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Reviewed, UniProtKB/Swiss-Prot P14209 (CD99_HUMAN)

Last modified November 25, 2008. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CD99 antigen
Alternative name(s):
    T-cell surface glycoprotein E2
    E2 antigen
    Protein MIC2
    12E7
    CD_antigen=CD99
Gene names
Name: CD99
Synonyms: MIC2, MIC2X, MIC2Y
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in T-cell adhesion processes. It is involved in spontaneous rosette formation with erythrocytes.

Subcellular location

Membrane; Single-pass type I membrane proteinPotential.

Post-translational modification

Extensively O-glycosylated.

Miscellaneous

The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Sequence similarities

Belongs to the CD99 family.

Ontologies

Keywords

   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
   PTMGlycoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm Ref.1

Traceable author statement. Source: ProtInc

integral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionprotein binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform I (identifier: P14209-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform II (identifier: P14209-2)

The sequence of this isoform differs from the canonical sequence as follows:
     159-185: AEQGEVDMESHRNANAEPAVQRTLLEK → DG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222
Chain23 – 185163CD99 antigen
PRO_0000021726

Regions

Topological domain23 – 122100Extracellular Potential
Transmembrane123 – 14725 Potential
Topological domain148 – 18538Cytoplasmic Potential

Natural variations

Alternative sequence159 – 18527AEQGE…TLLEK → DG in isoform II.
VSP_004324
Natural variant1661M → V: dbSNP rs4793.
VAR_014733
Natural variant1731N → I: dbSNP rs4717.
VAR_014734

Sequences

Sequence LengthMass (Da)Tools
Isoform I [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: C302E09E6B022EAB

FASTA18518,848
        10         20         30         40         50         60 
MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG DDFDLGDAVV 

        70         80         90        100        110        120 
DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS GGEGKGGSDG GGSHRKEGEE 

       130        140        150        160        170        180 
ADAPGVIPGI VGAVVVAVAG AISSFIAYQK KKLCFKENAE QGEVDMESHR NANAEPAVQR 


TLLEK 

« Hide

Isoform II [UniParc].

Checksum: 2BA54D31B410CAA8
Show »

16016,015

References

« Hide 'large scale' references
[1]"The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product."
Gelin C., Aubrit F., Phalipon A., Raynal B., Cole S., Kaczorek M., Bernard A.
EMBO J. 8:3253-3259(1989) [PubMed: 2479542] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE OF 23-39.
Tissue: T-cell.
[2]"An alternative splicing form of CD99 (MIC2)."
Park S.H., Hahn J.H., Kim M.K., Sohn H.W., Choi E.Y., Kim S.H.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM II).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I).
Tissue: Brain, Kidney, Skin and Uterus.
[4]"Molecular genetics of MIC2: a gene shared by the human X and Y chromosomes."
Darling S.M., Goodfellow P.J., Pym B., Banting G.S., Pritchard C., Goodfellow P.N.
Cold Spring Harb. Symp. Quant. Biol. 51:205-212(1986) [PubMed: 3472717] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-105.
[5]"Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the active X, the inactive X, and the Y chromosome."
Goodfellow P.J., Mondello C., Darling S.M., Pym B., Little P., Goodfellow P.N.
Proc. Natl. Acad. Sci. U.S.A. 85:5605-5609(1988) [PubMed: 2456574] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
+Additional computationally mapped references.

Cross-references

Sequence databases

X16996 mRNA. Translation: CAA34863.1.
U82164 mRNA. Translation: AAB58501.1.
BC002584 mRNA. Translation: AAH02584.1.
BC003147 mRNA. Translation: AAH03147.1.
BC010109 mRNA. Translation: AAH10109.1.
BC021620 mRNA. Translation: AAH21620.1.
BC024310 mRNA. Translation: AAH24310.1.
M16279 mRNA. Translation: AAA02999.1.
J03841 Genomic DNA. Translation: AAA59848.1.
PIRA60592. S06786.
RefSeqNP_001116370.1.
NP_002405.1.
UniGeneHs.654354

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP14209.

Genome annotation databases

EnsemblENSG00000002586. Homo sapiens. [Contig view]
GeneID4267.
KEGGhsa:4267.

Organism-specific databases

H-InvDBHIX0016631.
HGNCHGNC:7082. CD99.
HPACAB000020.
MIM313470. gene.
450000. gene.
PharmGKBPA30804.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP14209.
HOVERGENP14209.

Gene expression databases

ArrayExpressP14209.
CleanExHS_CD99.
GermOnlineENSG00000002586. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

LinkHubP14209.
NextBio16815.
SOURCESearch...

Entry information

Entry nameCD99_HUMAN
AccessionPrimary (citable) accession number: P14209
Secondary accession number(s): O00518
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 25, 2008
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents