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Protein

Hepatocyte growth factor

Gene

HGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.2 Publications

GO - Molecular functioni

  • chemoattractant activity Source: BHF-UCL
  • growth factor activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Serine protease homolog

Enzyme and pathway databases

BioCyciZFISH:ENSG00000019991-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6806942. MET Receptor Activation.
R-HSA-6807004. Negative regulation of MET activity.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8851805. MET activates RAS signaling.
R-HSA-8851907. MET activates PI3K/AKT signaling.
R-HSA-8865999. MET activates PTPN11.
R-HSA-8874081. MET activates PTK2 signaling.
R-HSA-8875513. MET interacts with TNS proteins.
R-HSA-8875555. MET activates RAP1 and RAC1.
R-HSA-8875656. MET receptor recycling.
R-HSA-8875791. MET activates STAT3.
SignaLinkiP14210.
SIGNORiP14210.

Protein family/group databases

MEROPSiS01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor
Alternative name(s):
Hepatopoietin-A
Scatter factor
Short name:
SF
Cleaved into the following 2 chains:
Gene namesi
Name:HGF
Synonyms:HPTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4893. HGF.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: GO_Central
  • membrane Source: UniProtKB
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 39 (DFNB39)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:608265

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi494R → Q: Loss of activity due to absence of proteolytic cleavage. 1 Publication1

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNETi3082.
MalaCardsiHGF.
MIMi608265. phenotype.
OpenTargetsiENSG00000019991.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA29269.

Chemistry databases

ChEMBLiCHEMBL5479.

Polymorphism and mutation databases

BioMutaiHGF.
DMDMi123116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000002809132 – 494Hepatocyte growth factor alpha chainAdd BLAST463
ChainiPRO_0000028092495 – 728Hepatocyte growth factor beta chainAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi70 ↔ 96
Disulfide bondi74 ↔ 84
Disulfide bondi128 ↔ 206
Disulfide bondi149 ↔ 189
Disulfide bondi177 ↔ 201
Disulfide bondi211 ↔ 288By similarity
Disulfide bondi232 ↔ 271By similarity
Disulfide bondi260 ↔ 283By similarity
GlycosylationiCAR_000021294N-linked (GlcNAc...) (complex)1
Disulfide bondi305 ↔ 383By similarity
Disulfide bondi326 ↔ 365By similarity
Disulfide bondi354 ↔ 377By similarity
Disulfide bondi391 ↔ 469By similarity
GlycosylationiCAR_000022402N-linked (GlcNAc...) (complex)1
Disulfide bondi412 ↔ 452By similarity
Disulfide bondi440 ↔ 464By similarity
GlycosylationiCAR_000023476O-linked (GalNAc...)1 Publication1
Disulfide bondi487 ↔ 604Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi519 ↔ 535By similarity
GlycosylationiCAR_000024566N-linked (GlcNAc...) (complex)1
Disulfide bondi612 ↔ 679By similarity
Disulfide bondi642 ↔ 658By similarity
GlycosylationiCAR_000025653N-linked (GlcNAc...) (complex)1
Disulfide bondi669 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP14210.
MaxQBiP14210.
PaxDbiP14210.
PeptideAtlasiP14210.
PRIDEiP14210.

PTM databases

iPTMnetiP14210.
PhosphoSitePlusiP14210.
UniCarbKBiP14210.

Miscellaneous databases

PMAP-CutDBP14210.

Expressioni

Gene expression databases

BgeeiENSG00000019991.
ExpressionAtlasiP14210. baseline and differential.
GenevisibleiP14210. HS.

Organism-specific databases

HPAiCAB010333.
HPA040360.
HPA044088.

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-1039104,EBI-10173507
MEOX2A4D1273EBI-1039104,EBI-10172134
METP085814EBI-1039104,EBI-1039152
MetP160562EBI-1039104,EBI-1798780From a different organism.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109330. 10 interactors.
DIPiDIP-37535N.
IntActiP14210. 7 interactors.
MINTiMINT-219560.
STRINGi9606.ENSP00000222390.

Chemistry databases

BindingDBiP14210.

Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 41Combined sources3
Beta strandi42 – 52Combined sources11
Beta strandi55 – 57Combined sources3
Beta strandi60 – 63Combined sources4
Helixi67 – 76Combined sources10
Turni77 – 79Combined sources3
Beta strandi80 – 82Combined sources3
Beta strandi86 – 90Combined sources5
Turni91 – 94Combined sources4
Beta strandi95 – 100Combined sources6
Beta strandi105 – 107Combined sources3
Beta strandi108 – 121Combined sources14
Helixi122 – 124Combined sources3
Beta strandi128 – 132Combined sources5
Beta strandi148 – 150Combined sources3
Beta strandi156 – 158Combined sources3
Helixi164 – 167Combined sources4
Turni168 – 171Combined sources4
Beta strandi187 – 193Combined sources7
Beta strandi198 – 200Combined sources3
Helixi206 – 209Combined sources4
Beta strandi211 – 213Combined sources3
Beta strandi239 – 241Combined sources3
Turni247 – 249Combined sources3
Turni251 – 254Combined sources4
Beta strandi270 – 274Combined sources5
Beta strandi279 – 282Combined sources4
Beta strandi508 – 525Combined sources18
Beta strandi528 – 532Combined sources5
Helixi533 – 535Combined sources3
Beta strandi537 – 539Combined sources3
Helixi541 – 543Combined sources3
Beta strandi544 – 549Combined sources6
Beta strandi551 – 554Combined sources4
Turni557 – 561Combined sources5
Beta strandi563 – 572Combined sources10
Beta strandi579 – 586Combined sources8
Beta strandi591 – 593Combined sources3
Beta strandi611 – 618Combined sources8
Beta strandi630 – 637Combined sources8
Helixi639 – 641Combined sources3
Turni646 – 648Combined sources3
Beta strandi656 – 660Combined sources5
Beta strandi662 – 664Combined sources3
Turni670 – 674Combined sources5
Beta strandi676 – 680Combined sources5
Beta strandi682 – 691Combined sources10
Beta strandi695 – 697Combined sources3
Beta strandi704 – 708Combined sources5
Helixi709 – 712Combined sources4
Helixi713 – 720Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHTX-ray2.00A/B35-210[»]
1GMNX-ray2.30A/B28-210[»]
1GMOX-ray3.00A/B/C/D/E/F/G/H28-210[»]
1GP9X-ray2.50A/B/C/D40-210[»]
1NK1X-ray2.50A/B28-210[»]
1SHYX-ray3.22A495-728[»]
1SI5X-ray2.53H495-728[»]
2HGFNMR-A31-127[»]
2QJ2X-ray1.81A/B28-209[»]
3HMSX-ray1.70A28-126[»]
3HMTX-ray2.00A/B28-126[»]
3HN4X-ray2.60A28-289[»]
3MKPX-ray2.81A/B/C/D28-210[»]
3SP8X-ray1.86A/B28-288[»]
4D3CX-ray2.62A32-210[»]
4K3JX-ray2.80A495-721[»]
4O3TX-ray2.99A495-728[»]
4O3UX-ray3.04A495-728[»]
5COEX-ray2.18A/B28-210[»]
5CP9X-ray1.90A/B28-210[»]
5CS1X-ray2.00A/B28-210[»]
5CS3X-ray2.50A/B28-210[»]
5CS5X-ray1.90A/B28-210[»]
5CS9X-ray2.00A/B28-210[»]
5CSQX-ray1.95A/B28-210[»]
5CT1X-ray2.00A/B28-210[»]
5CT2X-ray2.00A/B28-210[»]
5CT3X-ray2.00A/B28-210[»]
ProteinModelPortaliP14210.
SMRiP14210.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 123PANPROSITE-ProRule annotationAdd BLAST87
Domaini128 – 206Kringle 1PROSITE-ProRule annotationAdd BLAST79
Domaini211 – 288Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini305 – 383Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini391 – 469Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini495 – 721Peptidase S1PROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation
Contains 4 kringle domains.PROSITE-ProRule annotation
Contains 1 PAN domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOVERGENiHBG004381.
InParanoidiP14210.
KOiK05460.
OMAiGSESPWC.
OrthoDBiEOG091G0AH5.
PhylomeDBiP14210.
TreeFamiTF329901.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14210-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL
60 70 80 90 100
IKIDPALKIK TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP
110 120 130 140 150
FNSMSSGVKK EFGHEFDLYE NKDYIRNCII GKGRSYKGTV SITKSGIKCQ
160 170 180 190 200
PWSSMIPHEH SFLPSSYRGK DLQENYCRNP RGEEGGPWCF TSNPEVRYEV
210 220 230 240 250
CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP HRHKFLPERY
260 270 280 290 300
PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL
310 320 330 340 350
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR
360 370 380 390 400
ENYCRNPDGS ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM
410 420 430 440 450
GNLSQTRSGL TCSMWDKNME DLHRHIFWEP DASKLNENYC RNPDDDAHGP
460 470 480 490 500
WCYTGNPLIP WDYCPISRCE GDTTPTIVNL DHPVISCAKT KQLRVVNGIP
510 520 530 540 550
TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD LKDYEAWLGI
560 570 580 590 600
HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP
610 620 630 640 650
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV
660 670 680 690 700
TLNESEICAG AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP
710 720
NRPGIFVRVA YYAKWIHKII LTYKVPQS
Length:728
Mass (Da):83,134
Last modified:August 1, 1991 - v2
Checksum:i2D997938295ADD2F
GO
Isoform 2 (identifier: P14210-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-290: AD → ET
     291-728: Missing.

Show »
Length:290
Mass (Da):33,766
Checksum:iC8A18A6F0D63200A
GO
Isoform 3 (identifier: P14210-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.

Show »
Length:723
Mass (Da):82,602
Checksum:i627B1EF99FAD931B
GO
Isoform 4 (identifier: P14210-4) [UniParc]FASTAAdd to basket
Also known as: HGF/NK2

The sequence of this isoform differs from the canonical sequence as follows:
     287-296: TCADNTMNDT → NMRDITWALN
     297-728: Missing.

Note: Acts as a competitive antagonist in MET-signaling.
Show »
Length:296
Mass (Da):34,547
Checksum:iA45E456B87AE03BE
GO
Isoform 5 (identifier: P14210-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.
     289-290: AD → ET
     291-728: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):33,234
Checksum:i0A93B073EA86EA61
GO
Isoform 6 (identifier: P14210-6) [UniParc]FASTAAdd to basket
Also known as: HGF/NK1

The sequence of this isoform differs from the canonical sequence as follows:
     209-210: VE → GK
     211-728: Missing.

Show »
Length:210
Mass (Da):24,116
Checksum:i94A6EE9C50DE5A86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 33QR → HK in CAA34387 (PubMed:2531289).Curated2
Sequence conflicti78K → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti180P → T AA sequence (PubMed:1824873).Curated1
Sequence conflicti293M → V in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti300L → M in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti317V → A in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti336E → K in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti387H → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti416D → N in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti505I → V in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti509V → I in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti558D → E in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti561C → R in CAA34387 (PubMed:2531289).Curated1
Sequence conflicti592D → N AA sequence (PubMed:1824873).Curated1
Sequence conflicti595S → N in CAA34387 (PubMed:2531289).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014570153S → I.Corresponds to variant rs17566dbSNPEnsembl.1
Natural variantiVAR_019199304E → K.1 PublicationCorresponds to variant rs5745687dbSNPEnsembl.1
Natural variantiVAR_019200330D → Y.1 PublicationCorresponds to variant rs5745688dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009617161 – 165Missing in isoform 3 and isoform 5. 2 Publications5
Alternative sequenceiVSP_009618209 – 210VE → GK in isoform 6. 2 Publications2
Alternative sequenceiVSP_009619211 – 728Missing in isoform 6. 2 PublicationsAdd BLAST518
Alternative sequenceiVSP_009620287 – 296TCADNTMNDT → NMRDITWALN in isoform 4. 1 Publication10
Alternative sequenceiVSP_009622289 – 290AD → ET in isoform 2 and isoform 5. 3 Publications2
Alternative sequenceiVSP_009623291 – 728Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST438
Alternative sequenceiVSP_009621297 – 728Missing in isoform 4. 1 PublicationAdd BLAST432

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29145 mRNA. Translation: AAA52650.1.
X16323 mRNA. Translation: CAA34387.1.
M60718 mRNA. Translation: AAA52648.1.
D90334 Genomic DNA. Translation: BAA14348.1.
X57574 mRNA. Translation: CAA40802.1.
M55379 mRNA. No translation available.
M73239 mRNA. Translation: AAA64239.1.
M73240 mRNA. Translation: AAA64297.1.
M77227 mRNA. Translation: AAA35980.1.
L02931 mRNA. Translation: AAA52649.1.
U46010 mRNA. Translation: AAC50539.1.
AY246560 Genomic DNA. Translation: AAO61091.1.
AC004960 Genomic DNA. Translation: AAC71655.1.
CH236949 Genomic DNA. Translation: EAL24189.1.
BC022308 mRNA. Translation: AAH22308.1.
BC063485 mRNA. Translation: AAH63485.1.
BC105797 mRNA. Translation: AAI05798.1.
BC130284 mRNA. Translation: AAI30285.1.
BC130286 mRNA. Translation: AAI30287.1.
M75971
, M75967, M75966, M75968, M75969 Genomic DNA. Translation: AAG53459.1.
M75983
, M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA. Translation: AAG53460.1.
CCDSiCCDS47626.1. [P14210-3]
CCDS47627.1. [P14210-2]
CCDS47628.1. [P14210-5]
CCDS47629.1. [P14210-6]
CCDS5597.1. [P14210-1]
PIRiJH0579.
RefSeqiNP_000592.3. NM_000601.5. [P14210-1]
NP_001010931.1. NM_001010931.2. [P14210-2]
NP_001010932.1. NM_001010932.2. [P14210-3]
NP_001010933.1. NM_001010933.2. [P14210-5]
NP_001010934.1. NM_001010934.2. [P14210-6]
XP_006716019.1. XM_006715956.2. [P14210-1]
XP_011514417.1. XM_011516115.2. [P14210-3]
XP_016867586.1. XM_017012097.1. [P14210-2]
XP_016867587.1. XM_017012098.1. [P14210-5]
UniGeneiHs.396530.
Hs.561679.

Genome annotation databases

EnsembliENST00000222390; ENSP00000222390; ENSG00000019991. [P14210-1]
ENST00000423064; ENSP00000413829; ENSG00000019991. [P14210-6]
ENST00000444829; ENSP00000389854; ENSG00000019991. [P14210-2]
ENST00000453411; ENSP00000408270; ENSG00000019991. [P14210-5]
ENST00000457544; ENSP00000391238; ENSG00000019991. [P14210-3]
GeneIDi3082.
KEGGihsa:3082.
UCSCiuc003uhl.4. human. [P14210-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Hepatocyte growth factor entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29145 mRNA. Translation: AAA52650.1.
X16323 mRNA. Translation: CAA34387.1.
M60718 mRNA. Translation: AAA52648.1.
D90334 Genomic DNA. Translation: BAA14348.1.
X57574 mRNA. Translation: CAA40802.1.
M55379 mRNA. No translation available.
M73239 mRNA. Translation: AAA64239.1.
M73240 mRNA. Translation: AAA64297.1.
M77227 mRNA. Translation: AAA35980.1.
L02931 mRNA. Translation: AAA52649.1.
U46010 mRNA. Translation: AAC50539.1.
AY246560 Genomic DNA. Translation: AAO61091.1.
AC004960 Genomic DNA. Translation: AAC71655.1.
CH236949 Genomic DNA. Translation: EAL24189.1.
BC022308 mRNA. Translation: AAH22308.1.
BC063485 mRNA. Translation: AAH63485.1.
BC105797 mRNA. Translation: AAI05798.1.
BC130284 mRNA. Translation: AAI30285.1.
BC130286 mRNA. Translation: AAI30287.1.
M75971
, M75967, M75966, M75968, M75969 Genomic DNA. Translation: AAG53459.1.
M75983
, M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA. Translation: AAG53460.1.
CCDSiCCDS47626.1. [P14210-3]
CCDS47627.1. [P14210-2]
CCDS47628.1. [P14210-5]
CCDS47629.1. [P14210-6]
CCDS5597.1. [P14210-1]
PIRiJH0579.
RefSeqiNP_000592.3. NM_000601.5. [P14210-1]
NP_001010931.1. NM_001010931.2. [P14210-2]
NP_001010932.1. NM_001010932.2. [P14210-3]
NP_001010933.1. NM_001010933.2. [P14210-5]
NP_001010934.1. NM_001010934.2. [P14210-6]
XP_006716019.1. XM_006715956.2. [P14210-1]
XP_011514417.1. XM_011516115.2. [P14210-3]
XP_016867586.1. XM_017012097.1. [P14210-2]
XP_016867587.1. XM_017012098.1. [P14210-5]
UniGeneiHs.396530.
Hs.561679.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHTX-ray2.00A/B35-210[»]
1GMNX-ray2.30A/B28-210[»]
1GMOX-ray3.00A/B/C/D/E/F/G/H28-210[»]
1GP9X-ray2.50A/B/C/D40-210[»]
1NK1X-ray2.50A/B28-210[»]
1SHYX-ray3.22A495-728[»]
1SI5X-ray2.53H495-728[»]
2HGFNMR-A31-127[»]
2QJ2X-ray1.81A/B28-209[»]
3HMSX-ray1.70A28-126[»]
3HMTX-ray2.00A/B28-126[»]
3HN4X-ray2.60A28-289[»]
3MKPX-ray2.81A/B/C/D28-210[»]
3SP8X-ray1.86A/B28-288[»]
4D3CX-ray2.62A32-210[»]
4K3JX-ray2.80A495-721[»]
4O3TX-ray2.99A495-728[»]
4O3UX-ray3.04A495-728[»]
5COEX-ray2.18A/B28-210[»]
5CP9X-ray1.90A/B28-210[»]
5CS1X-ray2.00A/B28-210[»]
5CS3X-ray2.50A/B28-210[»]
5CS5X-ray1.90A/B28-210[»]
5CS9X-ray2.00A/B28-210[»]
5CSQX-ray1.95A/B28-210[»]
5CT1X-ray2.00A/B28-210[»]
5CT2X-ray2.00A/B28-210[»]
5CT3X-ray2.00A/B28-210[»]
ProteinModelPortaliP14210.
SMRiP14210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109330. 10 interactors.
DIPiDIP-37535N.
IntActiP14210. 7 interactors.
MINTiMINT-219560.
STRINGi9606.ENSP00000222390.

Chemistry databases

BindingDBiP14210.
ChEMBLiCHEMBL5479.

Protein family/group databases

MEROPSiS01.976.

PTM databases

iPTMnetiP14210.
PhosphoSitePlusiP14210.
UniCarbKBiP14210.

Polymorphism and mutation databases

BioMutaiHGF.
DMDMi123116.

Proteomic databases

EPDiP14210.
MaxQBiP14210.
PaxDbiP14210.
PeptideAtlasiP14210.
PRIDEiP14210.

Protocols and materials databases

DNASUi3082.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222390; ENSP00000222390; ENSG00000019991. [P14210-1]
ENST00000423064; ENSP00000413829; ENSG00000019991. [P14210-6]
ENST00000444829; ENSP00000389854; ENSG00000019991. [P14210-2]
ENST00000453411; ENSP00000408270; ENSG00000019991. [P14210-5]
ENST00000457544; ENSP00000391238; ENSG00000019991. [P14210-3]
GeneIDi3082.
KEGGihsa:3082.
UCSCiuc003uhl.4. human. [P14210-1]

Organism-specific databases

CTDi3082.
DisGeNETi3082.
GeneCardsiHGF.
GeneReviewsiHGF.
HGNCiHGNC:4893. HGF.
HPAiCAB010333.
HPA040360.
HPA044088.
MalaCardsiHGF.
MIMi142409. gene.
608265. phenotype.
neXtProtiNX_P14210.
OpenTargetsiENSG00000019991.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA29269.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOVERGENiHBG004381.
InParanoidiP14210.
KOiK05460.
OMAiGSESPWC.
OrthoDBiEOG091G0AH5.
PhylomeDBiP14210.
TreeFamiTF329901.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000019991-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1266695. Interleukin-7 signaling.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6806942. MET Receptor Activation.
R-HSA-6807004. Negative regulation of MET activity.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8851805. MET activates RAS signaling.
R-HSA-8851907. MET activates PI3K/AKT signaling.
R-HSA-8865999. MET activates PTPN11.
R-HSA-8874081. MET activates PTK2 signaling.
R-HSA-8875513. MET interacts with TNS proteins.
R-HSA-8875555. MET activates RAP1 and RAC1.
R-HSA-8875656. MET receptor recycling.
R-HSA-8875791. MET activates STAT3.
SignaLinkiP14210.
SIGNORiP14210.

Miscellaneous databases

ChiTaRSiHGF. human.
EvolutionaryTraceiP14210.
GeneWikiiHepatocyte_growth_factor.
GenomeRNAii3082.
PMAP-CutDBP14210.
PROiP14210.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000019991.
ExpressionAtlasiP14210. baseline and differential.
GenevisibleiP14210. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHGF_HUMAN
AccessioniPrimary (citable) accession number: P14210
Secondary accession number(s): A1L3U6
, Q02935, Q13494, Q14519, Q3KRB2, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 209 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.