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Protein

CD99 antigen

Gene

CD99

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000002586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen
Alternative name(s):
12E7
E2 antigen
Protein MIC2
T-cell surface glycoprotein E2
CD_antigen: CD99
Gene namesi
Name:CD99
Synonyms:MIC2, MIC2X, MIC2Y
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:7082. CD99.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 122ExtracellularSequence analysisAdd BLAST100
Transmembranei123 – 147HelicalSequence analysisAdd BLAST25
Topological domaini148 – 185CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4267.
OpenTargetsiENSG00000002586.
PharmGKBiPA30804.

Polymorphism and mutation databases

BioMutaiCD99.
DMDMi119049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002172623 – 185CD99 antigenAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei181PhosphothreonineCombined sources1

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP14209.
MaxQBiP14209.
PaxDbiP14209.
PeptideAtlasiP14209.
PRIDEiP14209.

PTM databases

iPTMnetiP14209.
PhosphoSitePlusiP14209.
SwissPalmiP14209.

Miscellaneous databases

PMAP-CutDBP14209.

Expressioni

Gene expression databases

BgeeiENSG00000002586.
CleanExiHS_CD99.
ExpressionAtlasiP14209. baseline and differential.
GenevisibleiP14209. HS.

Organism-specific databases

HPAiCAB000020.
HPA035304.

Interactioni

Protein-protein interaction databases

BioGridi110420. 12 interactors.
IntActiP14209. 8 interactors.
MINTiMINT-5004058.
STRINGi9606.ENSP00000370588.

Structurei

3D structure databases

ProteinModelPortaliP14209.
SMRiP14209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J50K. Eukaryota.
ENOG410YW6Q. LUCA.
GeneTreeiENSGT00730000111585.
HOGENOMiHOG000233665.
HOVERGENiHBG067989.
InParanoidiP14209.
KOiK06520.
OMAiESHRNAN.
PhylomeDBiP14209.
TreeFamiTF336273.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P14209-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG
60 70 80 90 100
DDFDLGDAVV DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS
110 120 130 140 150
GGEGKGGSDG GGSHRKEGEE ADAPGVIPGI VGAVVVAVAG AISSFIAYQK
160 170 180
KKLCFKENAE QGEVDMESHR NANAEPAVQR TLLEK
Length:185
Mass (Da):18,848
Last modified:January 1, 1990 - v1
Checksum:iC302E09E6B022EAB
GO
Isoform II (identifier: P14209-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG

Show »
Length:160
Mass (Da):16,015
Checksum:i2BA54D31B410CAA8
GO
Isoform 3 (identifier: P14209-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-49: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):17,128
Checksum:i5FE324D366C63D85
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014733166M → V.Corresponds to variant rs11556080dbSNPEnsembl.1
Natural variantiVAR_014734173N → I.Corresponds to variant rs4717dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04631534 – 49Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_004324159 – 185AEQGE…TLLEK → DG in isoform II. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16996 mRNA. Translation: CAA34863.1.
U82164 mRNA. Translation: AAB58501.1.
CR450286 mRNA. Translation: CAG29282.1.
AC006209 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98697.1.
CH471074 Genomic DNA. Translation: EAW98698.1.
BC002584 mRNA. Translation: AAH02584.1.
BC003147 mRNA. Translation: AAH03147.1.
BC010109 mRNA. Translation: AAH10109.1.
BC021620 mRNA. Translation: AAH21620.1.
BC024310 mRNA. Translation: AAH24310.1.
BQ948496 mRNA. No translation available.
M16279 mRNA. Translation: AAA02999.1.
J03841 Genomic DNA. Translation: AAA59848.1.
CCDSiCCDS14119.1. [P14209-1]
CCDS48071.1. [P14209-3]
CCDS75947.1. [P14209-2]
PIRiS06786. A60592.
RefSeqiNP_001116370.1. NM_001122898.2. [P14209-3]
NP_001308296.1. NM_001321367.1. [P14209-2]
NP_001308297.1. NM_001321368.1.
NP_001308298.1. NM_001321369.1.
NP_002405.1. NM_002414.4. [P14209-1]
UniGeneiHs.653349.

Genome annotation databases

EnsembliENST00000381187; ENSP00000370582; ENSG00000002586. [P14209-3]
ENST00000381192; ENSP00000370588; ENSG00000002586. [P14209-1]
ENST00000611428; ENSP00000479999; ENSG00000002586. [P14209-2]
ENST00000623253; ENSP00000485545; ENSG00000002586. [P14209-2]
GeneIDi4267.
KEGGihsa:4267.
UCSCiuc004cqm.4. human. [P14209-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16996 mRNA. Translation: CAA34863.1.
U82164 mRNA. Translation: AAB58501.1.
CR450286 mRNA. Translation: CAG29282.1.
AC006209 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98697.1.
CH471074 Genomic DNA. Translation: EAW98698.1.
BC002584 mRNA. Translation: AAH02584.1.
BC003147 mRNA. Translation: AAH03147.1.
BC010109 mRNA. Translation: AAH10109.1.
BC021620 mRNA. Translation: AAH21620.1.
BC024310 mRNA. Translation: AAH24310.1.
BQ948496 mRNA. No translation available.
M16279 mRNA. Translation: AAA02999.1.
J03841 Genomic DNA. Translation: AAA59848.1.
CCDSiCCDS14119.1. [P14209-1]
CCDS48071.1. [P14209-3]
CCDS75947.1. [P14209-2]
PIRiS06786. A60592.
RefSeqiNP_001116370.1. NM_001122898.2. [P14209-3]
NP_001308296.1. NM_001321367.1. [P14209-2]
NP_001308297.1. NM_001321368.1.
NP_001308298.1. NM_001321369.1.
NP_002405.1. NM_002414.4. [P14209-1]
UniGeneiHs.653349.

3D structure databases

ProteinModelPortaliP14209.
SMRiP14209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110420. 12 interactors.
IntActiP14209. 8 interactors.
MINTiMINT-5004058.
STRINGi9606.ENSP00000370588.

PTM databases

iPTMnetiP14209.
PhosphoSitePlusiP14209.
SwissPalmiP14209.

Polymorphism and mutation databases

BioMutaiCD99.
DMDMi119049.

Proteomic databases

EPDiP14209.
MaxQBiP14209.
PaxDbiP14209.
PeptideAtlasiP14209.
PRIDEiP14209.

Protocols and materials databases

DNASUi4267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381187; ENSP00000370582; ENSG00000002586. [P14209-3]
ENST00000381192; ENSP00000370588; ENSG00000002586. [P14209-1]
ENST00000611428; ENSP00000479999; ENSG00000002586. [P14209-2]
ENST00000623253; ENSP00000485545; ENSG00000002586. [P14209-2]
GeneIDi4267.
KEGGihsa:4267.
UCSCiuc004cqm.4. human. [P14209-1]

Organism-specific databases

CTDi4267.
DisGeNETi4267.
GeneCardsiCD99.
H-InvDBHIX0177591.
HGNCiHGNC:7082. CD99.
HPAiCAB000020.
HPA035304.
MIMi313470. gene.
450000. gene.
neXtProtiNX_P14209.
OpenTargetsiENSG00000002586.
PharmGKBiPA30804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J50K. Eukaryota.
ENOG410YW6Q. LUCA.
GeneTreeiENSGT00730000111585.
HOGENOMiHOG000233665.
HOVERGENiHBG067989.
InParanoidiP14209.
KOiK06520.
OMAiESHRNAN.
PhylomeDBiP14209.
TreeFamiTF336273.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000002586-MONOMER.

Miscellaneous databases

GeneWikiiCD99.
GenomeRNAii4267.
PMAP-CutDBP14209.
PROiP14209.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000002586.
CleanExiHS_CD99.
ExpressionAtlasiP14209. baseline and differential.
GenevisibleiP14209. HS.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD99_HUMAN
AccessioniPrimary (citable) accession number: P14209
Secondary accession number(s): A6NIW1, O00518, Q6ICV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.