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P14209 (CD99_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD99 antigen
Alternative name(s):
12E7
E2 antigen
Protein MIC2
T-cell surface glycoprotein E2
CD_antigen=CD99
Gene names
Name:CD99
Synonyms:MIC2, MIC2X, MIC2Y
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Extensively O-glycosylated.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities

Belongs to the CD99 family.

Ontologies

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform I (identifier: P14209-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform II (identifier: P14209-2)

The sequence of this isoform differs from the canonical sequence as follows:
     159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG
Isoform 3 (identifier: P14209-3)

The sequence of this isoform differs from the canonical sequence as follows:
     34-49: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Chain23 – 185163CD99 antigen
PRO_0000021726

Regions

Topological domain23 – 122100Extracellular Potential
Transmembrane123 – 14725Helical; Potential
Topological domain148 – 18538Cytoplasmic Potential

Natural variations

Alternative sequence34 – 4916Missing in isoform 3.
VSP_046315
Alternative sequence159 – 18527AEQGE…TLLEK → DG in isoform II.
VSP_004324
Natural variant1661M → V.
Corresponds to variant rs11556080 [ dbSNP | Ensembl ].
VAR_014733
Natural variant1731N → I.
Corresponds to variant rs4717 [ dbSNP | Ensembl ].
VAR_014734

Sequences

Sequence LengthMass (Da)Tools
Isoform I [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: C302E09E6B022EAB

FASTA18518,848
        10         20         30         40         50         60 
MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG DDFDLGDAVV 

        70         80         90        100        110        120 
DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS GGEGKGGSDG GGSHRKEGEE 

       130        140        150        160        170        180 
ADAPGVIPGI VGAVVVAVAG AISSFIAYQK KKLCFKENAE QGEVDMESHR NANAEPAVQR 


TLLEK 

« Hide

Isoform II [UniParc].

Checksum: 2BA54D31B410CAA8
Show »

FASTA16016,015
Isoform 3 [UniParc].

Checksum: 5FE324D366C63D85
Show »

FASTA16917,128

References

« Hide 'large scale' references
[1]"The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product."
Gelin C., Aubrit F., Phalipon A., Raynal B., Cole S., Kaczorek M., Bernard A.
EMBO J. 8:3253-3259(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I), PROTEIN SEQUENCE OF 23-39.
Tissue: T-cell.
[2]"An alternative splicing form of CD99 (MIC2)."
Park S.H., Hahn J.H., Kim M.K., Sohn H.W., Choi E.Y., Kim S.H.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM II).
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
[4]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS I AND 3).
Tissue: Brain, Kidney, Lung carcinoma, Skin and Uterus.
[7]"Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes."
Darling S.M., Goodfellow P.J., Pym B., Banting G.S., Pritchard C., Goodfellow P.N.
Cold Spring Harb. Symp. Quant. Biol. 51:205-212(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-105.
[8]"Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome."
Goodfellow P.J., Mondello C., Darling S.M., Pym B., Little P., Goodfellow P.N.
Proc. Natl. Acad. Sci. U.S.A. 85:5605-5609(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16996 mRNA. Translation: CAA34863.1.
U82164 mRNA. Translation: AAB58501.1.
CR450286 mRNA. Translation: CAG29282.1.
AC006209 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98697.1.
CH471074 Genomic DNA. Translation: EAW98698.1.
BC002584 mRNA. Translation: AAH02584.1.
BC003147 mRNA. Translation: AAH03147.1.
BC010109 mRNA. Translation: AAH10109.1.
BC021620 mRNA. Translation: AAH21620.1.
BC024310 mRNA. Translation: AAH24310.1.
BQ948496 mRNA. No translation available.
M16279 mRNA. Translation: AAA02999.1.
J03841 Genomic DNA. Translation: AAA59848.1.
CCDSCCDS14119.1. [P14209-1]
CCDS48071.1. [P14209-3]
PIRA60592. S06786.
RefSeqNP_001116370.1. NM_001122898.1. [P14209-3]
NP_001264639.1. NM_001277710.1. [P14209-2]
NP_002405.1. NM_002414.3. [P14209-1]
XP_005274592.1. XM_005274535.2. [P14209-2]
XP_005274856.1. XM_005274799.2. [P14209-2]
UniGeneHs.653349.

3D structure databases

ProteinModelPortalP14209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110420. 11 interactions.
IntActP14209. 4 interactions.
MINTMINT-5004058.
STRING9606.ENSP00000370588.

PTM databases

PhosphoSiteP14209.

Polymorphism databases

DMDM119049.

Proteomic databases

MaxQBP14209.
PaxDbP14209.
PRIDEP14209.

Protocols and materials databases

DNASU4267.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381187; ENSP00000370582; ENSG00000002586. [P14209-3]
ENST00000381192; ENSP00000370588; ENSG00000002586. [P14209-1]
GeneID4267.
KEGGhsa:4267.
UCSCuc004cqm.3. human. [P14209-1]
uc004cqn.4. human. [P14209-2]
uc010nda.3. human.

Organism-specific databases

CTD4267.
GeneCardsGC0XP002602.
H-InvDBHIX0177591.
HGNCHGNC:7082. CD99.
HPACAB000020.
HPA035304.
MIM313470. gene.
450000. gene.
neXtProtNX_P14209.
PharmGKBPA30804.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68406.
HOGENOMHOG000233665.
HOVERGENHBG067989.
InParanoidP14209.
KOK06520.
OMAESHRNAN.
OrthoDBEOG7QK0GC.
PhylomeDBP14209.
TreeFamTF336273.

Gene expression databases

ArrayExpressP14209.
BgeeP14209.
CleanExHS_CD99.
GenevestigatorP14209.

Family and domain databases

InterProIPR022078. CD99L2.
[Graphical view]
PfamPF12301. CD99L2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD99.
GenomeRNAi4267.
NextBio16815.
PMAP-CutDBP14209.
PROP14209.
SOURCESearch...

Entry information

Entry nameCD99_HUMAN
AccessionPrimary (citable) accession number: P14209
Secondary accession number(s): A6NIW1, O00518, Q6ICV7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries