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Protein

Polyphemusin-1

Gene
N/A
Organism
Limulus polyphemus (Atlantic horseshoe crab)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Significantly inhibits the growth of Gram-negative and Gram-positive bacteria.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Protein family/group databases

TCDBi1.C.34.2.1. the tachyplesin (tachyplesin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphemusin-1
Alternative name(s):
Polyphemusin I
OrganismiLimulus polyphemus (Atlantic horseshoe crab)
Taxonomic identifieri6850 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataMerostomataXiphosuraLimulidaeLimulus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444521 – 18Polyphemusin-1Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 171 Publication
Disulfide bondi8 ↔ 131 Publication
Modified residuei18Arginine amide2 Publications1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Hemocytes.

Structurei

Secondary structure

118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RKKNMR-A1-18[»]
1X7KNMR-A1-18[»]
2B5KNMR-A1-18[»]
SMRiP14215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14215.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachyplesin/polyphemusin family.Curated

Sequencei

Sequence statusi: Complete.

P14215-1 [UniParc]FASTAAdd to basket

« Hide

        10 
RRWCFRVCYR GFCYRKCR
Length:18
Mass (Da):2,459
Last modified:January 1, 1990 - v1
Checksum:iFB3FA109D2923504
GO

Sequence databases

PIRiJU0124.

Cross-referencesi

Sequence databases

PIRiJU0124.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RKKNMR-A1-18[»]
1X7KNMR-A1-18[»]
2B5KNMR-A1-18[»]
SMRiP14215.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.34.2.1. the tachyplesin (tachyplesin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP14215.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPPM1_LIMPO
AccessioniPrimary (citable) accession number: P14215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.