##gff-version 3 P14222 UniProtKB Signal peptide 1 21 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Chain 22 555 . . . ID=PRO_0000023609;Note=Perforin-1 P14222 UniProtKB Transmembrane 129 149 . . . Note=Beta stranded%3B Name%3DCH1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Transmembrane 257 279 . . . Note=Beta stranded%3B Name%3DCH2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Domain 27 375 . . . Note=MACPF;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00745 P14222 UniProtKB Domain 376 408 . . . Note=EGF-like P14222 UniProtKB Domain 397 519 . . . Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 P14222 UniProtKB Binding site 429 429 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 430 430 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 430 430 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 430 430 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 433 433 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 434 434 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 436 436 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 436 436 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 484 484 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 484 484 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 486 486 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 486 486 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 486 486 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 486 486 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 490 490 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 491 491 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 492 492 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Binding site 492 492 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Site 214 214 . . . Note=Important for oligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Site 344 344 . . . Note=Important for oligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Glycosylation 205 205 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 P14222 UniProtKB Glycosylation 549 549 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P14222 UniProtKB Disulfide bond 23 76 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 31 73 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 102 176 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 242 408 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 377 393 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 381 395 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 397 407 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 497 510 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Disulfide bond 525 534 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10820 P14222 UniProtKB Natural variant 4 4 . . . ID=VAR_061504;Note=R->H;Dbxref=dbSNP:rs35418374 P14222 UniProtKB Natural variant 50 50 . . . ID=VAR_010772;Note=In FHL2. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11179007;Dbxref=dbSNP:rs776299562,PMID:11179007 P14222 UniProtKB Natural variant 91 91 . . . ID=VAR_050482;Note=A->V;Dbxref=dbSNP:rs35947132 P14222 UniProtKB Natural variant 123 123 . . . ID=VAR_010773;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs139336186,PMID:16959974 P14222 UniProtKB Natural variant 135 135 . . . ID=VAR_029773;Note=V->M;Dbxref=dbSNP:rs12263572 P14222 UniProtKB Natural variant 183 183 . . . ID=VAR_010744;Note=In FHL2. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583959;Dbxref=dbSNP:rs104894183,PMID:10583959 P14222 UniProtKB Natural variant 224 224 . . . ID=VAR_010774;Note=In FHL2. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11179007;Dbxref=PMID:11179007 P14222 UniProtKB Natural variant 225 225 . . . ID=VAR_010745;Note=In FHL2. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583959;Dbxref=dbSNP:rs28933973,PMID:10583959 P14222 UniProtKB Natural variant 252 252 . . . ID=VAR_010746;Note=In FHL2. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583959;Dbxref=dbSNP:rs28933375,PMID:10583959 P14222 UniProtKB Natural variant 279 279 . . . ID=VAR_010747;Note=In FHL2. C->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583959;Dbxref=dbSNP:rs104894182,PMID:10583959 P14222 UniProtKB Natural variant 285 285 . . . ID=VAR_010775;Note=In FHL2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11179007;Dbxref=PMID:11179007 P14222 UniProtKB Natural variant 345 345 . . . ID=VAR_010748;Note=In FHL2. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583959;Dbxref=dbSNP:rs28933374,PMID:10583959 P14222 UniProtKB Natural variant 429 429 . . . ID=VAR_010749;Note=In FHL2. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10583959;Dbxref=dbSNP:rs104894181,PMID:10583959 P14222 UniProtKB Sequence conflict 332 332 . . . Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P14222 UniProtKB Sequence conflict 426 426 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305