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Protein

CD99 antigen

Gene

CD99

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).By similarity

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen
Alternative name(s):
12E7
E2 antigen
Protein MIC2
T-cell surface glycoprotein E2
CD_antigen: CD99
Gene namesi
Name:CD99
Synonyms:MIC2, MIC2X, MIC2Y
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000002586.18
HGNCiHGNC:7082 CD99
MIMi313470 gene
450000 gene
neXtProtiNX_P14209

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 122ExtracellularSequence analysisAdd BLAST100
Transmembranei123 – 147HelicalSequence analysisAdd BLAST25
Topological domaini148 – 185CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4267
OpenTargetsiENSG00000002586
PharmGKBiPA30804

Polymorphism and mutation databases

BioMutaiCD99
DMDMi119049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000002172623 – 185CD99 antigenAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphoserineCombined sources1
Modified residuei181PhosphothreonineCombined sources1

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP14209
MaxQBiP14209
PaxDbiP14209
PeptideAtlasiP14209
PRIDEiP14209

PTM databases

iPTMnetiP14209
PhosphoSitePlusiP14209
SwissPalmiP14209

Miscellaneous databases

PMAP-CutDBP14209

Expressioni

Gene expression databases

BgeeiENSG00000002586
CleanExiHS_CD99
ExpressionAtlasiP14209 baseline and differential
GenevisibleiP14209 HS

Organism-specific databases

HPAiCAB000020
HPA035304

Interactioni

Protein-protein interaction databases

BioGridi110420, 15 interactors
IntActiP14209, 9 interactors
STRINGi9606.ENSP00000370588

Structurei

3D structure databases

ProteinModelPortaliP14209
SMRiP14209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J50K Eukaryota
ENOG410YW6Q LUCA
GeneTreeiENSGT00730000111585
HOGENOMiHOG000233665
HOVERGENiHBG067989
InParanoidiP14209
KOiK06520
OMAiMESHRNA
PhylomeDBiP14209
TreeFamiTF336273

Family and domain databases

InterProiView protein in InterPro
IPR022078 CD99L2
PANTHERiPTHR15076 PTHR15076, 1 hit
PfamiView protein in Pfam
PF12301 CD99L2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform I (identifier: P14209-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG
60 70 80 90 100
DDFDLGDAVV DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS
110 120 130 140 150
GGEGKGGSDG GGSHRKEGEE ADAPGVIPGI VGAVVVAVAG AISSFIAYQK
160 170 180
KKLCFKENAE QGEVDMESHR NANAEPAVQR TLLEK
Length:185
Mass (Da):18,848
Last modified:January 1, 1990 - v1
Checksum:iC302E09E6B022EAB
GO
Isoform II (identifier: P14209-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG

Show »
Length:160
Mass (Da):16,015
Checksum:i2BA54D31B410CAA8
GO
Isoform 3 (identifier: P14209-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-49: Missing.

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):17,128
Checksum:i5FE324D366C63D85
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014733166M → V. Corresponds to variant dbSNP:rs4793Ensembl.1
Natural variantiVAR_014734173N → I. Corresponds to variant dbSNP:rs4717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04631534 – 49Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_004324159 – 185AEQGE…TLLEK → DG in isoform II. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16996 mRNA Translation: CAA34863.1
U82164 mRNA Translation: AAB58501.1
CR450286 mRNA Translation: CAG29282.1
AC006209 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98697.1
CH471074 Genomic DNA Translation: EAW98698.1
BC002584 mRNA Translation: AAH02584.1
BC003147 mRNA Translation: AAH03147.1
BC010109 mRNA Translation: AAH10109.1
BC021620 mRNA Translation: AAH21620.1
BC024310 mRNA Translation: AAH24310.1
BQ948496 mRNA No translation available.
M16279 mRNA Translation: AAA02999.1
J03841 Genomic DNA Translation: AAA59848.1
CCDSiCCDS14119.1 [P14209-1]
CCDS48071.1 [P14209-3]
CCDS75947.1 [P14209-2]
PIRiS06786 A60592
RefSeqiNP_001116370.1, NM_001122898.2 [P14209-3]
NP_001308296.1, NM_001321367.1 [P14209-2]
NP_001308297.1, NM_001321368.1
NP_001308298.1, NM_001321369.1
NP_002405.1, NM_002414.4 [P14209-1]
UniGeneiHs.653349

Genome annotation databases

EnsembliENST00000381187; ENSP00000370582; ENSG00000002586 [P14209-3]
ENST00000381192; ENSP00000370588; ENSG00000002586 [P14209-1]
ENST00000611428; ENSP00000479999; ENSG00000002586 [P14209-2]
ENST00000623253; ENSP00000485545; ENSG00000002586 [P14209-2]
GeneIDi4267
KEGGihsa:4267
UCSCiuc004cqm.4 human [P14209-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD99_HUMAN
AccessioniPrimary (citable) accession number: P14209
Secondary accession number(s): A6NIW1, O00518, Q6ICV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 28, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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