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P14209

- CD99_HUMAN

UniProt

P14209 - CD99_HUMAN

Protein

CD99 antigen

Gene

CD99

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD99 antigen
    Alternative name(s):
    12E7
    E2 antigen
    Protein MIC2
    T-cell surface glycoprotein E2
    CD_antigen: CD99
    Gene namesi
    Name:CD99
    Synonyms:MIC2, MIC2X, MIC2Y
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:7082. CD99.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 185163CD99 antigenPRO_0000021726Add
    BLAST

    Post-translational modificationi

    Extensively O-glycosylated.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP14209.
    PaxDbiP14209.
    PRIDEiP14209.

    PTM databases

    PhosphoSiteiP14209.

    Miscellaneous databases

    PMAP-CutDBP14209.

    Expressioni

    Gene expression databases

    ArrayExpressiP14209.
    BgeeiP14209.
    CleanExiHS_CD99.
    GenevestigatoriP14209.

    Organism-specific databases

    HPAiCAB000020.
    HPA035304.

    Interactioni

    Protein-protein interaction databases

    BioGridi110420. 11 interactions.
    IntActiP14209. 4 interactions.
    MINTiMINT-5004058.
    STRINGi9606.ENSP00000370588.

    Structurei

    3D structure databases

    ProteinModelPortaliP14209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 122100ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 18538CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei123 – 14725HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CD99 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68406.
    HOGENOMiHOG000233665.
    HOVERGENiHBG067989.
    InParanoidiP14209.
    KOiK06520.
    OMAiESHRNAN.
    OrthoDBiEOG7QK0GC.
    PhylomeDBiP14209.
    TreeFamiTF336273.

    Family and domain databases

    InterProiIPR022078. CD99L2.
    [Graphical view]
    PfamiPF12301. CD99L2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform I (identifier: P14209-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG    50
    DDFDLGDAVV DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS 100
    GGEGKGGSDG GGSHRKEGEE ADAPGVIPGI VGAVVVAVAG AISSFIAYQK 150
    KKLCFKENAE QGEVDMESHR NANAEPAVQR TLLEK 185
    Length:185
    Mass (Da):18,848
    Last modified:January 1, 1990 - v1
    Checksum:iC302E09E6B022EAB
    GO
    Isoform II (identifier: P14209-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG

    Show »
    Length:160
    Mass (Da):16,015
    Checksum:i2BA54D31B410CAA8
    GO
    Isoform 3 (identifier: P14209-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-49: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:169
    Mass (Da):17,128
    Checksum:i5FE324D366C63D85
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti166 – 1661M → V.
    Corresponds to variant rs11556080 [ dbSNP | Ensembl ].
    VAR_014733
    Natural varianti173 – 1731N → I.
    Corresponds to variant rs4717 [ dbSNP | Ensembl ].
    VAR_014734

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei34 – 4916Missing in isoform 3. 1 PublicationVSP_046315Add
    BLAST
    Alternative sequencei159 – 18527AEQGE…TLLEK → DG in isoform II. 1 PublicationVSP_004324Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16996 mRNA. Translation: CAA34863.1.
    U82164 mRNA. Translation: AAB58501.1.
    CR450286 mRNA. Translation: CAG29282.1.
    AC006209 Genomic DNA. No translation available.
    CH471074 Genomic DNA. Translation: EAW98697.1.
    CH471074 Genomic DNA. Translation: EAW98698.1.
    BC002584 mRNA. Translation: AAH02584.1.
    BC003147 mRNA. Translation: AAH03147.1.
    BC010109 mRNA. Translation: AAH10109.1.
    BC021620 mRNA. Translation: AAH21620.1.
    BC024310 mRNA. Translation: AAH24310.1.
    BQ948496 mRNA. No translation available.
    M16279 mRNA. Translation: AAA02999.1.
    J03841 Genomic DNA. Translation: AAA59848.1.
    CCDSiCCDS14119.1. [P14209-1]
    CCDS48071.1. [P14209-3]
    PIRiS06786. A60592.
    RefSeqiNP_001116370.1. NM_001122898.1. [P14209-3]
    NP_001264639.1. NM_001277710.1. [P14209-2]
    NP_002405.1. NM_002414.3. [P14209-1]
    XP_005274592.1. XM_005274535.2. [P14209-2]
    XP_005274856.1. XM_005274799.2. [P14209-2]
    UniGeneiHs.653349.

    Genome annotation databases

    EnsembliENST00000381187; ENSP00000370582; ENSG00000002586. [P14209-3]
    ENST00000381192; ENSP00000370588; ENSG00000002586. [P14209-1]
    GeneIDi4267.
    KEGGihsa:4267.
    UCSCiuc004cqm.3. human. [P14209-1]
    uc004cqn.4. human. [P14209-2]
    uc010nda.3. human.

    Polymorphism databases

    DMDMi119049.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16996 mRNA. Translation: CAA34863.1 .
    U82164 mRNA. Translation: AAB58501.1 .
    CR450286 mRNA. Translation: CAG29282.1 .
    AC006209 Genomic DNA. No translation available.
    CH471074 Genomic DNA. Translation: EAW98697.1 .
    CH471074 Genomic DNA. Translation: EAW98698.1 .
    BC002584 mRNA. Translation: AAH02584.1 .
    BC003147 mRNA. Translation: AAH03147.1 .
    BC010109 mRNA. Translation: AAH10109.1 .
    BC021620 mRNA. Translation: AAH21620.1 .
    BC024310 mRNA. Translation: AAH24310.1 .
    BQ948496 mRNA. No translation available.
    M16279 mRNA. Translation: AAA02999.1 .
    J03841 Genomic DNA. Translation: AAA59848.1 .
    CCDSi CCDS14119.1. [P14209-1 ]
    CCDS48071.1. [P14209-3 ]
    PIRi S06786. A60592.
    RefSeqi NP_001116370.1. NM_001122898.1. [P14209-3 ]
    NP_001264639.1. NM_001277710.1. [P14209-2 ]
    NP_002405.1. NM_002414.3. [P14209-1 ]
    XP_005274592.1. XM_005274535.2. [P14209-2 ]
    XP_005274856.1. XM_005274799.2. [P14209-2 ]
    UniGenei Hs.653349.

    3D structure databases

    ProteinModelPortali P14209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110420. 11 interactions.
    IntActi P14209. 4 interactions.
    MINTi MINT-5004058.
    STRINGi 9606.ENSP00000370588.

    PTM databases

    PhosphoSitei P14209.

    Polymorphism databases

    DMDMi 119049.

    Proteomic databases

    MaxQBi P14209.
    PaxDbi P14209.
    PRIDEi P14209.

    Protocols and materials databases

    DNASUi 4267.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381187 ; ENSP00000370582 ; ENSG00000002586 . [P14209-3 ]
    ENST00000381192 ; ENSP00000370588 ; ENSG00000002586 . [P14209-1 ]
    GeneIDi 4267.
    KEGGi hsa:4267.
    UCSCi uc004cqm.3. human. [P14209-1 ]
    uc004cqn.4. human. [P14209-2 ]
    uc010nda.3. human.

    Organism-specific databases

    CTDi 4267.
    GeneCardsi GC0XP002602.
    H-InvDB HIX0177591.
    HGNCi HGNC:7082. CD99.
    HPAi CAB000020.
    HPA035304.
    MIMi 313470. gene.
    450000. gene.
    neXtProti NX_P14209.
    PharmGKBi PA30804.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68406.
    HOGENOMi HOG000233665.
    HOVERGENi HBG067989.
    InParanoidi P14209.
    KOi K06520.
    OMAi ESHRNAN.
    OrthoDBi EOG7QK0GC.
    PhylomeDBi P14209.
    TreeFami TF336273.

    Miscellaneous databases

    GeneWikii CD99.
    GenomeRNAii 4267.
    NextBioi 16815.
    PMAP-CutDB P14209.
    PROi P14209.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14209.
    Bgeei P14209.
    CleanExi HS_CD99.
    Genevestigatori P14209.

    Family and domain databases

    InterProi IPR022078. CD99L2.
    [Graphical view ]
    Pfami PF12301. CD99L2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product."
      Gelin C., Aubrit F., Phalipon A., Raynal B., Cole S., Kaczorek M., Bernard A.
      EMBO J. 8:3253-3259(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM I), PROTEIN SEQUENCE OF 23-39.
      Tissue: T-cell.
    2. "An alternative splicing form of CD99 (MIC2)."
      Park S.H., Hahn J.H., Kim M.K., Sohn H.W., Choi E.Y., Kim S.H.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM II).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS I AND 3).
      Tissue: Brain, Kidney, Lung carcinoma, Skin and Uterus.
    7. "Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes."
      Darling S.M., Goodfellow P.J., Pym B., Banting G.S., Pritchard C., Goodfellow P.N.
      Cold Spring Harb. Symp. Quant. Biol. 51:205-212(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-105.
    8. "Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome."
      Goodfellow P.J., Mondello C., Darling S.M., Pym B., Little P., Goodfellow P.N.
      Proc. Natl. Acad. Sci. U.S.A. 85:5605-5609(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCD99_HUMAN
    AccessioniPrimary (citable) accession number: P14209
    Secondary accession number(s): A6NIW1, O00518, Q6ICV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3