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Protein

Sodium/potassium-transporting ATPase subunit beta-2

Gene

Atp1b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-2
Alternative name(s):
Adhesion molecule in glia
Short name:
AMOG
Sodium/potassium-dependent ATPase subunit beta-2
Gene namesi
Name:Atp1b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88109. Atp1b2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6728Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini68 – 290223ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • cytoplasm Source: MGI
  • sodium:potassium-exchanging ATPase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Sodium/potassium-transporting ATPase subunit beta-2PRO_0000219105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
Disulfide bondi129 ↔ 150By similarity
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi160 ↔ 177By similarity
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi200 ↔ 261By similarity
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)1 Publication
Glycosylationi250 – 2501N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14231.
PeptideAtlasiP14231.
PRIDEiP14231.

PTM databases

iPTMnetiP14231.
PhosphoSiteiP14231.
SwissPalmiP14231.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041329.
CleanExiMM_ATP1B2.
ExpressionAtlasiP14231. baseline and differential.
GenevisibleiP14231. MM.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP14231. 2 interactions.
MINTiMINT-4088594.
STRINGi10090.ENSMUSP00000047353.

Structurei

3D structure databases

ProteinModelPortaliP14231.
SMRiP14231. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 29098immunoglobulin-likeBy similarityAdd
BLAST

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP14231.
KOiK01540.
OMAiTESWDLY.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP14231.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF
60 70 80 90 100
LTAMFSLTMW VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNISDT
110 120 130 140 150
ESWGQHVQKL NKFLEPYNDS IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC
160 170 180 190 200
QFNRTQLGDC SGIGDPTHYG YSTGQPCVFI KMNRVINFYA GANQSMNVTC
210 220 230 240 250
VGKRDEDAEN LGHFVMFPAN GSIDLMYFPY YGKKFHVNYT QPLVAVKFLN
260 270 280 290
VTPNVEVNVE CRINAANIAT DDERDKFAGR VAFKLRINKT
Length:290
Mass (Da):33,344
Last modified:February 1, 1996 - v2
Checksum:i731836AFB23198D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16645 mRNA. Translation: CAA34638.1.
X56007 Genomic DNA. Translation: CAA39482.1.
M60897 Genomic DNA. No translation available.
BC042467 mRNA. Translation: AAH42467.1.
BC058763 mRNA. Translation: AAH58763.1.
CCDSiCCDS24898.1.
PIRiA34057.
S14235.
RefSeqiNP_038201.1. NM_013415.5.
UniGeneiMm.235204.

Genome annotation databases

EnsembliENSMUST00000047889; ENSMUSP00000047353; ENSMUSG00000041329.
GeneIDi11932.
KEGGimmu:11932.
UCSCiuc007jqo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16645 mRNA. Translation: CAA34638.1.
X56007 Genomic DNA. Translation: CAA39482.1.
M60897 Genomic DNA. No translation available.
BC042467 mRNA. Translation: AAH42467.1.
BC058763 mRNA. Translation: AAH58763.1.
CCDSiCCDS24898.1.
PIRiA34057.
S14235.
RefSeqiNP_038201.1. NM_013415.5.
UniGeneiMm.235204.

3D structure databases

ProteinModelPortaliP14231.
SMRiP14231. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14231. 2 interactions.
MINTiMINT-4088594.
STRINGi10090.ENSMUSP00000047353.

PTM databases

iPTMnetiP14231.
PhosphoSiteiP14231.
SwissPalmiP14231.

Proteomic databases

PaxDbiP14231.
PeptideAtlasiP14231.
PRIDEiP14231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047889; ENSMUSP00000047353; ENSMUSG00000041329.
GeneIDi11932.
KEGGimmu:11932.
UCSCiuc007jqo.1. mouse.

Organism-specific databases

CTDi482.
MGIiMGI:88109. Atp1b2.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP14231.
KOiK01540.
OMAiTESWDLY.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP14231.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp1b2. mouse.
PROiP14231.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041329.
CleanExiMM_ATP1B2.
ExpressionAtlasiP14231. baseline and differential.
GenevisibleiP14231. MM.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B2_MOUSE
AccessioniPrimary (citable) accession number: P14231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.