Reviewed,
UniProtKB/Swiss-Prot P14234 (FGR_MOUSE)
Last modified
February 9, 2010.
Version 102.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Proto-oncogene tyrosine-protein kinase Fgr EC=2.7.10.2 Alternative name(s): Proto-oncogene c-Fgr p55-Fgr | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 517 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subunit structure | Binds PTPNS1. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain. |
Ontologies
| Keywords | |
|---|---|
| Disease | Proto-oncogene |
| Domain | SH2 domain SH3 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase Tyrosine-protein kinase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | defense response to Gram-positive bacterium Inferred from genetic interaction. Source: MGI protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 517 | 517 | Proto-oncogene tyrosine-protein kinase Fgr | PRO_0000088092 | |||||
Regions | |||||||||
| Domain | 65 – 126 | 62 | SH3 | ||||||
| Domain | 132 – 229 | 98 | SH2 | ||||||
| Domain | 251 – 504 | 254 | Protein kinase | ||||||
| Nucleotide binding | 257 – 265 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 370 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 279 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 13 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 25 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 32 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 196 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 400 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||
| Modified residue | 511 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 517 | 1 | Phosphothreonine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 41 | 1 | N → T in CAA36437. Ref.2 | ||||||
| Sequence conflict | 212 | 1 | Q → R in CAA36437. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells." Yi T.L., Willman C.L. Oncogene 4:1081-1087(1989) [PubMed: 2674853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2J. |
| [2] | "Molecular cloning and sequencing of the murine c-fgr gene." King F.J., Cole M.D. Oncogene 5:337-344(1990) [PubMed: 2179817] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Monocytic leukemia. |
| [3] | "Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr." Gresham H.D., Dale B.M., Potter J.W., Chang P.W., Vines C.M., Lowell C.A., Lagenaur C.F., Willman C.L. J. Exp. Med. 191:515-528(2000) [PubMed: 10662797] [Abstract] Cited for: INTERACTION WITH PTPNS1. |
| [4] | "The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND TYR-400, MASS SPECTROMETRY. Tissue: Macrophage. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X16440 mRNA. Translation: CAA34463.1. X52191 mRNA. Translation: CAA36437.1. |
| IPI | IPI00123708. |
| PIR | A43807. |
| UniGene | Mm.271665 |
3D structure databases | |
| SMR | P14234. Positions 67-515. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P14234. |
PTM databases | |
| PhosphoSite | P14234. |
Proteomic databases | |
| PRIDE | P14234. |
Genome annotation databases | |
| Ensembl | ENSMUST00000030693; ENSMUSP00000030693; ENSMUSG00000028874; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:95527. Fgr. |
Phylogenomic databases | |
| eggNOG | maNOG09357. |
| HOGENOM | HBG755340. |
| HOVERGEN | P14234. |
| InParanoid | P14234. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.2. 244. |
Gene expression databases | |
| ArrayExpress | P14234. |
| Bgee | P14234. |
| Genevestigator | P14234. |
| GermOnline | ENSMUSG00000028874. Mus musculus. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000980. SH2. IPR001452. SH3_domain. IPR020473. SH3_region. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR020746. Tyr_prot_kinase_non-rcpt_Fgr. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| PANTHER | PTHR23256. Tyr_prot_kinase. 1 hit. PTHR23256:SF257. Tyr_prot_kinase_non-rcpt_Fgr. 1 hit. |
| Pfam | PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view] |
| PRINTS | PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. |
| SMART | SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | FGR_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P14234 Secondary accession number(s): Q61404 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


