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Reviewed, UniProtKB/Swiss-Prot P14219 (ADH1_PENAM)

Last modified January 19, 2010. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    ADH slow-allele
Gene names
Name: ADH1
OrganismPennisetum americanum (Pearl millet)
Taxonomic identifier4543 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACCAD clade › Panicoideae › Paniceae › Pennisetum

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Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Alcohol dehydrogenase 1
PRO_0000160710

Regions

Nucleotide binding202 – 2076NAD By similarity
Nucleotide binding295 – 2973NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity
Binding site2261NAD By similarity
Binding site2311NAD By similarity
Binding site3721NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
P14219-1 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: E4FB72DE7A2C3EC1

FASTA37940,916
        10         20         30         40         50         60 
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTSLCHTD VYFWEAKGQT 

        70         80         90        100        110        120 
PVFPRIFGHE AGGIIESVGE GVTDVAPGDH VLPVFTGECK ECPHCKSAES NMCDLLRINT 

       130        140        150        160        170        180 
VRGVMIGDGK SRFSINGKPI YHFVGTSTFS EYTVMHVGCV AKINPEAPLD KVCVLSCGIS 

       190        200        210        220        230        240 
TGLGASINVA KPPKGSTVAI FGLGAVGLAA AEGARIAGAS RIIGVDLNPS RFEEAKKFGC 

       250        260        270        280        290        300 
TEFVNPKDHN KPVQEVLADM TNGGVDRSVE CTGNINAMIQ AFECVHDGWG VAVLVGVPHK 

       310        320        330        340        350        360 
DAEFKTHPMN FLNERTLKGT FFGNFKPRTD LPNVVELYMK KELEVEKFIT HSVPFSEINK 

       370 
AFDLMAKGEG IRCIIRMEN

« Hide

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References

[1]"Nucleotide sequence encoding a slow allele of Adh1 in pearl millet."
Ha D.B.D., Buffard D., Berger F., Breda C., Esnault R.
Plant Mol. Biol. 14:453-455(1990) [PubMed: 2102826] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Massue.
Tissue: Root.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X16547 mRNA. Translation: CAA34547.1.
PIRDEILSP. S14905.

3D structure databases

SMRP14219. Positions 4-377.
ModBaseSearch...

Organism-specific databases

GrameneP14219.

Enzyme and pathway databases

BRENDA1.1.1.1. 265229.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1_PENAM
AccessionPrimary (citable) accession number: P14219
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 19, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents