Solute carrier family 2, facilitated glucose transporter member 2

Names and origin

Protein names

Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
    Glucose transporter type 2, liver
      Short name=GLUT-2

Gene names

Name:	Slc2a2
Synonyms:	Glut-2, Glut2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Hide | Top

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na⁺/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	In embryo, expressed in endoderm layer of yolk sac and liver primordium. Ref.7
Post-translational modification	N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. Ref.8
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Hide | Top

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Transmembrane
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	dehydroascorbic acid transport Inferred from direct assay. Source: UniProtKB glucose transport Inferred from direct assay. Source: UniProtKB transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	brush border Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: MGI
Molecular function	D-glucose transmembrane transporter activity Inferred from direct assay. Source: UniProtKB dehydroascorbic acid transporter activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 523

523

Solute carrier family 2, facilitated glucose transporter member 2

PRO_0000050347

Regions

Topological domain

1 – 10

10

Cytoplasmic Potential

Transmembrane

11 – 31

21

1 Potential

Topological domain

32 – 97

66

Extracellular Potential

Transmembrane

98 – 118

21

2 Potential

Topological domain

119 – 126

8

Cytoplasmic Potential

Transmembrane

127 – 147

21

3 Potential

Topological domain

148 – 157

10

Extracellular Potential

Transmembrane

158 – 178

21

4 Potential

Topological domain

179 – 186

8

Cytoplasmic Potential

Transmembrane

187 – 207

21

5 Potential

Topological domain

208 – 216

9

Extracellular Potential

Transmembrane

217 – 237

21

6 Potential

Topological domain

238 – 302

65

Cytoplasmic Potential

Transmembrane

303 – 323

21

7 Potential

Topological domain

324 – 337

14

Extracellular Potential

Transmembrane

338 – 358

21

8 Potential

Topological domain

359 – 367

9

Cytoplasmic Potential

Transmembrane

368 – 388

21

9 Potential

Topological domain

389 – 401

13

Extracellular Potential

Transmembrane

402 – 422

21

10 Potential

Topological domain

423 – 432

10

Cytoplasmic Potential

Transmembrane

433 – 453

21

11 Potential

Topological domain

454 – 460

7

Extracellular Potential

Transmembrane

461 – 481

21

12 Potential

Topological domain

482 – 523

42

Cytoplasmic Potential

Amino acid modifications

Modified residue

520

1

Phosphoserine Ref.9

Glycosylation

62

1

N-linked (GlcNAc...) Probable

Experimental info

Sequence conflict

106

1

G → D in CAA33719. Ref.2

Sequence conflict

181

1

T → N in CAA34855. Ref.1

Sequence conflict

327

1

S → T in CAA33719. Ref.2

Sequence conflict

351

1

F → L in CAA34855. Ref.1

Sequence conflict

432

1

P → S in CAA34855. Ref.1

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

P14246-1 [UniParc].

Last modified November 16, 2001. Version 3.
Checksum: F12B5376CBDB5F63
Show »

FASTA

523

57,107

        10         20         30         40         50         60 
MSEDKITGTL AFTVFTAVLS SFQFGYDIGV INAPQEVIIS HYRHVLGVPL DDRKAAINYD 

        70         80         90        100        110        120 
VNGTDTPLTV TPAYTTPAPW DEEETEGSAH IVTMLWSLSV SSFAVGGMVA SFFGGWLGDK 

       130        140        150        160        170        180 
LGRIKAMLAA NSLSLTGALL MGCSKFGPAH ALIIAGRSVS GLYCGLISGL VPMYIGEIAP 

       190        200        210        220        230        240 
TTLRGALGTL HQLALVTGIL ISQIAGLSFI LGNQDHWHIL LGLSAVPALL QCLLLLFCPE 

       250        260        270        280        290        300 
SPRYLYIKLE EEVRAKKSLK RLRGTEDVTK DINEMKKEKE EASTEQKVSV IQLFTDANYR 

       310        320        330        340        350        360 
QPILVALMLH MAQQFSGING IFYYSTSIFQ TAGISQPVYA TIGVGAINMI FTAVSVLLVE 

       370        380        390        400        410        420 
KAGRRTLFLT GMIGMFFCTI FMSVGLVLLD KFAWMSYVSM TAIFLFVSFF EIGPGPIPWF 

       430        440        450        460        470        480 
MVAEFFSQGP RPTALALAAF SNWVCNFVIA LCFQYIADFL GPYVFFLFAG VVLVFTLFTF 

       490        500        510        520 
FKVPETKGKS FEEIAAEFRK KSGSAPPRKA AVQMEFLASS ESV

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the mouse liver glucose transporter." Suzue K., Lodish H.F., Thorens B. Nucleic Acids Res. 17:10099-10099(1989) [PubMed: 2602116] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver.
[2]	"The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein." Asano T., Shibasaki Y., Lin J.L., Akanuma Y., Takaku F., Oka Y. Nucleic Acids Res. 17:6386-6386(1989) [PubMed: 2771649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Liver.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney and Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
[5]	"Characterization of the murine high Km glucose transporter GLUT2 gene and its transcriptional regulation by glucose in a differentiated insulin-secreting cell line." Waeber G., Thompson N., Haefliger J.-A., Nicod P. J. Biol. Chem. 269:26912-26919(1994) [PubMed: 7929431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
[6]	"Glucose transporter gene expression in early mouse embryos." Hogan A., Heyner S., Charron M.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Thorens B., Schultz G.A. Development 113:363-372(1991) [PubMed: 1765007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 384-496.
[7]	"Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos." Smith D.E., Gridley T. Development 116:555-561(1992) [PubMed: 1289053] [Abstract] Cited for: TISSUE SPECIFICITY. Strain: C57BL/6.
[8]	"Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes." Ohtsubo K., Takamatsu S., Minowa M.T., Yoshida A., Takeuchi M., Marth J.D. Cell 123:1307-1321(2005) [PubMed: 16377570] [Abstract] Cited for: GLYCOSYLATION AT ASN-62. Strain: 129/SvJ.
[9]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	X16986 mRNA. Translation: CAA34855.1. X15684 mRNA. Translation: CAA33719.1. S77926 mRNA. Translation: AAB20847.1. AK005068 mRNA. Translation: BAB23792.1. AK165430 mRNA. Translation: BAE38184.1. BC034675 mRNA. Translation: AAH34675.1. X78722 Genomic DNA. Translation: CAA55368.1.
IPI	IPI00311809.
PIR	S06920.
RefSeq	NP_112474.2.
UniGene	Mm.18443
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P14246.
PTM databases
PhosphoSite	P14246.
Proteomic databases
PRIDE	P14246.
Genome annotation databases
Ensembl	ENSMUST00000029240; ENSMUSP00000029240; ENSMUSG00000027690; Mus musculus. [Genome view]
GeneID	20526.
KEGG	mmu:20526.
UCSC	uc008oua.1. mouse.
Organism-specific databases
CTD	20526.
MGI	MGI:1095438. Slc2a2.
Phylogenomic databases
HOGENOM	P14246.
HOVERGEN	P14246.
Enzyme and pathway databases
Reactome	REACT_13641. Regulation of Beta-Cell Development.
Gene expression databases
ArrayExpress	P14246.
Bgee	P14246.
Genevestigator	P14246.
GermOnline	ENSMUSG00000027690. Mus musculus.
Family and domain databases
InterPro	IPR002440. Glc_transpt_2. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR01191. GLUCTRSPORT2. PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	298767.
SOURCE	Search...

Hide | Top

Entry information

Entry name

GTR2_MOUSE

Accession

Primary (citable) accession number: P14246
Secondary accession number(s): Q3TNA5, Q9DBA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	November 16, 2001
Last modified:	October 13, 2009
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents