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P14228 (PGK_HYPJE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk1
Synonyms:pgk
OrganismHypocrea jecorina (Trichoderma reesei)
Taxonomic identifier51453 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145890

Regions

Nucleotide binding372 – 3754ATP By similarity
Region24 – 263Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity
Binding site3431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P14228 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 72195841EAB7A4D7

FASTA41644,406
        10         20         30         40         50         60 
MSLSNKLSIT DVDLKGKRVL IRVDFNVPLD ENKKITNNQR IVGAIPTIKH ALDNGAKAVV 

        70         80         90        100        110        120 
LMSHLGRPNG AVNPKYSLKP VVPELERLLG KPVTFARDCV GPEVESIVND ADNGAVILLE 

       130        140        150        160        170        180 
NLRFHIEEEG SAKDKDGNKT KADKAKVEEF RKGLTALGDI YINDAFGTAH RAHSSMVGVD 

       190        200        210        220        230        240 
LPQKAAGFLM KKELDYFAKA LESPQRPFLA ILGGAKVSDK IQLIDNLLDK VDTLIVCGGM 

       250        260        270        280        290        300 
AFTFKKVLNN IPIGTSLFDE AGAKTCPSCR EAKAKNVKLV LPVDYITADK FDKDANTGTA 

       310        320        330        340        350        360 
TDESGIPDGW MGLDCGEKSI ELYKEAIADA KTILWNGPAG VFEFDKFANG TKATLDAVVE 

       370        380        390        400        410 
GCKNGKIVII GGGDTATVAA KYGVEDKLSH VSTGGGASLE LLEGKELPGV VALSSK 

« Hide

References

[1]"Isolation and characterization of the 3-phosphoglycerate kinase gene (pgk) from the filamentous fungus Trichoderma reesei."
Vanhanen S., Penttilae M., Lehtovaara P., Knowles J.K.C.
Curr. Genet. 15:181-186(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 26921 / CBS 392.92 / QM9414.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15764 Genomic DNA. Translation: CAA33770.1.
PIRTVTQGR. S07803.

3D structure databases

ProteinModelPortalP14228.
SMRP14228. Positions 2-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING51453.JGI21406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0126.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_HYPJE
AccessionPrimary (citable) accession number: P14228
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways