Reviewed, UniProtKB/Swiss-Prot P14210 (HGF_HUMAN)

Names and origin

Protein names

Recommended name:
    Hepatocyte growth factor
Alternative name(s):
    Scatter factor
      Short name=SF
    Hepatopoeitin-A
Cleaved into the following 2 chains:
    1- Recommended name:
            Hepatocyte growth factor alpha chain
    2- Recommended name:
            Hepatocyte growth factor beta chain

Gene names

Name:	HGF
Synonyms:	HPTA

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	728 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.
Subunit structure	Dimer of an alpha chain and a beta chain linked by a disulfide bond.
Sequence similarities	Belongs to the peptidase S1 family. Plasminogen subfamily. Contains 4 kringle domains. Contains 1 PAN domain. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Kringle Repeat Signal
Molecular function	Growth factor Serine protease homolog
PTM	Disulfide bond Glycoprotein Pyrrolidone carboxylic acid
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	epithelial to mesenchymal transition Traceable author statement. Source: HGNC mitosis Ref.2 Non-traceable author statement. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: InterPro regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Inferred from direct assay. Source: MGI
Cellular component	extracellular region Ref.2 Inferred from Experiment. Source: Reactome platelet alpha granule lumen Ref.2 Inferred from Experiment. Source: Reactome
Molecular function	growth factor activity Ref.2 Non-traceable author statement. Source: UniProtKB serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MET	P08581	2	EBI-1039104,EBI-1039152
Met	P16056	2	EBI-1039104,EBI-1798780	From a different organism.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P14210-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P14210-2)

The sequence of this isoform differs from the canonical sequence as follows:
     289-290: AD → ET
     291-728: Missing.

Isoform 3 (identifier: P14210-3)

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.

Isoform 4 (identifier: P14210-4)

The sequence of this isoform differs from the canonical sequence as follows:
     287-296: TCADNTMNDT → NMRDITWALN
     297-728: Missing.

Isoform 5 (identifier: P14210-5)

The sequence of this isoform differs from the canonical sequence as follows:
     161-165: Missing.
     289-290: AD → ET
     291-728: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: P14210-6)

Also known as: HGF/NK1;

The sequence of this isoform differs from the canonical sequence as follows:
     209-210: VE → GK
     211-728: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 31

31

Chain

32 – 494

463

Hepatocyte growth factor alpha chain

PRO_0000028091

Chain

495 – 728

234

Hepatocyte growth factor beta chain

PRO_0000028092

Regions

Domain

37 – 123

87

PAN

Domain

128 – 206

79

Kringle 1

Domain

211 – 288

78

Kringle 2

Domain

305 – 383

79

Kringle 3

Domain

391 – 469

79

Kringle 4

Domain

495 – 721

227

Peptidase S1

Amino acid modifications

Modified residue

32

1

Pyrrolidone carboxylic acid

Glycosylation

294

1

N-linked (GlcNAc...) (complex)

CAR_000021

Glycosylation

402

1

N-linked (GlcNAc...) (complex)

CAR_000022

Glycosylation

476

1

O-linked (GalNAc...) Ref.17

CAR_000023

Glycosylation

566

1

N-linked (GlcNAc...) (complex)

CAR_000024

Glycosylation

653

1

N-linked (GlcNAc...) (complex)

CAR_000025

Disulfide bond

70 ↔ 96

Disulfide bond

74 ↔ 84

Disulfide bond

128 ↔ 206

Disulfide bond

149 ↔ 189

Disulfide bond

177 ↔ 201

Disulfide bond

211 ↔ 288

By similarity

Disulfide bond

232 ↔ 271

By similarity

Disulfide bond

260 ↔ 283

By similarity

Disulfide bond

305 ↔ 383

By similarity

Disulfide bond

326 ↔ 365

By similarity

Disulfide bond

354 ↔ 377

By similarity

Disulfide bond

391 ↔ 469

By similarity

Disulfide bond

412 ↔ 452

By similarity

Disulfide bond

440 ↔ 464

By similarity

Disulfide bond

487 ↔ 604

Interchain (between alpha and beta chains) By similarity

Disulfide bond

519 ↔ 535

By similarity

Disulfide bond

612 ↔ 679

By similarity

Disulfide bond

642 ↔ 658

By similarity

Disulfide bond

669 ↔ 697

By similarity

Natural variations

Alternative sequence

161 – 165

5

Missing in isoform 3 and isoform 5.

VSP_009617

Alternative sequence

209 – 210

2

VE → GK in isoform 6.

VSP_009618

Alternative sequence

211 – 728

518

Missing in isoform 6.

VSP_009619

Alternative sequence

287 – 296

10

TCADNTMNDT → NMRDITWALN in isoform 4.

VSP_009620

Alternative sequence

289 – 290

2

AD → ET in isoform 2 and isoform 5.

VSP_009622

Alternative sequence

291 – 728

438

Missing in isoform 2 and isoform 5.

VSP_009623

Alternative sequence

297 – 728

432

Missing in isoform 4.

VSP_009621

Natural variant

153

1

S → I: dbSNP rs17566.

VAR_014570

Natural variant

304

1

E → K: dbSNP rs5745687. Ref.11

VAR_019199

Natural variant

330

1

D → Y: dbSNP rs5745688. Ref.11

VAR_019200

Experimental info

Mutagenesis

494

1

R → Q: Loss of activity due to absence of proteolytic cleavage. Ref.9

Sequence conflict

32 – 33

2

QR → HK in CAA34387. Ref.2

Sequence conflict

78

1

K → N in CAA34387. Ref.2

Sequence conflict

180

1

P → T AA sequence Ref.6

Sequence conflict

293

1

M → V in CAA34387. Ref.2

Sequence conflict

300

1

L → M in CAA34387. Ref.2

Sequence conflict

317

1

V → A in CAA34387. Ref.2

Sequence conflict

336

1

E → K in CAA34387. Ref.2

Sequence conflict

387

1

H → N in CAA34387. Ref.2

Sequence conflict

416

1

D → N in CAA34387. Ref.2

Sequence conflict

505

1

I → V in CAA34387. Ref.2

Sequence conflict

509

1

V → I in CAA34387. Ref.2

Sequence conflict

558

1

D → E in CAA34387. Ref.2

Sequence conflict

561

1

C → R in CAA34387. Ref.2

Sequence conflict

592

1

D → N AA sequence Ref.6

Sequence conflict

595

1

S → N in CAA34387. Ref.2

Secondary structure

1

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728

Helix Strand Turn

Details...

Helix

39 – 41

3

Beta strand

42 – 54

13

Beta strand

60 – 63

4

Helix

67 – 76

10

Turn

77 – 79

3

Beta strand

86 – 90

5

Turn

91 – 94

4

Beta strand

95 – 100

6

Beta strand

108 – 121

14

Helix

122 – 124

3

Beta strand

128 – 130

3

Beta strand

156 – 158

3

Helix

164 – 166

3

Beta strand

188 – 192

5

Beta strand

197 – 201

5

Turn

206 – 208

3

Beta strand

508 – 513

6

Beta strand

516 – 525

10

Beta strand

528 – 532

5

Helix

533 – 535

3

Helix

541 – 543

3

Beta strand

544 – 549

6

Turn

559 – 561

3

Beta strand

563 – 565

3

Beta strand

567 – 572

6

Beta strand

579 – 586

8

Beta strand

591 – 593

3

Beta strand

611 – 618

8

Beta strand

630 – 637

8

Helix

639 – 645

7

Turn

646 – 648

3

Beta strand

656 – 660

5

Beta strand

662 – 664

3

Turn

670 – 674

5

Beta strand

676 – 680

5

Beta strand

682 – 690

9

Beta strand

695 – 698

4

Beta strand

704 – 709

6

Helix

710 – 712

3

Helix

713 – 720

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1991. Version 2. Checksum: 2D997938295ADD2F	FASTA	728	83,134
	10 20 30 40 50 60 MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 70 80 90 100 110 120 TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 130 140 150 160 170 180 NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SFLPSSYRGK DLQENYCRNP 190 200 210 220 230 240 RGEEGGPWCF TSNPEVRYEV CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP 250 260 270 280 290 300 HRHKFLPERY PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL 310 320 330 340 350 360 ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR ENYCRNPDGS 370 380 390 400 410 420 ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM GNLSQTRSGL TCSMWDKNME 430 440 450 460 470 480 DLHRHIFWEP DASKLNENYC RNPDDDAHGP WCYTGNPLIP WDYCPISRCE GDTTPTIVNL 490 500 510 520 530 540 DHPVISCAKT KQLRVVNGIP TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD 550 560 570 580 590 600 LKDYEAWLGI HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP 610 620 630 640 650 660 NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV TLNESEICAG 670 680 690 700 710 720 AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP NRPGIFVRVA YYAKWIHKII LTYKVPQS
	Isoform 2. Checksum: C8A18A6F0D63200A	FASTA	290	33,766
	10 20 30 40 50 60 MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 70 80 90 100 110 120 TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 130 140 150 160 170 180 NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SFLPSSYRGK DLQENYCRNP 190 200 210 220 230 240 RGEEGGPWCF TSNPEVRYEV CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP 250 260 270 280 290 HRHKFLPERY PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCET
	Isoform 3. Checksum: 627B1EF99FAD931B	FASTA	723	82,602
	10 20 30 40 50 60 MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 70 80 90 100 110 120 TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 130 140 150 160 170 180 NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SYRGKDLQEN YCRNPRGEEG 190 200 210 220 230 240 GPWCFTSNPE VRYEVCDIPQ CSEVECMTCN GESYRGLMDH TESGKICQRW DHQTPHRHKF 250 260 270 280 290 300 LPERYPDKGF DDNYCRNPDG QPRPWCYTLD PHTRWEYCAI KTCADNTMND TDVPLETTEC 310 320 330 340 350 360 IQGQGEGYRG TVNTIWNGIP CQRWDSQYPH EHDMTPENFK CKDLRENYCR NPDGSESPWC 370 380 390 400 410 420 FTTDPNIRVG YCSQIPNCDM SHGQDCYRGN GKNYMGNLSQ TRSGLTCSMW DKNMEDLHRH 430 440 450 460 470 480 IFWEPDASKL NENYCRNPDD DAHGPWCYTG NPLIPWDYCP ISRCEGDTTP TIVNLDHPVI 490 500 510 520 530 540 SCAKTKQLRV VNGIPTRTNI GWMVSLRYRN KHICGGSLIK ESWVLTARQC FPSRDLKDYE 550 560 570 580 590 600 AWLGIHDVHG RGDEKCKQVL NVSQLVYGPE GSDLVLMKLA RPAVLDDFVS TIDLPNYGCT 610 620 630 640 650 660 IPEKTSCSVY GWGYTGLINY DGLLRVAHLY IMGNEKCSQH HRGKVTLNES EICAGAEKIG 670 680 690 700 710 720 SGPCEGDYGG PLVCEQHKMR MVLGVIVPGR GCAIPNRPGI FVRVAYYAKW IHKIILTYKV PQS
	Isoform 4. Checksum: A45E456B87AE03BE	FASTA	296	34,547
	10 20 30 40 50 60 MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 70 80 90 100 110 120 TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 130 140 150 160 170 180 NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SFLPSSYRGK DLQENYCRNP 190 200 210 220 230 240 RGEEGGPWCF TSNPEVRYEV CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP 250 260 270 280 290 HRHKFLPERY PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKNMRD ITWALN
	Isoform 5. Checksum: 0A93B073EA86EA61	FASTA	285	33,234
	10 20 30 40 50 60 MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 70 80 90 100 110 120 TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 130 140 150 160 170 180 NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SYRGKDLQEN YCRNPRGEEG 190 200 210 220 230 240 GPWCFTSNPE VRYEVCDIPQ CSEVECMTCN GESYRGLMDH TESGKICQRW DHQTPHRHKF 250 260 270 280 LPERYPDKGF DDNYCRNPDG QPRPWCYTLD PHTRWEYCAI KTCET
	Isoform 6 (HGF/NK1). Checksum: 94A6EE9C50DE5A86	FASTA	210	24,116
	10 20 30 40 50 60 MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 70 80 90 100 110 120 TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 130 140 150 160 170 180 NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SFLPSSYRGK DLQENYCRNP 190 200 210 RGEEGGPWCF TSNPEVRYEV CDIPQCSEGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor." Miyazawa K., Tsubouchi H., Naka D., Takahashi K., Okigaki M., Arakaki N., Nakayama H., Hirono S., Sakiyama O., Takahashi K., Gohda E., Daikuhara Y., Kitamura N. Biochem. Biophys. Res. Commun. 163:967-973(1989) [PubMed: 2528952] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"Molecular cloning and expression of human hepatocyte growth factor." Nakamura T., Nishizawa T., Hagiya M., Seki T., Shimonishi M., Sugimura A., Tashiro K., Shimizu S. Nature 342:440-443(1989) [PubMed: 2531289] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 55-73 AND 495-520. Tissue: Liver.
[3]	"Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte." Seki T., Ihara I., Sugimura A., Shimonishi M., Nishizawa T., Asami O., Hagiya M., Nakamura T., Shimizu S. Biochem. Biophys. Res. Commun. 172:321-327(1990) [PubMed: 2145836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Leukocyte.
[4]	"Organization of the human hepatocyte growth factor-encoding gene." Seki T., Hagiya M., Shimonishi M., Nakamura T., Shimizu S. Gene 102:213-219(1991) [PubMed: 1831432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[5]	"An alternatively processed mRNA generated from human hepatocyte growth factor gene." Miyazawa K., Kitamura A., Naka D., Kitamura N. Eur. J. Biochem. 197:15-22(1991) [PubMed: 1826653] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta.
[6]	"A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor." Rubin J.S., Chan A.M.-L., Bottaro D.P., Burgess W.H., Taylor W.G., Cech A.C., Hirschfield D.W., Wong J., Miki T., Finch P.W., Aaronson S.A. Proc. Natl. Acad. Sci. U.S.A. 88:415-419(1991) [PubMed: 1824873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), PROTEIN SEQUENCE OF 583-592. Tissue: Lung fibroblast.
[7]	"Evidence for the identity of human scatter factor and human hepatocyte growth factor." Weidner K.M., Arakaki N., Hartmann G., Vandekerckhove J., Weingart S., Rieder H., Fonatsch C., Tsubouchi H., Hishida T., Daikuhara Y., Birchmeier W. Proc. Natl. Acad. Sci. U.S.A. 88:7001-7005(1991) [PubMed: 1831266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Embryonic fibroblast.
[8]	"Identification of a competitive HGF antagonist encoded by an alternative transcript." Chan A.M.-L., Rubin J.S., Bottaro D.P., Hirschfield D.W., Chedid M., Aaronson S.A. Science 254:1382-1385(1991) [PubMed: 1720571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[9]	"A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis." Hartmann G., Naldini L., Weidner K.M., Sachs M., Vigna E., Comoglio P.M., Birchmeier W. Proc. Natl. Acad. Sci. U.S.A. 89:11574-11578(1992) [PubMed: 1280830] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), MUTAGENESIS OF ARG-494.
[10]	"Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity." Cioce V., Csaky K.G., Chan A.M.-L., Bottaro D.P., Taylor W.G., Jensen R., Aaronson S.A., Rubin J.S. J. Biol. Chem. 271:13110-13115(1996) [PubMed: 8662798] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[11]	NIEHS SNPs program Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-304 AND TYR-330.
[12]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6). Tissue: Brain.
[15]	"Structural organization and the transcription initiation site of the human hepatocyte growth factor gene." Miyazawa K., Kitamura A., Kitamura N. Biochemistry 30:9170-9176(1991) [PubMed: 1832556] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-208 AND 249-695 (ISOFORM 1).
[16]	"Identification of the N-terminal residue of the heavy chain of both native and recombinant human hepatocyte growth factor." Yoshiyama Y., Arakaki N., Naka D., Takahashi K., Hirono S., Kondo J., Nakayama H., Gohda E., Kitamura N., Tsubouchi H., Ishii T., Hishida T., Daikuhara Y. Biochem. Biophys. Res. Commun. 175:660-667(1991) [PubMed: 1826837] [Abstract] Cited for: SIGNAL SEQUENCE CLEAVAGE SITE.
[17]	"Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain." Shimizu N., Hara H., Sogabe T., Sakai H., Ihara I., Inoue H., Nakamura T., Shimizu S. Biochem. Biophys. Res. Commun. 189:1329-1335(1992) [PubMed: 1482348] [Abstract] Cited for: GLYCOSYLATION AT THR-476.
[18]	"Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding." Lokker N.A., Mark M.R., Luis E.A., Bennett G.L., Robbins K.A., Baker J.B., Godowski P.J. EMBO J. 11:2503-2510(1992) [PubMed: 1321034] [Abstract] Cited for: MUTAGENESIS.
[19]	"The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site." Zhou H., Mazzulla M.J., Kaufman J.D., Stahl S.J., Wingfield P.T., Rubin J.S., Bottaro D.P., Byrd R.A. Structure 6:109-116(1998) [PubMed: 9493272] [Abstract] Cited for: STRUCTURE BY NMR OF 31-127.
[20]	"Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution." Ultsch M., Lokker N.A., Godowski P.J., de Vos A.M. Structure 6:1383-1393(1998) [PubMed: 9817840] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 35-210.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Wikipedia

Hepatocyte growth factor entry

Cross-references

Sequence databases

EMBLGenBankDDBJ

M29145 mRNA. Translation: AAA52650.1.
X16323 mRNA. Translation: CAA34387.1.
M60718 mRNA. Translation: AAA52648.1.
D90334 Genomic DNA. Translation: BAA14348.1.
X57574 mRNA. Translation: CAA40802.1.
M55379 mRNA. No translation available.
M73239 mRNA. Translation: AAA64239.1.
M73240 mRNA. Translation: AAA64297.1.
M77227 mRNA. Translation: AAA35980.1.
L02931 mRNA. Translation: AAA52649.1.
U46010 mRNA. Translation: AAC50539.1.
AY246560 Genomic DNA. Translation: AAO61091.1.
AC004960 Genomic DNA. Translation: AAC71655.1.
CH236949 Genomic DNA. Translation: EAL24189.1.
BC022308 mRNA. Translation: AAH22308.1.
BC063485 mRNA. Translation: AAH63485.1.
BC105797 mRNA. Translation: AAI05798.1.
BC130284 mRNA. Translation: AAI30285.1.
BC130286 mRNA. Translation: AAI30287.1.
M75971 , M75967, M75966, M75968, M75969 Genomic DNA. Translation: AAG53459.1.
M75983 , M75972, M75973, M75974, M75975, M75976, M75977, M75978, M75979, M75980, M75981, M75982 Genomic DNA. Translation: AAG53460.1.

IPI

IPI00025767.
IPI00400878.
IPI00400879.
IPI00400880.
IPI00400881.
IPI00941852.

PIR

JH0579.

RefSeq

NP_000592.3.
NP_001010931.1.
NP_001010932.1.
NP_001010933.1.
NP_001010934.1.

UniGene

Hs.396530

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BHT	X-ray	2.00	A/B	35-210	[»]
1GMN	X-ray	2.30	A/B	30-210	[»]
1GMO	X-ray	3.00	A/B/C/D/E/F/G/H	30-210	[»]
1GP9	X-ray	2.50	A/B/C/D	40-210	[»]
1NK1	X-ray	2.50	A/B	30-210	[»]
1SHY	X-ray	3.22	A	495-728	[»]
1SI5	X-ray	2.53	H	495-728	[»]
2HGF	NMR	-	A	31-127	[»]
2QJ2	X-ray	1.81	A/B	28-209	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P14210. 2 interactions.

STRING

P14210.

Protein family/group databases

MEROPS

S01.976.

PTM databases

GlycoSuiteDB

P14210.

Proteomic databases

PRIDE

P14210.

Genome annotation databases

Ensembl

ENST00000222390; ENSP00000222390; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000354224; ENSP00000346164; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000394769; ENSP00000378250; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000412881; ENSP00000396307; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000421558; ENSP00000388592; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000423064; ENSP00000413829; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000444829; ENSP00000389854; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000453018; ENSP00000395468; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000453411; ENSP00000408270; ENSG00000019991; Homo sapiens. [Genome view]
ENST00000457544; ENSP00000391238; ENSG00000019991; Homo sapiens. [Genome view]

GeneID

3082.

KEGG

hsa:3082.

UCSC

uc003uhl.1. human.
uc003uhm.1. human.
uc003uhn.1. human.
uc003uho.1. human.

Organism-specific databases

CTD

3082.

GeneCards

GC07M081166.

H-InvDB

HIX0033620.

HGNC

HGNC:4893. HGF.

HPA

CAB010333.

MIM

142409. gene.

PharmGKB

PA29269.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P14210.

OMA

LTYKVPQ.

Enzyme and pathway databases

Pathway_Interaction_DB

arf6cyclingpathway. Arf6 signaling events.
faspathway. FAS signaling pathway (CD95).
fgf_pathway. FGF signaling pathway.
met_pathway. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
syndecan_1_pathway. Syndecan-1-mediated signaling events.

Reactome

REACT_604. Hemostasis.

Gene expression databases

ArrayExpress

P14210.

Bgee

P14210.

Genevestigator

P14210.

GermOnline

ENSG00000019991. Homo sapiens.

Family and domain databases

InterPro

IPR000001. Kringle.
IPR018056. Kringle_CS.
IPR018059. Kringle_sub.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
[Graphical view]

Gene3D

G3DSA:2.40.20.10. Kringle. 4 hits.

Pfam

PF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]

PRINTS

PR00722. CHYMOTRYPSIN.
PR00018. KRINGLE.

ProDom

PD000395. Kringle. 4 hits.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]

PROSITE

PS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

12211.

PMAP-CutDB

P14210.

SOURCE

Search...

Entry information

Entry name

HGF_HUMAN

Accession

Primary (citable) accession number: P14210
Secondary accession number(s): A1L3U6 , Q02935, Q13494, Q14519, Q3KRB2, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	August 1, 1991
Last modified:	November 3, 2009
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.