Reviewed,
UniProtKB/Swiss-Prot P14238 (FES_FELCA)
Last modified
September 1, 2009.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Proto-oncogene tyrosine-protein kinase Fes/Fps Short name=C-Fes EC=2.7.10.2 | ||||
| Gene names |
| ||||
| Organism | Felis catus (Cat) (Felis silvestris catus) | ||||
| Taxonomic identifier | 9685 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Protein attributes
| Sequence length | 820 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. Contains 1 FCH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. |
Ontologies
| Keywords | |
|---|---|
| Disease | Proto-oncogene |
| Domain | SH2 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 820 | 820 | Proto-oncogene tyrosine-protein kinase Fes/Fps | PRO_0000088085 | |||||
Regions | |||||||||
| Domain | 1 – 94 | 94 | FCH | ||||||
| Domain | 458 – 547 | 90 | SH2 | ||||||
| Domain | 559 – 820 | 262 | Protein kinase | ||||||
| Nucleotide binding | 565 – 573 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 681 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 588 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 711 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
Sequences
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References
| [1] | "Structure of the feline c-fes/fps proto-oncogene: genesis of a retroviral oncogene." Roebroek A.J.M., Schalken J.A., Onnekink C., Bloemers H.P.J., van de Ven W.J.M. J. Virol. 61:2009-2016(1987) [PubMed: 3553615] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
M16705 M16704 Genomic DNA. Translation: AAA30808.1. | |
| PIR | TVCTFF. A27824. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FGK based on UniProtKB P11362. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P14238. |
Phylogenomic databases | |
| HOVERGEN | P14238. |
Family and domain databases | |
| InterPro | IPR001060. FCH. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016250. TyrPK_fps. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| Pfam | PF00611. FCH. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000632. TyrPK_fps. 1 hit. |
| PRINTS | PR00401. SH2DOMAIN. PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00055. FCH. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS50133. FCH. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FES_FELCA | ||||||||
| Accession | Primary (citable) accession number: P14238 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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