glucose transport Source: UniProtKB
  • response to glucose Source: Ensembl
  • response to peptide hormone Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200. Hexose transport.
R-MMU-210745. Regulation of gene expression in beta cells.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:Slc2a2
Synonyms:Glut-2, Glut2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1095438. Slc2a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini32 – 9766ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini119 – 1268CytoplasmicSequence analysis
Transmembranei127 – 14721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 15710ExtracellularSequence analysis
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 1868CytoplasmicSequence analysis
Transmembranei187 – 20721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini208 – 2169ExtracellularSequence analysis
Transmembranei217 – 23721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini238 – 30265CytoplasmicSequence analysisAdd
BLAST
Transmembranei303 – 32321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini324 – 33714ExtracellularSequence analysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini359 – 3679CytoplasmicSequence analysis
Transmembranei368 – 38821Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini389 – 40113ExtracellularSequence analysisAdd
BLAST
Transmembranei402 – 42221Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini423 – 43210CytoplasmicSequence analysis
Transmembranei433 – 45321Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini454 – 4607ExtracellularSequence analysis
Transmembranei461 – 48121Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini482 – 52342CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basolateral plasma membrane Source: Ensembl
  • brush border Source: MGI
  • brush border membrane Source: Ensembl
  • cell-cell junction Source: MGI
  • cytoplasm Source: UniProtKB
  • cytosol Source: Ensembl
  • endosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Solute carrier family 2, facilitated glucose transporter member 2PRO_0000050347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)1 Publication
Modified residuei522 – 5221PhosphoserineCombined sources

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP14246.
MaxQBiP14246.
PaxDbiP14246.
PRIDEiP14246.

PTM databases

iPTMnetiP14246.
PhosphoSiteiP14246.

Expressioni

Tissue specificityi

In embryo, expressed in endoderm layer of yolk sac and liver primordium.1 Publication

Gene expression databases

BgeeiP14246.
ExpressionAtlasiP14246. baseline and differential.
GenevisibleiP14246. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1863175.
STRINGi10090.ENSMUSP00000029240.

Structurei

3D structure databases

ProteinModelPortaliP14246.
SMRiP14246. Positions 7-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni313 – 3197Monosaccharide bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP14246.
KOiK07593.
OMAiETEGSAH.
OrthoDBiEOG7QVM2R.
PhylomeDBiP14246.
TreeFamiTF313762.

Family and domain databases

InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDKITGTL AFTVFTAVLS SFQFGYDIGV INAPQEVIIS HYRHVLGVPL
60 70 80 90 100
DDRKAAINYD VNGTDTPLTV TPAYTTPAPW DEEETEGSAH IVTMLWSLSV
110 120 130 140 150
SSFAVGGMVA SFFGGWLGDK LGRIKAMLAA NSLSLTGALL MGCSKFGPAH
160 170 180 190 200
ALIIAGRSVS GLYCGLISGL VPMYIGEIAP TTLRGALGTL HQLALVTGIL
210 220 230 240 250
ISQIAGLSFI LGNQDHWHIL LGLSAVPALL QCLLLLFCPE SPRYLYIKLE
260 270 280 290 300
EEVRAKKSLK RLRGTEDVTK DINEMKKEKE EASTEQKVSV IQLFTDANYR
310 320 330 340 350
QPILVALMLH MAQQFSGING IFYYSTSIFQ TAGISQPVYA TIGVGAINMI
360 370 380 390 400
FTAVSVLLVE KAGRRTLFLT GMIGMFFCTI FMSVGLVLLD KFAWMSYVSM
410 420 430 440 450
TAIFLFVSFF EIGPGPIPWF MVAEFFSQGP RPTALALAAF SNWVCNFVIA
460 470 480 490 500
LCFQYIADFL GPYVFFLFAG VVLVFTLFTF FKVPETKGKS FEEIAAEFRK
510 520
KSGSAPPRKA AVQMEFLASS ESV
Length:523
Mass (Da):57,107
Last modified:November 16, 2001 - v3
Checksum:iF12B5376CBDB5F63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061G → D in CAA33719 (PubMed:2771649).Curated
Sequence conflicti181 – 1811T → N in CAA34855 (PubMed:2602116).Curated
Sequence conflicti327 – 3271S → T in CAA33719 (PubMed:2771649).Curated
Sequence conflicti351 – 3511F → L in CAA34855 (PubMed:2602116).Curated
Sequence conflicti432 – 4321P → S in CAA34855 (PubMed:2602116).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16986 mRNA. Translation: CAA34855.1.
X15684 mRNA. Translation: CAA33719.1.
S77926 mRNA. Translation: AAB20847.1.
AK005068 mRNA. Translation: BAB23792.1.
AK165430 mRNA. Translation: BAE38184.1.
BC034675 mRNA. Translation: AAH34675.1.
X78722 Genomic DNA. Translation: CAA55368.1.
CCDSiCCDS50880.1.
PIRiS06920.
RefSeqiNP_112474.2. NM_031197.2.
UniGeneiMm.18443.

Genome annotation databases

EnsembliENSMUST00000029240; ENSMUSP00000029240; ENSMUSG00000027690.
GeneIDi20526.
KEGGimmu:20526.
UCSCiuc008oua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16986 mRNA. Translation: CAA34855.1.
X15684 mRNA. Translation: CAA33719.1.
S77926 mRNA. Translation: AAB20847.1.
AK005068 mRNA. Translation: BAB23792.1.
AK165430 mRNA. Translation: BAE38184.1.
BC034675 mRNA. Translation: AAH34675.1.
X78722 Genomic DNA. Translation: CAA55368.1.
CCDSiCCDS50880.1.
PIRiS06920.
RefSeqiNP_112474.2. NM_031197.2.
UniGeneiMm.18443.

3D structure databases

ProteinModelPortaliP14246.
SMRiP14246. Positions 7-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1863175.
STRINGi10090.ENSMUSP00000029240.

PTM databases

iPTMnetiP14246.
PhosphoSiteiP14246.

Proteomic databases

EPDiP14246.
MaxQBiP14246.
PaxDbiP14246.
PRIDEiP14246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029240; ENSMUSP00000029240; ENSMUSG00000027690.
GeneIDi20526.
KEGGimmu:20526.
UCSCiuc008oua.2. mouse.

Organism-specific databases

CTDi6514.
MGIiMGI:1095438. Slc2a2.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP14246.
KOiK07593.
OMAiETEGSAH.
OrthoDBiEOG7QVM2R.
PhylomeDBiP14246.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-MMU-189200. Hexose transport.
R-MMU-210745. Regulation of gene expression in beta cells.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-70153. Glucose transport.

Miscellaneous databases

ChiTaRSiSlc2a2. mouse.
PROiP14246.
SOURCEiSearch...

Gene expression databases

BgeeiP14246.
ExpressionAtlasiP14246. baseline and differential.
GenevisibleiP14246. MM.

Family and domain databases

InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the mouse liver glucose transporter."
    Suzue K., Lodish H.F., Thorens B.
    Nucleic Acids Res. 17:10099-10099(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  2. "The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein."
    Asano T., Shibasaki Y., Lin J.L., Akanuma Y., Takaku F., Oka Y.
    Nucleic Acids Res. 17:6386-6386(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin-secreting cell line."
    Waeber G., Thompson N., Haefliger J.-A., Nicod P.
    J. Biol. Chem. 269:26912-26919(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
  6. "Glucose transporter gene expression in early mouse embryos."
    Hogan A., Heyner S., Charron M.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Thorens B., Schultz G.A.
    Development 113:363-372(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 384-496.
  7. "Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos."
    Smith D.E., Gridley T.
    Development 116:555-561(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  8. "Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes."
    Ohtsubo K., Takamatsu S., Minowa M.T., Yoshida A., Takeuchi M., Marth J.D.
    Cell 123:1307-1321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-62.
    Strain: 129/SvJ.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Liver.

Entry informationi

Entry nameiGTR2_MOUSE
AccessioniPrimary (citable) accession number: P14246
Secondary accession number(s): Q3TNA5, Q9DBA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 16, 2001
Last modified: June 8, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.