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P14209

- CD99_HUMAN

UniProt

P14209 - CD99_HUMAN

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Protein

CD99 antigen

Gene

CD99

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes By similarity.By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen
Alternative name(s):
12E7
E2 antigen
Protein MIC2
T-cell surface glycoprotein E2
CD_antigen: CD99
Gene namesi
Name:CD99
Synonyms:MIC2, MIC2X, MIC2Y
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:7082. CD99.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. focal adhesion Source: UniProtKB
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 185163CD99 antigenPRO_0000021726Add
BLAST

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP14209.
PaxDbiP14209.
PRIDEiP14209.

PTM databases

PhosphoSiteiP14209.

Miscellaneous databases

PMAP-CutDBP14209.

Expressioni

Gene expression databases

BgeeiP14209.
CleanExiHS_CD99.
ExpressionAtlasiP14209. baseline and differential.
GenevestigatoriP14209.

Organism-specific databases

HPAiCAB000020.
HPA035304.

Interactioni

Protein-protein interaction databases

BioGridi110420. 11 interactions.
IntActiP14209. 4 interactions.
MINTiMINT-5004058.
STRINGi9606.ENSP00000370588.

Structurei

3D structure databases

ProteinModelPortaliP14209.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 122100ExtracellularSequence AnalysisAdd
BLAST
Topological domaini148 – 18538CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 14725HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68406.
GeneTreeiENSGT00730000111585.
HOGENOMiHOG000233665.
HOVERGENiHBG067989.
InParanoidiP14209.
KOiK06520.
OMAiESHRNAN.
OrthoDBiEOG7QK0GC.
PhylomeDBiP14209.
TreeFamiTF336273.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform I (identifier: P14209-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG
60 70 80 90 100
DDFDLGDAVV DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS
110 120 130 140 150
GGEGKGGSDG GGSHRKEGEE ADAPGVIPGI VGAVVVAVAG AISSFIAYQK
160 170 180
KKLCFKENAE QGEVDMESHR NANAEPAVQR TLLEK
Length:185
Mass (Da):18,848
Last modified:January 1, 1990 - v1
Checksum:iC302E09E6B022EAB
GO
Isoform II (identifier: P14209-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG

Show »
Length:160
Mass (Da):16,015
Checksum:i2BA54D31B410CAA8
GO
Isoform 3 (identifier: P14209-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-49: Missing.

Note: No experimental confirmation available.

Show »
Length:169
Mass (Da):17,128
Checksum:i5FE324D366C63D85
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661M → V.
Corresponds to variant rs11556080 [ dbSNP | Ensembl ].
VAR_014733
Natural varianti173 – 1731N → I.
Corresponds to variant rs4717 [ dbSNP | Ensembl ].
VAR_014734

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 4916Missing in isoform 3. 1 PublicationVSP_046315Add
BLAST
Alternative sequencei159 – 18527AEQGE…TLLEK → DG in isoform II. 1 PublicationVSP_004324Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16996 mRNA. Translation: CAA34863.1.
U82164 mRNA. Translation: AAB58501.1.
CR450286 mRNA. Translation: CAG29282.1.
AC006209 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98697.1.
CH471074 Genomic DNA. Translation: EAW98698.1.
BC002584 mRNA. Translation: AAH02584.1.
BC003147 mRNA. Translation: AAH03147.1.
BC010109 mRNA. Translation: AAH10109.1.
BC021620 mRNA. Translation: AAH21620.1.
BC024310 mRNA. Translation: AAH24310.1.
BQ948496 mRNA. No translation available.
M16279 mRNA. Translation: AAA02999.1.
J03841 Genomic DNA. Translation: AAA59848.1.
CCDSiCCDS14119.1. [P14209-1]
CCDS48071.1. [P14209-3]
CCDS75947.1. [P14209-2]
PIRiS06786. A60592.
RefSeqiNP_001116370.1. NM_001122898.1. [P14209-3]
NP_001264639.1. NM_001277710.1. [P14209-2]
NP_002405.1. NM_002414.3. [P14209-1]
XP_005274592.1. XM_005274535.2. [P14209-2]
XP_005274856.1. XM_005274799.2. [P14209-2]
UniGeneiHs.653349.

Genome annotation databases

EnsembliENST00000381187; ENSP00000370582; ENSG00000002586. [P14209-3]
ENST00000381192; ENSP00000370588; ENSG00000002586. [P14209-1]
ENST00000611428; ENSP00000479999; ENSG00000002586. [P14209-2]
GeneIDi4267.
KEGGihsa:4267.
UCSCiuc004cqm.3. human. [P14209-1]
uc004cqn.4. human. [P14209-2]
uc010nda.3. human.

Polymorphism databases

DMDMi119049.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16996 mRNA. Translation: CAA34863.1 .
U82164 mRNA. Translation: AAB58501.1 .
CR450286 mRNA. Translation: CAG29282.1 .
AC006209 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98697.1 .
CH471074 Genomic DNA. Translation: EAW98698.1 .
BC002584 mRNA. Translation: AAH02584.1 .
BC003147 mRNA. Translation: AAH03147.1 .
BC010109 mRNA. Translation: AAH10109.1 .
BC021620 mRNA. Translation: AAH21620.1 .
BC024310 mRNA. Translation: AAH24310.1 .
BQ948496 mRNA. No translation available.
M16279 mRNA. Translation: AAA02999.1 .
J03841 Genomic DNA. Translation: AAA59848.1 .
CCDSi CCDS14119.1. [P14209-1 ]
CCDS48071.1. [P14209-3 ]
CCDS75947.1. [P14209-2 ]
PIRi S06786. A60592.
RefSeqi NP_001116370.1. NM_001122898.1. [P14209-3 ]
NP_001264639.1. NM_001277710.1. [P14209-2 ]
NP_002405.1. NM_002414.3. [P14209-1 ]
XP_005274592.1. XM_005274535.2. [P14209-2 ]
XP_005274856.1. XM_005274799.2. [P14209-2 ]
UniGenei Hs.653349.

3D structure databases

ProteinModelPortali P14209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110420. 11 interactions.
IntActi P14209. 4 interactions.
MINTi MINT-5004058.
STRINGi 9606.ENSP00000370588.

PTM databases

PhosphoSitei P14209.

Polymorphism databases

DMDMi 119049.

Proteomic databases

MaxQBi P14209.
PaxDbi P14209.
PRIDEi P14209.

Protocols and materials databases

DNASUi 4267.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381187 ; ENSP00000370582 ; ENSG00000002586 . [P14209-3 ]
ENST00000381192 ; ENSP00000370588 ; ENSG00000002586 . [P14209-1 ]
ENST00000611428 ; ENSP00000479999 ; ENSG00000002586 . [P14209-2 ]
GeneIDi 4267.
KEGGi hsa:4267.
UCSCi uc004cqm.3. human. [P14209-1 ]
uc004cqn.4. human. [P14209-2 ]
uc010nda.3. human.

Organism-specific databases

CTDi 4267.
GeneCardsi GC0XP002602.
H-InvDB HIX0177591.
HGNCi HGNC:7082. CD99.
HPAi CAB000020.
HPA035304.
MIMi 313470. gene.
450000. gene.
neXtProti NX_P14209.
PharmGKBi PA30804.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68406.
GeneTreei ENSGT00730000111585.
HOGENOMi HOG000233665.
HOVERGENi HBG067989.
InParanoidi P14209.
KOi K06520.
OMAi ESHRNAN.
OrthoDBi EOG7QK0GC.
PhylomeDBi P14209.
TreeFami TF336273.

Miscellaneous databases

GeneWikii CD99.
GenomeRNAii 4267.
NextBioi 16815.
PMAP-CutDB P14209.
PROi P14209.
SOURCEi Search...

Gene expression databases

Bgeei P14209.
CleanExi HS_CD99.
ExpressionAtlasi P14209. baseline and differential.
Genevestigatori P14209.

Family and domain databases

InterProi IPR022078. CD99L2.
[Graphical view ]
Pfami PF12301. CD99L2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product."
    Gelin C., Aubrit F., Phalipon A., Raynal B., Cole S., Kaczorek M., Bernard A.
    EMBO J. 8:3253-3259(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I), PROTEIN SEQUENCE OF 23-39.
    Tissue: T-cell.
  2. "An alternative splicing form of CD99 (MIC2)."
    Park S.H., Hahn J.H., Kim M.K., Sohn H.W., Choi E.Y., Kim S.H.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM II).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS I AND 3).
    Tissue: Brain, Kidney, Lung carcinoma, Skin and Uterus.
  7. "Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes."
    Darling S.M., Goodfellow P.J., Pym B., Banting G.S., Pritchard C., Goodfellow P.N.
    Cold Spring Harb. Symp. Quant. Biol. 51:205-212(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-105.
  8. "Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome."
    Goodfellow P.J., Mondello C., Darling S.M., Pym B., Little P., Goodfellow P.N.
    Proc. Natl. Acad. Sci. U.S.A. 85:5605-5609(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD99_HUMAN
AccessioniPrimary (citable) accession number: P14209
Secondary accession number(s): A6NIW1, O00518, Q6ICV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3